Analysis of clinical methods used to evaluate dyspnea in patients with chronic obstructive pulmonary disease.

abstract：:To investigate patterns of testing for human immunodeficiency virus (HIV) infection in tuberculosis patients, we obtained data from the tuberculosis registry and from medical records of 500 tuberculosis patients in Los Angeles County. Sixty-three percent of tuberculosis patients were tested for HIV infection, and mult...

journal_title：American journal of respiratory and critical care medicine

authors： Asch SM,London AS,Barnes PF,Gelberg L

更新日期：1997-01-01 00:00:00

abstract：:Positive pressure ventilation with large VTs has been shown to cause release of cytokines, including macrophage inflammatory protein-2 (MIP-2), a functional equivalent of human interleukin-8. The mechanisms regulating ventilation-induced cytokine production are unclear. Based on our previous in vitro model of lung cel...

journal_title：American journal of respiratory and critical care medicine

authors： Li LF,Yu L,Quinn DA

更新日期：2004-02-15 00:00:00

abstract：:It is controversial whether mutations in cystic fibrosis transmembrane conductance regulator intrinsically dysregulate inflammation. We characterized passage 2 human tracheobronchial epithelial cell cultures morphologically and physiologically and determined whether cytokine production or nuclear factor-kappaB activat...

journal_title：American journal of respiratory and critical care medicine

authors： Becker MN,Sauer MS,Muhlebach MS,Hirsh AJ,Wu Q,Verghese MW,Randell SH

更新日期：2004-03-01 00:00:00

abstract：:The aim of this study was to assess the influence of preservation solution type and extra- or intracellular composition on the occurrence of early graft dysfunction after clinical lung transplantation. For 170 patients who underwent a single (n = 124) or bilateral (n = 46) lung transplantation in two centers in Paris ...

journal_title：American journal of respiratory and critical care medicine

authors： Thabut G,Vinatier I,Brugière O,Lesèche G,Loirat P,Bisson A,Marty J,Fournier M,Mal H

更新日期：2001-10-01 00:00:00

abstract：:Early experience suggests that lung volume reduction surgery improves exercise tolerance as measured by the 6-min walk distance in patients with emphysema. To identify the physiologic mechanism(s) by which lung volume reduction surgery improved exercise, we performed progressive cardiopulmonary exercise testing, inclu...

journal_title：American journal of respiratory and critical care medicine

authors： Benditt JO,Lewis S,Wood DE,Klima L,Albert RK

更新日期：1997-08-01 00:00:00

abstract：:The present study was designed to examine whether clenbuterol (CLEN) could reduce dexamethasone (DEX)-induced diaphragm dysfunction. We studied four groups of New Zealand white (NZW) rabbits, each receiving one of the following daily injections subcutaneously for 2 wk: saline (control), DEX 3 mg/kg, DEX 3 mg/kg + CLEN...

journal_title：American journal of respiratory and critical care medicine

authors： Jiang TX,Cairns A,Road JD,Wilcox PG

更新日期：1996-12-01 00:00:00

abstract：RATIONALE:An increasing number of persons, exposed to high altitude for leisure, sport, or work, may suffer from severe high-altitude illness. OBJECTIVES:To assess, in a large cohort of subjects, the association between physiological parameters and the risk of altitude illness and their discrimination ability in a ris...

journal_title：American journal of respiratory and critical care medicine

authors： Richalet JP,Larmignat P,Poitrine E,Letournel M,Canouï-Poitrine F

更新日期：2012-01-15 00:00:00

abstract：:CD14 influences postnatal switching of T helper cell responses. CD14 C-159T has been associated with altered CD14 and IgE levels in cross-sectional studies. Identifying whether associations vary with age requires data from children of the same age followed longitudinally over many years. In this study, an unselected p...

journal_title：American journal of respiratory and critical care medicine

authors： O'Donnell AR,Toelle BG,Marks GB,Hayden CM,Laing IA,Peat JK,Goldblatt J,Le Souëf PN

更新日期：2004-03-01 00:00:00

abstract：:Rationale: The bHLH (basic helix-loop-helix) transcription factor TWIST1 (Twist-related protein 1) controls cell proliferation and differentiation in tissue development and disease processes. Recently, endothelial TWIST1 has been linked to pulmonary hypertension (PH) and endothelial-to-mesenchymal transition, yet the ...

journal_title：American journal of respiratory and critical care medicine

authors： Fan Y,Gu X,Zhang J,Sinn K,Klepetko W,Wu N,Foris V,Solymosi P,Kwapiszewska G,Kuebler WM

更新日期：2020-11-01 00:00:00

abstract：:Reduced diaphragm contractility has been described in normal subjects after whole body endurance exercise, and it indicates low frequency fatigue (LFF); it is unknown whether LFF is of clinical importance. We therefore studied the effect of treadmill exercise to exhaustion on diaphragm contractility in six patients wi...

journal_title：American journal of respiratory and critical care medicine

authors： Polkey MI,Kyroussis D,Keilty SE,Hamnegard CH,Mills GH,Green M,Moxham J

更新日期：1995-09-01 00:00:00

abstract：:We hypothesized that variation in extubating brain injured patients would affect the incidence of nosocomial pneumonia, length of stay, and hospital charges. In a prospective cohort of consecutive, intubated brain-injured patients, we evaluated daily: intubation status, spontaneous ventilatory parameters, gas exchange...

journal_title：American journal of respiratory and critical care medicine

authors： Coplin WM,Pierson DJ,Cooley KD,Newell DW,Rubenfeld GD

更新日期：2000-05-01 00:00:00

abstract：:Bronchial overproduction of leukotrienes and inhibition of prostaglandin synthesis are involved in the pathogenesis of aspirin-induced asthma. We investigated whether inhaled prostaglandin E2 (PGE2) attenuates the response to bronchial challenge with lysine acetylsalicylate (LASA) and the associated increase in urinar...

journal_title：American journal of respiratory and critical care medicine

authors： Sestini P,Armetti L,Gambaro G,Pieroni MG,Refini RM,Sala A,Vaghi A,Folco GC,Bianco S,Robuschi M

更新日期：1996-02-01 00:00:00

abstract：:Nitric oxide (NO) may play a part in pulmonary vascular regulation and bronchomotor control and has been detected in exhaled air. We report the release of NO from airway epithelial cells and its regulation by cyclic adenosine monophosphate (cAMP). To directly measure NO release, a highly specific amperometric sensor f...

journal_title：American journal of respiratory and critical care medicine

authors： Tamaoki J,Kondo M,Takemura H,Chiyotani A,Yamawaki I,Konno K

更新日期：1995-10-01 00:00:00

abstract：:Characterization of chemokine expression patterns in virus-infected epithelial cells provides important clues to the pathophysiology of such infections. The aim of this study was to determine the chemokine response pattern of respiratory epithelium when infected with respiratory syncytial virus (RSV). Macrophage infla...

journal_title：American journal of respiratory and critical care medicine

authors： Harrison AM,Bonville CA,Rosenberg HF,Domachowske JB

更新日期：1999-06-01 00:00:00

abstract：:Controversy exists regarding the clinical utility of pleural fluid pH, lactate dehydrogenase (LDH), and glucose for identifying complicated parapneumonic effusions that require drainage. In this report, we performed a meta-analysis of pertinent studies, using receiver operating characteristic (ROC) techniques, to asse...

journal_title：American journal of respiratory and critical care medicine

authors： Heffner JE,Brown LK,Barbieri C,DeLeo JM

更新日期：1995-06-01 00:00:00

abstract：:In patients with chronic obstructive pulmonary disease (COPD) the intensity of aerobic training is limited by dyspnea. Improving strength of the inspiratory muscles could enhance aerobic exercise training by reducing exercise-related dyspnea. We examined effects of home-based inspiratory muscle training (IMT) and cycl...

journal_title：American journal of respiratory and critical care medicine

authors： Larson JL,Covey MK,Wirtz SE,Berry JK,Alex CG,Langbein WE,Edwards L

更新日期：1999-08-01 00:00:00

abstract：:Asthmaexpert, an expert system (ES), was produced at the special request of several clinicians in order to better understand the medical decisions made clinical experts in managing an asthmatic patient. We describe and evaluate this knowledge base, focusing mainly on assessment of the severity of asthma. After compili...

journal_title：American journal of respiratory and critical care medicine

authors： Redier H,Daures JP,Michel C,Proudhon H,Vervloet D,Charpin D,Marsac J,Dusser D,Brambilla C,Wallaert B

更新日期：1995-02-01 00:00:00

abstract：:CC-chemokine receptor 3 (CCR3)-stimulating chemokines are likely to have important in vivo roles in the regulation of eosinophil, basophil, and potentially helper T cell type 2 and mast cell recruitment. We have developed techniques to investigate the actions of eotaxin and other chemokines on multiple leukocyte popul...

journal_title：American journal of respiratory and critical care medicine

authors： Bryan SA,Jose PJ,Topping JR,Wilhelm R,Soderberg C,Kertesz D,Barnes PJ,Williams TJ,Hansel TT,Sabroe I

更新日期：2002-06-15 00:00:00

abstract：:Retrospective studies have suggested that combination antibiotic therapy for severe bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a prospective, multicenter, international observational study of 844 adult patients with bacteremia due to Streptococcus pneumoniae. The effect of combin...

journal_title：American journal of respiratory and critical care medicine

authors： Baddour LM,Yu VL,Klugman KP,Feldman C,Ortqvist A,Rello J,Morris AJ,Luna CM,Snydman DR,Ko WC,Chedid MB,Hui DS,Andremont A,Chiou CC,International Pneumococcal Study Group.

更新日期：2004-08-15 00:00:00

abstract：:Smoking is the major risk factor for chronic respiratory symptoms, but dietary factors may also play a role. Most studies of diet and lung disease have been cross-sectional and conducted in populations with a Western-style diet. We analyzed the relation between dietary intake at baseline and new onset of cough with ph...

journal_title：American journal of respiratory and critical care medicine

authors： Butler LM,Koh WP,Lee HP,Yu MC,London SJ

更新日期：2004-08-01 00:00:00

abstract：RATIONALE:Brief recurrent apneas in preterm infants and adults can precipitate rapid and severe arterial O(2) desaturation for reasons that remain unclear. OBJECTIVES:We tested a mathematically derived hypothesis that when breathing terminates apnea, mixed-venous hypoxemia continues into the subsequent apnea; as a res...

journal_title：American journal of respiratory and critical care medicine

authors： Sands SA,Edwards BA,Kelly VJ,Skuza EM,Davidson MR,Wilkinson MH,Berger PJ

更新日期：2010-10-01 00:00:00

abstract：:The inflection points of the pressure-volume curve have been used for setting mechanical ventilation in patients with acute lung injury. However, the lung status at these points has never been specifically addressed. In 12 patients with early lung injury we traced both limbs of the pressure-volume curve by means of a ...

journal_title：American journal of respiratory and critical care medicine

authors： Albaiceta GM,Taboada F,Parra D,Luyando LH,Calvo J,Menendez R,Otero J

更新日期：2004-11-15 00:00:00

abstract：:Airway inflammation is involved in the pathogenesis of bronchial asthma. Intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen-1 alpha (LFA-1 alpha) and has been shown to be required for leukocyte migration into inflamed area. The purpose of this report was to investigate th...

journal_title：American journal of respiratory and critical care medicine

authors： Nagase T,Fukuchi Y,Matsuse T,Sudo E,Matsui H,Orimo H

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major challenge due to lack of effective drug therapy or accurate indicators for disease progression. Fibrocytes are circulating mesenchymal cell progenitors that are involved in tissue repair and fibrosis. OBJECTIVES:To test the hypoth...

journal_title：American journal of respiratory and critical care medicine

authors： Moeller A,Gilpin SE,Ask K,Cox G,Cook D,Gauldie J,Margetts PJ,Farkas L,Dobranowski J,Boylan C,O'Byrne PM,Strieter RM,Kolb M

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Intensive care unit (ICU) nurses work in a demanding environment where they are repetitively exposed to traumatic situations and stressful events. The psychological effects on nurses as a result of working in the ICU are relatively unknown. OBJECTIVE:To determine whether there is an increased prevalence of p...

journal_title：American journal of respiratory and critical care medicine

authors： Mealer ML,Shelton A,Berg B,Rothbaum B,Moss M

更新日期：2007-04-01 00:00:00

abstract：:Pulmonary emphysema and periodontal disease are each characterized by the uncontrolled proteolysis of connective tissue proteins by proteinases derived from human neutrophils. Although these diseases would not appear to be related in terms of the initial insult to individual tissues, the ultimate result in each diseas...

journal_title：American journal of respiratory and critical care medicine

authors： Travis J,Pike R,Imamura T,Potempa J

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:The inadequacy of effector T-cell response in containment of tubercle bacilli is believed to result in the development of disseminated forms of tuberculosis (TB), such as miliary tuberculosis (MTB). Regulatory T cells (Treg) plausibly play a critical role in the immunopathogenesis of disseminated TB by suppre...

journal_title：American journal of respiratory and critical care medicine

authors： Sharma PK,Saha PK,Singh A,Sharma SK,Ghosh B,Mitra DK

更新日期：2009-06-01 00:00:00

abstract：RATIONALE:Epidemiological studies in older individuals have found an association between the use of angiotensin-converting enzyme (ACE) inhibition (ACE-I) therapy and preserved locomotor muscle mass, strength, and walking speed. ACE-I therapy might therefore have a role in the context of pulmonary rehabilitation (PR). ...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis KJ,Meyrick VM,Mehta B,Haji GS,Li K,Montgomery H,Man WD,Polkey MI,Hopkinson NS

更新日期：2016-12-01 00:00:00

abstract：RATIONALE:In the absence of active tuberculosis, a positive tuberculin skin test (TST) or interferon-γ release assay (IGRA) result defines latent infection with Mycobacterium tuberculosis, although test results may vary depending on immunodeficiency. OBJECTIVES:This study compared the performance of TST and IGRAs in f...

journal_title：American journal of respiratory and critical care medicine

authors： Sester M,van Leth F,Bruchfeld J,Bumbacea D,Cirillo DM,Dilektasli AG,Domínguez J,Duarte R,Ernst M,Eyuboglu FO,Gerogianni I,Girardi E,Goletti D,Janssens JP,Julander I,Lange B,Latorre I,Losi M,Markova R,Matteelli A,M

更新日期：2014-11-15 00:00:00

abstract：:Although airway inflammation is recognized as a key feature of asthma, the characteristics of airway inflammation in children with acute severe asthma are not well defined. The aim of this study was to describe the characteristics of airway inflammation in children with an acute exacerbation of asthma using sputum cel...

journal_title：American journal of respiratory and critical care medicine

authors： Norzila MZ,Fakes K,Henry RL,Simpson J,Gibson PG

更新日期：2000-03-01 00:00:00