Abstract:
:To elucidate the apparent contradictions in vascular remodeling in the lungs of patients with idiopathic pulmonary fibrosis, we evaluated alveolar vascularity in relation to the various degrees of fibrosis in surgically biopsied lungs of usual interstitial pneumonia. Alveolar capillary endothelial cells were intensely immunoreactive with CD34 but not with von Willebrand factor. Vascular density, that is, the relative ratio of capillary area to total area of alveolar walls, was significantly higher at low grades of fibrosis than in control lungs, whereas vascular density gradually decreased as the degree of fibrosis increased and was lower than that of control lungs in the most extensively fibrotic lesions. No vessels were observed inside fibroblastic foci. The potent angiogenic factors vascular endothelial growth factor and interleukin-8 were abundantly produced by capillary endothelial cells and alveolar epithelial cells in highly vascularized alveolar walls. In contrast, venules with CD34-negative but von Willebrand factor-positive endothelial cells localized in the center of the fibrotic lesions were slightly increased and identified as postcapillary venules by three-dimensional reconstructed images. These results indicate the presence of heterogeneous vascular remodeling in usual interstitial pneumonia.
journal_name
Am J Respir Crit Care Medauthors
Ebina M,Shimizukawa M,Shibata N,Kimura Y,Suzuki T,Endo M,Sasano H,Kondo T,Nukiwa Tdoi
10.1164/rccm.200308-1111OCkeywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
1203-8issue
11eissn
1073-449Xissn
1535-4970pii
200308-1111OCjournal_volume
169pub_type
杂志文章abstract:RATIONALE:Donor mesenchymal stromal/stem cell (MSC) expansion and fibrotic differentiation is associated with development of bronchiolitis obliterans syndrome (BOS) in human lung allografts. However, the regulators of fibrotic differentiation of these resident mesenchymal cells are not well understood. OBJECTIVES:This...
journal_title:American journal of respiratory and critical care medicine
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章,多中心研究,评审
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更新日期:2015-06-01 00:00:00
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更新日期:2006-01-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2020-12-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2001-11-15 00:00:00
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更新日期:1998-07-01 00:00:00
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更新日期:2005-12-15 00:00:00
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更新日期:2008-09-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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更新日期:1994-01-01 00:00:00
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更新日期:1996-10-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2012-07-15 00:00:00
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更新日期:2011-05-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2009-07-15 00:00:00
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更新日期:2017-09-15 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2009-10-01 00:00:00
abstract::The effect of a dental appliance (DA) is usually evaluated in a single mandibular position reached after several weeks and corresponding to either improvement of symptoms or intolerance to any further advancement. The purpose of this study was to test the feasibility of one-night evaluation of the efficacy of a DA. Th...
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更新日期:2002-04-15 00:00:00
abstract:RATIONALE:Daily azithromycin decreases acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but long-term side effects are unknown. OBJECTIVES:To identify the types of exacerbations most likely to be reduced and clinical subgroups most likely to benefit from azithromycin, 250 mg daily, added to usual...
journal_title:American journal of respiratory and critical care medicine
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更新日期:2014-06-15 00:00:00
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更新日期:2008-12-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Lung cancer screening (LCS) has the potential to reduce the risk of lung cancer death in healthy individuals, but the impact of coexisting chronic illnesses on LCS outcomes has not been well defined. Consideration of the complex relationship between baseline risk of lung cancer, treatment-related harms, and ...
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更新日期:2018-07-15 00:00:00
abstract:RATIONALE:Pulmonary hypertension (PH) is a life-threatening disease, characterized by vascular remodeling and vasoconstriction. Evidence suggests that oxidative stress may contribute to the pathogenesis and/or development of PH. OBJECTIVES:In the present study, we examined whether intratracheal gene transfer of human ...
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更新日期:2008-01-15 00:00:00
abstract::The plasma level of fibrinogen is felt to be an independent risk factor for vascular events. Obstructive sleep apnea (OSA) has a high prevalence in patients with stroke and may also be an independent risk factor. The aim of our study was to determine the association between OSA and plasma levels of fibrinogen in patie...
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更新日期:2000-12-01 00:00:00
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更新日期:2010-10-15 00:00:00