Vascular reactivity in sepsis: importance of controls and role of nitric oxide.

abstract：RATIONALE:Inhaled human insulin (INH; Exubera [human insulin (recombinant DNA origin) Inhalation Powder]) causes small changes in pulmonary function and increases in insulin antibodies compared with subcutaneous (SC) insulin. OBJECTIVES:To investigate the relationship between changes in pulmonary function and insulin ...

journal_title：American journal of respiratory and critical care medicine

authors： Teeter JG,Riese RJ

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:Epidemiological studies in older individuals have found an association between the use of angiotensin-converting enzyme (ACE) inhibition (ACE-I) therapy and preserved locomotor muscle mass, strength, and walking speed. ACE-I therapy might therefore have a role in the context of pulmonary rehabilitation (PR). ...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis KJ,Meyrick VM,Mehta B,Haji GS,Li K,Montgomery H,Man WD,Polkey MI,Hopkinson NS

更新日期：2016-12-01 00:00:00

abstract：RATIONALE:Smoking is the largest contributor to lung cancer risk, and those who continue to smoke after diagnosis have a worse survival. Screening for lung cancer with low-dose computed tomography (LDCT) reduces mortality in high-risk individuals. Smoking cessation is an essential component of a high-quality screening ...

journal_title：American journal of respiratory and critical care medicine

authors： Tanner NT,Kanodra NM,Gebregziabher M,Payne E,Halbert CH,Warren GW,Egede LE,Silvestri GA

更新日期：2016-03-01 00:00:00

abstract：:The involvement of platelet-activating factor (PAF) in bronchial hyperresponsiveness (BHR) in bronchial asthma has been controversial. To determine whether PAF is involved in BHR in humans, we carried out a randomized, double-blind, placebo-controlled, two-phase cross-over study on the effects of Y-24180, a potent, sp...

journal_title：American journal of respiratory and critical care medicine

authors： Hozawa S,Haruta Y,Ishioka S,Yamakido M

更新日期：1995-10-01 00:00:00

abstract：:Clinicians are frequently faced with patients in whom the radiographic resolution of community-acquired pneumonia seems delayed. Previous studies of radiographic resolution of the disease have yielded conflicting results. We prospectively assessed the radiographic resolution of pneumonia in 81 non-immuno-compromised p...

journal_title：American journal of respiratory and critical care medicine

authors： Mittl RL Jr,Schwab RJ,Duchin JS,Goin JE,Albeida SM,Miller WT

更新日期：1994-03-01 00:00:00

abstract：:Poor adherence to medication regimens may be contributing to the recent increase in asthma morbidity and mortality. We examined patient characteristics that may influence adherence to twice-daily inhaled steroid regimens. Fifty adults with moderate to severe asthma completed questionnaires examining sociodemographics,...

journal_title：American journal of respiratory and critical care medicine

authors： Apter AJ,Reisine ST,Affleck G,Barrows E,ZuWallack RL

更新日期：1998-06-01 00:00:00

abstract：:To determine the usefulness of positron emission tomography with fluoro-2-deoxyglucose (PET-FDG) in assessing mediastinal disease in patients with non-small-cell lung cancer (NSCLC) and to compare its yield to that of computed tomography (CT), we performed a prospective consecutive sample investigation in a university...

journal_title：American journal of respiratory and critical care medicine

authors： Chin R Jr,Ward R,Keyes JW,Choplin RH,Reed JC,Wallenhaupt S,Hudspeth AS,Haponik EF

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:In the normal lung, breathing and deep inspirations potently antagonize bronchoconstriction, but in the asthmatic lung this salutary effect is substantially attenuated or even reversed. To explain these findings, the prevailing hypothesis focuses on contracting airway smooth muscle and posits a nonlinear dyna...

journal_title：American journal of respiratory and critical care medicine

authors： Lavoie TL,Krishnan R,Siegel HR,Maston ED,Fredberg JJ,Solway J,Dowell ML

更新日期：2012-08-01 00:00:00

abstract：:Effects of cigarette smoking and smoking cessation on rate of FEV1 decline over 6 yr were examined in 4,451 Japanese-American men from the Honolulu Heart Program who were 45 to 68 yr of age at baseline (1965-1968). Within-person regression was used to calculate annual change in FEV1. Rates of FEV1 decline varied stron...

journal_title：American journal of respiratory and critical care medicine

authors： Burchfiel CM,Marcus EB,Curb JD,Maclean CJ,Vollmer WM,Johnson LR,Fong KO,Rodriguez BL,Masaki KH,Buist AS

更新日期：1995-06-01 00:00:00

abstract：RATIONALE:Chronic infection with Burkholderia cepacia complex bacteria in cystic fibrosis is associated with accelerated decline in pulmonary function and increased mortality. Clinical implications of the recently characterized genomovar VI, B. dolosa, are unknown. OBJECTIVES:Characterization of impact of B. dolosa on...

journal_title：American journal of respiratory and critical care medicine

authors： Kalish LA,Waltz DA,Dovey M,Potter-Bynoe G,McAdam AJ,Lipuma JJ,Gerard C,Goldmann D

更新日期：2006-02-15 00:00:00

abstract：:The failure of patients to adhere to physician-prescribed regimens, either pharmacologic or behavioral, has been well documented in medical literature. Poor adherence to asthma medication regimens has been repeatedly demonstrated in both children and adults, with rates of nonadherence commonly reported from 30 to 70%....

journal_title：American journal of respiratory and critical care medicine

authors： Rand CS,Wise RA

更新日期：1994-02-01 00:00:00

abstract：:The lungs of newborn rats exposed to 60% oxygen for 14 days develop an injury that shares morphologic similarities to human bronchopulmonary dysplasia (BPD). Neutrophil influx into the lung, as part of an inflammatory response, may play a pivotal role in the development of BPD. A neutrophil chemokine, cytokine-induced...

journal_title：American journal of respiratory and critical care medicine

authors： Yi M,Jankov RP,Belcastro R,Humes D,Copland I,Shek S,Sweezey NB,Post M,Albertine KH,Auten RL,Tanswell AK

更新日期：2004-12-01 00:00:00

abstract：:If lipid peroxidation (LP) contributes to organ dysfunction in sepsis rather than simply reflecting established injury, it should occur soon after the onset of the septic insult, and it may not progress uniformly in all organs. We assessed whether LP occurs within 90 min after onset of continuous intravenous endotoxin...

journal_title：American journal of respiratory and critical care medicine

authors： Clements NC Jr,Habib MP

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD). OBJECTIVES:To determine the effect of inhaled corticosteroids with or without long-acting beta(2)-adrenergic agonist on systemic biomarkers of inflammation. METHODS:W...

journal_title：American journal of respiratory and critical care medicine

authors： Sin DD,Man SF,Marciniuk DD,Ford G,FitzGerald M,Wong E,York E,Mainra RR,Ramesh W,Melenka LS,Wilde E,Cowie RL,Williams D,Gan WQ,Rousseau R,ABC (Advair, Biomarkers in COPD) Investigators.

更新日期：2008-06-01 00:00:00

abstract：:Obstructive sleep-disordered breathing is associated with cardiovascular disease in adults, and elevated C-reactive protein (CRP) has been proposed as a link between the two disorders. We hypothesized that children with sleep-disordered breathing have higher CRP values than do control subjects. CRP was measured in 39 ...

journal_title：American journal of respiratory and critical care medicine

authors： Kaditis AG,Alexopoulos EI,Kalampouka E,Kostadima E,Germenis A,Zintzaras E,Gourgoulianis K

更新日期：2005-02-01 00:00:00

abstract：RATIONALE:Activin-A is up-regulated in various respiratory disorders. However, its precise role in pulmonary pathophysiology has not been adequately substantiated in vivo. OBJECTIVES:To investigate in vivo the consequences of dysregulated Activin-A expression in the lung and identify key Activin-A-induced processes th...

journal_title：American journal of respiratory and critical care medicine

authors： Apostolou E,Stavropoulos A,Sountoulidis A,Xirakia C,Giaglis S,Protopapadakis E,Ritis K,Mentzelopoulos S,Pasternack A,Foster M,Ritvos O,Tzelepis GE,Andreakos E,Sideras P

更新日期：2012-02-15 00:00:00

abstract：RATIONALE:Implementation of intervention strategies to prevent lung damage in early cystic fibrosis (CF) requires objective outcome measures that capture and track lung disease. OBJECTIVES:To define the utility of the Lung Clearance Index (LCI), measured by multiple breath washout, as a means to track disease progress...

journal_title：American journal of respiratory and critical care medicine

authors： Stanojevic S,Davis SD,Retsch-Bogart G,Webster H,Davis M,Johnson RC,Jensen R,Pizarro ME,Kane M,Clem CC,Schornick L,Subbarao P,Ratjen FA

更新日期：2017-05-01 00:00:00

abstract：RATIONALE:Cigarette smoke is the major risk factor in the development of chronic obstructive pulmonary disease (COPD). Lipidomics is a novel and emerging research field that may provide new insights in the origins of chronic inflammatory diseases, such as COPD. OBJECTIVES:To investigate whether expression of the sputu...

journal_title：American journal of respiratory and critical care medicine

authors： Telenga ED,Hoffmann RF,Ruben t'Kindt,Hoonhorst SJ,Willemse BW,van Oosterhout AJ,Heijink IH,van den Berge M,Jorge L,Sandra P,Postma DS,Sandra K,ten Hacken NH

更新日期：2014-07-15 00:00:00

abstract：:The inflammatory events in the airways at the time of acute respiratory failure from acute severe asthma are poorly understood. To determine the patterns of cellular inflammation in the airways in acute severe asthma, we analyzed tracheal aspirates collected within 12 h of intubation from patients intubated emergently...

journal_title：American journal of respiratory and critical care medicine

authors： Ordoñez CL,Shaughnessy TE,Matthay MA,Fahy JV

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:The association between aging and idiopathic pulmonary fibrosis is established. The associations between aging-related biomarkers and interstitial lung abnormalities (ILA) have not been comprehensively evaluated. OBJECTIVE:Evaluate associations between aging biomarkers, ILA, and all-cause mortality. METHODS...

journal_title：American journal of respiratory and critical care medicine

authors： Sanders JL,Putman RK,Dupuis J,Xu H,Murabito JM,Araki T,Nishino M,Benjamin EJ,Levy DL,Vasan RS,Washko GR,Curtis JL,Freeman CM,Bowler R,Hatabu H,O'Connor GT,Hunninghake GM

更新日期：2020-10-20 00:00:00

abstract：:We review recent advances in the use of corticosteroids (CS) in pediatric lung disease. CS are frequently used, systemically or by inhalation. Their mechanisms of action in pulmonary diseases are ill defined. CS exert direct inhibitory effects on many inflammatory cells through genomic mechanisms. There is a time lag ...

journal_title：American journal of respiratory and critical care medicine

authors： de Benedictis FM,Bush A

更新日期：2012-01-01 00:00:00

abstract：RATIONALE:The IL-1 receptor-associated kinase (IRAK-1) plays a central role in TLR2- and TLR4-induced activation of nuclear factor (NF)-kappaB, a critical event in the transcriptional regulation of many sepsis-associated proinflammatory mediators. There are two haplotypes for the IRAK-1 gene in Caucasians, with the var...

journal_title：American journal of respiratory and critical care medicine

authors： Arcaroli J,Silva E,Maloney JP,He Q,Svetkauskaite D,Murphy JR,Abraham E

更新日期：2006-06-15 00:00:00

abstract：RATIONALE:Cystic fibrosis (CF) is characterized by dietary antioxidant deficiencies, which may contribute to an oxidant-antioxidant imbalance and oxidative stress. OBJECTIVES:Evaluate the effects of an oral antioxidant-enriched multivitamin supplement on antioxidant concentrations, markers of inflammation and oxidativ...

journal_title：American journal of respiratory and critical care medicine

authors： Sagel SD,Khan U,Jain R,Graff G,Daines CL,Dunitz JM,Borowitz D,Orenstein DM,Abdulhamid I,Noe J,Clancy JP,Slovis B,Rock MJ,McCoy KS,Strausbaugh S,Livingston FR,Papas KA,Shaffer ML

更新日期：2018-09-01 00:00:00

abstract：:The period covered by this update can be considered as the most exciting period in idiopathic pulmonary fibrosis (IPF) research. It started with the identification of genetic variants that are associated with IPF in the majority of patients and continued with discovery of molecular and genetic biomarkers that predict ...

journal_title：American journal of respiratory and critical care medicine

authors： Rosas IO,Kaminski N

更新日期：2015-02-01 00:00:00

abstract：RATIONALE:Childhood sleep-disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience s...

journal_title：American journal of respiratory and critical care medicine

authors： Tamanyan K,Walter LM,Weichard A,Davey MJ,Nixon GM,Biggs SN,Horne RSC

更新日期：2018-06-01 00:00:00

abstract：RATIONALE:The perception of dyspnea and pain show many similarities. Initial imaging studies suggested an important role of the insular cortex for the perception of both sensations. However, little is known about the cortical processing of dyspnea. OBJECTIVES:This study investigated the influence of lesions of the ins...

journal_title：American journal of respiratory and critical care medicine

authors： Schön D,Rosenkranz M,Regelsberger J,Dahme B,Büchel C,von Leupoldt A

更新日期：2008-12-01 00:00:00

abstract：:Airway remodeling may lead to irreversible loss of lung function in asthma. The impact of childhood asthma, airway responsiveness, atopy, and smoking on airway remodeling was investigated in a birth cohort studied longitudinally to age 26. A low postbronchodilator ratio of forced exhaled volume in 1 second (FEV1) to v...

journal_title：American journal of respiratory and critical care medicine

authors： Rasmussen F,Taylor DR,Flannery EM,Cowan JO,Greene JM,Herbison GP,Sears MR

更新日期：2002-06-01 00:00:00

abstract：:Lone cryptogenic fibrosing alveolitis (CFA) is a progressive interstitial lung disease, with a median survival of 3 to 6 yr from the onset of dyspnea. CFA can be subdivided into prognostically significant histopathologic patterns, including nonspecific interstitial pneumonia (NSIP). We reviewed 78 patients with a clin...

journal_title：American journal of respiratory and critical care medicine

authors： Nicholson AG,Colby TV,du Bois RM,Hansell DM,Wells AU

更新日期：2000-12-01 00:00:00

abstract：:An imbalance of proinflammatory cytokines such as TNF-alpha, IL-1 beta, and the neutrophil chemotactic factor IL-8 and inhibitors (e.g., soluble TNF receptors and IL-1ra) in the lung during the first week of life may contribute to prolonged pulmonary inflammation and fibrosis in bronchopulmonary dysplasia (BPD). Disod...

journal_title：American journal of respiratory and critical care medicine

authors： Viscardi RM,Hasday JD,Gumpper KF,Taciak V,Campbell AB,Palmer TW

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:Lack of health insurance maybe an independent risk factor for mortality and differential treatment in critical illness. OBJECTIVES:To determine whether uninsured critically ill patients had differences in 30-day mortality and critical care service use compared with those with private insurance and to determi...

journal_title：American journal of respiratory and critical care medicine

authors： Lyon SM,Benson NM,Cooke CR,Iwashyna TJ,Ratcliffe SJ,Kahn JM

更新日期：2011-10-01 00:00:00