Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.

abstract：:The physiopathology of chronic cough remains obscure. We evaluated the possibility that chronic cough in nonasthmatic subjects is associated with airway inflammation, and if this is so, what the relationship between this inflammation and the possible etiology of cough might be, as well as its response to inhaled stero...

journal_title：American journal of respiratory and critical care medicine

authors： Boulet LP,Milot J,Boutet M,St Georges F,Laviolette M

更新日期：1994-02-01 00:00:00

abstract：:Partial liquid ventilation (PLV) has been shown to be an effective means of improving oxygenation in the injured lung. However, little is known about how approach to ventilation during PLV affects gas exchange and pulmonary mechanics. We hypothesized that gas exchange and pulmonary mechanics would be best with positiv...

journal_title：American journal of respiratory and critical care medicine

authors： Fujino Y,Kirmse M,Hess D,Kacmarek RM

更新日期：1999-04-01 00:00:00

abstract：:The expression of renin-angiotensin system components and the elevation of angiotensin-converting enzyme (ACE) in a number of fibrotic lung diseases suggests angiotensin II (AII) could play a role in the pathogenesis of pulmonary fibrosis. However, the effect of AII on lung fibroblasts has not previously been assessed...

journal_title：American journal of respiratory and critical care medicine

authors： Marshall RP,McAnulty RJ,Laurent GJ

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:The rate of progression of most interstitial lung diseases (ILD) is unpredictable. Fibrocytes are circulating bone marrow-derived cells that have been implicated in the pathogenesis of lung fibrosis. Hermansky-Pudlak syndrome (HPS), a genetic cause of ILD in early adulthood, allows for study of biomarkers of ...

journal_title：American journal of respiratory and critical care medicine

authors： Trimble A,Gochuico BR,Markello TC,Fischer R,Gahl WA,Lee JK,Kim Y,Burdick MD,Strieter RM,Mehrad B

更新日期：2014-12-15 00:00:00

abstract：RATIONALE:Brief recurrent apneas in preterm infants and adults can precipitate rapid and severe arterial O(2) desaturation for reasons that remain unclear. OBJECTIVES:We tested a mathematically derived hypothesis that when breathing terminates apnea, mixed-venous hypoxemia continues into the subsequent apnea; as a res...

journal_title：American journal of respiratory and critical care medicine

authors： Sands SA,Edwards BA,Kelly VJ,Skuza EM,Davidson MR,Wilkinson MH,Berger PJ

更新日期：2010-10-01 00:00:00

abstract：:Although the incidence of pulmonary hypertension is higher in female patients, numerous experimental studies have demonstrated better outcome in female animals, exacerbation of the disease after ovariectomy, and a strong protective effect of estrogen: a phenomenon known as the "estrogen paradox" of pulmonary hypertens...

journal_title：American journal of respiratory and critical care medicine

authors： Umar S,Rabinovitch M,Eghbali M

更新日期：2012-07-15 00:00:00

abstract：RATIONALE:Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. OBJECTIVES:We sought to identify donor, recipient, and perioperative risk factors for PGD. METHODS:We performed a 10-center p...

journal_title：American journal of respiratory and critical care medicine

authors： Diamond JM,Lee JC,Kawut SM,Shah RJ,Localio AR,Bellamy SL,Lederer DJ,Cantu E,Kohl BA,Lama VN,Bhorade SM,Crespo M,Demissie E,Sonett J,Wille K,Orens J,Shah AS,Weinacker A,Arcasoy S,Shah PD,Wilkes DS,Ware LB,Palme

更新日期：2013-03-01 00:00:00

abstract：:Transbronchial biopsies (TBBs) are useful to diagnose acute rejection and infection in patients with lung transplants. The value of routine surveillance biopsies (S-TBBs) is not known, and such biopsies with a clinical indication are not without risk and are expensive. One hundred twenty-six 6-mo survivors of heart-lu...

journal_title：American journal of respiratory and critical care medicine

authors： Tamm M,Sharples LD,Higenbottam TW,Stewart S,Wallwork J

更新日期：1997-05-01 00:00:00

abstract：RATIONALE:Poor adherence is common in difficult-to-control asthma. Distinguishing patients with difficult-to-control asthma who respond to inhaled corticosteroids (ICS) from refractory asthma is an important clinical challenge. OBJECTIVES:Suppression of fractional exhaled nitric oxide (FeNO) with directly observed ICS...

journal_title：American journal of respiratory and critical care medicine

authors： Heaney LG,Busby J,Bradding P,Chaudhuri R,Mansur AH,Niven R,Pavord ID,Lindsay JT,Costello RW,Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

更新日期：2019-02-15 00:00:00

abstract：RATIONALE:The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown. OBJECTIVES:To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi J,Hang JQ,Mehta AJ,Zhang HX,Dai HL,Su L,Eisen EA,Christiani DC

更新日期：2010-07-15 00:00:00

abstract：RATIONALE:Bronchiolitis is the most common lower respiratory infection in infants; however, it remains unclear which infants with bronchiolitis will develop severe illness. In addition, although emerging evidence indicates associations of the upper-airway microbiome with bronchiolitis severity, little is known about th...

journal_title：American journal of respiratory and critical care medicine

authors： Stewart CJ,Mansbach JM,Wong MC,Ajami NJ,Petrosino JF,Camargo CA Jr,Hasegawa K

更新日期：2017-10-01 00:00:00

abstract：RATIONALE:The role of NADPH oxidase activation in pneumonia is complex because reactive oxygen species contribute to both microbial killing and regulation of the acute pulmonary infiltrate. The relative importance of each role remains poorly defined in community-acquired pneumonia. OBJECTIVES:We evaluated the contribu...

journal_title：American journal of respiratory and critical care medicine

authors： Marriott HM,Jackson LE,Wilkinson TS,Simpson AJ,Mitchell TJ,Buttle DJ,Cross SS,Ince PG,Hellewell PG,Whyte MK,Dockrell DH

更新日期：2008-04-15 00:00:00

abstract：:To investigate the mechanisms underlying ventilator-dependence in patients with chronic obstructive pulmonary disease (COPD), and to assess the effects of the combination of positive end-expiratory pressure (PEEP) and pressure-support ventilation (PSV) on inspiratory muscle effort, we investigated respiratory mechanic...

journal_title：American journal of respiratory and critical care medicine

authors： Appendini L,Purro A,Patessio A,Zanaboni S,Carone M,Spada E,Donner CF,Rossi A

更新日期：1996-11-01 00:00:00

abstract：RATIONALE:The mechanism by which acute allograft rejection leads to chronic rejection remains poorly understood despite its common occurrence. Exosomes, membrane vesicles released from cells within the lung allograft, contain a diverse array of biomolecules that closely reflect the biologic state of the cell and tissue...

journal_title：American journal of respiratory and critical care medicine

authors： Gregson AL,Hoji A,Injean P,Poynter ST,Briones C,Palchevskiy V,Weigt SS,Shino MY,Derhovanessian A,Sayah D,Saggar R,Ross D,Ardehali A,Lynch JP 3rd,Belperio JA

更新日期：2015-12-15 00:00:00

abstract：:Recently described surgical approaches to the treatment of emphysema, including buttressed stapled volume reduction and laser coagulation, are associated with variable clinical outcomes. We examined objective preoperative factors as predictors of response to treatment in patients enrolled in a randomized trial of stap...

journal_title：American journal of respiratory and critical care medicine

authors： Brenner M,McKenna R Jr,Gelb A,Osann K,Schein MJ,Panzera J,Wong H,Berns MW,Wilson AF

更新日期：1997-04-01 00:00:00

abstract：:Most patients with cystic fibrosis (CF) are infected by Pseudomonas aeruginosa. Dextran exhibits anti-adhesive effects in preventing attachment of P. aeruginosa to epithelial cells (1). The initial purpose of this study was to evaluate the potential of dextran to alter the rheology and ciliary transportability of CF s...

journal_title：American journal of respiratory and critical care medicine

authors： Feng W,Garrett H,Speert DP,King M

更新日期：1998-03-01 00:00:00

abstract：RATIONALE:Recent findings have demonstrated that muscarinic M(3) receptor stimulation enhances airway smooth muscle proliferation to peptide growth factors in vitro. Because both peptide growth factor expression and acetylcholine release are known to be augmented in allergic airway inflammation, it is possible that ant...

journal_title：American journal of respiratory and critical care medicine

authors： Gosens R,Bos IS,Zaagsma J,Meurs H

更新日期：2005-05-15 00:00:00

abstract：:Decision analysis was used to compare three alternative strategies for a 6-mo course of treatment for tuberculosis: directly observed drug therapy (DOT), self-administered fixed-dose combination drug therapy, and self-administered conventional individual drug therapy. Estimates of effectiveness were obtained from the ...

journal_title：American journal of respiratory and critical care medicine

authors： Moore RD,Chaulk CP,Griffiths R,Cavalcante S,Chaisson RE

更新日期：1996-10-01 00:00:00

abstract：:To investigate repair mechanisms in bleomycin-induced pulmonary fibrosis, we used mice deficient in gamma-glutamyl transpeptidase (GGT-/-), a key enzyme in glutathione (GSH) and cysteine metabolism. Seventy-two hours after bleomycin (0.03 U/g), GGT-/- mice displayed a different inflammatory response to wild-type mice ...

journal_title：American journal of respiratory and critical care medicine

authors： Pardo A,Ruiz V,Arreola JL,Ramírez R,Cisneros-Lira J,Gaxiola M,Barrios R,Kala SV,Lieberman MW,Selman M

更新日期：2003-03-15 00:00:00

abstract：:Genetic factors are likely to contribute to the variable presentation of community-acquired pneumonia (CAP). The purpose of this prospective cohort study was to determine whether the LTalpha+250 (TNFbeta+250) and TNFalpha-308 gene polymorphisms are associated with different presentations of CAP. Septic shock (SS) was ...

journal_title：American journal of respiratory and critical care medicine

authors： Waterer GW,Quasney MW,Cantor RM,Wunderink RG

更新日期：2001-06-01 00:00:00

abstract：:Burkholderia gladioli has been reported as colonizing the airways of patients with cystic fibrosis (CF) but has not previously been associated with adverse outcome. We describe six patients with CF in whom the same strain of B. gladioli, on the basis of ribotyping and biochemical characteristics, was grown in their sp...

journal_title：American journal of respiratory and critical care medicine

authors： Wilsher ML,Kolbe J,Morris AJ,Welch DF

更新日期：1997-04-01 00:00:00

abstract：:We present a case of a pulmonary nodular lesion in an immunocompetent patient documented at open lung biopsy to be due to Mycobacterium haemophilum. This organism has recently been recognized as a cause of disease in immunocompromised patients, presenting predominantly as skin lesions, arthritis, and rarely pneumonia....

journal_title：American journal of respiratory and critical care medicine

authors： White DA,Kiehn TE,Bondoc AY,Massarella SA

更新日期：1999-10-01 00:00:00

abstract：RATIONALE:Despite increasing recognition of bone morphogenetic protein (BMP) signaling in tissue remodeling, the expression pattern of ligands and signaling pathways remain undefined in the asthmatic airway. OBJECTIVES:To determine expression of BMP ligands (BMP-2, BMP-4, and BMP-7) and type I and type II receptors (A...

journal_title：American journal of respiratory and critical care medicine

authors： Kariyawasam HH,Xanthou G,Barkans J,Aizen M,Kay AB,Robinson DS

更新日期：2008-05-15 00:00:00

abstract：:The severity of asthma can be graded from mild intermittent to severe persistent. Airway inflammation is a feature of persistent asthma. We compared several markers of inflammation in mucosal biopsies and bronchoalveolar lavage fluid (BAL fluid) from 12 healthy control subjects, 24 patients with intermittent asthma, a...

journal_title：American journal of respiratory and critical care medicine

authors： Vignola AM,Chanez P,Campbell AM,Souques F,Lebel B,Enander I,Bousquet J

更新日期：1998-02-01 00:00:00

abstract：:REM-related oxygen desaturation occurs in advanced Duchenne muscular dystrophy (DMD) and might be an independent predictor of disease progression. We have followed 18 patients for 10 yr after an initial respiratory sleep study or until death or onset of nasal ventilation. We measured baseline spirometry, blood gas ten...

journal_title：American journal of respiratory and critical care medicine

authors： Phillips MF,Smith PE,Carroll N,Edwards RH,Calverley PM

更新日期：1999-07-01 00:00:00

abstract：:The appearance of portable chest radiographs (CXRs) may be affected by changes in ventilation, particularly when patients are mechanically ventilated. Synchronization of the CXR with the ventilatory cycle should limit the influence of respiratory variation on the appearance of the CXR. This study evaluates the effect ...

journal_title：American journal of respiratory and critical care medicine

authors： Langevin PB,Hellein V,Harms SM,Tharp WK,Cheung-Seekit C,Lampotang S

更新日期：1999-12-01 00:00:00

abstract：:In unilateral lung injury, application of global positive end-expiratory pressure (PEEP) may cause overdistension of normal alveoli and redistribution of blood flow to diseased lung areas, thereby worsening oxygenation. We hypothesized that selective application of tracheal gas insufflation (TGI) will recruit the inju...

journal_title：American journal of respiratory and critical care medicine

authors： Blanch L,Van der Kloot TE,Youngblood AM,Murias G,Naveira A,Adams AB,Romero PV,Nahum A

更新日期：2001-08-15 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is used to ameliorate neutropenia in patients after antineoplastic treatment. It has also been suggested as an adjunct treatment in septic patients; however, the recruitment and priming of leukocytes by GM-CSF bears the hazard of a hyperinflammatory response. I...

journal_title：American journal of respiratory and critical care medicine

authors： Wollin L,Uhlig S,Nüsing R,Wendel A

更新日期：2001-02-01 00:00:00

abstract：RATIONALE:Drug-resistant tuberculosis transmission in hospitals threatens staff and patient health. Surgical face masks used by patients with tuberculosis (TB) are believed to reduce transmission but have not been rigorously tested. OBJECTIVES:We sought to quantify the efficacy of surgical face masks when worn by pati...

journal_title：American journal of respiratory and critical care medicine

authors： Dharmadhikari AS,Mphahlele M,Stoltz A,Venter K,Mathebula R,Masotla T,Lubbe W,Pagano M,First M,Jensen PA,van der Walt M,Nardell EA

更新日期：2012-05-15 00:00:00

abstract：RATIONALE:Severe asthma is a major public health issue throughout the world. Increased bronchial smooth muscle (BSM) mass, a characteristic feature of airway remodeling in severe asthma, is associated with resistance to high-intensity treatment and poor prognosis. In vitro, the Ca(2+)-channel blocker gallopamil decreas...

journal_title：American journal of respiratory and critical care medicine

authors： Girodet PO,Dournes G,Thumerel M,Begueret H,Dos Santos P,Ozier A,Dupin I,Trian T,Montaudon M,Laurent F,Marthan R,Berger P

更新日期：2015-04-15 00:00:00