Analysis of plasma-protein leakage and local secretion in sputum from patients with asthma and chronic obstructive pulmonary disease.

abstract：:During dynamic hyperinflation, the ventilatory pump is facing increased demand because it must overcome the intrinsic positive end-expiratory pressure (PEEPi) and decreased capacity since it must operate at a dynamically increased end-expiratory lung volume (EELV). The aim of this study was to evaluate the relative pr...

journal_title：American journal of respiratory and critical care medicine

authors： Yan S,Kayser B

更新日期：1997-08-01 00:00:00

abstract：:Acute lung injury was produced in C57BL/6 mice by the intratracheal (i.t.) administration of bleomycin (BLM). Following injection of 0.1 U BLM, CD3+ lymphocytes and the production of the T-helper-1 (Th1) lymphokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) were increased in lung and lymph nodes. The produ...

journal_title：American journal of respiratory and critical care medicine

authors： Sharma SK,MacLean JA,Pinto C,Kradin RL

更新日期：1996-07-01 00:00:00

abstract：:Rationale: Growing evidence suggests that compromised lung health may be linked to dementia and worsening cognitive ability. Objectives: To test the hypothesis that impaired lung function or lung disease in midlife is associated with greater risk of incident dementia and mild cognitive impairment (MCI) later in life. ...

journal_title：American journal of respiratory and critical care medicine

authors： Lutsey PL,Chen N,Mirabelli MC,Lakshminarayan K,Knopman DS,Vossel KA,Gottesman RF,Mosley TH,Alonso A

更新日期：2019-06-01 00:00:00

abstract：:Platelets are an important, albeit generally underappreciated, component of the inflammatory cascade. Platelets are known to contribute to inflammation in atherosclerosis, stroke, and asthma. They produce a large number of proinflammatory lipid mediators and cytokines, and play a vital role in recruitment of leukocyte...

journal_title：American journal of respiratory and critical care medicine

authors： O'Sullivan BP,Michelson AD

更新日期：2006-03-01 00:00:00

abstract：:The objective of this study was to evaluate the effectiveness of an asthma education program on morbidity, knowledge, and compliance with inhaled corticosteroid treatment using a prospective, randomized, controlled, one-year-before/one-year-after protocol. After rigorous optimization of asthma therapy under the care o...

journal_title：American journal of respiratory and critical care medicine

authors： Coté J,Cartier A,Robichaud P,Boutin H,Malo JL,Rouleau M,Fillion A,Lavallée M,Krusky M,Boulet LP

更新日期：1997-05-01 00:00:00

abstract：:Ventilation was measured in 31 difficult-to-wean patients while pressure support (PS) was reduced by 5 cm H2O every 20 min. Weaning had to be aborted in 14 of 31 patients (Group F) because they met predefined distress criteria. The remaining 17 patients who were able to complete the "weaning test" (Group S) had larger...

journal_title：American journal of respiratory and critical care medicine

authors： Stroetz RW,Hubmayr RD

更新日期：1995-09-01 00:00:00

abstract：:This study examines hemodialysis clearances of isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and ethambutol (EMB). Seven chronic hemodialysis patients were studied. Six were given single oral doses (INH 300 mg, RIF 600 mg, PZA 1000 mg, and EMB 25 mg/kg) 2 h before hemodialysis (Cobe Centrysystem 3 hemodialysis ...

journal_title：American journal of respiratory and critical care medicine

authors： Malone RS,Fish DN,Spiegel DM,Childs JM,Peloquin CA

更新日期：1999-05-01 00:00:00

abstract：:Recent studies suggest that a nitric oxide (NO) deficiency and elevated arginase activity may play a role in the pathogenesis of asthma. Although much attention has been directed toward measurements of exhaled NO in asthma, no studies to date have evaluated levels of plasma arginase or arginine, the substrate for NO p...

journal_title：American journal of respiratory and critical care medicine

authors： Morris CR,Poljakovic M,Lavrisha L,Machado L,Kuypers FA,Morris SM Jr

更新日期：2004-07-15 00:00:00

abstract：:The timing and magnitude of airway narrowing in central apneas is unknown. We have developed a method of apnea classification that relies on the transmission of cardiac airflow oscillation to indicate airway patency. Using a theoretical model, we showed that the amplitude of the cardiac airflow oscillation is proporti...

journal_title：American journal of respiratory and critical care medicine

authors： Lemke RP,Idiong N,Al-Saedi S,Kwiatkowski K,Cates DB,Rigatto H

更新日期：1998-02-01 00:00:00

abstract：:We have investigated the efficacy of a clarithromycin-containing four-drug regimen for Mycobacterium avium complex (MAC) pulmonary disease in 46 patients without acquired immunodeficiency syndrome (AIDS). The patients were 14 males and 32 females with a mean age of 60.9 +/- 11.5 yr. Patients received 10 mg/kg/d of cla...

journal_title：American journal of respiratory and critical care medicine

authors： Tanaka E,Kimoto T,Tsuyuguchi K,Watanabe I,Matsumoto H,Niimi A,Suzuki K,Murayama T,Amitani R,Kuze F

更新日期：1999-09-01 00:00:00

abstract：:Keratinocyte growth factor (KGF) induces transient proliferation of alveolar type II cells (AEII) associated with surfactant alterations. To test the hypothesis that homeostasis of intracellular phospholipid stores is maintained under KGF-induced hyperplasia, we (1) collected tissue from adult rat lungs, fixed for lig...

journal_title：American journal of respiratory and critical care medicine

authors： Fehrenbach A,Bube C,Hohlfeld JM,Stevens P,Tschernig T,Hoymann HG,Krug N,Fehrenbach H

更新日期：2003-05-01 00:00:00

abstract：RATIONALE:Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. The pleiotropic cytokine tumor necrosis factor-alpha is essential to control tuberculosis infection, and various tumor necrosis factor family members and their respecti...

journal_title：American journal of respiratory and critical care medicine

authors： Möller M,Flachsbart F,Till A,Thye T,Horstmann RD,Meyer CG,Osei I,van Helden PD,Hoal EG,Schreiber S,Nebel A,Franke A

更新日期：2010-02-15 00:00:00

abstract：RATIONALE:Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Among others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known. OBJECTIVES:To identify additional risk loci for sarcoidosis and its acute and chronic subforms, we a...

journal_title：American journal of respiratory and critical care medicine

authors： Fischer A,Schmid B,Ellinghaus D,Nothnagel M,Gaede KI,Schürmann M,Lipinski S,Rosenstiel P,Zissel G,Höhne K,Petrek M,Kolek V,Pabst S,Grohé C,Grunewald J,Ronninger M,Eklund A,Padyukov L,Gieger C,Wichmann HE,Nebel A,

更新日期：2012-11-01 00:00:00

abstract：RATIONALE:T-bet (TBX21 or T-box 21) is a critical regulator of T-helper 1 lineage commitment and IFN-gamma production. Knockout mice lacking T-bet develop airway hyperresponsiveness (AHR) to methacholine, peribronchial eosinophilic and lymphocytic inflammation, and increased type III collagen deposition below the bronc...

journal_title：American journal of respiratory and critical care medicine

authors： Raby BA,Hwang ES,Van Steen K,Tantisira K,Peng S,Litonjua A,Lazarus R,Giallourakis C,Rioux JD,Sparrow D,Silverman EK,Glimcher LH,Weiss ST

更新日期：2006-01-01 00:00:00

abstract：:Airway pathology has been extensively investigated in adulthood asthma, whereas only few studies examined bronchial biopsies in childhood asthma. To evaluate the airway pathology in children with asthma, we analyzed bronchial biopsies obtained from 23 children undergoing bronchoscopy for clinical indications other tha...

journal_title：American journal of respiratory and critical care medicine

authors： Barbato A,Turato G,Baraldo S,Bazzan E,Calabrese F,Tura M,Zuin R,Beghe B,Maestrelli P,Fabbri LM,Saetta M

更新日期：2003-10-01 00:00:00

abstract：RATIONALE:Levels of the soluble form of the receptor for advanced glycation end-products (sRAGE) are elevated during acute respiratory distress syndrome (ARDS) and correlate with severity and prognosis. Alveolar fluid clearance (AFC) is necessary for the resolution of lung edema but is impaired in most patients with AR...

journal_title：American journal of respiratory and critical care medicine

authors： Jabaudon M,Blondonnet R,Roszyk L,Bouvier D,Audard J,Clairefond G,Fournier M,Marceau G,Déchelotte P,Pereira B,Sapin V,Constantin JM

更新日期：2015-07-15 00:00:00

abstract：:Interleukin-5 (IL-5) is a potent eosinophilopoietic factor implicated in the chronic inflammatory cell accumulation accompanying bronchial asthma. However, its role in stimulating eosinophil differentiation within the bone marrow following allergen exposure remains to be elucidated. The aims of our study were to deter...

journal_title：American journal of respiratory and critical care medicine

authors： Minshall EM,Schleimer R,Cameron L,Minnicozzi M,Egan RW,Gutierrez-Ramos JC,Eidelman DH,Hamid Q

更新日期：1998-09-01 00:00:00

abstract：:In asthma, the acute increment of airway responsiveness caused by exposure to allergen is associated with influx of eosinophils into the airways. The relationship between chronic airway hyperresponsiveness and airway inflammation is unclear, as they do not change consistently following long-term anti-inflammatory trea...

journal_title：American journal of respiratory and critical care medicine

authors： Crimi E,Spanevello A,Neri M,Ind PW,Rossi GA,Brusasco V

更新日期：1998-01-01 00:00:00

abstract：:We investigated airway responsiveness to mannitol, a new hyperosmolar challenge, in persons hyperresponsive to airway drying. We studied 36 asthmatic subjects, 18 to 40 yr of age, responsive to exercise (n = 23) and eucapnic hyperventilation (n = 28) defined by a 10% fall in FEV1. Fifteen subjects performed both chall...

journal_title：American journal of respiratory and critical care medicine

authors： Brannan JD,Koskela H,Anderson SD,Chew N

更新日期：1998-10-01 00:00:00

abstract：:There is a growing understanding of the effects and potential pathophysiological role of the ETs in asthma and several of the criteria required to strongly implicate ET-1 as a mediator in this disease have been fulfilled. However, some of the information is preliminary, equivocal and requires confirmation. Furthermore...

journal_title：American journal of respiratory and critical care medicine

authors： Hay DW,Henry PJ,Goldie RG

更新日期：1996-12-01 00:00:00

abstract：RATIONALE:Oxygen is commonly administered after extubation. Although several devices are available, data about their clinical efficacy are scarce. OBJECTIVES:To compare the effects of the Venturi mask and the nasal high-flow (NHF) therapy on PaO2/FiO2SET ratio after extubation. Secondary endpoints were to assess effec...

journal_title：American journal of respiratory and critical care medicine

authors： Maggiore SM,Idone FA,Vaschetto R,Festa R,Cataldo A,Antonicelli F,Montini L,De Gaetano A,Navalesi P,Antonelli M

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:The vast majority of children around the world undergoing adenotonsillectomy for obstructive sleep apnea-hypopnea syndrome (OSA) are not objectively diagnosed by nocturnal polysomnography because of access availability and cost issues. Automated analysis of nocturnal oximetry (nSpO2), which is readily and glo...

journal_title：American journal of respiratory and critical care medicine

authors： Hornero R,Kheirandish-Gozal L,Gutiérrez-Tobal GC,Philby MF,Alonso-Álvarez ML,Álvarez D,Dayyat EA,Xu Z,Huang YS,Tamae Kakazu M,Li AM,Van Eyck A,Brockmann PE,Ehsan Z,Simakajornboon N,Kaditis AG,Vaquerizo-Villar F,Crespo S

更新日期：2017-12-15 00:00:00

abstract：RATIONALE:There is a need to develop novel noninvasive imaging biomarkers that help to evaluate antiinflammatory asthma treatments. OBJECTIVES:To investigate whether the extent of the segmental lung edema measured noninvasively using turbo-inversion recovery-magnitude magnetic resonance imaging (TIRM MRI) corresponds ...

journal_title：American journal of respiratory and critical care medicine

authors： Vogel-Claussen J,Renne J,Hinrichs J,Schönfeld C,Gutberlet M,Schaumann F,Winkler C,Faulenbach C,Krug N,Wacker FK,Hohlfeld JM

更新日期：2014-03-15 00:00:00

abstract：RATIONALE:The impact of asthma on chronic lung function deficits is well known. However, there has been little study of ethnic differences in these asthma-associated deficits. OBJECTIVES:To examine whether there are ethnic differences in the effects of asthma on children's lung function. METHODS:We evaluated the impa...

journal_title：American journal of respiratory and critical care medicine

authors： Zhang Y,McConnell R,Gilliland F,Berhane K

更新日期：2011-03-01 00:00:00

abstract：RATIONALE:There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum. OBJECTIVES:To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD an...

journal_title：American journal of respiratory and critical care medicine

authors： Sin DD,Miller BE,Duvoix A,Man SF,Zhang X,Silverman EK,Connett JE,Anthonisen NA,Wise RA,Tashkin D,Celli BR,Edwards LD,Locantore N,Macnee W,Tal-Singer R,Lomas DA,ECLIPSE Investigators.

更新日期：2011-05-01 00:00:00

abstract：:We assessed the influence of current indoor levels of fungi, house dust mite allergen (Der p 1), and cat allergen (Fel d 1) on sensitization and asthma in adults. A total of 485 adults answered a questionnaire and had skin prick tests and lung function tests. Dust and air samples were collected from their bedrooms. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Dharmage S,Bailey M,Raven J,Mitakakis T,Cheng A,Guest D,Rolland J,Forbes A,Thien F,Abramson M,Walters EH

更新日期：2001-07-01 00:00:00

abstract：:The aim of this study was to assess the influence of preservation solution type and extra- or intracellular composition on the occurrence of early graft dysfunction after clinical lung transplantation. For 170 patients who underwent a single (n = 124) or bilateral (n = 46) lung transplantation in two centers in Paris ...

journal_title：American journal of respiratory and critical care medicine

authors： Thabut G,Vinatier I,Brugière O,Lesèche G,Loirat P,Bisson A,Marty J,Fournier M,Mal H

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:In a pulmonary process characterized by spatially heterogeneous loss of aeration, the impairment of gas exchange is expected to depend on the regional distribution of perfusion relative to that of aeration. OBJECTIVES:To investigate how regional aeration, shunt, and perfusion are interrelated at different le...

journal_title：American journal of respiratory and critical care medicine

authors： Musch G,Bellani G,Vidal Melo MF,Harris RS,Winkler T,Schroeder T,Venegas JG

更新日期：2008-02-01 00:00:00

abstract：:The renin angiotensin system plays an important role in the development of pulmonary artery remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary hypertension as may occur in patients with COPD. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T...

journal_title：American journal of respiratory and critical care medicine

authors： van Suylen RJ,Wouters EF,Pennings HJ,Cheriex EC,van Pol PE,Ambergen AW,Vermelis AM,Daemen MJ

更新日期：1999-06-01 00:00:00

abstract：:Central airway obstruction is a problem facing all medical and surgical subspecialists caring for patients with chest diseases. The incidence of this disorder appears to be rising because of the epidemic of lung cancer; however, benign causes of central airway obstruction are being seen more frequently as well. The mo...

journal_title：American journal of respiratory and critical care medicine

authors： Ernst A,Feller-Kopman D,Becker HD,Mehta AC

更新日期：2004-06-15 00:00:00