Incorporating Coexisting Chronic Illness into Decisions about Patient Selection for Lung Cancer Screening. An Official American Thoracic Society Research Statement.

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. OBJECTIVES:To determine the effects of continuous positive airway pressure (CPAP) on renal function in subjects with coexisting OSA and cardiovascular dise...

journal_title：American journal of respiratory and critical care medicine

authors： Loffler KA,Heeley E,Freed R,Anderson CS,Brockway B,Corbett A,Chang CL,Douglas JA,Ferrier K,Graham N,Hamilton GS,Hlavac M,McArdle N,McLachlan J,Mukherjee S,Naughton MT,Thien F,Young A,Grunstein RR,Palmer LJ,Woodman

更新日期：2017-12-01 00:00:00

abstract：:In a prospective, controlled, and randomized clinical trial, we examined the effects of treatment with vitamin D (1,000 IU/d), calcium (1 g/d), and ethane-1-hydroxy-1,1-diphosphonate (EHDP; 7.5 mg/kg body weight) on vertebral bone mass in fourteen asthmatics undergoing long-term treatment with systemically applied cor...

journal_title：American journal of respiratory and critical care medicine

authors： Worth H,Stammen D,Keck E

更新日期：1994-08-01 00:00:00

abstract：:We describe two reliable methods for high-throughput screening of proteinase inhibitor (PI) S and PI Z alpha(1)-antitrypsin (alpha(1)-AT) deficiency alleles from dried blood spot (DBS) specimens using the LightCycler fluorimetric analyzer. The method was used to study 72 patients with chronic obstructive pulmonary dis...

journal_title：American journal of respiratory and critical care medicine

authors： Rodriguez F,Jardí R,Costa X,Cotrina M,Galimany R,Vidal R,Miravitlles M

更新日期：2002-09-15 00:00:00

abstract：RATIONALE:Improved ventilation strategies have been the mainstay for reducing mortality in acute respiratory distress syndrome. Their unique clinical effectiveness is, however, unmatched by our understanding of the underlying mechanobiology, and their impact on alveolar dynamics and gas exchange remains largely specula...

journal_title：American journal of respiratory and critical care medicine

authors： Tabuchi A,Nickles HT,Kim M,Semple JW,Koch E,Brochard L,Slutsky AS,Pries AR,Kuebler WM

更新日期：2016-02-15 00:00:00

abstract：RATIONALE:The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors. OBJECTIVES:First, to compare the diagnostic performance of the TST and a form of in vitro IFN-gamma release assay (IFNGRA) in the c...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson ST,Williams AJ,Brown JR,Newton SM,Simsova M,Nicol MP,Sebo P,Levin M,Wilkinson RJ,Wilkinson KA

更新日期：2006-05-01 00:00:00

abstract：:The exact influence of sleep-related breathing disorder (SRBD) on blood pressure control remains unknown. We investigated the influence of different degrees of SRBD on daytime blood pressure and its association to documented hypertension by examining 1,190 consecutive patients referred for diagnosis of SRBD. The proto...

journal_title：American journal of respiratory and critical care medicine

authors： Grote L,Ploch T,Heitmann J,Knaack L,Penzel T,Peter JH

更新日期：1999-12-01 00:00:00

abstract：:Current evidence suggests that patients with obstructive sleep apnea (OSA) may have augmented pharyngeal dilator muscle activity during wakefulness, to compensate for deficient anatomy. However, the isolated effect of sleep on the activity of these muscles (comparing OSA patients with controls) has not been studied. W...

journal_title：American journal of respiratory and critical care medicine

authors： Mezzanotte WS,Tangel DJ,White DP

更新日期：1996-06-01 00:00:00

abstract：:In 1976-1992 245 new cases of asthma induced by diisocyanates were diagnosed, caused by hexamethylene diisocyanate (HDI) in 39%, diphenylmethane diisocyanate (MDI) in 39%, and toluene diisocyanate (TDI) in 17% of the cases. Our aim was to study the clinical outcome of diisocyanate-induced asthma. A questionnaire was s...

journal_title：American journal of respiratory and critical care medicine

authors： Piirilä PL,Nordman H,Keskinen HM,Luukkonen R,Salo SP,Tuomi TO,Tuppurainen M

更新日期：2000-08-01 00:00:00

abstract：:Asthma in adults may be associated with chronic airflow obstruction, possibly resulting from airway disease in early life and/or a greater rate of decline in lung function in adult life compared with those with asthma. Treatment and cigarette smoking may also influence the rate of decline of lung function. The aim of ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Palmer LJ,Kicic E,Maxwell PS,Lagan SE,Ryan GF,Musk AW

更新日期：2005-01-15 00:00:00

abstract：RATIONALE:Immediate graft performance after lung transplantation is associated with short- and long-term clinical outcomes. However, the biologic mechanism that determines outcomes is not fully understood. OBJECTIVES:To investigate the impact of cell death signals at 24 and 48 hours after lung transplantation on short...

journal_title：American journal of respiratory and critical care medicine

authors： Hashimoto K,Besla R,Zamel R,Juvet S,Kim H,Azad S,Waddell TK,Cypel M,Liu M,Keshavjee S

更新日期：2016-07-01 00:00:00

abstract：:Snoring and sleeping apnea are reportedly associated with morbidity. We used home monitoring (MESAM IV) to measure snoring and sleep apnea in 294 men aged 40 to 65 yr from the volunteer register of the Busselton (Australia) Health Survey. In this group, 81% snored for more than 10% of the night and 22% for more than h...

journal_title：American journal of respiratory and critical care medicine

authors： Bearpark H,Elliott L,Grunstein R,Cullen S,Schneider H,Althaus W,Sullivan C

更新日期：1995-05-01 00:00:00

abstract：:Products of the prostaglandin H synthase (PGHS) metabolic pathway are thought to play a role in the pathogenesis of asthma. We determined the level of expression of the constitutive (PGHS-1) and inducible (PGHS-2) isoforms of the enzyme in induced sputum and bronchial biopsies of patients with asthma, patients with ch...

journal_title：American journal of respiratory and critical care medicine

authors： Taha R,Olivenstein R,Utsumi T,Ernst P,Barnes PJ,Rodger IW,Giaid A

更新日期：2000-02-01 00:00:00

abstract：RATIONALE:Although commonly used as the primary outcome measure of clinical trials in pulmonary arterial hypertension (PAH), the minimal important difference (MID) of the 6-minute walk test (6MWT) has not been well defined for this population of patients. OBJECTIVES:To estimate the MID in the 6MWT in patients with PAH...

journal_title：American journal of respiratory and critical care medicine

authors： Mathai SC,Puhan MA,Lam D,Wise RA

更新日期：2012-09-01 00:00:00

abstract：RATIONALE:Obesity, especially truncal obesity, is a risk factor for asthma incidence, prevalence, and severity. Chitinase 3-like-1 (Chi3l1) is an evolutionarily conserved moiety that plays a critical role in antipathogen and Th2 responses. However, the mechanisms that underlie the association between asthma and obesity...

journal_title：American journal of respiratory and critical care medicine

authors： Ahangari F,Sood A,Ma B,Takyar S,Schuyler M,Qualls C,Dela Cruz CS,Chupp GL,Lee CG,Elias JA

更新日期：2015-04-01 00:00:00

abstract：:Lone cryptogenic fibrosing alveolitis (CFA) is a progressive interstitial lung disease, with a median survival of 3 to 6 yr from the onset of dyspnea. CFA can be subdivided into prognostically significant histopathologic patterns, including nonspecific interstitial pneumonia (NSIP). We reviewed 78 patients with a clin...

journal_title：American journal of respiratory and critical care medicine

authors： Nicholson AG,Colby TV,du Bois RM,Hansell DM,Wells AU

更新日期：2000-12-01 00:00:00

abstract：RATIONALE:Levels of the soluble form of the receptor for advanced glycation end-products (sRAGE) are elevated during acute respiratory distress syndrome (ARDS) and correlate with severity and prognosis. Alveolar fluid clearance (AFC) is necessary for the resolution of lung edema but is impaired in most patients with AR...

journal_title：American journal of respiratory and critical care medicine

authors： Jabaudon M,Blondonnet R,Roszyk L,Bouvier D,Audard J,Clairefond G,Fournier M,Marceau G,Déchelotte P,Pereira B,Sapin V,Constantin JM

更新日期：2015-07-15 00:00:00

abstract：:There is a need for quick, reliable, and noninvasive lung function tests to assess airway obstruction in preschool children both for pediatric pulmonary care as well as for research purposes. We studied feasibility, reproducibility, and validity of measurements of the respiratory system using the interrupter technique...

journal_title：American journal of respiratory and critical care medicine

authors： Merkus PJ,Mijnsbergen JY,Hop WC,de Jongste JC

更新日期：2001-05-01 00:00:00

abstract：:Rationale: Interstitial macrophages (IMs) and airspace macrophages (AMs) play critical roles in lung homeostasis and host defense, and are central to the pathogenesis of a number of lung diseases. However, the absolute numbers of macrophages and the precise anatomic locations they occupy in the healthy human lung have...

journal_title：American journal of respiratory and critical care medicine

authors： Hume PS,Gibbings SL,Jakubzick CV,Tuder RM,Curran-Everett D,Henson PM,Smith BJ,Janssen WJ

更新日期：2020-05-15 00:00:00

abstract：:Rationale: Recent studies have demonstrated that extracellular vesicles (EVs) released during acute lung injury (ALI) were inflammatory.Objectives: The current study was undertaken to test the role of EVs induced and released from severe Escherichia coli pneumonia (E. coli EVs) in the pathogenesis of ALI and to determ...

journal_title：American journal of respiratory and critical care medicine

authors： Liu A,Park JH,Zhang X,Sugita S,Naito Y,Lee JH,Kato H,Hao Q,Matthay MA,Lee JW

更新日期：2019-11-15 00:00:00

abstract：:Previous studies suggest that lung function tests using monodisperse aerosols can help to identify early stages of lung diseases. We investigated intrapulmonary particle loss and aerosol bolus dispersion-a marker of convective gas transport-in 32 women with asymptomatic nonspecific bronchial hyperresponsiveness (BHR) ...

journal_title：American journal of respiratory and critical care medicine

authors： Kohlhäufl M,Brand P,Scheuch G,Meyer TS,Schulz H,Häussinger K,Heyder J

更新日期：1999-03-01 00:00:00

abstract：:The aim of this study was to assess positive end-expiratory pressure (PEEP)-induced lung overdistension and alveolar recruitment in six patients with acute lung injury (ALI) using a computed tomographic (CT) scan method. Lung overdistension was first determined in six healthy volunteers in whom CT sections were obtain...

journal_title：American journal of respiratory and critical care medicine

authors： Vieira SR,Puybasset L,Richecoeur J,Lu Q,Cluzel P,Gusman PB,Coriat P,Rouby JJ

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. OBJECTIVES:We defined the burden of life-threatening (O(2) saturation [O(2) sat] ≤ ...

journal_title：American journal of respiratory and critical care medicine

authors： Ferolla FM,Hijano DR,Acosta PL,Rodríguez A,Dueñas K,Sancilio A,Barboza E,Caría A,Gago GF,Almeida RE,Castro L,Pozzolo C,Martínez MV,Grimaldi LA,Rebec B,Calvo M,Henrichsen J,Nocito C,González M,Barbero G,Losada JV,

更新日期：2013-05-01 00:00:00

abstract：:In mechanically ventilated patients, pressure and flow tracings can be used to assess respiratory pump muscle activity or rest. When the ventilation is delivered through an endotracheal tube, the respiratory system can be considered a one-compartment model, and activation of the respiratory muscles results in deformat...

journal_title：American journal of respiratory and critical care medicine

authors： Jounieaux V,Parreira VF,Delguste P,Aubert G,Rodenstein DO

更新日期：1997-06-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a condition in which continuous bronchodilation may have clinical advantages. This study evaluated salmeterol, a beta-agonist bronchodilator with a duration of action substantially longer than that of short-acting beta-agonists, compared with ipratropium, an anticholiner...

journal_title：American journal of respiratory and critical care medicine

authors： Rennard SI,Anderson W,ZuWallack R,Broughton J,Bailey W,Friedman M,Wisniewski M,Rickard K

更新日期：2001-04-01 00:00:00

abstract：:Infection of the cystic fibrosis (CF) airways elicits an exaggerated, interleukin-8 (IL-8) mediated, neutrophil inflammatory response. Necrosing neutrophils release DNA and actin into the airways, increasing the viscoelasticity of airway secretions. Mucolytics aim to improve airway clearance by reducing this viscoelas...

journal_title：American journal of respiratory and critical care medicine

authors： Perks B,Shute JK

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:Chronic infection with Burkholderia cepacia complex bacteria in cystic fibrosis is associated with accelerated decline in pulmonary function and increased mortality. Clinical implications of the recently characterized genomovar VI, B. dolosa, are unknown. OBJECTIVES:Characterization of impact of B. dolosa on...

journal_title：American journal of respiratory and critical care medicine

authors： Kalish LA,Waltz DA,Dovey M,Potter-Bynoe G,McAdam AJ,Lipuma JJ,Gerard C,Goldmann D

更新日期：2006-02-15 00:00:00

abstract：:During dynamic hyperinflation, the ventilatory pump is facing increased demand because it must overcome the intrinsic positive end-expiratory pressure (PEEPi) and decreased capacity since it must operate at a dynamically increased end-expiratory lung volume (EELV). The aim of this study was to evaluate the relative pr...

journal_title：American journal of respiratory and critical care medicine

authors： Yan S,Kayser B

更新日期：1997-08-01 00:00:00

abstract：:Bronchoalveolar lavage (BAL) is increasingly used in the pediatric age group. However, normal values for BAL fluid (BALF) constituents are lacking. As part of an investigation to define reference values in children, we studied lymphocyte surface markers of BALF in 28 children 3 to 16 yr of age without bronchopulmonary...

journal_title：American journal of respiratory and critical care medicine

authors： Ratjen F,Bredendiek M,Zheng L,Brendel M,Costabel U

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part caused by abnormal purine nucleotide regulation of ion transport, contribute to the pathogenesis of CB. OBJECTIVE...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson WH,Coakley RD,Button B,Henderson AG,Zeman KL,Alexis NE,Peden DB,Lazarowski ER,Davis CW,Bailey S,Fuller F,Almond M,Qaqish B,Bordonali E,Rubinstein M,Bennett WD,Kesimer M,Boucher RC

更新日期：2015-07-15 00:00:00

abstract：:A higher exposure to endotoxin was hypothesized to contribute to lower prevalence of allergic sensitization and hay fever in children growing up on a farm. We studied the association between house dust endotoxin and allergic sensitization. We randomly selected 740 children, aged between 5 and 10 years, from a group of...

journal_title：American journal of respiratory and critical care medicine

authors： Gehring U,Bischof W,Fahlbusch B,Wichmann HE,Heinrich J

更新日期：2002-10-01 00:00:00