The mysterious pulmonary brush cell: a cell in search of a function.

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening, interstitial lung disease of unknown etiology. The median survival of patients with IPF is only 2 to 3 years, yet some patients live much longer. Respiratory failure resulting from disease progression is the most frequent cause of death. To date w...

journal_title：American journal of respiratory and critical care medicine

authors： Ley B,Collard HR,King TE Jr

更新日期：2011-02-15 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is hypothesized to be influenced by genes within pathways involved with obesity, craniofacial development, inflammation, and ventilatory control. OBJECTIVES:We conducted the first candidate gene study of OSA using family data from European Americans and African Americans, select...

journal_title：American journal of respiratory and critical care medicine

authors： Larkin EK,Patel SR,Goodloe RJ,Li Y,Zhu X,Gray-McGuire C,Adams MD,Redline S

更新日期：2010-10-01 00:00:00

abstract：:Allergen-induced bronchoconstriction involves mast cell activation. Tryptase is a mast cell serine protease that is released during this process, but little is known about the action of tryptase in the airway. The purpose of this study was to determine: (1) if aerosolized tryptase causes bronchoconstriction, and (2) t...

journal_title：American journal of respiratory and critical care medicine

authors： Molinari JF,Scuri M,Moore WR,Clark J,Tanaka R,Abraham WM

更新日期：1996-09-01 00:00:00

abstract：:A major cause of morbidity and mortality following lung transplantation is posttransplant lymphoproliferative disease (PTLD). In a retrospective cohort analysis of pediatric patients, we evaluated the risk factors associated with PTLD in 128 first-time lung transplant recipients from 1990 to 1997. The greatest risk fa...

journal_title：American journal of respiratory and critical care medicine

authors： Cohen AH,Sweet SC,Mendeloff E,Mallory GB Jr,Huddleston CB,Kraus M,Kelly M,Hayashi R,DeBaun MR

更新日期：2000-04-01 00:00:00

abstract：:Rationale: Recent studies have demonstrated that extracellular vesicles (EVs) released during acute lung injury (ALI) were inflammatory.Objectives: The current study was undertaken to test the role of EVs induced and released from severe Escherichia coli pneumonia (E. coli EVs) in the pathogenesis of ALI and to determ...

journal_title：American journal of respiratory and critical care medicine

authors： Liu A,Park JH,Zhang X,Sugita S,Naito Y,Lee JH,Kato H,Hao Q,Matthay MA,Lee JW

更新日期：2019-11-15 00:00:00

abstract：RATIONALE:Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community. OBJECTIVES:To determine whether lung transplant recipients can be chronically infected by rhinovirus and the potential clinical impact. METHODS:We first ide...

journal_title：American journal of respiratory and critical care medicine

authors： Kaiser L,Aubert JD,Pache JC,Deffernez C,Rochat T,Garbino J,Wunderli W,Meylan P,Yerly S,Perrin L,Letovanec I,Nicod L,Tapparel C,Soccal PM

更新日期：2006-12-15 00:00:00

abstract：:Pleural disease both before and after organ transplantation has important implications. Pleural effusions are common in candidates for heart, liver, and kidney transplantation. A thoracentesis is not mandatory in these patients, but it should be performed if clinical or radiologic features suggest that the effusion is...

journal_title：American journal of respiratory and critical care medicine

authors： Judson MA,Sahn SA

更新日期：1996-03-01 00:00:00

abstract：:We examined the efficacy and the acceptance of an oral device (SnorEx) causing a forward displacement of the tongue for the treatment of sleep-disordered breathing (SDB). Twenty-three consecutive subjects with SDB were investigated. Noncompliance (NC) of use of the oral appliance was observed in 74% (17 of 23) of the ...

journal_title：American journal of respiratory and critical care medicine

authors： Schönhofer B,Stoohs RA,Rager H,Wenzel M,Wenzel G,Köhler D

更新日期：1997-02-01 00:00:00

abstract：RATIONALE:Immunophenotypes of antiviral responses, and their relationship with asthma, allergy, and lower respiratory tract infections, are poorly understood. OBJECTIVES:We characterized multiple cytokine responses of peripheral blood mononuclear cells to rhinovirus stimulation, and their relationship with clinical ou...

journal_title：American journal of respiratory and critical care medicine

authors： Custovic A,Belgrave D,Lin L,Bakhsoliani E,Telcian AG,Solari R,Murray CS,Walton RP,Curtin J,Edwards MR,Simpson A,Rattray M,Johnston SL

更新日期：2018-05-15 00:00:00

abstract：RATIONALE:Exposure to combustion-derived air pollution is associated with an early (1-2 h) and sustained (24 h) rise in cardiovascular morbidity and mortality. We have previously demonstrated that inhalation of diesel exhaust causes an immediate (within 2 h) impairment of vascular and endothelial function in humans. O...

journal_title：American journal of respiratory and critical care medicine

authors： Törnqvist H,Mills NL,Gonzalez M,Miller MR,Robinson SD,Megson IL,Macnee W,Donaldson K,Söderberg S,Newby DE,Sandström T,Blomberg A

更新日期：2007-08-15 00:00:00

abstract：:The renin angiotensin system plays an important role in the development of pulmonary artery remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary hypertension as may occur in patients with COPD. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T...

journal_title：American journal of respiratory and critical care medicine

authors： van Suylen RJ,Wouters EF,Pennings HJ,Cheriex EC,van Pol PE,Ambergen AW,Vermelis AM,Daemen MJ

更新日期：1999-06-01 00:00:00

abstract：:We surveyed pulmonologists to determine which procedures they do in practice, where they learned the procedures, and how much training they recommend to attain and maintain clinical competence in each. We mailed a survey to a random sample of 1,000 members of the American College of Physicians who were identified as p...

journal_title：American journal of respiratory and critical care medicine

authors： Tape TG,Blank LL,Wigton RS

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:The perception of dyspnea and pain show many similarities. Initial imaging studies suggested an important role of the insular cortex for the perception of both sensations. However, little is known about the cortical processing of dyspnea. OBJECTIVES:This study investigated the influence of lesions of the ins...

journal_title：American journal of respiratory and critical care medicine

authors： Schön D,Rosenkranz M,Regelsberger J,Dahme B,Büchel C,von Leupoldt A

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:Corticosteroids are the antiinflammatory treatment of choice in asthma. Treatment guidelines are mainly symptom-driven but symptoms are not closely related to airway inflammation. The fraction of nitric oxide in exhaled air (FENO) is a marker of airway inflammation in asthma. OBJECTIVE:We evaluated whether t...

journal_title：American journal of respiratory and critical care medicine

authors： Pijnenburg MW,Bakker EM,Hop WC,De Jongste JC

更新日期：2005-10-01 00:00:00

abstract：:In animal models of endotoxemia, sepsis is associated with the accumulation of leukocytes and altered microvascular perfusion. In order to test the hypothesis that bacterial sepsis upregulates leukocyte-endothelial adhesion, we used intravital microscopy to examine the flow behavior of leukocytes in the postcapillary ...

journal_title：American journal of respiratory and critical care medicine

authors： Piper RD,Pitt-Hyde ML,Anderson LA,Sibbald WJ,Potter RF

更新日期：1998-01-01 00:00:00

abstract：:We investigated whether exposure to ozone (O(3)) 24 hours after an allergen challenge test would increase airway eosinophilia induced by allergen in subjects with mild asthma with late airway response. Twelve subjects with mild atopic asthma participated in a randomized, single-blind study. Subjects underwent allergen...

journal_title：American journal of respiratory and critical care medicine

authors： Vagaggini B,Taccola M,Cianchetti S,Carnevali S,Bartoli ML,Bacci E,Dente FL,Di Franco A,Giannini D,Paggiaro PL

更新日期：2002-10-15 00:00:00

abstract：:Background: This document provides clinical recommendations for the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). It represents a collaborative effort on the part of a panel of expert COPD clinicians and researchers along with a team of methodologists under the guidance of the American Thora...

journal_title：American journal of respiratory and critical care medicine

authors： Nici L,Mammen MJ,Charbek E,Alexander PE,Au DH,Boyd CM,Criner GJ,Donaldson GC,Dreher M,Fan VS,Gershon AS,Han MK,Krishnan JA,Martinez FJ,Meek PM,Morgan M,Polkey MI,Puhan MA,Sadatsafavi M,Sin DD,Washko GR,Wedzicha

更新日期：2020-05-01 00:00:00

abstract：RATIONALE:Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of renal endothelial cell injury) associated with hypoxemia. OBJECTIVES:To determine whether (1) cigarette smoke (CS)-induced pulmonary and renal endothelial cell injury explains the association between albumin...

journal_title：American journal of respiratory and critical care medicine

authors： Polverino F,Laucho-Contreras ME,Petersen H,Bijol V,Sholl LM,Choi ME,Divo M,Pinto-Plata V,Chetta A,Tesfaigzi Y,Celli BR,Owen CA

更新日期：2017-06-01 00:00:00

abstract：RATIONALE:Limited information exists on the prevalence of tuberculosis and adequacy of case finding in African populations with high rates of HIV. OBJECTIVES:To estimate the prevalence of bacteriologically confirmed pulmonary tuberculosis (PTB) and the fraction attributable to HIV, and to evaluate case detection. MET...

journal_title：American journal of respiratory and critical care medicine

authors： van't Hoog AH,Laserson KF,Githui WA,Meme HK,Agaya JA,Odeny LO,Muchiri BG,Marston BJ,DeCock KM,Borgdorff MW

更新日期：2011-05-01 00:00:00

abstract：:We have recently demonstrated the development of systemic hypertension in a canine model of obstructive sleep apnea (OSA), but the underlying physiological mechanisms were not identified. Therefore, the purpose of this study was to examine the effect of OSA on arterial baroreceptor control of heart rate (HR) in this c...

journal_title：American journal of respiratory and critical care medicine

authors： Brooks D,Horner RL,Floras JS,Kozar LF,Render-Teixeira CL,Phillipson EA

更新日期：1999-04-01 00:00:00

abstract：:A histologic feature of usual interstitial pneumonia is the presence of fibroblastic foci. As some patients with usual interstitial pneumonia and an underlying collagen vascular disease have a better prognosis, we hypothesized that they would have fewer fibroblastic foci. Pathologists reviewed surgical lung biopsies f...

journal_title：American journal of respiratory and critical care medicine

authors： Flaherty KR,Colby TV,Travis WD,Toews GB,Mumford J,Murray S,Thannickal VJ,Kazerooni EA,Gross BH,Lynch JP 3rd,Martinez FJ

更新日期：2003-05-15 00:00:00

abstract：:We measured the plasma levels of adrenomedullin (AM), a novel vasodilating peptide, in 89 patients with various forms of systemic inflammatory response syndrome (SIRS) and 13 healthy volunteers serving as controls. Plasma levels of AM in SIRS (burns: 20.5 +/- 3. 2 fmol/ml [mean +/- SEM]; pancreatitis: 13.8 +/- 3.8 fmo...

journal_title：American journal of respiratory and critical care medicine

authors： Ueda S,Nishio K,Minamino N,Kubo A,Akai Y,Kangawa K,Matsuo H,Fujimura Y,Yoshioka A,Masui K,Doi N,Murao Y,Miyamoto S

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:Pure oxygen causes more oxidative stress than room air in resuscitation of asphyctic neonates, and consequently could be associated with increased tissue damage. OBJECTIVES:To compare damage caused to heart and kidneys on reoxygenation in severely asphyctic term neonates resuscitated with room air (RAR) or 1...

journal_title：American journal of respiratory and critical care medicine

authors： Vento M,Sastre J,Asensi MA,Viña J

更新日期：2005-12-01 00:00:00

abstract：RATIONALE:The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson, Arizona, we previously described four phenotypes based on the occurrence of wheezing lower respiratory illnesses before ...

journal_title：American journal of respiratory and critical care medicine

authors： Morgan WJ,Stern DA,Sherrill DL,Guerra S,Holberg CJ,Guilbert TW,Taussig LM,Wright AL,Martinez FD

更新日期：2005-11-15 00:00:00

abstract：:The role of nitric oxide (NO) in the host-defense against human tuberculosis (TB) is controversial. Although experimental evidence indicates that NO may play an important role in controlling TB, its expression in human tuberculous lungs has not been systematically characterized. We therefore investigated the expressio...

journal_title：American journal of respiratory and critical care medicine

authors： Choi HS,Rai PR,Chu HW,Cool C,Chan ED

更新日期：2002-07-15 00:00:00

abstract：RATIONALE:Numerous studies have been published on the new Mycobacterium tuberculosis (MTB)-specific IFN-gamma release assays. However, their prognostic value for progression from latent tuberculosis infection (LTBI) to active TB has yet to be established. OBJECTIVES:To compare the QuantiFERON-TB Gold In-Tube assay (QF...

journal_title：American journal of respiratory and critical care medicine

authors： Diel R,Loddenkemper R,Meywald-Walter K,Niemann S,Nienhaus A

更新日期：2008-05-15 00:00:00

abstract：:Genes for the chemokine receptors CCR5 and CCR2 are characterized by polymorphisms resulting in a nonfunctional receptor expression. Ligands for CCR2 and CCR5 (chemokines monocyte chemotactic protein-1 [MCP-1] and RANTES) are implicated in the pathogenesis of sarcoidosis. We have, therefore, analyzed polymorphisms of ...

journal_title：American journal of respiratory and critical care medicine

authors： Petrek M,Drábek J,Kolek V,Zlámal J,Welsh KI,Bunce M,Weigl E,Du Bois R

更新日期：2000-09-01 00:00:00

abstract：:The respiratory-related evoked potential (RREP) is the electroencephalographic response to brief inspiratory occlusion. The P3 component of the response reflects the active cognitive processing of stimulus information. This study investigated the RREP in 16 subjects with asthma and 16 control subjects. In addition, au...

journal_title：American journal of respiratory and critical care medicine

authors： Webster KE,Colrain IM

更新日期：2002-07-01 00:00:00

abstract：RATIONALE:Tidal volume and plateau pressure limitation decreases mortality in acute respiratory distress syndrome. Computed tomography demonstrated a small, normally aerated compartment on the top of poorly aerated and nonaerated compartments that may be hyperinflated by tidal inflation. OBJECTIVES:We hypothesized tha...

journal_title：American journal of respiratory and critical care medicine

authors： Terragni PP,Rosboch G,Tealdi A,Corno E,Menaldo E,Davini O,Gandini G,Herrmann P,Mascia L,Quintel M,Slutsky AS,Gattinoni L,Ranieri VM

更新日期：2007-01-15 00:00:00

abstract：RATIONALE:The airway surface liquid, the thin layer of liquid covering the airways, is essential for mucociliary clearance and as a barrier against microbial and other noxious agents. Proteins secreted into the airway surface liquid by epithelial and nonepithelial cells may be important in innate immunity and to improv...

journal_title：American journal of respiratory and critical care medicine

authors： Candiano G,Bruschi M,Pedemonte N,Caci E,Liberatori S,Bini L,Pellegrini C,Viganò M,O'Connor BJ,Lee TH,Galietta LJ,Zegarra-Moran O

更新日期：2005-11-01 00:00:00