Altered Exosomal RNA Profiles in Bronchoalveolar Lavage from Lung Transplants with Acute Rejection.

abstract：:In anaphylactic shock (AS), the relative effects of the autacoids including histamine, prostaglandins, and leukotrienes on causing cardiovascular collapse and the extent to which receptor blocking agents and pathway inhibitors may prevent this collapse are not clear. In a ragweed model of anaphylaxis, we examined whet...

journal_title：American journal of respiratory and critical care medicine

authors： Chrusch C,Sharma S,Unruh H,Bautista E,Duke K,Becker A,Kepron W,Mink SN

更新日期：1999-10-01 00:00:00

abstract：:The aim of this study was to assess the influence of preservation solution type and extra- or intracellular composition on the occurrence of early graft dysfunction after clinical lung transplantation. For 170 patients who underwent a single (n = 124) or bilateral (n = 46) lung transplantation in two centers in Paris ...

journal_title：American journal of respiratory and critical care medicine

authors： Thabut G,Vinatier I,Brugière O,Lesèche G,Loirat P,Bisson A,Marty J,Fournier M,Mal H

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:Cytokine receptors can be markers defining different T-cell subsets and considered as therapeutic targets. The association of IL-6 and IL-6 receptor α (IL-6Rα) with asthma was reported, suggesting their involvement in asthma. OBJECTIVES:To determine whether and how IL-6Rα defines a distinct effector memory (...

journal_title：American journal of respiratory and critical care medicine

authors： Lee N,You S,Shin MS,Lee WW,Kang KS,Kim SH,Kim WU,Homer RJ,Kang MJ,Montgomery RR,Dela Cruz CS,Shaw AC,Lee PJ,Chupp GL,Hwang D,Kang I

更新日期：2014-12-15 00:00:00

abstract：:The role of immunoglobulin E (IgE) in the development and course of impaired ventilatory function and chronic obstructive pulmonary disease (COPD) required further study. This role has been examined in the longitudinal Tucson Epidemiological Study of Airways Obstructive Disease, which started in 1972. The association ...

journal_title：American journal of respiratory and critical care medicine

authors： Sherrill DL,Lebowitz MD,Halonen M,Barbee RA,Burrows B

更新日期：1995-07-01 00:00:00

abstract：:We sought to characterize polymorphisms in the proximal coding region of the lipopolysaccharide binding protein gene and to determine whether a previously reported variant was associated with sepsis complicated by organ failure or shock after trauma. We used multiple analytical methods, including pyrosequencing, restr...

journal_title：American journal of respiratory and critical care medicine

authors： Barber RC,O'Keefe GE

更新日期：2003-05-15 00:00:00

abstract：:To elucidate the apparent contradictions in vascular remodeling in the lungs of patients with idiopathic pulmonary fibrosis, we evaluated alveolar vascularity in relation to the various degrees of fibrosis in surgically biopsied lungs of usual interstitial pneumonia. Alveolar capillary endothelial cells were intensely...

journal_title：American journal of respiratory and critical care medicine

authors： Ebina M,Shimizukawa M,Shibata N,Kimura Y,Suzuki T,Endo M,Sasano H,Kondo T,Nukiwa T

更新日期：2004-06-01 00:00:00

abstract：:The nasal mucosal is the first site of contact with inhaled antigens. However, the nature of local immune responses and the role of nasal-associated lymphoid tissue (NALT) in those responses have rarely been studied. To characterize the cells involved in mucosally derived immune responses, NALT and Peyer's patch (PP) ...

journal_title：American journal of respiratory and critical care medicine

authors： Heritage PL,Underdown BJ,Arsenault AL,Snider DP,McDermott MR

更新日期：1997-10-01 00:00:00

abstract：:The impact of methicillin resistance on morbidity and mortality of patients suffering from severe Staphylococcus aureus infections remains highly controversial. We analyzed a retrospective cohort of 97 patients with methicillin-susceptible and 74 patients with methicillin-resistant Staphylococcus aureus ventilator-ass...

journal_title：American journal of respiratory and critical care medicine

authors： Combes A,Luyt CE,Fagon JY,Wollf M,Trouillet JL,Gibert C,Chastre J,PNEUMA Trial Group.

更新日期：2004-10-01 00:00:00

abstract：:The failure of patients to adhere to physician-prescribed regimens, either pharmacologic or behavioral, has been well documented in medical literature. Poor adherence to asthma medication regimens has been repeatedly demonstrated in both children and adults, with rates of nonadherence commonly reported from 30 to 70%....

journal_title：American journal of respiratory and critical care medicine

authors： Rand CS,Wise RA

更新日期：1994-02-01 00:00:00

abstract：:Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the National Heart, Lung, and Blood Institute. Decades of clinical research in acute respiratory distress syndrome, acute respiratory failure, pneumonia, and sepsis have...

journal_title：American journal of respiratory and critical care medicine

authors： Semler MW,Bernard GR,Aaron SD,Angus DC,Biros MH,Brower RG,Calfee CS,Colantuoni EA,Ferguson ND,Gong MN,Hopkins RO,Hough CL,Iwashyna TJ,Levy BD,Martin TR,Matthay MA,Mizgerd JP,Moss M,Needham DM,Self WH,Seymour CW,

更新日期：2020-03-09 00:00:00

abstract：RATIONALE:An asthma predisposition locus on chromosome 17q12-q21 has recently been replicated in different ethnic groups. OBJECTIVES:To characterize the asthma and atopy phenotypes in early childhood that associate with the 17q12-21 locus. METHODS:The single nucleotide polymorphism (SNP), rs7216389, was genotyped in ...

journal_title：American journal of respiratory and critical care medicine

authors： Bisgaard H,Bønnelykke K,Sleiman PM,Brasholt M,Chawes B,Kreiner-Møller E,Stage M,Kim C,Tavendale R,Baty F,Pipper CB,Palmer CN,Hakonarsson H

更新日期：2009-02-01 00:00:00

abstract：RATIONALE:The vast majority of children around the world undergoing adenotonsillectomy for obstructive sleep apnea-hypopnea syndrome (OSA) are not objectively diagnosed by nocturnal polysomnography because of access availability and cost issues. Automated analysis of nocturnal oximetry (nSpO2), which is readily and glo...

journal_title：American journal of respiratory and critical care medicine

authors： Hornero R,Kheirandish-Gozal L,Gutiérrez-Tobal GC,Philby MF,Alonso-Álvarez ML,Álvarez D,Dayyat EA,Xu Z,Huang YS,Tamae Kakazu M,Li AM,Van Eyck A,Brockmann PE,Ehsan Z,Simakajornboon N,Kaditis AG,Vaquerizo-Villar F,Crespo S

更新日期：2017-12-15 00:00:00

abstract：:Because interleukin 8 (IL-8) is a potent neutrophil chemotactic and activating cytokine, we investigated IL-8 production in relation to neutrophil migration and elastase release in the human lung during unilateral community-acquired pneumonia (CAP). In 17 patients, the local response in the involved lung was compared ...

journal_title：American journal of respiratory and critical care medicine

authors： Boutten A,Dehoux MS,Seta N,Ostinelli J,Venembre P,Crestani B,Dombret MC,Durand G,Aubier M

更新日期：1996-01-01 00:00:00

abstract：:Decreases in gastric mucosal pH (pHi) are associated with splanchnic hypoxia in animals and with increased mortality in patients. In the present study we measured changes in gastric pHi with a tonometer in septic patients after a short-term infusion of dobutamine. These changes were compared with concurrent alteration...

journal_title：American journal of respiratory and critical care medicine

authors： Gutierrez G,Clark C,Brown SD,Price K,Ortiz L,Nelson C

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson, Arizona, we previously described four phenotypes based on the occurrence of wheezing lower respiratory illnesses before ...

journal_title：American journal of respiratory and critical care medicine

authors： Morgan WJ,Stern DA,Sherrill DL,Guerra S,Holberg CJ,Guilbert TW,Taussig LM,Wright AL,Martinez FD

更新日期：2005-11-15 00:00:00

abstract：RATIONALE:Daily azithromycin decreases acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but long-term side effects are unknown. OBJECTIVES:To identify the types of exacerbations most likely to be reduced and clinical subgroups most likely to benefit from azithromycin, 250 mg daily, added to usual...

journal_title：American journal of respiratory and critical care medicine

authors： Han MK,Tayob N,Murray S,Dransfield MT,Washko G,Scanlon PD,Criner GJ,Casaburi R,Connett J,Lazarus SC,Albert R,Woodruff P,Martinez FJ

更新日期：2014-06-15 00:00:00

abstract：:Currently the diagnosis of chronic obstructive pulmonary disease (COPD) requires the demonstration of airflow limitation, defined as a post-bronchodilator FEV1/FVC <0.7, a measurement that remains methodologically robust and widely available. FEV1 is one of the most powerful predictors of clinically relevant outcomes ...

journal_title：American journal of respiratory and critical care medicine

authors： Han MK,Agusti A,Celli BR,Criner GJ,Halpin DMG,Roche N,Papi A,Stockley RA,Wedzicha J,Vogelmeier CF

更新日期：2020-11-19 00:00:00

abstract：:In a prospective study, we screened specimens from 190 mechanically ventilated patients hospitalized in a surgical intensive care unit, and from the environment to assess risks and routes of colonization/infection. Specimens from various sites were collected on admission and once a week throughout each patient's stay....

journal_title：American journal of respiratory and critical care medicine

authors： Talon D,Mulin B,Rouget C,Bailly P,Thouverez M,Viel JF

更新日期：1998-03-01 00:00:00

abstract：:Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with primary pulmonary hypertension (PPH) has been speculative. Mutations in the bone morphogenetic protein recepto...

journal_title：American journal of respiratory and critical care medicine

authors： Runo JR,Vnencak-Jones CL,Prince M,Loyd JE,Wheeler L,Robbins IM,Lane KB,Newman JH,Johnson J,Nichols WC,Phillips JA 3rd

更新日期：2003-03-15 00:00:00

abstract：RATIONALE:Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of renal endothelial cell injury) associated with hypoxemia. OBJECTIVES:To determine whether (1) cigarette smoke (CS)-induced pulmonary and renal endothelial cell injury explains the association between albumin...

journal_title：American journal of respiratory and critical care medicine

authors： Polverino F,Laucho-Contreras ME,Petersen H,Bijol V,Sholl LM,Choi ME,Divo M,Pinto-Plata V,Chetta A,Tesfaigzi Y,Celli BR,Owen CA

更新日期：2017-06-01 00:00:00

abstract：:The etiology of sleep disruption in patients in intensive care units (ICUs) is poorly understood, but is thought to be related to environmental stimuli, especially noise. We sampled 203 patients (121 males and 82 females) from different ICUs (cardiac [CCU], cardiac stepdown [CICU], medical [MICU], and surgical [SICU])...

journal_title：American journal of respiratory and critical care medicine

authors： Freedman NS,Kotzer N,Schwab RJ

更新日期：1999-04-01 00:00:00

abstract：:To investigate whether the language of dyspnea provides relevant clinical information in addition to that provided by ratings of overall dyspnea intensity when assessing subjective response to therapy, we conducted a prospective study in a cohort of 25 patients with acute asthma presenting to the emergency department ...

journal_title：American journal of respiratory and critical care medicine

authors： Moy ML,Lantin ML,Harver A,Schwartzstein RM

更新日期：1998-09-01 00:00:00

abstract：:REM-related oxygen desaturation occurs in advanced Duchenne muscular dystrophy (DMD) and might be an independent predictor of disease progression. We have followed 18 patients for 10 yr after an initial respiratory sleep study or until death or onset of nasal ventilation. We measured baseline spirometry, blood gas ten...

journal_title：American journal of respiratory and critical care medicine

authors： Phillips MF,Smith PE,Carroll N,Edwards RH,Calverley PM

更新日期：1999-07-01 00:00:00

abstract：:The effects of glutathione-S-transferase (GST) M1, GSTT1, and GSTP1 genotypes on lung function growth were investigated in 1,940 children enrolled in the Children's Health Study as fourth graders (aged 8-11 years) in two cohorts during 1993 and 1996 and were followed annually over a 4-year period. Genotypes for GSTM1 ...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Gauderman WJ,Vora H,Rappaport E,Dubeau L

更新日期：2002-09-01 00:00:00

abstract：RATIONALE:Genetic alterations on 8p22 have been implicated in multiple cancers, including lung cancer. In this region, genetic variants of the class A scavenger receptor (SR-A) gene have been associated with prostate cancer risk and have been highlighted as a potential susceptibility gene of cancer. OBJECTIVES:To dete...

journal_title：American journal of respiratory and critical care medicine

authors： Ben J,Jin G,Zhang Y,Ma B,Bai H,Chen J,Zhang H,Gong Q,Zhou X,Zhang H,Qian L,Zhu X,Li X,Yang Q,Hu Z,Xu Y,Shen H,Chen Q

更新日期：2012-10-15 00:00:00

abstract：RATIONALE:Inhaled human insulin (INH; Exubera [human insulin (recombinant DNA origin) Inhalation Powder]) causes small changes in pulmonary function and increases in insulin antibodies compared with subcutaneous (SC) insulin. OBJECTIVES:To investigate the relationship between changes in pulmonary function and insulin ...

journal_title：American journal of respiratory and critical care medicine

authors： Teeter JG,Riese RJ

更新日期：2006-06-01 00:00:00

abstract：:Transbronchial biopsies (TBBs) are useful to diagnose acute rejection and infection in patients with lung transplants. The value of routine surveillance biopsies (S-TBBs) is not known, and such biopsies with a clinical indication are not without risk and are expensive. One hundred twenty-six 6-mo survivors of heart-lu...

journal_title：American journal of respiratory and critical care medicine

authors： Tamm M,Sharples LD,Higenbottam TW,Stewart S,Wallwork J

更新日期：1997-05-01 00:00:00

abstract：RATIONALE:Statin use has been linked to improved lung health in asthma and chronic obstructive pulmonary disease. We hypothesize that statins inhibit allergic airway inflammation and reduce airway hyperreactivity via a mevalonate-dependent mechanism. OBJECTIVES:To determine whether simvastatin attenuates airway inflam...

journal_title：American journal of respiratory and critical care medicine

authors： Zeki AA,Franzi L,Last J,Kenyon NJ

更新日期：2009-10-15 00:00:00

abstract：:The stimuli controlling pharyngeal dilator muscles are poorly defined. Local mechanoreceptors are a leading possibility. To address this, we assessed the relationship between two dilator muscle electromyograms (EMGs, i.e., genioglossus [GG-an inspiratory phasic muscle], tensor palatini [TP-a tonically active muscle]) ...

journal_title：American journal of respiratory and critical care medicine

authors： Malhotra A,Pillar G,Fogel RB,Beauregard J,Edwards JK,Slamowitz DI,Shea SA,White DP

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:The mechanisms by which oxidants are sensed by cells and cause inflammation are not well understood. OBJECTIVES:This study aimed to determine how cells "sense" soluble oxidants and how this is translated into an inflammatory reaction. METHODS:Monocytes, macrophages, or HEK293 cells (stably transfected with ...

journal_title：American journal of respiratory and critical care medicine

authors： Paul-Clark MJ,McMaster SK,Sorrentino R,Sriskandan S,Bailey LK,Moreno L,Ryffel B,Quesniaux VF,Mitchell JA

更新日期：2009-02-15 00:00:00