Abstract:
:To determine whether the cytokine interleukin (IL)-1 beta directly affects airway smooth muscle functions and, if so, what the mechanism of action is, we studied canine isolated bronchial segments under isometric conditions in vitro. Incubation of tissues with human recombinant IL-1 beta (10 ng/ml) for 150 min decreased the contractile responses to acetylcholine, histamine, and KCl. The inhibitory effect of IL-1 beta on the acetylcholine (10(-3) M)-induced contraction was concentration-dependent, the maximal decrease from the baseline contraction being 52 +/- 8% (mean +/- SD, p < 0.001) observed with 10 ng/ml IL-1 beta. Intracellular levels of cyclic AMP and cyclic GMP were not significantly altered by IL-1 beta. The IL-1 beta-induced inhibition of the contractile responses was not affected by pretreatment of tissues with indomethacin or propranolol, but it was greatly attenuated by mechanical removal of epithelium. These results suggest that IL-1 beta may play a protective role against bronchoconstrictor responses via epithelium-dependent mechanism such as the release of epithelium-derived relaxing factor.
journal_name
Am J Respir Crit Care Medauthors
Tamaoki J,Yamawaki I,Takeyama K,Chiyotani A,Yamauchi F,Konno Kdoi
10.1164/ajrccm.149.1.8111570subject
Has Abstractpub_date
1994-01-01 00:00:00pages
134-7issue
1eissn
1073-449Xissn
1535-4970journal_volume
149pub_type
杂志文章abstract::To be most effective, noninvasive ventilation (NIV) ventilators should synchronize well with patients' breathing. However, the speed with which different ventilators can respond to the transitions between inspiration and expiration may vary, and abnormal respiratory mechanics and mask leaks may exacerbate this problem...
journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
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journal_title:American journal of respiratory and critical care medicine
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journal_title:American journal of respiratory and critical care medicine
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journal_title:American journal of respiratory and critical care medicine
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journal_title:American journal of respiratory and critical care medicine
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更新日期:1997-11-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2000-06-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-10-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2017-09-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2000-12-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-06-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2005-06-15 00:00:00
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更新日期:1998-07-01 00:00:00
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更新日期:1999-03-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2005-06-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2003-07-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2008-09-01 00:00:00
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abstract::Interleukin (IL)-2 has a central role in regulating T cell responses to Mycobacterium tuberculosis. Adjunctive immunotherapy with recombinant human IL-2 was studied in a randomized, placebo-controlled, double-blinded trial in 110 human immunodeficiency virus-seronegative adults in whom smear-positive, drug-susceptible...
journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-07-15 00:00:00
abstract::The purpose of the study was to examine risk factors for nosocomial pneumonia in the surgical and medical/respiratory intensive care unit (ICU) populations. In a public teaching hospital, all cases of nosocomial pneumonia in the surgical and medical/respiratory ICUs (n = 20, respectively) were identified by prospectiv...
journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2013-10-15 00:00:00