Macrophage migration inhibitory factor promotes tumor growth in the context of lung injury and repair.

abstract：:This study investigated the clinico-pathologic correlation of tumor angiogenesis in non-small-cell lung cancers. Formalin-fixed, paraffin-embedded surgical specimens of 55 consecutive patients with primary non-small-cell lung cancers were examined. Included were 26 squamous cell carcinomas and 29 adenocarcinomas. Twen...

journal_title：American journal of respiratory and critical care medicine

authors： Yuan A,Yang PC,Yu CJ,Lee YC,Yao YT,Chen CL,Lee LN,Kuo SH,Luh KT

更新日期：1995-12-01 00:00:00

abstract：:Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the National Heart, Lung, and Blood Institute. Decades of clinical research in acute respiratory distress syndrome, acute respiratory failure, pneumonia, and sepsis have...

journal_title：American journal of respiratory and critical care medicine

authors： Semler MW,Bernard GR,Aaron SD,Angus DC,Biros MH,Brower RG,Calfee CS,Colantuoni EA,Ferguson ND,Gong MN,Hopkins RO,Hough CL,Iwashyna TJ,Levy BD,Martin TR,Matthay MA,Mizgerd JP,Moss M,Needham DM,Self WH,Seymour CW,

更新日期：2020-03-09 00:00:00

abstract：:Exaggerated airway narrowing in response to bronchoconstricting stimuli is a characteristic feature of asthmatic subjects. It is unknown whether the site of airway narrowing differs in asthmatic subjects from that observed in normal subjects. Increased airway wall thickness has been suggested as a contributing cause f...

journal_title：American journal of respiratory and critical care medicine

authors： Okazawa M,Müller N,McNamara AE,Child S,Verburgt L,Paré PD

更新日期：1996-11-01 00:00:00

abstract：:Ethane is a product of lipid peroxidation as a result of oxidative stress and can be detected in the exhaled air. Oxidative stress plays a role in the pathogenesis of asthma. We measured exhaled ethane in 26 asthmatic subjects (mean age +/- SEM, 38 +/- 8 yr; 15 male, FEV(1) 60 +/- 4%) and compared it with exhaled nitr...

journal_title：American journal of respiratory and critical care medicine

authors： Paredi P,Kharitonov SA,Barnes PJ

更新日期：2000-10-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA), a treatable sleep disorder that is associated with alterations in glucose metabolism in individuals without diabetes, is a highly prevalent comorbidity of type 2 diabetes. However, it is not known whether the severity of OSA is a predictor of glycemic control in patients with di...

journal_title：American journal of respiratory and critical care medicine

authors： Aronsohn RS,Whitmore H,Van Cauter E,Tasali E

更新日期：2010-03-01 00:00:00

abstract：:The purpose of this study was to evaluate the physiologic responses to endurance training in patients with moderate to severe airflow obstruction by specifically looking at changes in skeletal muscle enzymatic activities. Eleven patients (age = 65 +/- 7 yr, mean +/- SD, FEV1 = 36 +/- 11% of predicted value, range = 24...

journal_title：American journal of respiratory and critical care medicine

authors： Maltais F,LeBlanc P,Simard C,Jobin J,Bérubé C,Bruneau J,Carrier L,Belleau R

更新日期：1996-08-01 00:00:00

abstract：:Effective treatment of tuberculosis requires adherence to a minimum of 6 months treatment with multiple drugs. To improve adherence and cure rates, directly observed therapy is recommended for the treatment of pulmonary tuberculosis. We compared treatment outcomes among all culture-positive patients treated for active...

journal_title：American journal of respiratory and critical care medicine

authors： Jasmer RM,Seaman CB,Gonzalez LC,Kawamura LM,Osmond DH,Daley CL

更新日期：2004-09-01 00:00:00

abstract：:In this case-control family study of sleep-disordered breathing (SDB), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucasians. A total of 225 African-Americans and 622 Caucasians, ages 2 to 86 yr, recruited as members of families with an individual with known sleep apnea (85 inde...

journal_title：American journal of respiratory and critical care medicine

authors： Redline S,Tishler PV,Hans MG,Tosteson TD,Strohl KP,Spry K

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:An objective and simple prognostic model for patients with pulmonary embolism could be helpful in guiding initial intensity of treatment. OBJECTIVES:To develop a clinical prediction rule that accurately classifies patients with pulmonary embolism into categories of increasing risk of mortality and other adve...

journal_title：American journal of respiratory and critical care medicine

authors： Aujesky D,Obrosky DS,Stone RA,Auble TE,Perrier A,Cornuz J,Roy PM,Fine MJ

更新日期：2005-10-15 00:00:00

abstract：:In addition to its central role in hemostasis, thrombin may play a role in inflammation and remodeling. To investigate the contribution of thrombin to allergic airway inflammation in asthma, we used an enzymatic assay to determine thrombin activity in bronchoalveolar lavage fluid obtained from 19 subjects with atopic ...

journal_title：American journal of respiratory and critical care medicine

authors： Terada M,Kelly EA,Jarjour NN

更新日期：2004-02-01 00:00:00

abstract：:To investigate interactions between the endothelium and leukocytes in patients with sepsis, we measured soluble adhesion molecules (sE-selectin and sICAM-1), von Willebrand factor antigen (vWf:Ag), myeloperoxidase (MPO), and lactoferrin (Lacto-f) as plasma markers of endothelial and neutrophil activation. We tested wh...

journal_title：American journal of respiratory and critical care medicine

authors： Kayal S,Jaïs JP,Aguini N,Chaudière J,Labrousse J

更新日期：1998-03-01 00:00:00

abstract：RATIONALE:Ipsilateral recurrence rates of spontaneous pneumothorax after video-assisted thoracoscopic surgery are higher than rates after open thoracotomy. OBJECTIVES:This study was conducted to determine whether additional minocycline pleurodesis would be effective in diminishing recurrence after video-assisted thora...

journal_title：American journal of respiratory and critical care medicine

authors： Chen JS,Hsu HH,Chen RJ,Kuo SW,Huang PM,Tsai PR,Lee JM,Lee YC

更新日期：2006-03-01 00:00:00

abstract：:If lipid peroxidation (LP) contributes to organ dysfunction in sepsis rather than simply reflecting established injury, it should occur soon after the onset of the septic insult, and it may not progress uniformly in all organs. We assessed whether LP occurs within 90 min after onset of continuous intravenous endotoxin...

journal_title：American journal of respiratory and critical care medicine

authors： Clements NC Jr,Habib MP

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Occupational exposure to beryllium (Be) can result in chronic granulomatous inflammation characterized by the presence of Be-specific CD4+ T cells. Studies show that oxidative stress plays a role in the pathogenesis of chronic inflammatory disorders. OBJECTIVES:We hypothesized that Be-induced oxidative stres...

journal_title：American journal of respiratory and critical care medicine

authors： Dobis DR,Sawyer RT,Gillespie MM,Huang J,Newman LS,Maier LA,Day BJ

更新日期：2008-05-01 00:00:00

abstract：:Pneumonectomized rats develop pulmonary hypertension (PH) and pulmonary vascular neointimal formation 4 wk after monocrotaline (MCT) administration. Male Sprague-Dawley rats were injected with MCT (60 mg/kg) on Day 7 after left pneumonectomy. Three groups (n = 5) received 40-O-(2-hydroxyethyl)-rapamycin (RAD, 2.5 mg/k...

journal_title：American journal of respiratory and critical care medicine

authors： Nishimura T,Faul JL,Berry GJ,Veve I,Pearl RG,Kao PN

更新日期：2001-02-01 00:00:00

abstract：RATIONALE:Studies in humans and rodents have indicated a causative role for CD8(+) T cells in IgE-mediated allergic inflammation, but their function is still controversial. OBJECTIVES:To analyze the role of allergen-specific CD8(+) T cells during the development of allergic airway inflammation in two parallel but dive...

journal_title：American journal of respiratory and critical care medicine

authors： Aguilar-Pimentel JA,Alessandrini F,Huster KM,Jakob T,Schulz H,Behrendt H,Ring J,de Angelis MH,Busch DH,Mempel M,Ollert M

更新日期：2010-01-01 00:00:00

abstract：RATIONALE:Epithelial-mesenchymal transition (EMT) plays a key role in the development of chronic obstructive pulmonary disease (COPD) and lung cancer. OBJECTIVES:There are five major EMT regulatory genes (Snai1, Slug, Zeb1, Zeb2, and Twist1) involved in EMT. We hypothesized that germline variants in these genes may in...

journal_title：American journal of respiratory and critical care medicine

authors： Yang L,Yang X,Ji W,Deng J,Qiu F,Yang R,Fang W,Zhang L,Huang D,Xie C,Zhang H,Zhong N,Ran P,Zhou Y,Lu J

更新日期：2014-01-15 00:00:00

abstract：:T cells in the airways are considered to play a key role in orchestrating the inflammatory response of asthma through the elaboration of specific cytokines. Using flow cytometry we have investigated the T-cell response of sensitized asthmatic airways 6 h after local allergen provocation. Twelve subjects with atopic as...

journal_title：American journal of respiratory and critical care medicine

authors： Gratziou C,Carroll M,Montefort S,Teran L,Howarth PH,Holgate ST

更新日期：1996-02-01 00:00:00

abstract：:The molecular sources of reactive oxygen species (ROS) in skeletal muscles are not well understood. We hypothesized that nonphagocyte NAD(P)H oxidase could be a source of ROS in muscle fibers. We thus investigated the existence, structure, and contribution of nonphagocyte NAD(P)H oxidase to ROS production in rat skele...

journal_title：American journal of respiratory and critical care medicine

authors： Javeshghani D,Magder SA,Barreiro E,Quinn MT,Hussain SN

更新日期：2002-02-01 00:00:00

abstract：:Nitric oxide (NO) produced in the airways can be either detrimental or protective to the host. To investigate the role of NO in the pathogenesis of exercise-induced bronchoconstriction (EIB), we measured exhaled NO (ENO) after exercise challenge in 39 asthmatic and six normal children. FEV(1) and ENO were measured bef...

journal_title：American journal of respiratory and critical care medicine

authors： Terada A,Fujisawa T,Togashi K,Miyazaki T,Katsumata H,Atsuta J,Iguchi K,Kamiya H,Togari H

更新日期：2001-11-15 00:00:00

abstract：RATIONALE:The use of high-frequency oscillatory ventilation (HFOV) for acute respiratory failure in children is prevalent despite the lack of efficacy data. OBJECTIVES:To compare the outcomes of patients with acute respiratory failure managed with HFOV within 24-48 hours of endotracheal intubation with those receiving...

journal_title：American journal of respiratory and critical care medicine

authors： Bateman ST,Borasino S,Asaro LA,Cheifetz IM,Diane S,Wypij D,Curley MA,RESTORE Study Investigators.

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:The American Thoracic Society/European Respiratory Society International Consensus Classification panel identified the clinical entity idiopathic nonspecific interstitial pneumonia (NSIP) as a provisional diagnosis and recommended further study. OBJECTIVES:We hypothesized that idiopathic NSIP is an autoimmun...

journal_title：American journal of respiratory and critical care medicine

authors： Kinder BW,Collard HR,Koth L,Daikh DI,Wolters PJ,Elicker B,Jones KD,King TE Jr

更新日期：2007-10-01 00:00:00

abstract：:The human pleural space is lined by a single layer of mesothelial cells, the intracellular pH (pH(i)) of which has never been investigated. In the present study, the intrinsic buffering power of H+ ions (beta(i)) and the pH(i) regulatory systems were investigated in primary cultures of human pleural mesothelial cells ...

journal_title：American journal of respiratory and critical care medicine

authors： Liaw YS,Yang PC,Yu CJ,Kuo SH,Luh KT,Lin YJ,Wu ML

更新日期：1997-02-01 00:00:00

abstract：RATIONALE:The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown. OBJECTIVES:To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi J,Hang JQ,Mehta AJ,Zhang HX,Dai HL,Su L,Eisen EA,Christiani DC

更新日期：2010-07-15 00:00:00

abstract：RATIONALE:Although the transplantation of induced pluripotent stem cell (iPSC)-derived cells harbors enormous potential for the treatment of pulmonary diseases, in vivo data demonstrating clear therapeutic benefits of human iPSC-derived cells in lung disease models are missing. OBJECTIVES:We have tested the therapeuti...

journal_title：American journal of respiratory and critical care medicine

authors： Happle C,Lachmann N,Ackermann M,Mirenska A,Göhring G,Thomay K,Mucci A,Hetzel M,Glomb T,Suzuki T,Chalk C,Glage S,Dittrich-Breiholz O,Trapnell B,Moritz T,Hansen G

更新日期：2018-08-01 00:00:00

abstract：:Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha released from alveolar macrophages (AM) in pulmonary tuberculosis (TB) are important in host defense against mycobacterial infection. Nitric oxide (NO) production is enhanced in AM of TB patients. We examined whether NO was implicated in (IL)-1beta and TNF-a...

journal_title：American journal of respiratory and critical care medicine

authors： Kuo HP,Wang CH,Huang KS,Lin HC,Yu CT,Liu CY,Lu LC

更新日期：2000-01-01 00:00:00

abstract：:Cilomilast (Ariflo), a new oral phosphodiesterase-4 selective inhibitor, improves lung function in chronic obstructive pulmonary disease (COPD). We have evaluated its antiinflammatory effects in 59 patients with COPD randomized to receive cilomilast, 15 mg two times a day, or placebo for 12 weeks. Induced sputum diffe...

journal_title：American journal of respiratory and critical care medicine

authors： Gamble E,Grootendorst DC,Brightling CE,Troy S,Qiu Y,Zhu J,Parker D,Matin D,Majumdar S,Vignola AM,Kroegel C,Morell F,Hansel TT,Rennard SI,Compton C,Amit O,Tat T,Edelson J,Pavord ID,Rabe KF,Barnes NC,Jeffery PK

更新日期：2003-10-15 00:00:00

abstract：:Studies have shown evidence of significant parent-offspring and sibling correlation in FEV1, but familial aggregation of decline of FEV1 over time has not been reported. Our study population comprised 392 families enrolled in the Tucson Epidemiological Study of Airway Obstructive Diseases. Subjects were older than 18 ...

journal_title：American journal of respiratory and critical care medicine

authors： Kurzius-Spencer M,Sherrill DL,Holberg CJ,Martinez FD,Lebowitz MD

更新日期：2001-10-01 00:00:00

abstract：:The inflection points of the pressure-volume curve have been used for setting mechanical ventilation in patients with acute lung injury. However, the lung status at these points has never been specifically addressed. In 12 patients with early lung injury we traced both limbs of the pressure-volume curve by means of a ...

journal_title：American journal of respiratory and critical care medicine

authors： Albaiceta GM,Taboada F,Parra D,Luyando LH,Calvo J,Menendez R,Otero J

更新日期：2004-11-15 00:00:00

abstract：:It is controversial whether obstructive sleep apnea (OSA) causes pulmonary hypertension (PH) in the absence of hypoxemic lung disease. To investigate this further we measured awake pulmonary hemodynamics, pulmonary gas exchange, and small airways function in 32 patients with OSA (apnea- hypopnea index, mean +/- SE, 46...

journal_title：American journal of respiratory and critical care medicine

authors： Sajkov D,Wang T,Saunders NA,Bune AJ,Neill AM,Douglas Mcevoy R

更新日期：1999-05-01 00:00:00