Angiotensin II is mitogenic for human lung fibroblasts via activation of the type 1 receptor.

abstract：BACKGROUND:The use of biomass as a cooking fuel is commonplace in developing countries and has been associated with chronic bronchitis and obstructive airway disease. METHODS:A cross-sectional survey was done in the village of Solis, close to Mexico City. Lifelong nonsmoking women 38 yr of age or older (n=841) complet...

journal_title：American journal of respiratory and critical care medicine

authors： Regalado J,Pérez-Padilla R,Sansores R,Páramo Ramirez JI,Brauer M,Paré P,Vedal S

更新日期：2006-10-15 00:00:00

abstract：:Serum concentrations of neuron-specific enolase (NSE) were measured in 135 patients with benign pulmonary diseases who also underwent a clinical, laboratory, and radiologic evaluation. Eleven percent of the patients as a whole and 27.3% of those who were tuberculous had abnormal serum levels of NSE. Significant differ...

journal_title：American journal of respiratory and critical care medicine

authors： Collazos J,Esteban C,Fernández A,Genollá J

更新日期：1994-07-01 00:00:00

abstract：:We examined the influence of gender on the polysomnographic features of obstructive sleep apnea (OSA) in a retrospective study of 830 patients with OSA diagnosed by overnight polysomnography (PSG). The severity of OSA was determined from the apnea- hypopnea index (AHI) for total sleep time (AHI(TST)), and was classifi...

journal_title：American journal of respiratory and critical care medicine

authors： O'Connor C,Thornley KS,Hanly PJ

更新日期：2000-05-01 00:00:00

abstract：:In this study, 12 male baboons were delivered by hysterotomy at 75% of gestation. The development of a nonlethal baboon model permitted a study of lung growth and development in long-term survivors. Control animals were ventilated with clinically appropriate oxygen for the 21 d study period. BPD animals were ventilate...

journal_title：American journal of respiratory and critical care medicine

authors： Coalson JJ,Winter V,deLemos RA

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:The serial computed tomography findings and prognosis of the acute exacerbation of idiopathic pulmonary fibrosis (IPF) are not yet well defined in a larger number of cases. OBJECTIVES:To evaluate the parenchymal abnormalities and prognosis using high-resolution computed tomography (HRCT) in acute exacerbatio...

journal_title：American journal of respiratory and critical care medicine

authors： Akira M,Kozuka T,Yamamoto S,Sakatani M

更新日期：2008-08-15 00:00:00

abstract：RATIONALE:HIV-1-induced interstitial pneumonitis (IP) is a serious complication of HIV-1 infection, characterized by inflammation and cellular infiltration in lungs, often leading to respiratory failure and death. The barrier function of the pulmonary endothelium is caused in part by tight junction (TJ) proteins, such ...

journal_title：American journal of respiratory and critical care medicine

authors： Li H,Singh S,Potula R,Persidsky Y,Kanmogne GD

更新日期：2014-07-01 00:00:00

abstract：:The nasal antiinflammatory effects produced by maintenance treatment with topical steroids include reduced production of cytokines. The present study explored nasal mucosal effects induced during the first 9 h after a single dose of topical budesonide. Nine subjects with allergic rhinitis due to birch or timothy polle...

journal_title：American journal of respiratory and critical care medicine

authors： Linden M,Svensson C,Andersson E,Andersson M,Greiff L,Persson CG

更新日期：2000-11-01 00:00:00

abstract：:Endothelins (ET-1, ET-2, ET-3) are potent bronchoconstrictors and growth-promoting mediators. They are released from various cells such as endothelial and epithelial cells. In the airways, ETs are released under basal and stimulated conditions. In patients with status asthmaticus and other pulmonary disorders, the exp...

journal_title：American journal of respiratory and critical care medicine

authors： Yang Q,Battistini B,D'Orléans-Juste P,Jeng AY,Sirois P

更新日期：1997-06-01 00:00:00

abstract：:The physiopathology of chronic cough remains obscure. We evaluated the possibility that chronic cough in nonasthmatic subjects is associated with airway inflammation, and if this is so, what the relationship between this inflammation and the possible etiology of cough might be, as well as its response to inhaled stero...

journal_title：American journal of respiratory and critical care medicine

authors： Boulet LP,Milot J,Boutet M,St Georges F,Laviolette M

更新日期：1994-02-01 00:00:00

abstract：:Alveolar macrophages (AMs) are considered major effector cells in host defense against respiratory tract infections by virtue of their potent phagocytic properties. In addition, AMs may regulate the host inflammatory response to infection by production of cytokines and by their capacity to phagocytose apoptotic polymo...

journal_title：American journal of respiratory and critical care medicine

authors： Knapp S,Leemans JC,Florquin S,Branger J,Maris NA,Pater J,van Rooijen N,van der Poll T

更新日期：2003-01-15 00:00:00

abstract：RATIONALE:Intensive care unit (ICU) nurses work in a demanding environment where they are repetitively exposed to traumatic situations and stressful events. The psychological effects on nurses as a result of working in the ICU are relatively unknown. OBJECTIVE:To determine whether there is an increased prevalence of p...

journal_title：American journal of respiratory and critical care medicine

authors： Mealer ML,Shelton A,Berg B,Rothbaum B,Moss M

更新日期：2007-04-01 00:00:00

abstract：:Although all the well-recognized muscles of expiration are paralyzed after traumatic transection of the lower cervical cord, tetraplegic subjects can still empty their lungs actively by contracting the clavicular portion of the pectoralis major. It is not known, however, whether contraction of this muscle bundle may r...

journal_title：American journal of respiratory and critical care medicine

authors： Estenne M,Van Muylem A,Gorini M,Kinnear W,Heilporn A,De Troyer A

更新日期：1994-10-01 00:00:00

abstract：:Based on serial lung function measurements performed in 142 children (68 males; 74 females) with cystic fibrosis (CF), prospectively evaluated over an age range of 6 to 20 years, we attempted to determine whether the lung clearance index (LCI) as a measure of ventilation inhomogeneities could be a discriminating facto...

journal_title：American journal of respiratory and critical care medicine

authors： Kraemer R,Blum A,Schibler A,Ammann RA,Gallati S

更新日期：2005-02-15 00:00:00

abstract：RATIONALE:Secondhand tobacco smoke (SHS) and traffic-related air pollutants are associated with asthma and allergy. Diesel exhaust particles (DEPs) and SHS can interact with allergens in exacerbating allergic airway diseases through generation of reactive oxygen species. Glutathione S-transferases (GSTs) metabolize rea...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Li YF,Gong H Jr,Diaz-Sanchez D

更新日期：2006-12-15 00:00:00

abstract：:To help assess short-term respiratory responses to summertime air pollution, we exposed 24 asthmatic volunteers aged 11-18 in a chamber to respirable acid aerosol (mass median aerodynamic diameter 0.66 micron) plus 0.3 ppm nitrogen dioxide (NO2) plus 0.2 ppm ozone (O3). The aerosol contained available hydrogen ions (H...

journal_title：American journal of respiratory and critical care medicine

authors： Linn WS,Anderson KR,Shamoo DA,Edwards SA,Webb TL,Hackney JD,Gong H Jr

更新日期：1995-09-01 00:00:00

abstract：:In addition to its central role in hemostasis, thrombin may play a role in inflammation and remodeling. To investigate the contribution of thrombin to allergic airway inflammation in asthma, we used an enzymatic assay to determine thrombin activity in bronchoalveolar lavage fluid obtained from 19 subjects with atopic ...

journal_title：American journal of respiratory and critical care medicine

authors： Terada M,Kelly EA,Jarjour NN

更新日期：2004-02-01 00:00:00

abstract：:Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are important for disease pathogenesis. Objectives: To determine whether s...

journal_title：American journal of respiratory and critical care medicine

authors： Reyfman PA,Walter JM,Joshi N,Anekalla KR,McQuattie-Pimentel AC,Chiu S,Fernandez R,Akbarpour M,Chen CI,Ren Z,Verma R,Abdala-Valencia H,Nam K,Chi M,Han S,Gonzalez-Gonzalez FJ,Soberanes S,Watanabe S,Williams KJN,Flozak

更新日期：2019-06-15 00:00:00

abstract：RATIONALE:Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part caused by abnormal purine nucleotide regulation of ion transport, contribute to the pathogenesis of CB. OBJECTIVE...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson WH,Coakley RD,Button B,Henderson AG,Zeman KL,Alexis NE,Peden DB,Lazarowski ER,Davis CW,Bailey S,Fuller F,Almond M,Qaqish B,Bordonali E,Rubinstein M,Bennett WD,Kesimer M,Boucher RC

更新日期：2015-07-15 00:00:00

abstract：:We produced ovalbumin (OVA)-sensitized rats as an animal model of nasal allergy. Intranasal instillation of OVA induced hypertrophic and metaplastic changes of goblet cells in nasal epithelium of OVA- sensitized rats. Intraepithelial mucosubstance in nasal mucosa increased significantly at 24 h after 3 or 7 d of OVA i...

journal_title：American journal of respiratory and critical care medicine

authors： Shimizu T,Hirano H,Majima Y,Sakakura Y

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD). OBJECTIVES:To determine the effect of inhaled corticosteroids with or without long-acting beta(2)-adrenergic agonist on systemic biomarkers of inflammation. METHODS:W...

journal_title：American journal of respiratory and critical care medicine

authors： Sin DD,Man SF,Marciniuk DD,Ford G,FitzGerald M,Wong E,York E,Mainra RR,Ramesh W,Melenka LS,Wilde E,Cowie RL,Williams D,Gan WQ,Rousseau R,ABC (Advair, Biomarkers in COPD) Investigators.

更新日期：2008-06-01 00:00:00

abstract：:It has been nearly a century since the first suggestion that a soluble factor in plasma or serum might be responsible for the symptoms of allergic disease and asthma, and more than 30 yr since immunoglobulin E (IgE) was identified as the key molecule in mediating what are now described as type 1 hypersensitivity react...

journal_title：American journal of respiratory and critical care medicine

authors： Platts-Mills TA

更新日期：2001-10-15 00:00:00

abstract：:Induced sputum using hypertonic saline (HS) is a useful research tool to study airway inflammation (AI). HS provocation testing can also be used to measure airway hyperresponsiveness (AHR). A combined HS challenge and sputum induction procedure has been developed to permit assessment of AI and AHR in a single test. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Jones PD,Hankin R,Simpson J,Gibson PG,Henry RL

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:The promise of newborn screening (NBS) for cystic fibrosis (CF) has not been fully realized, and the extent of improvement in respiratory outcomes is unclear. We hypothesized that significant lung disease was present at diagnosis. OBJECTIVES:To determine the extent of lung disease in a geographically defined...

journal_title：American journal of respiratory and critical care medicine

authors： Sly PD,Brennan S,Gangell C,de Klerk N,Murray C,Mott L,Stick SM,Robinson PJ,Robertson CF,Ranganathan SC,Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST-CF).

更新日期：2009-07-15 00:00:00

abstract：BACKGROUND:Measurements of upper airway size and shape are important in investigating the pathophysiology of obstructive sleep apnea (OSA) and in devising, applying, and determining the effectiveness of treatment modalities. We describe an endoscopic optical technique (anatomic optical coherence tomography, aOCT) that ...

journal_title：American journal of respiratory and critical care medicine

authors： Armstrong JJ,Leigh MS,Sampson DD,Walsh JH,Hillman DR,Eastwood PR

更新日期：2006-01-15 00:00:00

abstract：RATIONALE:The mechanisms by which oxidants are sensed by cells and cause inflammation are not well understood. OBJECTIVES:This study aimed to determine how cells "sense" soluble oxidants and how this is translated into an inflammatory reaction. METHODS:Monocytes, macrophages, or HEK293 cells (stably transfected with ...

journal_title：American journal of respiratory and critical care medicine

authors： Paul-Clark MJ,McMaster SK,Sorrentino R,Sriskandan S,Bailey LK,Moreno L,Ryffel B,Quesniaux VF,Mitchell JA

更新日期：2009-02-15 00:00:00

abstract：:Previous study of adrenergic control of the tracheal vasculature in rats (1) demonstrated that beta-adrenergic blockade heightened arteriolar and large venular contractile responses to norepinephrine, a nonselective alpha-adrenergic agonist. The present study was undertaken to confirm the presence of functional beta-a...

journal_title：American journal of respiratory and critical care medicine

authors： Corboz MR,Ballard ST,Inglis SK,Taylor AE

更新日期：1996-03-01 00:00:00

abstract：:In order to assess the usefulness of sputum analysis in studying plasma-protein exudation and local secretion of proteins in the airways, we measured specific proteins in the sputum sol phase (SSP) and sputum gel phase (SGP) from patients with stable asthma or chronic obstructive pulmonary disease (COPD). Protein leve...

journal_title：American journal of respiratory and critical care medicine

authors： Schoonbrood DF,Lutter R,Habets FJ,Roos CM,Jansen HM,Out TA

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:The around-the-clock presence of an in-house attending critical care physician (24/7 coverage) is purported to be associated with improved outcomes among high-risk children with critical illness. OBJECTIVES:To evaluate the association of 24/7 in-house coverage with outcomes in children with critical illness....

journal_title：American journal of respiratory and critical care medicine

authors： Gupta P,Rettiganti M,Rice TB,Wetzel RC

更新日期：2016-12-15 00:00:00

abstract：:Humans exhibit an acute inflammatory response in the lungs after controlled laboratory exposure to ozone. The present study was designed to test whether biomarkers of inflammation are detectable in humans exposed to ozone and associated copollutants under natural conditions outdoors. Bronchoscopy with bronchoalveolar ...

journal_title：American journal of respiratory and critical care medicine

authors： Kinney PL,Nilsen DM,Lippmann M,Brescia M,Gordon T,McGovern T,El-Fawal H,Devlin RB,Rom WN

更新日期：1996-11-01 00:00:00

abstract：:Airway remodeling may lead to irreversible loss of lung function in asthma. The impact of childhood asthma, airway responsiveness, atopy, and smoking on airway remodeling was investigated in a birth cohort studied longitudinally to age 26. A low postbronchodilator ratio of forced exhaled volume in 1 second (FEV1) to v...

journal_title：American journal of respiratory and critical care medicine

authors： Rasmussen F,Taylor DR,Flannery EM,Cowan JO,Greene JM,Herbison GP,Sears MR

更新日期：2002-06-01 00:00:00