The effect of salmeterol on markers of airway inflammation following segmental allergen challenge.

abstract：RATIONALE:Constitutive activation of the epidermal growth factor receptor (EGFR) is prevalent in epithelial cancers, particularly in non-small cell lung carcinoma (NSCLC). Mutations identified in EGFR predict the sensitivity to EGFR-targeted therapy. Detection of these mutations is mainly based on tissue biopsy, which ...

journal_title：American journal of respiratory and critical care medicine

authors： Wei F,Lin CC,Joon A,Feng Z,Troche G,Lira ME,Chia D,Mao M,Ho CL,Su WC,Wong DT

更新日期：2014-11-15 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：:The effects of exposure to environmental tobacco smoke (ETS) on pulmonary function were investigated in a random sample of 1,033 adults aged 40 to 69 yr from a residential area in Beijing. Compared with those not exposed, those exposed to ETS either at home or at work were associated with a 102-ml (SE = 40 ml) reducti...

journal_title：American journal of respiratory and critical care medicine

authors： Xu X,Li B

更新日期：1995-01-01 00:00:00

abstract：:Poor adherence to medication regimens may be contributing to the recent increase in asthma morbidity and mortality. We examined patient characteristics that may influence adherence to twice-daily inhaled steroid regimens. Fifty adults with moderate to severe asthma completed questionnaires examining sociodemographics,...

journal_title：American journal of respiratory and critical care medicine

authors： Apter AJ,Reisine ST,Affleck G,Barrows E,ZuWallack RL

更新日期：1998-06-01 00:00:00

abstract：:Cell death is intertwined with life in development, homeostasis, pathology, and aging. Until recently, apoptosis was the best known form of programmed cell death, whereas necrosis was for a long time considered accidental owing to physicochemical injury. However, identification of crucial signaling and execution molec...

journal_title：American journal of respiratory and critical care medicine

authors： Moreno-Gonzalez G,Vandenabeele P,Krysko DV

更新日期：2016-08-15 00:00:00

abstract：RATIONALE:The airway surface liquid, the thin layer of liquid covering the airways, is essential for mucociliary clearance and as a barrier against microbial and other noxious agents. Proteins secreted into the airway surface liquid by epithelial and nonepithelial cells may be important in innate immunity and to improv...

journal_title：American journal of respiratory and critical care medicine

authors： Candiano G,Bruschi M,Pedemonte N,Caci E,Liberatori S,Bini L,Pellegrini C,Viganò M,O'Connor BJ,Lee TH,Galietta LJ,Zegarra-Moran O

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids. This has been linked to a reduction of histone deacetylase-2 as a result of oxidative stress and is reversed by theophylline. OBJECTIVES:To determine the role of phosphoinositide-3-kinase-delta (PI3K-δ) on the...

journal_title：American journal of respiratory and critical care medicine

authors： To Y,Ito K,Kizawa Y,Failla M,Ito M,Kusama T,Elliott WM,Hogg JC,Adcock IM,Barnes PJ

更新日期：2010-10-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is common in people with hypertension, particularly resistant hypertension. Treatment with an antihypertensive agent alone is often insufficient to control hypertension in patients with OSA. OBJECTIVES:To determine whether continuous positive airway pressure (CPAP) added to trea...

journal_title：American journal of respiratory and critical care medicine

authors： Thunström E,Manhem K,Rosengren A,Peker Y

更新日期：2016-02-01 00:00:00

abstract：:In animal models of endotoxemia, sepsis is associated with the accumulation of leukocytes and altered microvascular perfusion. In order to test the hypothesis that bacterial sepsis upregulates leukocyte-endothelial adhesion, we used intravital microscopy to examine the flow behavior of leukocytes in the postcapillary ...

journal_title：American journal of respiratory and critical care medicine

authors： Piper RD,Pitt-Hyde ML,Anderson LA,Sibbald WJ,Potter RF

更新日期：1998-01-01 00:00:00

abstract：:Pulmonary emphysema and periodontal disease are each characterized by the uncontrolled proteolysis of connective tissue proteins by proteinases derived from human neutrophils. Although these diseases would not appear to be related in terms of the initial insult to individual tissues, the ultimate result in each diseas...

journal_title：American journal of respiratory and critical care medicine

authors： Travis J,Pike R,Imamura T,Potempa J

更新日期：1994-12-01 00:00:00

abstract：:In patients with chronic obstructive pulmonary disease (COPD) the intensity of aerobic training is limited by dyspnea. Improving strength of the inspiratory muscles could enhance aerobic exercise training by reducing exercise-related dyspnea. We examined effects of home-based inspiratory muscle training (IMT) and cycl...

journal_title：American journal of respiratory and critical care medicine

authors： Larson JL,Covey MK,Wirtz SE,Berry JK,Alex CG,Langbein WE,Edwards L

更新日期：1999-08-01 00:00:00

abstract：RATIONALE:There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum. OBJECTIVES:To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD an...

journal_title：American journal of respiratory and critical care medicine

authors： Sin DD,Miller BE,Duvoix A,Man SF,Zhang X,Silverman EK,Connett JE,Anthonisen NA,Wise RA,Tashkin D,Celli BR,Edwards LD,Locantore N,Macnee W,Tal-Singer R,Lomas DA,ECLIPSE Investigators.

更新日期：2011-05-01 00:00:00

abstract：RATIONALE:Oxygen is commonly administered after extubation. Although several devices are available, data about their clinical efficacy are scarce. OBJECTIVES:To compare the effects of the Venturi mask and the nasal high-flow (NHF) therapy on PaO2/FiO2SET ratio after extubation. Secondary endpoints were to assess effec...

journal_title：American journal of respiratory and critical care medicine

authors： Maggiore SM,Idone FA,Vaschetto R,Festa R,Cataldo A,Antonicelli F,Montini L,De Gaetano A,Navalesi P,Antonelli M

更新日期：2014-08-01 00:00:00

abstract：:The intestinal immune system discriminates between potentially harmful and harmless foreign proteins. The basis for this differential response may be related to the conditions of antigen presentation by antigen-presenting cells, as determined by their phenotype or activation state. How these conditions affect specific...

journal_title：American journal of respiratory and critical care medicine

authors： Smith KM,Eaton AD,Finlayson LM,Garside P

更新日期：2000-10-01 00:00:00

abstract：:This study describes the natural history of atopic and wheezy disorders from birth to adult life in a cohort at risk of atopy. One hundred subjects born in Poole, England, were selected at birth in 1976 on the basis that at least one parent was atopic. Subjects were examined annually in the preschool years, and at the...

journal_title：American journal of respiratory and critical care medicine

authors： Rhodes HL,Thomas P,Sporik R,Holgate ST,Cogswell JJ

更新日期：2002-01-15 00:00:00

abstract：:Clinically, the spread of infectious agents between subjects undergoing spirometry is quite uncommon. There is almost no documentation in the medical literature on this subject. We studied the retrieval of nonpathogenic Escherichia coli after aerosolizing organisms into standard pulmonary function tubing of a type tha...

journal_title：American journal of respiratory and critical care medicine

authors： Hiebert T,Miles J,Okeson GC

更新日期：1999-02-01 00:00:00

abstract：:Gold-induced pulmonary disease is difficult to diagnose, especially, in the case in which interstitial pneumonia appears in the course of gold therapy for rheumatoid arthritis. We analyzed the literature to define the clinical features and prognosis of gold-induced pulmonary disease, and to identify those features tha...

journal_title：American journal of respiratory and critical care medicine

authors： Tomioka R,King TE Jr

更新日期：1997-03-01 00:00:00

abstract：RATIONALE:Little is known about human club cells, dome-shaped cells with dense cytoplasmic granules and microvilli that represent the major secretory cells of the human small airways (at least sixth-generation bronchi). OBJECTIVES:To define the ontogeny and biology of the human small airway epithelium club cell. METH...

journal_title：American journal of respiratory and critical care medicine

authors： Zuo WL,Shenoy SA,Li S,O'Beirne SL,Strulovici-Barel Y,Leopold PL,Wang G,Staudt MR,Walters MS,Mason C,Kaner RJ,Mezey JG,Crystal RG

更新日期：2018-12-01 00:00:00

abstract：:We have previously reported differential impairment of pulmonary and systemic vascular contractility in hyperdynamic sepsis. The objectives of this study were (1) to determine whether the magnitude of this phenomenon depends on the control group chosen for comparison, and (2) to examine the role of nitric oxide (NO) i...

journal_title：American journal of respiratory and critical care medicine

authors： Yaghi A,Paterson NA,McCormack DG

更新日期：1995-03-01 00:00:00

abstract：:Arousal from sleep produces transient increases in systemic blood pressure, leading to the suggestion that repeated arousals are associated with a sustained increase in daytime blood pressure. Using data from the Wisconsin Sleep Cohort Study, a population-based study, we tested the hypothesis that sleep fragmentation ...

journal_title：American journal of respiratory and critical care medicine

authors： Morrell MJ,Finn L,Kim H,Peppard PE,Badr MS,Young T

更新日期：2000-12-01 00:00:00

abstract：:Sarcoidosis is a systemic, granulomatous disorder with a high rate of spontaneous remission indicating the presence of antiinflammatory mechanisms. Antiinflammatory mediators such as interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) should be able to induce spontaneous remission of sarcoidosis. By ...

journal_title：American journal of respiratory and critical care medicine

authors： Zissel G,Homolka J,Schlaak J,Schlaak M,Müller-Quernheim J

更新日期：1996-09-01 00:00:00

abstract：:To determine the status of activation of lymphocytes and the role of cytokines on the inflammatory response of the bronchial mucosa in toluene diisocyanate (TDI) asthma, we performed a quantitative analysis of bronchial biopsies obtained from 15 subjects with TDI-induced asthma and seven normal control subjects. Marke...

journal_title：American journal of respiratory and critical care medicine

authors： Maestrelli P,di Stefano A,Occari P,Turato G,Milani G,Pivirotto F,Mapp CE,Fabbri LM,Saetta M

更新日期：1995-03-01 00:00:00

abstract：:The aim of the study was to determine risk factors for severe community-acquired pneumonia (CAP) as well as to compare microbial patterns of severe CAP to a previous study from our respiratory intensive care unit (ICU) originating from 1984 to 1987. Patients admitted to the ICU according to clinical judgment were defi...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Ewig S,Torres A,Arancibia F,Marco F,Mensa J,Sanchez M,Martinez JA

更新日期：1999-09-01 00:00:00

abstract：:The safety of sputum induction and the reproducibility of measurements in induced sputum in multicenter studies is unknown. We examined the safety of sputum induction in a two-visit, six-center study in 79 subjects with moderate to severe asthma (mean +/- SD FEV(1) 71 +/- 12% predicted, 67% taking inhaled corticostero...

journal_title：American journal of respiratory and critical care medicine

authors： Fahy JV,Boushey HA,Lazarus SC,Mauger EA,Cherniack RM,Chinchilli VM,Craig TJ,Drazen JM,Ford JG,Fish JE,Israel E,Kraft M,Lemanske RF,Martin RJ,McLean D,Peters SP,Sorkness C,Szefler SJ,NHLBI Asthma Clinical Research Netw

更新日期：2001-05-01 00:00:00

abstract：RATIONALE:The temporal stability of adult asthma phenotypes identified using clustering methods has never been addressed. Longitudinal cluster-based methods may provide novel insights in the study of the natural history of asthma. OBJECTIVES:To compare the stability of cluster-based asthma phenotype structures a decad...

journal_title：American journal of respiratory and critical care medicine

authors： Boudier A,Curjuric I,Basagaña X,Hazgui H,Anto JM,Bousquet J,Bridevaux PO,Dupuis-Lozeron E,Garcia-Aymerich J,Heinrich J,Janson C,Künzli N,Leynaert B,de Marco R,Rochat T,Schindler C,Varraso R,Pin I,Probst-Hensch N,Sun

更新日期：2013-09-01 00:00:00

abstract：:Airway hyperresponsiveness in asthma has been attributed to impaired ability of deep inspiration (DI) to stretch airway smooth muscle. We have retested this hypothesis by comparing the responses to methacholine of 10 asthmatic and 10 control subjects. After each dose subjects breathed tidally without deep inspiration ...

journal_title：American journal of respiratory and critical care medicine

authors： Burns GP,Gibson GJ

更新日期：1998-07-01 00:00:00

abstract：RATIONALE:Allergic bronchopulmonary aspergillosis (ABPA) is characterized by a Th2 immune response. Mouse models suggest a critical role for the Th2 chemokines thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in ABPA. OBJECTIVES:To determine whether serum levels of TARC and MDC ...

journal_title：American journal of respiratory and critical care medicine

authors： Hartl D,Latzin P,Zissel G,Krane M,Krauss-Etschmann S,Griese M

更新日期：2006-06-15 00:00:00

abstract：:Secretory leukocyte protease inhibitor (SLPI) and elafin are structurally similar, low-molecular-weight antiproteases produced in the lung. We have developed a simple method for distinguishing the antiprotease activities of SLPI and elafin in lung lavage fluid from those of alpha 1-antitrypsin (alpha 1-AT) that is bas...

journal_title：American journal of respiratory and critical care medicine

authors： Nadziejko C,Finkelstein I,Balmes JR

更新日期：1995-11-01 00:00:00

abstract：:This Executive Summary of the Global Strategy for the Diagnosis, Management, and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 report focuses primarily on the revised and novel parts of the document. The most significant changes include: (1) the assessment of chronic obstructiv...

journal_title：American journal of respiratory and critical care medicine

authors： Vogelmeier CF,Criner GJ,Martinez FJ,Anzueto A,Barnes PJ,Bourbeau J,Celli BR,Chen R,Decramer M,Fabbri LM,Frith P,Halpin DM,López Varela MV,Nishimura M,Roche N,Rodriguez-Roisin R,Sin DD,Singh D,Stockley R,Vestbo J,W

更新日期：2017-03-01 00:00:00

abstract：:Overproduction of NO by an inducible NO synthase (iNOS) plays a major role in the pathophysiology of septic shock, and selective inhibition of iNOS in this setting could be of great therapeutic value. In the present study, we evaluated the effects of L-canavanine, a selective iNOS inhibitor, in an animal model of sept...

journal_title：American journal of respiratory and critical care medicine

authors： Liaudet L,Fishman D,Markert M,Perret C,Feihl F

更新日期：1997-05-01 00:00:00