Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study.

abstract：RATIONALE:Controlled mechanical ventilation (CMV) results in atrophy of the human diaphragm. The autophagy-lysosome pathway (ALP) contributes to skeletal muscle proteolysis, but its contribution to diaphragmatic protein degradation in mechanically ventilated patients is unknown. OBJECTIVES:To evaluate the autophagy pa...

journal_title：American journal of respiratory and critical care medicine

authors： Hussain SN,Mofarrahi M,Sigala I,Kim HC,Vassilakopoulos T,Maltais F,Bellenis I,Chaturvedi R,Gottfried SB,Metrakos P,Danialou G,Matecki S,Jaber S,Petrof BJ,Goldberg P

更新日期：2010-12-01 00:00:00

abstract：RATIONALE:Secondhand tobacco smoke (SHS) and traffic-related air pollutants are associated with asthma and allergy. Diesel exhaust particles (DEPs) and SHS can interact with allergens in exacerbating allergic airway diseases through generation of reactive oxygen species. Glutathione S-transferases (GSTs) metabolize rea...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Li YF,Gong H Jr,Diaz-Sanchez D

更新日期：2006-12-15 00:00:00

abstract：:Brush cells, also termed tuft, caveolated, multivesicular, and fibrillovesicular cells, are part of the epithelial layer in the gastrointestinal and respiratory tracts. The cells are characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli cont...

journal_title：American journal of respiratory and critical care medicine

authors： Reid L,Meyrick B,Antony VB,Chang LY,Crapo JD,Reynolds HY

更新日期：2005-07-01 00:00:00

abstract：:The place of surgical treatment in obstructive sleep apnea syndrome (OSAS) remains unclear. Uvulopalatopharyngoplasty (UPPP) has a response rate of 41% overall and only 5% when retrolingual narrowing is present. Thus, in cases with suspected hypopharyngeal collapse maxillofacial surgery has been proposed with improved...

journal_title：American journal of respiratory and critical care medicine

authors： Bettega G,Pépin JL,Veale D,Deschaux C,Raphaël B,Lévy P

更新日期：2000-08-01 00:00:00

abstract：:REM-related oxygen desaturation occurs in advanced Duchenne muscular dystrophy (DMD) and might be an independent predictor of disease progression. We have followed 18 patients for 10 yr after an initial respiratory sleep study or until death or onset of nasal ventilation. We measured baseline spirometry, blood gas ten...

journal_title：American journal of respiratory and critical care medicine

authors： Phillips MF,Smith PE,Carroll N,Edwards RH,Calverley PM

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:Asthma treatment might improve when inhaled steroids are titrated on airway inflammation. Fractional exhaled nitric oxide (FeNO0.05), a marker of eosinophilic airway inflammation, can be measured at home. OBJECTIVES:We assessed daily FeNO0.05 telemonitoring in the management of childhood asthma. METHODS:Chi...

journal_title：American journal of respiratory and critical care medicine

authors： de Jongste JC,Carraro S,Hop WC,CHARISM Study Group.,Baraldi E

更新日期：2009-01-15 00:00:00

abstract：:Although transbronchial lung biopsy (TBBx) is widely acknowledged as the "gold standard" for diagnosis of acute rejection, controversy exists regarding the need to perform follow-up procedures. Over a 5-yr period, we performed 1,142 TBBx of which 173 were follow-up TBBx in 99 patients with pulmonary allograft rejectio...

journal_title：American journal of respiratory and critical care medicine

authors： Aboyoun CL,Tamm M,Chhajed PN,Hopkins P,Malouf MA,Rainer S,Glanville AR

更新日期：2001-08-01 00:00:00

abstract：:To compare the effectiveness of information delivered to family members of critically ill patients by junior and senior physicians, we performed a prospective randomized multicenter trial in 11 French intensive care units. Patients (n = 220) were allocated at random to having their family members receive information b...

journal_title：American journal of respiratory and critical care medicine

authors： Moreau D,Goldgran-Toledano D,Alberti C,Jourdain M,Adrie C,Annane D,Garrouste-Orgeas M,Lefrant JY,Papazian L,Quinio P,Pochard F,Azoulay E

更新日期：2004-02-15 00:00:00

abstract：:We aimed to elucidate the relationships between pleural (Ppl), esophageal (Pes), and superimposed gravitational pressures in acute lung injury, and to understand the mechanisms of recruitment and derecruitment. In six dogs with oleic acid respiratory failure, we measured Pes and Ppl in the uppermost, middle, and most ...

journal_title：American journal of respiratory and critical care medicine

authors： Pelosi P,Goldner M,McKibben A,Adams A,Eccher G,Caironi P,Losappio S,Gattinoni L,Marini JJ

更新日期：2001-07-01 00:00:00

abstract：RATIONALE:Clinical benefits of fixed-dose 100-mg subcutaneous (SC) mepolizumab in prednisone-dependent patients are modest when sputum eosinophilia is not adequately controlled. OBJECTIVES:This study compared treatment response of weight-adjusted intravenous (IV) reslizumab in patients previously treated with 100-mg S...

journal_title：American journal of respiratory and critical care medicine

authors： Mukherjee M,Aleman Paramo F,Kjarsgaard M,Salter B,Nair G,LaVigne N,Radford K,Sehmi R,Nair P

更新日期：2018-01-01 00:00:00

abstract：:Measurement of respiratory compliance is advocated for assessing the severity of acute respiratory failure (ARF). Recently, the administration of an automated constant flow of 15 L/min was proposed as a method easier to implement at the bedside than supersyringe or inspiratory occlusions methods. However, pressure-vol...

journal_title：American journal of respiratory and critical care medicine

authors： Lu Q,Vieira SR,Richecoeur J,Puybasset L,Kalfon P,Coriat P,Rouby JJ

更新日期：1999-01-01 00:00:00

abstract：:Alveolar epithelial type II cells (AET2) respond with exocytosis of surfactant containing lamellar bodies to stimulation with mechanical stretch and secretagogues, a process that is fundamental for maintaining alveolar stability and lung gas exchange. In the present study in cultured rat AET2, we employed botulinum C2...

journal_title：American journal of respiratory and critical care medicine

authors： Rose F,Kürth-Landwehr C,Sibelius U,Reuner KH,Aktories K,Seeger W,Grimminger F

更新日期：1999-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a syndrome of chronic wasting, in part associated with a chronic inflammatory response. The aim of this study was to investigate cross-sectionally and prospectively the potential role of leptin in relation to systemic inflammation in the regulation of the energy balance ...

journal_title：American journal of respiratory and critical care medicine

authors： Schols AM,Creutzberg EC,Buurman WA,Campfield LA,Saris WH,Wouters EF

更新日期：1999-10-01 00:00:00

abstract：:The clinical significance of minimal acute rejection (grade A1) in lung transplant recipients is unknown. We prospectively analyzed 1,159 transbronchial lung biopsies in 184 patients. Two hundred seventy-nine biopsies in 128 participants confirmed A1 histology at a mean postoperative day of 229 +/- 340. Sixty four of ...

journal_title：American journal of respiratory and critical care medicine

authors： Hopkins PM,Aboyoun CL,Chhajed PN,Malouf MA,Plit ML,Rainer SP,Glanville AR

更新日期：2004-11-01 00:00:00

abstract：:Heart failure is associated with Cheyne-Stokes breathing, which fragments patients' sleep. Correction of respiratory disturbance may reduce sleep fragmentation and excessive daytime sleepiness. This randomized prospective parallel trial assesses whether nocturnal-assist servoventilation improves daytime sleepiness com...

journal_title：American journal of respiratory and critical care medicine

authors： Pepperell JC,Maskell NA,Jones DR,Langford-Wiley BA,Crosthwaite N,Stradling JR,Davies RJ

更新日期：2003-11-01 00:00:00

abstract：:This prospective community-based study of infants born in inner London was undertaken to examine the association between premorbid airway function and subsequent wheezing in the first year of life and to explore the influence on this association of a family history of asthma and maternal smoking during pregnancy. Heal...

journal_title：American journal of respiratory and critical care medicine

authors： Dezateux C,Stocks J,Dundas I,Fletcher ME

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:Chronic infection with Burkholderia cepacia complex bacteria in cystic fibrosis is associated with accelerated decline in pulmonary function and increased mortality. Clinical implications of the recently characterized genomovar VI, B. dolosa, are unknown. OBJECTIVES:Characterization of impact of B. dolosa on...

journal_title：American journal of respiratory and critical care medicine

authors： Kalish LA,Waltz DA,Dovey M,Potter-Bynoe G,McAdam AJ,Lipuma JJ,Gerard C,Goldmann D

更新日期：2006-02-15 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) has been associated with kidney function loss, which may be related to changes in the renin-angiotensin system (RAS). OBJECTIVES:We sought to determine the effect of continuous positive airway pressure (CPAP) of patients with OSA on renal hemodynamics at baseline and in response...

journal_title：American journal of respiratory and critical care medicine

authors： Nicholl DD,Hanly PJ,Poulin MJ,Handley GB,Hemmelgarn BR,Sola DY,Ahmed SB

更新日期：2014-09-01 00:00:00

abstract：RATIONALE:Airways obstruction with thick, adherent mucus is a pathophysiologic and clinical feature of muco-obstructive respiratory diseases, including chronic obstructive pulmonary disease, asthma, and cystic fibrosis (CF). Mucins, the dominant biopolymer in mucus, organize into complex polymeric networks via the form...

journal_title：American journal of respiratory and critical care medicine

authors： Ehre C,Rushton ZL,Wang B,Hothem LN,Morrison CB,Fontana NC,Markovetz MR,Delion MF,Kato T,Villalon D,Thelin WR,Esther CR Jr,Hill DB,Grubb BR,Livraghi-Butrico A,Donaldson SH,Boucher RC

更新日期：2019-01-15 00:00:00

abstract：:In this study, 12 male baboons were delivered by hysterotomy at 75% of gestation. The development of a nonlethal baboon model permitted a study of lung growth and development in long-term survivors. Control animals were ventilated with clinically appropriate oxygen for the 21 d study period. BPD animals were ventilate...

journal_title：American journal of respiratory and critical care medicine

authors： Coalson JJ,Winter V,deLemos RA

更新日期：1995-08-01 00:00:00

abstract：:Rationale: The management of indeterminate pulmonary nodules (IPNs) remains challenging, resulting in invasive procedures and delays in diagnosis and treatment. Strategies to decrease the rate of unnecessary invasive procedures and optimize surveillance regimens are needed.Objectives: To develop and validate a deep le...

journal_title：American journal of respiratory and critical care medicine

authors： Massion PP,Antic S,Ather S,Arteta C,Brabec J,Chen H,Declerck J,Dufek D,Hickes W,Kadir T,Kunst J,Landman BA,Munden RF,Novotny P,Peschl H,Pickup LC,Santos C,Smith GT,Talwar A,Gleeson F

更新日期：2020-07-15 00:00:00

abstract：RATIONALE:In the absence of a surgical lung biopsy, patients diagnosed with idiopathic pulmonary fibrosis (IPF) in clinical practice could participate in the INPULSIS trials of nintedanib if they had honeycombing and/or traction bronchiectasis plus reticulation, without atypical features of usual interstitial pneumonia...

journal_title：American journal of respiratory and critical care medicine

authors： Raghu G,Wells AU,Nicholson AG,Richeldi L,Flaherty KR,Le Maulf F,Stowasser S,Schlenker-Herceg R,Hansell DM

更新日期：2017-01-01 00:00:00

abstract：RATIONALE:Acute lung injury (ALI) acts as a complex genetic trait, yet its genetic risk factors remain incompletely understood. Large-scale genotyping has not previously been reported for ALI. OBJECTIVES:To identify ALI risk variants after major trauma using a large-scale candidate gene approach. METHODS:We performed...

journal_title：American journal of respiratory and critical care medicine

authors： Meyer NJ,Li M,Feng R,Bradfield J,Gallop R,Bellamy S,Fuchs BD,Lanken PN,Albelda SM,Rushefski M,Aplenc R,Abramova H,Atochina-Vasserman EN,Beers MF,Calfee CS,Cohen MJ,Pittet JF,Christiani DC,O'Keefe GE,Ware LB,May AK

更新日期：2011-05-15 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with systemic hypertension. Either overnight intermittent hypoxia, or the recurrent arousals that occur in OSA, could cause the daytime increases in blood pressure (BP). OBJECTIVES:To establish the role of intermittent hypoxia in the increased morning BP in patient...

journal_title：American journal of respiratory and critical care medicine

authors： Turnbull CD,Sen D,Kohler M,Petousi N,Stradling JR

更新日期：2019-01-15 00:00:00

abstract：:Several studies have found that sleep deprivation reduces the hypercapnic ventilatory response (HCVR). Such results may have been affected by uncontrolled activities or environmental influences during the sleep deprivation period. The current study determined the "pure" effect of sleep deprivation on respiratory contr...

journal_title：American journal of respiratory and critical care medicine

authors： Spengler CM,Shea SA

更新日期：2000-04-01 00:00:00

abstract：:From an Aspergillus fumigatus complementary deoxyribonucleic acid (cDNA) library displayed on phage surface, an allergen formally termed rAsp f 3 was cloned. The open-reading frame of the cloned gene for the allergen encodes a protein of 168 amino acids with a predicted molecular mass of 18.5 kD, showing 36% identity ...

journal_title：American journal of respiratory and critical care medicine

authors： Hemmann S,Blaser K,Crameri R

更新日期：1997-12-01 00:00:00

abstract：:We tested the hypothesis that hyperresponsiveness of the upper airway (UAHR) is present in patients with chronic cough of diverse etiology. We determined the frequency of bronchial hyperresponsiveness (BHR), hyperresponsiveness of the upper airway, sputum eosinophilia, pulmonary aspiration, and psychological symptoms ...

journal_title：American journal of respiratory and critical care medicine

authors： Carney IK,Gibson PG,Murree-Allen K,Saltos N,Olson LG,Hensley MJ

更新日期：1997-07-01 00:00:00

abstract：:The effects of glutathione-S-transferase (GST) M1, GSTT1, and GSTP1 genotypes on lung function growth were investigated in 1,940 children enrolled in the Children's Health Study as fourth graders (aged 8-11 years) in two cohorts during 1993 and 1996 and were followed annually over a 4-year period. Genotypes for GSTM1 ...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Gauderman WJ,Vora H,Rappaport E,Dubeau L

更新日期：2002-09-01 00:00:00

abstract：RATIONALE:Despite intensive research, sepsis displays the most prevalent cause of death on intensive care units. The hallmark of sepsis is an overshooting T-cell death that reduces host defense mechanisms and that is associated with poor patient survival. Previous in vitro studies revealed that the expression of the tr...

journal_title：American journal of respiratory and critical care medicine

authors： Schmidt MV,Paulus P,Kuhn AM,Weigert A,Morbitzer V,Zacharowski K,Kempf VA,Brüne B,von Knethen A

更新日期：2011-07-01 00:00:00

abstract：:In a prospective, controlled, and randomized clinical trial, we examined the effects of treatment with vitamin D (1,000 IU/d), calcium (1 g/d), and ethane-1-hydroxy-1,1-diphosphonate (EHDP; 7.5 mg/kg body weight) on vertebral bone mass in fourteen asthmatics undergoing long-term treatment with systemically applied cor...

journal_title：American journal of respiratory and critical care medicine

authors： Worth H,Stammen D,Keck E

更新日期：1994-08-01 00:00:00