Production of nitric oxide (NO) in intrathoracic airways of normal humans.

abstract：RATIONALE:Levels of the soluble form of the receptor for advanced glycation end-products (sRAGE) are elevated during acute respiratory distress syndrome (ARDS) and correlate with severity and prognosis. Alveolar fluid clearance (AFC) is necessary for the resolution of lung edema but is impaired in most patients with AR...

journal_title：American journal of respiratory and critical care medicine

authors： Jabaudon M,Blondonnet R,Roszyk L,Bouvier D,Audard J,Clairefond G,Fournier M,Marceau G,Déchelotte P,Pereira B,Sapin V,Constantin JM

更新日期：2015-07-15 00:00:00

abstract：:We determined if pulmonary peptidoleukotrienes contribute to the pathogenesis of chronic lung disease of extreme prematurity (CLD) by measuring urinary leukotriene E4 (uLTE4). Study patients had a birth weight < 1000 g and were about 28 d old when they were classified as normal control subjects (n = 8) or as having CL...

journal_title：American journal of respiratory and critical care medicine

authors： Davidson D,Drafta D,Wilkens BA

更新日期：1995-03-01 00:00:00

abstract：:Normoxic lung ischemia/reperfusion (I/R) leads to oxidative injury of the pulmonary tissue. We analyzed angiotensin-converting enzyme (ACE) in perfused rat lungs upon I/R in order to assess the endothelial injury produced. I/R led to a time-dependent increase in ACE activity in the perfusate, from 145+/-14 mU to 252+/...

journal_title：American journal of respiratory and critical care medicine

authors： Atochina EN,Muzykantov VR,Al-Mehdi AB,Danilov SM,Fisher AB

更新日期：1997-10-01 00:00:00

abstract：RATIONALE:The role of NADPH oxidase activation in pneumonia is complex because reactive oxygen species contribute to both microbial killing and regulation of the acute pulmonary infiltrate. The relative importance of each role remains poorly defined in community-acquired pneumonia. OBJECTIVES:We evaluated the contribu...

journal_title：American journal of respiratory and critical care medicine

authors： Marriott HM,Jackson LE,Wilkinson TS,Simpson AJ,Mitchell TJ,Buttle DJ,Cross SS,Ince PG,Hellewell PG,Whyte MK,Dockrell DH

更新日期：2008-04-15 00:00:00

abstract：:Cigarette smoking causes the development of chronic bronchitis and chronic obstructive pulmonary disease. We hypothesized that exposure to cigarette smoke might initiate release of inflammatory mediators by bronchial epithelial cells. To evaluate this, the effect of cigarette smoke extract (CSE) on IL-8 release from c...

journal_title：American journal of respiratory and critical care medicine

authors： Mio T,Romberger DJ,Thompson AB,Robbins RA,Heires A,Rennard SI

更新日期：1997-05-01 00:00:00

abstract：RATIONALE:Activin-A is up-regulated in various respiratory disorders. However, its precise role in pulmonary pathophysiology has not been adequately substantiated in vivo. OBJECTIVES:To investigate in vivo the consequences of dysregulated Activin-A expression in the lung and identify key Activin-A-induced processes th...

journal_title：American journal of respiratory and critical care medicine

authors： Apostolou E,Stavropoulos A,Sountoulidis A,Xirakia C,Giaglis S,Protopapadakis E,Ritis K,Mentzelopoulos S,Pasternack A,Foster M,Ritvos O,Tzelepis GE,Andreakos E,Sideras P

更新日期：2012-02-15 00:00:00

abstract：:Large pleural effusions are typically associated with dyspnea and potential respiratory compromise. Experimental evidence suggests that with large effusions, increased intrapleural pressure may be transmitted to the pericardial space, resulting in impaired cardiac filling and reduced stroke volume. We report two cases...

journal_title：American journal of respiratory and critical care medicine

authors： Kaplan LM,Epstein SK,Schwartz SL,Cao QL,Pandian NG

更新日期：1995-03-01 00:00:00

abstract：:Chronic bacterial infection and neutrophilic inflammation characterize cystic fibrosis (CF) pulmonary disease. In many disorders, inflammation and angiogenesis are codependent phenomena. We previously noted excessive angiogenesis in CF tissues and elevated vascular endothelial growth factor (VEGF) in random serum samp...

journal_title：American journal of respiratory and critical care medicine

authors： McColley SA,Stellmach V,Boas SR,Jain M,Crawford SE

更新日期：2000-06-01 00:00:00

abstract：:Inhaled corticosteroids are effective antiinflammatory therapy for asthma; however, they do not completely abolish allergen-induced airway inflammation. Leukotriene modifiers attenuate both early and late allergen responses and have antiinflammatory properties. We reasoned that treatment with budesonide and montelukas...

journal_title：American journal of respiratory and critical care medicine

authors： Leigh R,Vethanayagam D,Yoshida M,Watson RM,Rerecich T,Inman MD,O'Byrne PM

更新日期：2002-11-01 00:00:00

abstract：:Despite several codes of research ethics, the issuance of comprehensive rules regarding informed consent by governmental agencies, and numerous writings on the subject of informed consent, many commentators still question the quality of the informed consent process in clinical research. A major concern is that investi...

journal_title：American journal of respiratory and critical care medicine

authors： Silverman HJ

更新日期：1996-09-01 00:00:00

abstract：:We hypothesized that variation in extubating brain injured patients would affect the incidence of nosocomial pneumonia, length of stay, and hospital charges. In a prospective cohort of consecutive, intubated brain-injured patients, we evaluated daily: intubation status, spontaneous ventilatory parameters, gas exchange...

journal_title：American journal of respiratory and critical care medicine

authors： Coplin WM,Pierson DJ,Cooley KD,Newell DW,Rubenfeld GD

更新日期：2000-05-01 00:00:00

abstract：:Rationale: Viral infections are major drivers of exacerbations and clinical burden in patients with asthma and chronic obstructive pulmonary disease (COPD). IFN-β is a key component of the innate immune response to viral infection. To date, studies of inhaled IFN-β treatment have not demonstrated a significant effect ...

journal_title：American journal of respiratory and critical care medicine

authors： Watson A,Spalluto CM,McCrae C,Cellura D,Burke H,Cunoosamy D,Freeman A,Hicks A,Hühn M,Ostridge K,Staples KJ,Vaarala O,Wilkinson T

更新日期：2020-01-01 00:00:00

abstract：:There is a subgroup of cigarette smokers who are more susceptible than others to the deleterious effects of cigarette smoke and to chronic airflow obstruction. The study of histopathologic and physiologic differences between these "susceptible" smokers and "resistant" smokers, who do not develop clinically significant...

journal_title：American journal of respiratory and critical care medicine

authors： Aguayo SM

更新日期：1994-06-01 00:00:00

abstract：:T cells in the airways are considered to play a key role in orchestrating the inflammatory response of asthma through the elaboration of specific cytokines. Using flow cytometry we have investigated the T-cell response of sensitized asthmatic airways 6 h after local allergen provocation. Twelve subjects with atopic as...

journal_title：American journal of respiratory and critical care medicine

authors： Gratziou C,Carroll M,Montefort S,Teran L,Howarth PH,Holgate ST

更新日期：1996-02-01 00:00:00

abstract：:This study aimed to examine the performance characteristics of four high-frequency oscillatory-type ventilators, using an in vitro model of the intubated neonatal respiratory system. Each ventilator was examined across its operative range of settings and at varying model lung compliance (C) and resistance. The oscilla...

journal_title：American journal of respiratory and critical care medicine

authors： Pillow JJ,Wilkinson MH,Neil HL,Ramsden CA

更新日期：2001-09-15 00:00:00

abstract：BACKGROUND:Measurements of upper airway size and shape are important in investigating the pathophysiology of obstructive sleep apnea (OSA) and in devising, applying, and determining the effectiveness of treatment modalities. We describe an endoscopic optical technique (anatomic optical coherence tomography, aOCT) that ...

journal_title：American journal of respiratory and critical care medicine

authors： Armstrong JJ,Leigh MS,Sampson DD,Walsh JH,Hillman DR,Eastwood PR

更新日期：2006-01-15 00:00:00

abstract：:The present study was undertaken to determine if a synthetic peptide, KLLLLKLLLLKLLLLKLLLLK (KL4), in which K = lysine and L = leucine, in an aqueous dispersion of phospholipids (DPPC and POPG), would expand pulmonary alveoli and improve gas exchange in premature human infants with respiratory distress syndrome (RDS)....

journal_title：American journal of respiratory and critical care medicine

authors： Cochrane CG,Revak SD,Merritt TA,Heldt GP,Hallman M,Cunningham MD,Easa D,Pramanik A,Edwards DK,Alberts MS

更新日期：1996-01-01 00:00:00

abstract：:The upper airway undergoes progressive changes during childhood. Using magnetic resonance imaging (MRI), we studied the growth relationships of the tissues surrounding the upper airway (bone and soft tissues) in 92 normal children (47% males; range, 1 to 11 yr) who underwent brain MRI. None had symptoms of sleep-disor...

journal_title：American journal of respiratory and critical care medicine

authors： Arens R,McDonough JM,Corbin AM,Hernandez ME,Maislin G,Schwab RJ,Pack AI

更新日期：2002-01-01 00:00:00

abstract：:Positive pressure ventilation with large VTs has been shown to cause release of cytokines, including macrophage inflammatory protein-2 (MIP-2), a functional equivalent of human interleukin-8. The mechanisms regulating ventilation-induced cytokine production are unclear. Based on our previous in vitro model of lung cel...

journal_title：American journal of respiratory and critical care medicine

authors： Li LF,Yu L,Quinn DA

更新日期：2004-02-15 00:00:00

abstract：:Bronchial overproduction of leukotrienes and inhibition of prostaglandin synthesis are involved in the pathogenesis of aspirin-induced asthma. We investigated whether inhaled prostaglandin E2 (PGE2) attenuates the response to bronchial challenge with lysine acetylsalicylate (LASA) and the associated increase in urinar...

journal_title：American journal of respiratory and critical care medicine

authors： Sestini P,Armetti L,Gambaro G,Pieroni MG,Refini RM,Sala A,Vaghi A,Folco GC,Bianco S,Robuschi M

更新日期：1996-02-01 00:00:00

abstract：:Successful bronchodilator therapy with a metered-dose inhaler (MDI) in intubated, mechanically ventilated patients requires adequate delivery of aerosol to the lower respiratory tract. We determined the effect of ventilator mode, inspiratory flow pattern, humidity, and spontaneous respiratory effort on albuterol deliv...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JB,Dhand R,Duarte AG,Jenne JW,Tobin MJ

更新日期：1996-08-01 00:00:00

abstract：:The place of surgical treatment in obstructive sleep apnea syndrome (OSAS) remains unclear. Uvulopalatopharyngoplasty (UPPP) has a response rate of 41% overall and only 5% when retrolingual narrowing is present. Thus, in cases with suspected hypopharyngeal collapse maxillofacial surgery has been proposed with improved...

journal_title：American journal of respiratory and critical care medicine

authors： Bettega G,Pépin JL,Veale D,Deschaux C,Raphaël B,Lévy P

更新日期：2000-08-01 00:00:00

abstract：:Colony-forming units of Mycobacterium tuberculosis in sputum were counted at 2-day intervals in 100 patients treated with 22 regimens of isoniazid, rifampin, pyrazinamide, ethambutol, or streptomycin, given alone or in combinations. The exponential fall in colony-forming units was measured by linear regression coeffic...

journal_title：American journal of respiratory and critical care medicine

authors： Jindani A,Doré CJ,Mitchison DA

更新日期：2003-05-15 00:00:00

abstract：RATIONALE:From the late 1970s to the early 1990s, studies found that mortality rates for pulmonary fibrosis were increasing. Recent data for mortality from pulmonary fibrosis are unavailable. OBJECTIVES:We sought to determine mortality rates for pulmonary fibrosis in the United States from 1992 through 2003. METHODS:...

journal_title：American journal of respiratory and critical care medicine

authors： Olson AL,Swigris JJ,Lezotte DC,Norris JM,Wilson CG,Brown KK

更新日期：2007-08-01 00:00:00

abstract：:The reaction of nitric oxide (NO) and superoxide anions (O(2)(-)) in the airway results in the formation of peroxynitrite, a highly reactive oxidant species. Peroxynitrite reacts with tyrosine residues in proteins to form the stable product nitrotyrosine. We investigated whether nitrotyrosine in exhaled breath condens...

journal_title：American journal of respiratory and critical care medicine

authors： Hanazawa T,Kharitonov SA,Barnes PJ

更新日期：2000-10-01 00:00:00

abstract：RATIONALE:The rate of progression of most interstitial lung diseases (ILD) is unpredictable. Fibrocytes are circulating bone marrow-derived cells that have been implicated in the pathogenesis of lung fibrosis. Hermansky-Pudlak syndrome (HPS), a genetic cause of ILD in early adulthood, allows for study of biomarkers of ...

journal_title：American journal of respiratory and critical care medicine

authors： Trimble A,Gochuico BR,Markello TC,Fischer R,Gahl WA,Lee JK,Kim Y,Burdick MD,Strieter RM,Mehrad B

更新日期：2014-12-15 00:00:00

abstract：:Phosphodiesterase (PDE)-5 degrades guanosine 3',5'cyclic monophosphate (cGMP) and its inhibitor sildenafil citrate (Viagra) treats erectile dysfunction by smooth muscle relaxation through elevated cGMP. Sildenafil was examined in two guinea pig models of airways disease: guinea pigs exposed to LPS or sensitized guinea...

journal_title：American journal of respiratory and critical care medicine

authors： Toward TJ,Smith N,Broadley KJ

更新日期：2004-01-15 00:00:00

abstract：RATIONALE:Protein kinase C zeta (PKCζ) has been reported to act as a tumor suppressor. Deletion of PKCζ in experimental cancer models has been shown to increase tumor growth. However, the mechanisms of PKCζ down-regulation in cancerous cells have not been previously described. OBJECTIVES:To determine the molecular mec...

journal_title：American journal of respiratory and critical care medicine

authors： Queisser MA,Dada LA,Deiss-Yehiely N,Angulo M,Zhou G,Kouri FM,Knab LM,Liu J,Stegh AH,DeCamp MM,Budinger GR,Chandel NS,Ciechanover A,Iwai K,Sznajder JI

更新日期：2014-09-15 00:00:00

abstract：:Induced sputum using hypertonic saline (HS) is a useful research tool to study airway inflammation (AI). HS provocation testing can also be used to measure airway hyperresponsiveness (AHR). A combined HS challenge and sputum induction procedure has been developed to permit assessment of AI and AHR in a single test. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Jones PD,Hankin R,Simpson J,Gibson PG,Henry RL

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:End-tidal CO2 (EtCO2) is used to monitor cardiopulmonary resuscitation (CPR), but it can be affected by intrathoracic airway closure. Chest compressions induce oscillations in expired CO2, and this could reflect variable degrees of airway patency. OBJECTIVES:To understand the impact of airway closure during ...

journal_title：American journal of respiratory and critical care medicine

authors： Grieco DL,J Brochard L,Drouet A,Telias I,Delisle S,Bronchti G,Ricard C,Rigollot M,Badat B,Ouellet P,Charbonney E,Mancebo J,Mercat A,Savary D,Richard JM

更新日期：2019-03-15 00:00:00