Sleep deprivation per se does not decrease the hypercapnic ventilatory response in humans.

abstract：:The physiopathology of chronic cough remains obscure. We evaluated the possibility that chronic cough in nonasthmatic subjects is associated with airway inflammation, and if this is so, what the relationship between this inflammation and the possible etiology of cough might be, as well as its response to inhaled stero...

journal_title：American journal of respiratory and critical care medicine

authors： Boulet LP,Milot J,Boutet M,St Georges F,Laviolette M

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:There is conflicting information about the development and resolution of airway inflammation and airway hyperresponsiveness (AHR) after repeated airway exposure to allergen in sensitized mice. METHODS:Sensitized BALB/c and C57BL/6 mice were exposed to repeated allergen challenge on 3, 7, or 11 occasions. Air...

journal_title：American journal of respiratory and critical care medicine

authors： Koya T,Kodama T,Takeda K,Miyahara N,Yang ES,Taube C,Joetham A,Park JW,Dakhama A,Gelfand EW

更新日期：2006-01-01 00:00:00

abstract：RATIONALE:The vast majority of children around the world undergoing adenotonsillectomy for obstructive sleep apnea-hypopnea syndrome (OSA) are not objectively diagnosed by nocturnal polysomnography because of access availability and cost issues. Automated analysis of nocturnal oximetry (nSpO2), which is readily and glo...

journal_title：American journal of respiratory and critical care medicine

authors： Hornero R,Kheirandish-Gozal L,Gutiérrez-Tobal GC,Philby MF,Alonso-Álvarez ML,Álvarez D,Dayyat EA,Xu Z,Huang YS,Tamae Kakazu M,Li AM,Van Eyck A,Brockmann PE,Ehsan Z,Simakajornboon N,Kaditis AG,Vaquerizo-Villar F,Crespo S

更新日期：2017-12-15 00:00:00

abstract：:We investigated the source of intravascular fat in systemic organs (brain, heart, and kidney) after massive pulmonary fat embolism during cemented arthroplasty. We used a bilateral cemented arthroplasty (BCA) in anesthetized mongrel dogs that simulates a cemented total-hip replacement procedure. We hypothesized that d...

journal_title：American journal of respiratory and critical care medicine

authors： Byrick RJ,Mullen JB,Mazer CD,Guest CB

更新日期：1994-11-01 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：:From an Aspergillus fumigatus complementary deoxyribonucleic acid (cDNA) library displayed on phage surface, an allergen formally termed rAsp f 3 was cloned. The open-reading frame of the cloned gene for the allergen encodes a protein of 168 amino acids with a predicted molecular mass of 18.5 kD, showing 36% identity ...

journal_title：American journal of respiratory and critical care medicine

authors： Hemmann S,Blaser K,Crameri R

更新日期：1997-12-01 00:00:00

abstract：RATIONALE:The rapid diagnosis of pulmonary tuberculosis (TB) is difficult when acid fast bacilli (AFB) cannot be detected in sputum smears. OBJECTIVES:Following a proof of principle study, we examined in routine clinical practice whether individuals with sputum AFB smear-negative TB can be discriminated from those wit...

journal_title：American journal of respiratory and critical care medicine

authors： Jafari C,Thijsen S,Sotgiu G,Goletti D,Domínguez Benítez JA,Losi M,Eberhardt R,Kirsten D,Kalsdorf B,Bossink A,Latorre I,Migliori GB,Strassburg A,Winteroll S,Greinert U,Richeldi L,Ernst M,Lange C,Tuberculosis Network Eu

更新日期：2009-10-01 00:00:00

abstract：:Human T lymphotropic virus type I (HTLV-I) is the etiological agent of adult T cell leukemia, and reports suggest that several other clinical conditions are associated with HTLV-I infection, including myelopathy and inflammatory pulmonary diseases. However, the clinical entity of HTLV-I-associated lung disease remains...

journal_title：American journal of respiratory and critical care medicine

authors： Kawakami K,Miyazato A,Iwakura Y,Saito A

更新日期：1999-09-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is associated with significant morbidity and mortality despite aggressive therapy. Thirty-eight patients with biopsy-proven IPF were studied to identify pretreatment features that could be used to predict short-term improvement in pulmonary function and improved longer term survival...

journal_title：American journal of respiratory and critical care medicine

authors： Gay SE,Kazerooni EA,Toews GB,Lynch JP 3rd,Gross BH,Cascade PN,Spizarny DL,Flint A,Schork MA,Whyte RI,Popovich J,Hyzy R,Martinez FJ

更新日期：1998-04-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) has recently been noted to function as a pulmotrophic factor for lung regeneration. The present study was conducted to determine if HGF would be induced in a rat model of pulmonary ischemia-reperfusion (IR) injury, which was established by occlusion of the left lung, and to examine the s...

journal_title：American journal of respiratory and critical care medicine

authors： Yamada T,Hisanaga M,Nakajima Y,Mizuno S,Matsumoto K,Nakamura T,Nakano H

更新日期：2000-08-01 00:00:00

abstract：:The safety of sputum induction and the reproducibility of measurements in induced sputum in multicenter studies is unknown. We examined the safety of sputum induction in a two-visit, six-center study in 79 subjects with moderate to severe asthma (mean +/- SD FEV(1) 71 +/- 12% predicted, 67% taking inhaled corticostero...

journal_title：American journal of respiratory and critical care medicine

authors： Fahy JV,Boushey HA,Lazarus SC,Mauger EA,Cherniack RM,Chinchilli VM,Craig TJ,Drazen JM,Ford JG,Fish JE,Israel E,Kraft M,Lemanske RF,Martin RJ,McLean D,Peters SP,Sorkness C,Szefler SJ,NHLBI Asthma Clinical Research Netw

更新日期：2001-05-01 00:00:00

abstract：:To elucidate which cells are synthesizing tenascin in usual interstitial pneumonia (UIP) we have analyzed thoracoscopic or open lung biopsies from 30 patients with UIP by mRNA in situ hybridization, using (35)S-labeled tenascin RNA probes. The phenotype of the cells expressing tenascin mRNA was confirmed by immunohist...

journal_title：American journal of respiratory and critical care medicine

authors： Pääkkö P,Kaarteenaho-Wiik R,Pöllänen R,Soini Y

更新日期：2000-03-01 00:00:00

abstract：:Effects of nitric oxide (NO) and aerosolized terbutaline inhalation on ventilation-perfusion (VA/Q) distributions were determined during methacholine-induced bronchoconstriction in nine mechanically ventilated pigs. Animals inhaled, in random order, zero, 20, and 80 parts per million (ppm) of NO or aerosolized terbuta...

journal_title：American journal of respiratory and critical care medicine

authors： Putensen C,Räsänen J,López FA

更新日期：1995-01-01 00:00:00

abstract：RATIONALE:The mechanism by which acute allograft rejection leads to chronic rejection remains poorly understood despite its common occurrence. Exosomes, membrane vesicles released from cells within the lung allograft, contain a diverse array of biomolecules that closely reflect the biologic state of the cell and tissue...

journal_title：American journal of respiratory and critical care medicine

authors： Gregson AL,Hoji A,Injean P,Poynter ST,Briones C,Palchevskiy V,Weigt SS,Shino MY,Derhovanessian A,Sayah D,Saggar R,Ross D,Ardehali A,Lynch JP 3rd,Belperio JA

更新日期：2015-12-15 00:00:00

abstract：:alpha-Tocopherol is a potent antioxidant that effectively protects biological membranes against oxidative injury through coordination with ascorbic acid. Because propofol has a phenolic structure similar to that of alpha-tocopherol, this intravenous anesthetic may also have similar antioxidant activity. To test this h...

journal_title：American journal of respiratory and critical care medicine

authors： Tsuchiya M,Asada A,Kasahara E,Sato EF,Shindo M,Inoue M

更新日期：2002-01-01 00:00:00

abstract：:The purpose of this study was to describe the nature of diaphragm injury, to quantify the injury and number of macrophages at the light microscopic level, and to determine their association with airflow obstruction in humans. Partial-thickness diaphragm biopsies were obtained from 21 subjects going for thoracotomy sur...

journal_title：American journal of respiratory and critical care medicine

authors： Macgowan NA,Evans KG,Road JD,Reid WD

更新日期：2001-06-01 00:00:00

abstract：:In patients with chronic obstructive pulmonary disease (COPD) the intensity of aerobic training is limited by dyspnea. Improving strength of the inspiratory muscles could enhance aerobic exercise training by reducing exercise-related dyspnea. We examined effects of home-based inspiratory muscle training (IMT) and cycl...

journal_title：American journal of respiratory and critical care medicine

authors： Larson JL,Covey MK,Wirtz SE,Berry JK,Alex CG,Langbein WE,Edwards L

更新日期：1999-08-01 00:00:00

abstract：:Noninflammatory structural alterations, variously referred to as airway remodeling, are well documented in the asthmatic airway. However, the pathogenesis of these alterations, the importance of airway remodeling in generating the asthma phenotype, and the natural history of airway remodeling responses have not been a...

journal_title：American journal of respiratory and critical care medicine

authors： Zhu Z,Lee CG,Zheng T,Chupp G,Wang J,Homer RJ,Noble PW,Hamid Q,Elias JA

更新日期：2001-11-15 00:00:00

abstract：:POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare variant of plasma cell dyscrasia with multiple systemic manifestations. We followed the progress of 20 patients with POEMS syndrome in our institution over a 10-yr period. Pulmonary hypertension (PH) was ob...

journal_title：American journal of respiratory and critical care medicine

authors： Lesprit P,Godeau B,Authier FJ,Soubrier M,Zuber M,Larroche C,Viard JP,Wechsler B,Gherardi R

更新日期：1998-03-01 00:00:00

abstract：RATIONALE:Pulmonary infection in cystic fibrosis (CF) is polymicrobial and it is possible that anaerobic bacteria, not detected by routine aerobic culture methods, reside within infected anaerobic airway mucus. OBJECTIVES:To determine whether anaerobic bacteria are present in the sputum of patients with CF. METHODS:S...

journal_title：American journal of respiratory and critical care medicine

authors： Tunney MM,Field TR,Moriarty TF,Patrick S,Doering G,Muhlebach MS,Wolfgang MC,Boucher R,Gilpin DF,McDowell A,Elborn JS

更新日期：2008-05-01 00:00:00

abstract：RATIONALE:Severe asthma is a major public health issue throughout the world. Increased bronchial smooth muscle (BSM) mass, a characteristic feature of airway remodeling in severe asthma, is associated with resistance to high-intensity treatment and poor prognosis. In vitro, the Ca(2+)-channel blocker gallopamil decreas...

journal_title：American journal of respiratory and critical care medicine

authors： Girodet PO,Dournes G,Thumerel M,Begueret H,Dos Santos P,Ozier A,Dupin I,Trian T,Montaudon M,Laurent F,Marthan R,Berger P

更新日期：2015-04-15 00:00:00

abstract：:The influx of neutrophils into the lung is a sentinel event in LPS-induced acute lung inflammation. Previous studies have shown that systemic inhibition of p38 decreases LPS-induced neutrophil influx into the alveolar space but has no effect on pulmonary parenchymal neutrophil accumulation or on microvascular leak, in...

journal_title：American journal of respiratory and critical care medicine

authors： Arndt PG,Young SK,Lieber JG,Fessler MB,Nick JA,Worthen GS

更新日期：2005-05-01 00:00:00

abstract：RATIONALE:In the normal lung, breathing and deep inspirations potently antagonize bronchoconstriction, but in the asthmatic lung this salutary effect is substantially attenuated or even reversed. To explain these findings, the prevailing hypothesis focuses on contracting airway smooth muscle and posits a nonlinear dyna...

journal_title：American journal of respiratory and critical care medicine

authors： Lavoie TL,Krishnan R,Siegel HR,Maston ED,Fredberg JJ,Solway J,Dowell ML

更新日期：2012-08-01 00:00:00

abstract：:When dyspnea must be assessed clinically, there are three methods of assessment: the measurement of dyspnea with activities of daily living using clinical dyspnea ratings such as the modified Medical Research Council (MRC), the Baseline Dyspnea Index (BDI), and the Oxygen Cost Diagram (OCD); the measurement of dyspnea...

journal_title：American journal of respiratory and critical care medicine

authors： Hajiro T,Nishimura K,Tsukino M,Ikeda A,Koyama H,Izumi T

更新日期：1998-10-01 00:00:00

abstract：:Salbutamol inhibits neutropenia, increased airway resistance, and gas exchange abnormalities provoked by platelet-activating factor (PAF) challenge in normal persons. To further explore the intriguing dissociation between spirometric abnormalities and gas exchange defects shown in patients with asthma, we investigated...

journal_title：American journal of respiratory and critical care medicine

authors： Díaz O,Barberà JA,Marrades R,Chung KF,Roca J,Rodriguez-Roisin R

更新日期：1997-07-01 00:00:00

abstract：:Patients in whom acid-fast bacilli smear-positive pulmonary tuberculosis was newly diagnosed were randomized to receive 400 mg moxifloxacin, 300 mg isonaizid, or 600 mg rifampin daily for 5 days. Sixteen-hour overnight sputa collections were made for the 2 days before and for 5 days of monotherapy. Bactericidal activi...

journal_title：American journal of respiratory and critical care medicine

authors： Gosling RD,Uiso LO,Sam NE,Bongard E,Kanduma EG,Nyindo M,Morris RW,Gillespie SH

更新日期：2003-12-01 00:00:00

abstract：RATIONALE:Defining the biogeography of bacterial populations in human body habitats is a high priority for understanding microbial-host relationships in health and disease. The healthy lung was traditionally considered sterile, but this notion has been challenged by emerging molecular approaches that enable comprehensi...

journal_title：American journal of respiratory and critical care medicine

authors： Charlson ES,Bittinger K,Haas AR,Fitzgerald AS,Frank I,Yadav A,Bushman FD,Collman RG

更新日期：2011-10-15 00:00:00

abstract：:CD14 influences postnatal switching of T helper cell responses. CD14 C-159T has been associated with altered CD14 and IgE levels in cross-sectional studies. Identifying whether associations vary with age requires data from children of the same age followed longitudinally over many years. In this study, an unselected p...

journal_title：American journal of respiratory and critical care medicine

authors： O'Donnell AR,Toelle BG,Marks GB,Hayden CM,Laing IA,Peat JK,Goldblatt J,Le Souëf PN

更新日期：2004-03-01 00:00:00

abstract：:Long-term effects of high doses of inhaled corticosteroids (ICS) on bone density and metabolism are still uncertain. Fifty-one patients (37 male, 14 female) using beclomethasone or budesonide at a daily dose > 800 microgram/d (high-dose group [Group HD] mean: 983 microgram/d [prescribed dose x estimated compliance]) o...

journal_title：American journal of respiratory and critical care medicine

authors： Boulet LP,Milot J,Gagnon L,Poubelle PE,Brown J

更新日期：1999-03-01 00:00:00

abstract：:The forced oscillation technique (FOT) and interrupter technique are particularly attractive for pediatric use as they require only passive cooperation from the patient. We compared the sensitivity and specificity of these methods for detecting airway obstruction and its reversibility in 118 children (3-16 yr) with as...

journal_title：American journal of respiratory and critical care medicine

authors： Delacourt C,Lorino H,Fuhrman C,Herve-Guillot M,Reinert P,Harf A,Housset B

更新日期：2001-09-15 00:00:00