Tenascin mRNA expression at the foci of recent injury in usual interstitial pneumonia.

abstract：RATIONALE:During acute lung injury (ALI) the macrophage pool expands markedly as inflammatory monocytes migrate from the circulation to the airspaces. As inflammation resolves, macrophage numbers return to preinjury levels and normal tissue structure and function are restored. OBJECTIVES:To determine the fate of resid...

journal_title：American journal of respiratory and critical care medicine

authors： Janssen WJ,Barthel L,Muldrow A,Oberley-Deegan RE,Kearns MT,Jakubzick C,Henson PM

更新日期：2011-09-01 00:00:00

abstract：RATIONALE:Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition with unclear pathogenesis. Two competing theories of the pathogenesis of EIB differ regarding the inflammatory basis of this condition. OBJECTIVES:Our goals were to establish whether epithelial cell and mast cell activation with relea...

journal_title：American journal of respiratory and critical care medicine

authors： Hallstrand TS,Moody MW,Wurfel MM,Schwartz LB,Henderson WR Jr,Aitken ML

更新日期：2005-09-15 00:00:00

abstract：RATIONALE:Chronic infection with Burkholderia cepacia complex bacteria in cystic fibrosis is associated with accelerated decline in pulmonary function and increased mortality. Clinical implications of the recently characterized genomovar VI, B. dolosa, are unknown. OBJECTIVES:Characterization of impact of B. dolosa on...

journal_title：American journal of respiratory and critical care medicine

authors： Kalish LA,Waltz DA,Dovey M,Potter-Bynoe G,McAdam AJ,Lipuma JJ,Gerard C,Goldmann D

更新日期：2006-02-15 00:00:00

abstract：:We prospectively analyzed the diagnostic yield and safety of ultrasound (US)-guided transthoracic needle aspiration biopsy in the histologic diagnosis of 40 patients with superior vena cava (SVC) syndrome. During a 4-yr period, 40 patients with SVC obstruction were admitted to National Taiwan University Hospital. Of t...

journal_title：American journal of respiratory and critical care medicine

authors： Ko JC,Yang PC,Yuan A,Chang DB,Yu CJ,Wu HD,Lee LN,Kuo SH,Luh KT

更新日期：1994-03-01 00:00:00

abstract：RATIONALE:Although frequent, little is known about early-onset pneumonia that occurs in the postresuscitation period. Although induced hypothermia is recommended as a method of improving neurological outcome, its influence on the occurrence of early-onset pneumonia is not well defined. OBJECTIVES:To describe the incid...

journal_title：American journal of respiratory and critical care medicine

authors： Perbet S,Mongardon N,Dumas F,Bruel C,Lemiale V,Mourvillier B,Carli P,Varenne O,Mira JP,Wolff M,Cariou A

更新日期：2011-11-01 00:00:00

abstract：:We examined the efficacy and the acceptance of an oral device (SnorEx) causing a forward displacement of the tongue for the treatment of sleep-disordered breathing (SDB). Twenty-three consecutive subjects with SDB were investigated. Noncompliance (NC) of use of the oral appliance was observed in 74% (17 of 23) of the ...

journal_title：American journal of respiratory and critical care medicine

authors： Schönhofer B,Stoohs RA,Rager H,Wenzel M,Wenzel G,Köhler D

更新日期：1997-02-01 00:00:00

abstract：:Thyroid transcription factor-1 (TTF-1) deficiency syndrome is characterized by neurologic, thyroidal, and pulmonary dysfunction. Children usually have mild-to-severe respiratory symptoms and occasionally die of respiratory failure. Herein, we describe an infant with a constitutional 14q12-21.3 haploid deletion encompa...

journal_title：American journal of respiratory and critical care medicine

authors： Galambos C,Levy H,Cannon CL,Vargas SO,Reid LM,Cleveland R,Lindeman R,deMello DE,Wert SE,Whitsett JA,Perez-Atayde AR,Kozakewich H

更新日期：2010-08-15 00:00:00

abstract：RATIONALE:Although commonly used as the primary outcome measure of clinical trials in pulmonary arterial hypertension (PAH), the minimal important difference (MID) of the 6-minute walk test (6MWT) has not been well defined for this population of patients. OBJECTIVES:To estimate the MID in the 6MWT in patients with PAH...

journal_title：American journal of respiratory and critical care medicine

authors： Mathai SC,Puhan MA,Lam D,Wise RA

更新日期：2012-09-01 00:00:00

abstract：RATIONALE:Smoking is the largest contributor to lung cancer risk, and those who continue to smoke after diagnosis have a worse survival. Screening for lung cancer with low-dose computed tomography (LDCT) reduces mortality in high-risk individuals. Smoking cessation is an essential component of a high-quality screening ...

journal_title：American journal of respiratory and critical care medicine

authors： Tanner NT,Kanodra NM,Gebregziabher M,Payne E,Halbert CH,Warren GW,Egede LE,Silvestri GA

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The relative roles of mucus plugs and emphysema in mechanisms of airflow limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) are uncertain. METHODS:We analyzed computed tomography (CT) lung images and lung function in participants in the Subpopulations and Intermediate Outc...

journal_title：American journal of respiratory and critical care medicine

authors： Dunican EM,Elicker BM,Henry T,Gierada DS,Schiebler ML,Anderson W,Barjaktarevic I,Barr RG,Bleecker ER,Boucher RC,Bowler RP,Christenson SA,Comellas A,Cooper CB,Couper D,Criner GJ,Dransfield M,Doerschuk CM,Drummond MB,

更新日期：2020-11-12 00:00:00

abstract：:Knowledge of the local and regional doses of inhaled particulates is crucial for inhalation therapy and for understanding the progression of pulmonary disease. We studied the deposition pattern of radioactively tagged particles in rats with chronic bronchitis. Rats were exposed to sulfur dioxide (SO2; 236 +/- 14 ppm) ...

journal_title：American journal of respiratory and critical care medicine

authors： Sweeney TD,Skornik WA,Brain JD,Hatch V,Godleski JJ

更新日期：1995-02-01 00:00:00

abstract：:In vivo, IgE production is related to bronchial hyperresponsiveness and, in vitro, passive sensitization of human airways with asthmatic serum containing a high concentration of IgE enhances the contractile response to a variety of agonists. However, cell types implicated in this IgE sensitization are not fully determ...

journal_title：American journal of respiratory and critical care medicine

authors： Berger P,Walls AF,Marthan R,Tunon-de-Lara JM

更新日期：1998-02-01 00:00:00

abstract：:Patients with pulmonary Mycobacterium avium complex (MAC) infection occasionally have neither past histories of pulmonary diseases nor underlying immunodeficiency conditions. Therefore, we hypothesized that MAC may be linked with a disease-susceptibility gene and determined human leukocyte-associated antigens (HLA) in...

journal_title：American journal of respiratory and critical care medicine

authors： Takahashi M,Ishizaka A,Nakamura H,Kobayashi K,Nakamura M,Namiki M,Sekita T,Okajima S

更新日期：2000-07-01 00:00:00

abstract：:Arousal is believed to be needed for upper airway opening in obstructive hypopneas-apneas, without compelling evidence to support this notion. The association may be incidental. I studied the temporal relation between arousal and opening and impact of arousal on flow response at opening in 82 patients (apnea-hypopnea ...

journal_title：American journal of respiratory and critical care medicine

authors： Younes M

更新日期：2004-03-01 00:00:00

abstract：:The effects of glutathione-S-transferase (GST) M1, GSTT1, and GSTP1 genotypes on lung function growth were investigated in 1,940 children enrolled in the Children's Health Study as fourth graders (aged 8-11 years) in two cohorts during 1993 and 1996 and were followed annually over a 4-year period. Genotypes for GSTM1 ...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Gauderman WJ,Vora H,Rappaport E,Dubeau L

更新日期：2002-09-01 00:00:00

abstract：:Rationale: Recent retrospective evidence suggests the efficacy of early norepinephrine administration during resuscitation; however, prospective data to support this assertion are scarce. Objectives: To conduct a phase II trial evaluating the hypothesis that early low-dose norepinephrine in adults with sepsis with hyp...

journal_title：American journal of respiratory and critical care medicine

authors： Permpikul C,Tongyoo S,Viarasilpa T,Trainarongsakul T,Chakorn T,Udompanturak S

更新日期：2019-05-01 00:00:00

abstract：:The demand for intensivists is increasing around the world, not only to meet the needs of a growing aging population, but also to fill positions in the intensive care unit now occupied by other specialists, since there is compelling evidence that the presence of critical care practitioners improves patient outcomes. N...

journal_title：American journal of respiratory and critical care medicine

authors： Estenssoro E,Valente Barbas CS,Briva A

更新日期：2013-01-15 00:00:00

abstract：:To determine if gastric intramucosal pH changes during weaning from mechanical ventilation are related to gastric mucosal blood flow modifications, we studied 16 ventilator-supported patients with chronic obstructive pulmonary disease (COPD) who tolerated a 2-h trial of spontaneous breathing with pressure support vent...

journal_title：American journal of respiratory and critical care medicine

authors： Bocquillon N,Mathieu D,Neviere R,Lefebvre N,Marechal X,Wattel F

更新日期：1999-11-01 00:00:00

abstract：:The cysteinyl leukotrienes (CysLTs) are important mediators of human asthma. Pharmacologic and clinical studies show that the CysLTs exert most of their bronchoconstrictive and proinflammatory effects through activation of a putative, 7-transmembrane domain, G-protein-coupled receptor, the CysLT1 receptor. The initial...

journal_title：American journal of respiratory and critical care medicine

authors： Figueroa DJ,Breyer RM,Defoe SK,Kargman S,Daugherty BL,Waldburger K,Liu Q,Clements M,Zeng Z,O'Neill GP,Jones TR,Lynch KR,Austin CP,Evans JF

更新日期：2001-01-01 00:00:00

abstract：:Hepatopulmonary syndrome (HPS) is characterized by intrapulmonary vascular dilatations and an increased alveoloarterial oxygen difference (AaPO(2)). These abnormalities are related to augmented pulmonary nitric oxide (NO) production, dependent primarily on increases in the expression and activity of inducible NO-synth...

journal_title：American journal of respiratory and critical care medicine

authors： Rabiller A,Nunes H,Lebrec D,Tazi KA,Wartski M,Dulmet E,Libert JM,Mougeot C,Moreau R,Mazmanian M,Humbert M,Hervé P

更新日期：2002-08-15 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is common in people with hypertension, particularly resistant hypertension. Treatment with an antihypertensive agent alone is often insufficient to control hypertension in patients with OSA. OBJECTIVES:To determine whether continuous positive airway pressure (CPAP) added to trea...

journal_title：American journal of respiratory and critical care medicine

authors： Thunström E,Manhem K,Rosengren A,Peker Y

更新日期：2016-02-01 00:00:00

abstract：RATIONALE:Biomass exposure is an important risk factor for chronic obstructive pulmonary disease (COPD). However, the time-course behavior of FEV1 in subjects exposed to biomass is unknown. OBJECTIVES:We undertook this study to determine the FEV1 rate decline in subjects exposed to biomass. METHODS:Pulmonary function...

journal_title：American journal of respiratory and critical care medicine

authors： Ramírez-Venegas A,Sansores RH,Quintana-Carrillo RH,Velázquez-Uncal M,Hernandez-Zenteno RJ,Sánchez-Romero C,Velazquez-Montero A,Flores-Trujillo F

更新日期：2014-11-01 00:00:00

abstract：:Although numerous reports have described the improvement in PAO2 in patients in the prone position, the underlying mechanism has yet to be determined. Some authors have suggested this phenomenon may be related to an increase in functional residual capacity (FRC); however, no previous studies have described positional ...

journal_title：American journal of respiratory and critical care medicine

authors： Numa AH,Hammer J,Newth CJ

更新日期：1997-10-01 00:00:00

abstract：:Nebulized aerosols are commonly used to deliver drugs into the lungs of patients with cystic fibrosis (CF). The aim of this study was to assess the effectiveness of pressure-support (PS) ventilation in increasing aerosol deposition within the lungs of children with CF. An in vitro study demonstrated the feasibility of...

journal_title：American journal of respiratory and critical care medicine

authors： Fauroux B,Itti E,Pigeot J,Isabey D,Meignan M,Ferry G,Lofaso F,Willemot JM,Clément A,Harf A

更新日期：2000-12-01 00:00:00

abstract：:Several modalities of ventilatory support have been proposed to gradually withdraw patients from mechanical ventilation, but their respective effects on the outcome of weaning from mechanical ventilation are not known. We conducted a randomized trial in three intensive care units in mechanically ventilated patients wh...

journal_title：American journal of respiratory and critical care medicine

authors： Brochard L,Rauss A,Benito S,Conti G,Mancebo J,Rekik N,Gasparetto A,Lemaire F

更新日期：1994-10-01 00:00:00

abstract：:Clinically, the spread of infectious agents between subjects undergoing spirometry is quite uncommon. There is almost no documentation in the medical literature on this subject. We studied the retrieval of nonpathogenic Escherichia coli after aerosolizing organisms into standard pulmonary function tubing of a type tha...

journal_title：American journal of respiratory and critical care medicine

authors： Hiebert T,Miles J,Okeson GC

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:Pulmonary hypertension (PH) is a life-threatening disease, characterized by vascular remodeling and vasoconstriction. Evidence suggests that oxidative stress may contribute to the pathogenesis and/or development of PH. OBJECTIVES:In the present study, we examined whether intratracheal gene transfer of human ...

journal_title：American journal of respiratory and critical care medicine

authors： Kamezaki F,Tasaki H,Yamashita K,Tsutsui M,Koide S,Nakata S,Tanimoto A,Okazaki M,Sasaguri Y,Adachi T,Otsuji Y

更新日期：2008-01-15 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. The prevalence of HP is higher than recognized, especially its chronic form. Mechanisms of disease are still incompletely known. Strategies to im...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JN,Ortega HG,Reynolds HY,Cormier YF,Fan LL,Franks TJ,Kreiss K,Kunkel S,Lynch D,Quirce S,Rose C,Schleimer RP,Schuyler MR,Selman M,Trout D,Yoshizawa Y

更新日期：2005-04-01 00:00:00

abstract：:Transbronchial biopsies (TBBs) are useful to diagnose acute rejection and infection in patients with lung transplants. The value of routine surveillance biopsies (S-TBBs) is not known, and such biopsies with a clinical indication are not without risk and are expensive. One hundred twenty-six 6-mo survivors of heart-lu...

journal_title：American journal of respiratory and critical care medicine

authors： Tamm M,Sharples LD,Higenbottam TW,Stewart S,Wallwork J

更新日期：1997-05-01 00:00:00

abstract：:The aim of this prospective study was to detect subjects in the general population with objective signs of chronic obstructive pulmonary disease (COPD) or asthma at an early stage. This was done by means of a two-stage protocol involving screening and a subsequent 2-yr monitoring of all subjects with positive results ...

journal_title：American journal of respiratory and critical care medicine

authors： van den Boom G,van Schayck CP,van Möllen MP,Tirimanna PR,den Otter JJ,van Grunsven PM,Buitendijk MJ,van Herwaarden CL,van Weel C

更新日期：1998-12-01 00:00:00