Measuring adherence to asthma medication regimens.

abstract：:We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma pathogenesis. Compatible with a central role for eosinophils and mast cells in asthma, sputum of asthmatic subjects c...

journal_title：American journal of respiratory and critical care medicine

authors： Louis R,Shute J,Biagi S,Stanciu L,Marrelli F,Tenor H,Hidi R,Djukanović R

更新日期：1997-02-01 00:00:00

abstract：:Rationale: To detect pulmonary arterial hypertension (PAH) at any early stage is a promising approach to optimize the outcome. Objectives: To investigate the impact of school ECG-based screening on detecting idiopathic or heritable (I/H)-PAH in the general pediatric population. Methods: This was a nationwide survey of...

journal_title：American journal of respiratory and critical care medicine

authors： Sawada H,Mitani Y,Nakayama T,Fukushima H,Kogaki S,Igarashi T,Ichida F,Ono Y,Nakanishi T,Doi S,Ishikawa S,Matsushima M,Yamada O,Saji T

更新日期：2019-06-01 00:00:00

abstract：:A dysfunction of pathways that normally cause contraction or relaxation of airways has been proposed to explain heightened levels of responsiveness produced by various insults to the airway. For example, we previously reported (4) that infection of cotton rats with the human respiratory syncytial virus (HRSV) leads to...

journal_title：American journal of respiratory and critical care medicine

authors： Colasurdo GN,Hemming VG,Prince GA,Gelfand AS,Loader JE,Larsen GL

更新日期：1998-05-01 00:00:00

abstract：:The aim of this study was to evaluate the effect of two body positions (supine and semirecumbency) on the dynamics of gastroesophageal reflux (GER) in 15 patients requiring mechanical ventilation and having a nasogastric tube in place. Samples of gastric contents, pharyngeal and bronchial secretions, and blood were ob...

journal_title：American journal of respiratory and critical care medicine

authors： Orozco-Levi M,Torres A,Ferrer M,Piera C,el-Ebiary M,de la Bellacasa JP,Rodriguez-Roisin R

更新日期：1995-10-01 00:00:00

abstract：RATIONALE:Immunophenotypes of antiviral responses, and their relationship with asthma, allergy, and lower respiratory tract infections, are poorly understood. OBJECTIVES:We characterized multiple cytokine responses of peripheral blood mononuclear cells to rhinovirus stimulation, and their relationship with clinical ou...

journal_title：American journal of respiratory and critical care medicine

authors： Custovic A,Belgrave D,Lin L,Bakhsoliani E,Telcian AG,Solari R,Murray CS,Walton RP,Curtin J,Edwards MR,Simpson A,Rattray M,Johnston SL

更新日期：2018-05-15 00:00:00

abstract：:A continuously mixed series of microbial communities inhabits various points of the respiratory tract, with community composition determined by distance from colonization sources, colonization rates, and extinction rates. Ecology and evolution theory developed in the context of biogeography is relevant to clinical mic...

journal_title：American journal of respiratory and critical care medicine

authors： Whiteson KL,Bailey B,Bergkessel M,Conrad D,Delhaes L,Felts B,Harris JK,Hunter R,Lim YW,Maughan H,Quinn R,Salamon P,Sullivan J,Wagner BD,Rainey PB

更新日期：2014-06-01 00:00:00

abstract：:The impact of methicillin resistance on morbidity and mortality of patients suffering from severe Staphylococcus aureus infections remains highly controversial. We analyzed a retrospective cohort of 97 patients with methicillin-susceptible and 74 patients with methicillin-resistant Staphylococcus aureus ventilator-ass...

journal_title：American journal of respiratory and critical care medicine

authors： Combes A,Luyt CE,Fagon JY,Wollf M,Trouillet JL,Gibert C,Chastre J,PNEUMA Trial Group.

更新日期：2004-10-01 00:00:00

abstract：RATIONALE:The rate of progression of most interstitial lung diseases (ILD) is unpredictable. Fibrocytes are circulating bone marrow-derived cells that have been implicated in the pathogenesis of lung fibrosis. Hermansky-Pudlak syndrome (HPS), a genetic cause of ILD in early adulthood, allows for study of biomarkers of ...

journal_title：American journal of respiratory and critical care medicine

authors： Trimble A,Gochuico BR,Markello TC,Fischer R,Gahl WA,Lee JK,Kim Y,Burdick MD,Strieter RM,Mehrad B

更新日期：2014-12-15 00:00:00

abstract：RATIONALE:Improved ventilation strategies have been the mainstay for reducing mortality in acute respiratory distress syndrome. Their unique clinical effectiveness is, however, unmatched by our understanding of the underlying mechanobiology, and their impact on alveolar dynamics and gas exchange remains largely specula...

journal_title：American journal of respiratory and critical care medicine

authors： Tabuchi A,Nickles HT,Kim M,Semple JW,Koch E,Brochard L,Slutsky AS,Pries AR,Kuebler WM

更新日期：2016-02-15 00:00:00

abstract：RATIONALE:There is a need to develop novel noninvasive imaging biomarkers that help to evaluate antiinflammatory asthma treatments. OBJECTIVES:To investigate whether the extent of the segmental lung edema measured noninvasively using turbo-inversion recovery-magnitude magnetic resonance imaging (TIRM MRI) corresponds ...

journal_title：American journal of respiratory and critical care medicine

authors： Vogel-Claussen J,Renne J,Hinrichs J,Schönfeld C,Gutberlet M,Schaumann F,Winkler C,Faulenbach C,Krug N,Wacker FK,Hohlfeld JM

更新日期：2014-03-15 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrotic disorder underlain by aberrant wound healing of repeated lung injury. Environmental triggers and genetic background are likely to act as modifiers of the fibrotic response. Erythrocyte complement receptor 1 is a membrane protein mediating the transport of immu...

journal_title：American journal of respiratory and critical care medicine

authors： Zorzetto M,Ferrarotti I,Trisolini R,Lazzari Agli L,Scabini R,Novo M,De Silvestri A,Patelli M,Martinetti M,Cuccia M,Poletti V,Pozzi E,Luisetti M

更新日期：2003-08-01 00:00:00

abstract：:The inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1 beta), have been associated with accelerated metabolism and protein turnover following exogenous administration in normal humans. We hypothesized that these inflammatory cytokines might contribute to the weight-losing proc...

journal_title：American journal of respiratory and critical care medicine

authors： de Godoy I,Donahoe M,Calhoun WJ,Mancino J,Rogers RM

更新日期：1996-02-01 00:00:00

abstract：:Based on serial lung function measurements performed in 142 children (68 males; 74 females) with cystic fibrosis (CF), prospectively evaluated over an age range of 6 to 20 years, we attempted to determine whether the lung clearance index (LCI) as a measure of ventilation inhomogeneities could be a discriminating facto...

journal_title：American journal of respiratory and critical care medicine

authors： Kraemer R,Blum A,Schibler A,Ammann RA,Gallati S

更新日期：2005-02-15 00:00:00

abstract：:Most data about the course of occupational asthma after removal from exposure are based upon the longitudinal assessment of employees exposed to substances inducing late asthmatic reactions in bronchial provocation tests. It was the aim of this study to describe the course of immediate-type occupational asthma after a...

journal_title：American journal of respiratory and critical care medicine

authors： Merget R,Reineke M,Rueckmann A,Bergmann EM,Schultze-Werninghaus G

更新日期：1994-10-01 00:00:00

abstract：:Recently described surgical approaches to the treatment of emphysema, including buttressed stapled volume reduction and laser coagulation, are associated with variable clinical outcomes. We examined objective preoperative factors as predictors of response to treatment in patients enrolled in a randomized trial of stap...

journal_title：American journal of respiratory and critical care medicine

authors： Brenner M,McKenna R Jr,Gelb A,Osann K,Schein MJ,Panzera J,Wong H,Berns MW,Wilson AF

更新日期：1997-04-01 00:00:00

abstract：:Loss of lung elastic recoil causing hyperinflation with increased TLC and decreased diffusing capacity and expiratory airflow are physiologic hallmarks of emphysema. We studied lung mechanics in 10 patients (seven men and three women) aged 69 +/- 9 yr (mean +/- SD) who had fixed, severe expiratory airflow limitation w...

journal_title：American journal of respiratory and critical care medicine

authors： Gelb AF,Zamel N,Hogg JC,Müller NL,Schein MJ

更新日期：1998-09-01 00:00:00

abstract：RATIONALE:When subclavian access is not possible, controversy exists between the internal jugular and femoral sites for the choice of central-venous access in intensive care unit patients. OBJECTIVES:To compare infection and colonization rates of short-term jugular and femoral catheters. METHODS:Using data from two m...

journal_title：American journal of respiratory and critical care medicine

authors： Timsit JF,Bouadma L,Mimoz O,Parienti JJ,Garrouste-Orgeas M,Alfandari S,Plantefeve G,Bronchard R,Troche G,Gauzit R,Antona M,Canet E,Bohe J,Herrault MC,Schwebel C,Ruckly S,Souweine B,Lucet JC

更新日期：2013-11-15 00:00:00

abstract：:Allergen-induced bronchoconstriction involves mast cell activation. Tryptase is a mast cell serine protease that is released during this process, but little is known about the action of tryptase in the airway. The purpose of this study was to determine: (1) if aerosolized tryptase causes bronchoconstriction, and (2) t...

journal_title：American journal of respiratory and critical care medicine

authors： Molinari JF,Scuri M,Moore WR,Clark J,Tanaka R,Abraham WM

更新日期：1996-09-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening, interstitial lung disease of unknown etiology. The median survival of patients with IPF is only 2 to 3 years, yet some patients live much longer. Respiratory failure resulting from disease progression is the most frequent cause of death. To date w...

journal_title：American journal of respiratory and critical care medicine

authors： Ley B,Collard HR,King TE Jr

更新日期：2011-02-15 00:00:00

abstract：:This prospective community-based study of infants born in inner London was undertaken to examine the association between premorbid airway function and subsequent wheezing in the first year of life and to explore the influence on this association of a family history of asthma and maternal smoking during pregnancy. Heal...

journal_title：American journal of respiratory and critical care medicine

authors： Dezateux C,Stocks J,Dundas I,Fletcher ME

更新日期：1999-02-01 00:00:00

abstract：:We investigated the relationship between the extent of pulmonary emphysema, assessed by quantitative high-resolution computed tomography (HRCT), and lung mechanics in 24 patients with chronic obstructive pulmonary disease (COPD). The extent of emphysema was quantified as the relative lung area with CT numbers < -950 H...

journal_title：American journal of respiratory and critical care medicine

authors： Baldi S,Miniati M,Bellina CR,Battolla L,Catapano G,Begliomini E,Giustini D,Giuntini C

更新日期：2001-08-15 00:00:00

abstract：:Antimicrobial stewardship involves a multifaceted approach that strives to combat the emergence of resistance, improve clinical outcomes, and control costs by improving antimicrobial use. Therefore, stewardship is of great importance and relevance in the intensive care unit. Clinical decision support systems, biomarke...

journal_title：American journal of respiratory and critical care medicine

authors： Lawrence KL,Kollef MH

更新日期：2009-03-15 00:00:00

abstract：:The expression of renin-angiotensin system components and the elevation of angiotensin-converting enzyme (ACE) in a number of fibrotic lung diseases suggests angiotensin II (AII) could play a role in the pathogenesis of pulmonary fibrosis. However, the effect of AII on lung fibroblasts has not previously been assessed...

journal_title：American journal of respiratory and critical care medicine

authors： Marshall RP,McAnulty RJ,Laurent GJ

更新日期：2000-06-01 00:00:00

abstract：:The aim of the study was to determine whether closing pressures or vascular distensibility can be used to describe liver venous hemodynamics when right atrial pressure is raised. The study was performed using a vascularly isolated pig liver preparation that allowed the independent control of portal vein and hepatic ar...

journal_title：American journal of respiratory and critical care medicine

authors： Brienza N,Ayuse T,O'Donnell CP,Permutt S,Robotham JL

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community. OBJECTIVES:To determine whether lung transplant recipients can be chronically infected by rhinovirus and the potential clinical impact. METHODS:We first ide...

journal_title：American journal of respiratory and critical care medicine

authors： Kaiser L,Aubert JD,Pache JC,Deffernez C,Rochat T,Garbino J,Wunderli W,Meylan P,Yerly S,Perrin L,Letovanec I,Nicod L,Tapparel C,Soccal PM

更新日期：2006-12-15 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is used to ameliorate neutropenia in patients after antineoplastic treatment. It has also been suggested as an adjunct treatment in septic patients; however, the recruitment and priming of leukocytes by GM-CSF bears the hazard of a hyperinflammatory response. I...

journal_title：American journal of respiratory and critical care medicine

authors： Wollin L,Uhlig S,Nüsing R,Wendel A

更新日期：2001-02-01 00:00:00

abstract：RATIONALE:The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown. OBJECTIVES:To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi J,Hang JQ,Mehta AJ,Zhang HX,Dai HL,Su L,Eisen EA,Christiani DC

更新日期：2010-07-15 00:00:00

abstract：RATIONALE:Secondhand smoke exposure (SHSe) is a significant modifiable risk for respiratory health in children. Although SHSe is declining overall, it has increased for low-income and minority populations. Implementation of effective SHSe interventions within community organizations has the potential for significant pu...

journal_title：American journal of respiratory and critical care medicine

authors： Eakin MN,Rand CS,Borrelli B,Bilderback A,Hovell M,Riekert KA

更新日期：2014-06-15 00:00:00

abstract：:The mechanism responsible for the increased air-space permeability in cigarette smokers is unknown. The aim of this study was to assess the acute and chronic effects of cigarette smoking on epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Fourteen cigarette smokers underwent 99mT...

journal_title：American journal of respiratory and critical care medicine

authors： Morrison D,Rahman I,Lannan S,MacNee W

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:S100A12 is overexpressed during inflammation and is a marker of inflammatory disease. Furthermore, it has been ascribed to the group of damage-associated molecular pattern molecules that promote inflammation. However, the exact role of human S100A12 during early steps of immune activation and sepsis is only p...

journal_title：American journal of respiratory and critical care medicine

authors： Foell D,Wittkowski H,Kessel C,Lüken A,Weinhage T,Varga G,Vogl T,Wirth T,Viemann D,Björk P,van Zoelen MA,Gohar F,Srikrishna G,Kraft M,Roth J

更新日期：2013-06-15 00:00:00