The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease.

abstract：:Within the last few years, increasing evidence of relative adrenal insufficiency in septic shock evoked a reassessment of hydrocortisone therapy. To evaluate the effects of hydrocortisone on the balance between proinflammatory and antiinflammation, 40 patients with septic shock were randomized in a double-blind crosso...

journal_title：American journal of respiratory and critical care medicine

authors： Keh D,Boehnke T,Weber-Cartens S,Schulz C,Ahlers O,Bercker S,Volk HD,Doecke WD,Falke KJ,Gerlach H

更新日期：2003-02-15 00:00:00

abstract：:The nasal mucosal is the first site of contact with inhaled antigens. However, the nature of local immune responses and the role of nasal-associated lymphoid tissue (NALT) in those responses have rarely been studied. To characterize the cells involved in mucosally derived immune responses, NALT and Peyer's patch (PP) ...

journal_title：American journal of respiratory and critical care medicine

authors： Heritage PL,Underdown BJ,Arsenault AL,Snider DP,McDermott MR

更新日期：1997-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening, interstitial lung disease of unknown etiology. The median survival of patients with IPF is only 2 to 3 years, yet some patients live much longer. Respiratory failure resulting from disease progression is the most frequent cause of death. To date w...

journal_title：American journal of respiratory and critical care medicine

authors： Ley B,Collard HR,King TE Jr

更新日期：2011-02-15 00:00:00

abstract：:Normative spirometric values were derived from 5,042 white (of mainly European ancestry) and black (of mainly African ancestry) men and women paper plant workers who are never-smokers, with no respiratory symptoms or diagnoses and no history of occupational exposure to fibrogenic dusts or irritant chemicals. This coho...

journal_title：American journal of respiratory and critical care medicine

authors： Glindmeyer HW,Lefante JJ,McColloster C,Jones RN,Weill H

更新日期：1995-02-01 00:00:00

abstract：:Rationale: Mathematical modeling is used to understand disease dynamics, forecast trends, and inform public health prioritization. We conducted a comparative analysis of tuberculosis (TB) epidemiology and potential intervention effects in California, using three previously developed epidemiologic models of TB.Objectiv...

journal_title：American journal of respiratory and critical care medicine

authors： Menzies NA,Parriott A,Shrestha S,Dowdy DW,Cohen T,Salomon JA,Marks SM,Hill AN,Winston CA,Asay GR,Barry P,Readhead A,Flood J,Kahn JG,Shete PB

更新日期：2020-02-01 00:00:00

abstract：:During dynamic hyperinflation, the ventilatory pump is facing increased demand because it must overcome the intrinsic positive end-expiratory pressure (PEEPi) and decreased capacity since it must operate at a dynamically increased end-expiratory lung volume (EELV). The aim of this study was to evaluate the relative pr...

journal_title：American journal of respiratory and critical care medicine

authors： Yan S,Kayser B

更新日期：1997-08-01 00:00:00

abstract：:Acute sustained hypoxia causes an early rise in ventilation, followed by a reduction in ventilation ("roll off") after several minutes to levels below the peak but above baseline. The underlying mechanism(s) of this biphasic response is unclear. Hypoxia induces changes in the release and metabolic turnover of glutamat...

journal_title：American journal of respiratory and critical care medicine

authors： Soto-Arape I,Burton MD,Kazemi H

更新日期：1995-04-01 00:00:00

abstract：:In order to determine the long-term sequelae of prune belly syndrome (PBS) and whether the absence of abdominal wall musculature impairs exercise performance we studied nine patients 6 to 31 yr of age with PBS. Conventional spirometry, lung volumes, DLCO, and respiratory muscle strength were measured. A progressive 1-...

journal_title：American journal of respiratory and critical care medicine

authors： Ewig JM,Griscom NT,Wohl ME

更新日期：1996-04-01 00:00:00

abstract：:Guidelines, protocols, and checklists (together called "protocols") can be immensely helpful in the clinical arena. However, clinicians and health care systems relying on protocols must assess whether benefits are being accrued, whether such "benefits" are real, and whether harm can be detected. These concerns are imp...

journal_title：American journal of respiratory and critical care medicine

authors： Kavanagh BP,Nurok M

更新日期：2016-01-01 00:00:00

abstract：:Inflammation is a critical component of asthma. Drugs that control asthma generally reduce the degree of airway inflammation. There is theoretical controversy surrounding the effects of beta(2)-agonists on airway inflammation, with some studies suggesting an anti-inflammatory effect, and others predicting a proinflamm...

journal_title：American journal of respiratory and critical care medicine

authors： Calhoun WJ,Hinton KL,Kratzenberg JJ

更新日期：2001-03-01 00:00:00

abstract：RATIONALE:Although current resuscitation guidelines are rescuer focused, the opportunity exists to develop patient-centered resuscitation strategies that optimize the hemodynamic response of the individual in the hopes to improve survival. OBJECTIVES:To determine if titrating cardiopulmonary resuscitation (CPR) to blo...

journal_title：American journal of respiratory and critical care medicine

authors： Sutton RM,Friess SH,Naim MY,Lampe JW,Bratinov G,Weiland TR 3rd,Garuccio M,Nadkarni VM,Becker LB,Berg RA

更新日期：2014-12-01 00:00:00

abstract：RATIONALE:Low blood levels of 25-hydroxyvitamin D (25[OH]D) have been associated with a higher risk of respiratory infections in general populations and higher risk of exacerbations of lung disease in people with asthma. We hypothesized that low blood levels of 25(OH)D in patients with chronic obstructive pulmonary dis...

journal_title：American journal of respiratory and critical care medicine

authors： Kunisaki KM,Niewoehner DE,Connett JE,COPD Clinical Research Network.

更新日期：2012-02-01 00:00:00

abstract：RATIONALE:Patients with acute lung injury have impaired function of the lung surfactant system. Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation and have suggested that treatment of patients with severe d...

journal_title：American journal of respiratory and critical care medicine

authors： Spragg RG,Taut FJ,Lewis JF,Schenk P,Ruppert C,Dean N,Krell K,Karabinis A,Günther A

更新日期：2011-04-15 00:00:00

abstract：RATIONALE:Platelets may interact with the immune system in tuberculosis (TB) to regulate human inflammatory responses that lead to morbidity and spread of infection. OBJECTIVES:To identify a functional role of platelets in the innate inflammatory and matrix-degrading response in TB. METHODS:Markers of platelet activa...

journal_title：American journal of respiratory and critical care medicine

authors： Fox KA,Kirwan DE,Whittington AM,Krishnan N,Robertson BD,Gilman RH,López JW,Singh S,Porter JC,Friedland JS

更新日期：2018-07-15 00:00:00

abstract：:A study was done to compare the efficacy and safety of the coprescription of salmeterol 50 microgram twice daily or 100 microgram twice daily with beclomethasone dipropionate (BDP) 500 micrograms twice daily (SALM 50 and SALM 100) with BDP 1,000 microgram twice daily (BDP 1,000) in patients with asthma not controlled ...

journal_title：American journal of respiratory and critical care medicine

authors： Woolcock A,Lundback B,Ringdal N,Jacques LA

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:Spirometric detection of airway obstruction in adults requires separate predictive formulae for each ethnicity and sex for percentage of FEV(1)/FVC (%FEV(1)/FVC) and percentage of FEV(3)/FVC (%FEV(3)/FVC), the major measurements for defining airway obstruction. OBJECTIVES:To eliminate the need for multiple f...

journal_title：American journal of respiratory and critical care medicine

authors： Hansen JE,Sun XG,Wasserman K

更新日期：2006-09-01 00:00:00

abstract：:The epidemiologic characteristics of lung cancer in Taiwan differ from those in other parts of the world in low male-to-female ratio, the high percentage of adenocarcinoma, and the relatively high percentage of nonsmokers who are victims. To investigate possible correlation between p53 gene alteration and the unique c...

journal_title：American journal of respiratory and critical care medicine

authors： Lee LN,Shew JY,Sheu JC,Lee YC,Lee WC,Fang MT,Chang HF,Yu CJ,Yang PC,Luh KT

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:The relative contribution of body proportion and social exposures to ethnic differences in lung function has not previously been reported in the United Kingdom. OBJECTIVES:To examine ethnic differences in lung function in relation to anthropometry and social and psychosocial factors in early adolescence. ME...

journal_title：American journal of respiratory and critical care medicine

authors： Whitrow MJ,Harding S

更新日期：2008-06-01 00:00:00

abstract：:The purpose of the present study is twofold: to evaluate alterations in total phospholipid content and individual phospholipid classes of the surfactant, and to detect markers of inflammatory reaction in bronchoalveolar lavage (BAL) from patients with hydrostatic pulmonary edema (HPE). Mechanically ventilated patients...

journal_title：American journal of respiratory and critical care medicine

authors： Nakos G,Pneumatikos J,Tsangaris I,Tellis C,Lekka M

更新日期：1997-03-01 00:00:00

abstract：:The aim of the study was to determine whether closing pressures or vascular distensibility can be used to describe liver venous hemodynamics when right atrial pressure is raised. The study was performed using a vascularly isolated pig liver preparation that allowed the independent control of portal vein and hepatic ar...

journal_title：American journal of respiratory and critical care medicine

authors： Brienza N,Ayuse T,O'Donnell CP,Permutt S,Robotham JL

更新日期：1995-08-01 00:00:00

abstract：:Rationale: Chronic cough is characterized by frequent urges to cough and a heightened sensitivity to inhaled irritants. Airway sensory nerves trigger cough. We hypothesized that sensory nerve density is increased in chronic cough, which may contribute to excessive and persistent coughing.Objectives: To measure airway ...

journal_title：American journal of respiratory and critical care medicine

authors： Shapiro CO,Proskocil BJ,Oppegard LJ,Blum ED,Kappel NL,Chang CH,Fryer AD,Jacoby DB,Costello RW,Drake MG

更新日期：2021-02-01 00:00:00

abstract：RATIONALE:FVC has emerged as a standard primary endpoint in clinical trials evaluating novel therapies for patients with idiopathic pulmonary fibrosis (IPF). However, it has recently been proposed that all-cause mortality or a composite comprised of all-cause mortality and all-cause nonelective hospitalization be adopt...

journal_title：American journal of respiratory and critical care medicine

authors： King TE Jr,Albera C,Bradford WZ,Costabel U,du Bois RM,Leff JA,Nathan SD,Sahn SA,Valeyre D,Noble PW

更新日期：2014-04-01 00:00:00

abstract：RATIONALE:Systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) portends worse outcome than other forms of PAH. Vasoconstrictive and vascular remodeling actions of endothelin (ET) 1 and angiotensin (Ang) II via endothelin receptor type A (ETAR) and Ang receptor type-1 (AT1R) activation are implicate...

journal_title：American journal of respiratory and critical care medicine

authors： Becker MO,Kill A,Kutsche M,Guenther J,Rose A,Tabeling C,Witzenrath M,Kühl AA,Heidecke H,Ghofrani HA,Tiede H,Schermuly RT,Nickel N,Hoeper MM,Lukitsch I,Gollasch M,Kuebler WM,Bock S,Burmester GR,Dragun D,Riemekasten

更新日期：2014-10-01 00:00:00

abstract：:Sarcoidosis is a systemic granulomatous disease of unknown etiology that primarily affects the lungs. The etiology remains unclear; however, environmental, genetic, ethnic, and familial factors probably modify expression of the disease. As an example, African Americans are at greater risk of mortality and morbidity th...

journal_title：American journal of respiratory and critical care medicine

authors： Martin WJ 2nd,Iannuzzi MC,Gail DB,Peavy HH

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:Ventilation-perfusion scintigraphy is highly sensitive for pulmonary embolism (PE), but its clinical usefulness is limited by its nondiagnostic rate. Objective analysis of single photon emission computed tomography (SPECT) three-dimensional scintigraphy may improve its diagnostic performance compared with sub...

journal_title：American journal of respiratory and critical care medicine

authors： Harris B,Bailey D,Miles S,Bailey E,Rogers K,Roach P,Thomas P,Hensley M,King GG

更新日期：2007-06-01 00:00:00

abstract：RATIONALE:Many authors have suggested that the mechanism by which atelectasis contributes to injury is through the repetitive opening and closing of distal airways in lung regions that are atelectatic. However, neither the topographic nor mechanistic relationships between atelectasis and distribution of lung injury are...

journal_title：American journal of respiratory and critical care medicine

authors： Tsuchida S,Engelberts D,Peltekova V,Hopkins N,Frndova H,Babyn P,McKerlie C,Post M,McLoughlin P,Kavanagh BP

更新日期：2006-08-01 00:00:00

abstract：:Diseases of the respiratory tract are among the leading causes of death in the world population. Increasing evidence points to a key role of the innate immune system with its pattern recognition receptors (PRRs) in both infectious and noninfectious lung diseases, which include pneumonia, chronic obstructive pulmonary ...

journal_title：American journal of respiratory and critical care medicine

authors： Opitz B,van Laak V,Eitel J,Suttorp N

更新日期：2010-06-15 00:00:00

abstract：:The incidence of mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in children with intermediate sweat chloride levels is unknown. The results of 2,349 sweat tests performed at two Belgian university hospitals were reviewed. Intermediate chloride concentrations were observed in 98 subjec...

journal_title：American journal of respiratory and critical care medicine

authors： Lebecque P,Leal T,De Boeck C,Jaspers M,Cuppens H,Cassiman JJ

更新日期：2002-03-15 00:00:00

abstract：:Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with primary pulmonary hypertension (PPH) has been speculative. Mutations in the bone morphogenetic protein recepto...

journal_title：American journal of respiratory and critical care medicine

authors： Runo JR,Vnencak-Jones CL,Prince M,Loyd JE,Wheeler L,Robbins IM,Lane KB,Newman JH,Johnson J,Nichols WC,Phillips JA 3rd

更新日期：2003-03-15 00:00:00

abstract：RATIONALE:The development of host-targeted, prophylactic, and therapeutic interventions against tuberculosis requires a better understanding of the immune mechanisms that determine the outcome of infection with Mycobacterium tuberculosis. OBJECTIVES:To identify T-cell-dependent mechanisms that are protective in tuberc...

journal_title：American journal of respiratory and critical care medicine

authors： Busch M,Herzmann C,Kallert S,Zimmermann A,Höfer C,Mayer D,Zenk SF,Muche R,Lange C,Bloom BR,Modlin RL,Stenger S,TBornotTB Network.

更新日期：2016-08-01 00:00:00