Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis.

abstract：:This study was designed to evaluate the value and applicability of tidal breathing pattern analysis to assess airflow obstruction in young children. The time needed to reach maximal tidal expiratory flow (TME) divided by total expiratory time (TE) was measured in 228 healthy children 3 to 11 yr of age, 64 patients wit...

journal_title：American journal of respiratory and critical care medicine

authors： van der Ent CK,Brackel HJ,van der Laag J,Bogaard JM

更新日期：1996-04-01 00:00:00

abstract：:Hepatopulmonary syndrome (HPS) is characterized by intrapulmonary vascular dilatations and an increased alveoloarterial oxygen difference (AaPO(2)). These abnormalities are related to augmented pulmonary nitric oxide (NO) production, dependent primarily on increases in the expression and activity of inducible NO-synth...

journal_title：American journal of respiratory and critical care medicine

authors： Rabiller A,Nunes H,Lebrec D,Tazi KA,Wartski M,Dulmet E,Libert JM,Mougeot C,Moreau R,Mazmanian M,Humbert M,Hervé P

更新日期：2002-08-15 00:00:00

abstract：RATIONALE:Hyponatremia is associated with decompensated heart failure and poor prognosis in patients with left ventricular systolic dysfunction. OBJECTIVES:We sought to determine if hyponatremia is associated with right heart failure and worse prognosis in patients with pulmonary arterial hypertension (PAH). METHODS:...

journal_title：American journal of respiratory and critical care medicine

authors： Forfia PR,Mathai SC,Fisher MR,Housten-Harris T,Hemnes AR,Champion HC,Girgis RE,Hassoun PM

更新日期：2008-06-15 00:00:00

abstract：:CD14 influences postnatal switching of T helper cell responses. CD14 C-159T has been associated with altered CD14 and IgE levels in cross-sectional studies. Identifying whether associations vary with age requires data from children of the same age followed longitudinally over many years. In this study, an unselected p...

journal_title：American journal of respiratory and critical care medicine

authors： O'Donnell AR,Toelle BG,Marks GB,Hayden CM,Laing IA,Peat JK,Goldblatt J,Le Souëf PN

更新日期：2004-03-01 00:00:00

abstract：:Many persons say that they "don't know" whether they snore. The purpose of this study was to investigate the prevalence and correlates of such responses in an elderly population. Subjects were 1715 members (1,155 men, 560 women) of a previously defined cohort (Western Group Collaborative Study) followed prospectively ...

journal_title：American journal of respiratory and critical care medicine

authors： Bliwise DL,Swan GE,Carmelli D,La Rue A

更新日期：1999-12-01 00:00:00

abstract：:Interleukin (IL)-2 has a central role in regulating T cell responses to Mycobacterium tuberculosis. Adjunctive immunotherapy with recombinant human IL-2 was studied in a randomized, placebo-controlled, double-blinded trial in 110 human immunodeficiency virus-seronegative adults in whom smear-positive, drug-susceptible...

journal_title：American journal of respiratory and critical care medicine

authors： Johnson JL,Ssekasanvu E,Okwera A,Mayanja H,Hirsch CS,Nakibali JG,Jankus DD,Eisenach KD,Boom WH,Ellner JJ,Mugerwa RD,Uganda-Case Western Reserve University Research Collaboration.

更新日期：2003-07-15 00:00:00

abstract：:The failure of patients to adhere to physician-prescribed regimens, either pharmacologic or behavioral, has been well documented in medical literature. Poor adherence to asthma medication regimens has been repeatedly demonstrated in both children and adults, with rates of nonadherence commonly reported from 30 to 70%....

journal_title：American journal of respiratory and critical care medicine

authors： Rand CS,Wise RA

更新日期：1994-02-01 00:00:00

abstract：:A protective role for dietary antioxidants in asthma has been proposed. However, epidemiological evidence to implicate antioxidant vitamins is weak, and data on the role of flavonoid-rich foods and antioxidant trace elements are lacking. We carried out a population-based case-control study in South London, UK, to inve...

journal_title：American journal of respiratory and critical care medicine

authors： Shaheen SO,Sterne JA,Thompson RL,Songhurst CE,Margetts BM,Burney PG

更新日期：2001-11-15 00:00:00

abstract：RATIONALE:Chronic hypoxia induces pulmonary vascular remodeling, pulmonary hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms driving these responses. Hypoxia-inducible factor-1α (HIF-1α) is a master regulator of transcription in hypoxic cells, up-regulating genes involved in ...

journal_title：American journal of respiratory and critical care medicine

authors： Ball MK,Waypa GB,Mungai PT,Nielsen JM,Czech L,Dudley VJ,Beussink L,Dettman RW,Berkelhamer SK,Steinhorn RH,Shah SJ,Schumacker PT

更新日期：2014-02-01 00:00:00

abstract：:Pneumonectomized rats develop pulmonary hypertension (PH) and pulmonary vascular neointimal formation 4 wk after monocrotaline (MCT) administration. Male Sprague-Dawley rats were injected with MCT (60 mg/kg) on Day 7 after left pneumonectomy. Three groups (n = 5) received 40-O-(2-hydroxyethyl)-rapamycin (RAD, 2.5 mg/k...

journal_title：American journal of respiratory and critical care medicine

authors： Nishimura T,Faul JL,Berry GJ,Veve I,Pearl RG,Kao PN

更新日期：2001-02-01 00:00:00

abstract：:Oral mandibular advancement devices are becoming an increasingly important treatment alternative for obstructive sleep apnea (OSA). The first aim of the study was to determine whether a new oral elastic mandibular advancement device (EMA) prevents pharyngeal airway closure during sleep in patients with OSA. The second...

journal_title：American journal of respiratory and critical care medicine

authors： Henke KG,Frantz DE,Kuna ST

更新日期：2000-02-01 00:00:00

abstract：:The renin angiotensin system plays an important role in the development of pulmonary artery remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary hypertension as may occur in patients with COPD. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T...

journal_title：American journal of respiratory and critical care medicine

authors： van Suylen RJ,Wouters EF,Pennings HJ,Cheriex EC,van Pol PE,Ambergen AW,Vermelis AM,Daemen MJ

更新日期：1999-06-01 00:00:00

abstract：:Wheezing in childhood is not a single disorder and different wheezing-associated respiratory illnesses have been recently described. We investigated the association between wheezing conditions and familial, pre-, peri-, and postnatal risk factors. We studied 16,333 children, 6 to 7 yr old, enrolled in a population-bas...

journal_title：American journal of respiratory and critical care medicine

authors： Rusconi F,Galassi C,Corbo GM,Forastiere F,Biggeri A,Ciccone G,Renzoni E

更新日期：1999-11-01 00:00:00

abstract：RATIONALE:Chronic lung diseases are associated with cardiovascular disease. How these associations evolve from young adulthood forward is unknown. Understanding the preclinical history of these associations could inform prevention strategies for common heart-lung conditions. OBJECTIVES:To use the Coronary Artery Risk ...

journal_title：American journal of respiratory and critical care medicine

authors： Cuttica MJ,Colangelo LA,Shah SJ,Lima J,Kishi S,Arynchyn A,Jacobs DR Jr,Thyagarajan B,Liu K,Lloyd-Jones D,Kalhan R

更新日期：2015-07-01 00:00:00

abstract：:A higher exposure to endotoxin was hypothesized to contribute to lower prevalence of allergic sensitization and hay fever in children growing up on a farm. We studied the association between house dust endotoxin and allergic sensitization. We randomly selected 740 children, aged between 5 and 10 years, from a group of...

journal_title：American journal of respiratory and critical care medicine

authors： Gehring U,Bischof W,Fahlbusch B,Wichmann HE,Heinrich J

更新日期：2002-10-01 00:00:00

abstract：:To investigate patterns of testing for human immunodeficiency virus (HIV) infection in tuberculosis patients, we obtained data from the tuberculosis registry and from medical records of 500 tuberculosis patients in Los Angeles County. Sixty-three percent of tuberculosis patients were tested for HIV infection, and mult...

journal_title：American journal of respiratory and critical care medicine

authors： Asch SM,London AS,Barnes PF,Gelberg L

更新日期：1997-01-01 00:00:00

abstract：:The aim of this study was to evaluate the effect of two body positions (supine and semirecumbency) on the dynamics of gastroesophageal reflux (GER) in 15 patients requiring mechanical ventilation and having a nasogastric tube in place. Samples of gastric contents, pharyngeal and bronchial secretions, and blood were ob...

journal_title：American journal of respiratory and critical care medicine

authors： Orozco-Levi M,Torres A,Ferrer M,Piera C,el-Ebiary M,de la Bellacasa JP,Rodriguez-Roisin R

更新日期：1995-10-01 00:00:00

abstract：:We have undertaken this retrospective study to determine factors associated with in-hospital mortality and morbidity in 80 adult patients with severe Streptococcus pneumoniae meningitis. Clinical characteristics at admission of patients infected with susceptible (n = 54) and nonsusceptible (n = 17) strains to penicill...

journal_title：American journal of respiratory and critical care medicine

authors： Auburtin M,Porcher R,Bruneel F,Scanvic A,Trouillet JL,Bédos JP,Régnier B,Wolff M

更新日期：2002-03-01 00:00:00

abstract：:Epidemiologic investigation has established an association between exposure to particulate matter (PM) and human health in the Utah Valley. Reduction of particle mass during the temporary closure of a local steel mill was associated with diminished morbidity and mortality. We tested the hypothesis that the biologic ef...

journal_title：American journal of respiratory and critical care medicine

authors： Ghio AJ,Devlin RB

更新日期：2001-08-15 00:00:00

abstract：:The inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1 beta), have been associated with accelerated metabolism and protein turnover following exogenous administration in normal humans. We hypothesized that these inflammatory cytokines might contribute to the weight-losing proc...

journal_title：American journal of respiratory and critical care medicine

authors： de Godoy I,Donahoe M,Calhoun WJ,Mancino J,Rogers RM

更新日期：1996-02-01 00:00:00

abstract：:While signal transducer and activator of transcription protein 6 (STAT6) is important in interleukin-4 (IL-4)-induced commitment of CD4(+) T cells to the T helper cell, type 2 (Th2) phenotype and IgE isotype switching in B cells, its role in other IL-4-mediated events and their impact upon the allergic response is les...

journal_title：American journal of respiratory and critical care medicine

authors： Tomkinson A,Kanehiro A,Rabinovitch N,Joetham A,Cieslewicz G,Gelfand EW

更新日期：1999-10-01 00:00:00

abstract：:Microscopic examination of tissue sections of mycobacterial lesions frequently results in few or no bacilli seen, even if the lesions appear active histologically. This might be due to the effects of the fixative fluid and/or organic solvent, both of which are conventionally used to make tissue sections for histopatho...

journal_title：American journal of respiratory and critical care medicine

authors： Fukunaga H,Murakami T,Gondo T,Sugi K,Ishihara T

更新日期：2002-10-01 00:00:00

abstract：RATIONALE:Neutrophils are key players in chronic obstructive pulmonary disease (COPD), and increased numbers of neutrophils are present in sputum and lung tissue of patients with COPD. Interestingly, immunoglobulin free light chains (IgLC) are able to prolong the life of neutrophils; therefore, IgLC may contribute to t...

journal_title：American journal of respiratory and critical care medicine

authors： Braber S,Thio M,Blokhuis BR,Henricks PA,Koelink PJ,Groot Kormelink T,Bezemer GF,Kerstjens HA,Postma DS,Garssen J,Kraneveld AD,Redegeld FA,Folkerts G

更新日期：2012-04-15 00:00:00

abstract：:Rationale: Viral infections are major drivers of exacerbations and clinical burden in patients with asthma and chronic obstructive pulmonary disease (COPD). IFN-β is a key component of the innate immune response to viral infection. To date, studies of inhaled IFN-β treatment have not demonstrated a significant effect ...

journal_title：American journal of respiratory and critical care medicine

authors： Watson A,Spalluto CM,McCrae C,Cellura D,Burke H,Cunoosamy D,Freeman A,Hicks A,Hühn M,Ostridge K,Staples KJ,Vaarala O,Wilkinson T

更新日期：2020-01-01 00:00:00

abstract：:The role of strain difference in the response to cigarette smoke was investigated in mice. Mice of the strains DBA/2 and C57BL/6J responded to acute cigarette smoke with a decrease of the antioxidant defenses of their bronchoalveolar lavage (BAL) fluids. On the other hand, under these conditions ICR mice increased the...

journal_title：American journal of respiratory and critical care medicine

authors： Cavarra E,Bartalesi B,Lucattelli M,Fineschi S,Lunghi B,Gambelli F,Ortiz LA,Martorana PA,Lungarella G

更新日期：2001-09-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrotic disorder underlain by aberrant wound healing of repeated lung injury. Environmental triggers and genetic background are likely to act as modifiers of the fibrotic response. Erythrocyte complement receptor 1 is a membrane protein mediating the transport of immu...

journal_title：American journal of respiratory and critical care medicine

authors： Zorzetto M,Ferrarotti I,Trisolini R,Lazzari Agli L,Scabini R,Novo M,De Silvestri A,Patelli M,Martinetti M,Cuccia M,Poletti V,Pozzi E,Luisetti M

更新日期：2003-08-01 00:00:00

abstract：RATIONALE:Standard physiologic assessments of extubation readiness in patients with acute hypoxemic respiratory failure (AHRF) may not reflect lung injury resolution and could adversely affect clinical decision-making and patient outcomes. OBJECTIVES:We hypothesized that elevations in inflammatory plasma biomarkers so...

journal_title：American journal of respiratory and critical care medicine

authors： Alladina J,Levy SD,Cho JL,Brait KL,Rao SR PhD,Camacho A,Hibbert KA,Harris RS,Medoff BD,Januzzi JL,Thompson BT,Bajwa EK

更新日期：2021-01-05 00:00:00

abstract：:To quantify changes in tissue oxygenation of pathologic lungs, we applied a novel method using near-infrared spectroscopy (NIRs). In in vitro experiments, we assayed the effect of photon scattering on the absorption spectra of an in vitro system simulating structures of lung, which consists of test tube containing air...

journal_title：American journal of respiratory and critical care medicine

authors： Noriyuki T,Ohdan H,Yoshioka S,Miyata Y,Asahara T,Dohi K

更新日期：1997-11-01 00:00:00

abstract：:During Operation Everest III (Comex '97), to assess the consequences of altitude-induced hypoxia, eight volunteers were decompressed in a hypobaric chamber, with a decompression profile simulating the climb of Mount Everest. Cardiac function was assessed using a combination of M-mode and two-dimensional echocardiograp...

journal_title：American journal of respiratory and critical care medicine

authors： Boussuges A,Molenat F,Burnet H,Cauchy E,Gardette B,Sainty JM,Jammes Y,Richalet JP

更新日期：2000-01-01 00:00:00

abstract：:The aim of this study was to compare the effects of salmeterol and beclomethasone on lung function and symptoms in children with mild to moderate asthma. Sixty-seven children not treated with inhaled corticosteroids were randomized in a double-blind parallel study either to salmeterol 50 micrograms b.i.d. or beclometh...

journal_title：American journal of respiratory and critical care medicine

authors： Verberne AA,Frost C,Roorda RJ,van der Laag H,Kerrebijn KF

更新日期：1997-09-01 00:00:00