The effect of an anti-CD3 monoclonal antibody on bleomycin-induced lymphokine production and lung injury.

abstract：:The effect of suplatast tosilate, which has been proven to inhibit T-cell synthesis of IL-4 and IL-5, on the response to antigen inhalation challenge was investigated in sensitized guinea pigs. The animals were given an oral dose of 30 or 100 mg/kg of suplatast or vehicle (distilled water) daily for 1 wk before antige...

journal_title：American journal of respiratory and critical care medicine

authors： Iijima H,Tamura G,Hsiue TR,Liu Y,Taniguchi H,Shirato K

更新日期：1999-07-01 00:00:00

abstract：:Systemic inflammation is present in chronic obstructive pulmonary disease (COPD), which has been linked to cardiovascular morbidity and mortality. We determined the effects of oral and inhaled corticosteroids on serum markers of inflammation in patients with stable COPD. We recruited 41 patients with mild to moderate ...

journal_title：American journal of respiratory and critical care medicine

authors： Sin DD,Lacy P,York E,Man SF

更新日期：2004-10-01 00:00:00

abstract：RATIONALE:Inhibition of pharyngeal motoneurons accompanies REM sleep and is a cause of hypoventilation and obstructive sleep apnea in humans. One explanation posits that the neurotransmitters glycine and γ-aminobutyric acid are responsible for REM sleep motor inhibition. However, blockade of that mechanism at cranial m...

journal_title：American journal of respiratory and critical care medicine

authors： Grace KP,Hughes SW,Horner RL

更新日期：2013-02-01 00:00:00

abstract：RATIONALE:The American Thoracic Society/European Respiratory Society International Consensus Classification panel identified the clinical entity idiopathic nonspecific interstitial pneumonia (NSIP) as a provisional diagnosis and recommended further study. OBJECTIVES:We hypothesized that idiopathic NSIP is an autoimmun...

journal_title：American journal of respiratory and critical care medicine

authors： Kinder BW,Collard HR,Koth L,Daikh DI,Wolters PJ,Elicker B,Jones KD,King TE Jr

更新日期：2007-10-01 00:00:00

abstract：RATIONALE:Respiratory syncytial virus (RSV) is the leading cause of childhood lower respiratory infection, yet viable therapies are lacking. Two major challenges have stalled antiviral development: ethical difficulties in performing pediatric proof-of-concept studies and the prevailing concept that the disease is immun...

journal_title：American journal of respiratory and critical care medicine

authors： DeVincenzo JP,Wilkinson T,Vaishnaw A,Cehelsky J,Meyers R,Nochur S,Harrison L,Meeking P,Mann A,Moane E,Oxford J,Pareek R,Moore R,Walsh E,Studholme R,Dorsett P,Alvarez R,Lambkin-Williams R

更新日期：2010-11-15 00:00:00

abstract：:Airway hyperresponsiveness in asthma has been attributed to impaired ability of deep inspiration (DI) to stretch airway smooth muscle. We have retested this hypothesis by comparing the responses to methacholine of 10 asthmatic and 10 control subjects. After each dose subjects breathed tidally without deep inspiration ...

journal_title：American journal of respiratory and critical care medicine

authors： Burns GP,Gibson GJ

更新日期：1998-07-01 00:00:00

abstract：:Men have higher prevalence rates of chronic obstructive pulmonary disease (COPD) than women, which has been attributed to the historically higher rates of cigarette smoking in males. However, the increased rates of cigarette smoking in females within the last several decades have been associated with steadily increasi...

journal_title：American journal of respiratory and critical care medicine

authors： Silverman EK,Weiss ST,Drazen JM,Chapman HA,Carey V,Campbell EJ,Denish P,Silverman RA,Celedon JC,Reilly JJ,Ginns LC,Speizer FE

更新日期：2000-12-01 00:00:00

abstract：:Salbutamol inhibits neutropenia, increased airway resistance, and gas exchange abnormalities provoked by platelet-activating factor (PAF) challenge in normal persons. To further explore the intriguing dissociation between spirometric abnormalities and gas exchange defects shown in patients with asthma, we investigated...

journal_title：American journal of respiratory and critical care medicine

authors： Díaz O,Barberà JA,Marrades R,Chung KF,Roca J,Rodriguez-Roisin R

更新日期：1997-07-01 00:00:00

abstract：RATIONALE:Bacterial pneumonia is a major cause of morbidity for HIV-infected persons and contributes to excess mortality in this population. OBJECTIVES:To evaluate the frequency and risk factors for occurrence of bacterial pneumonia in the present era of potent antiretroviral therapy. METHODS:We evaluated data from a...

journal_title：American journal of respiratory and critical care medicine

authors： Gordin FM,Roediger MP,Girard PM,Lundgren JD,Miro JM,Palfreeman A,Rodriguez-Barradas MC,Wolff MJ,Easterbrook PJ,Clezy K,Slater LN

更新日期：2008-09-15 00:00:00

abstract：RATIONALE:Brief recurrent apneas in preterm infants and adults can precipitate rapid and severe arterial O(2) desaturation for reasons that remain unclear. OBJECTIVES:We tested a mathematically derived hypothesis that when breathing terminates apnea, mixed-venous hypoxemia continues into the subsequent apnea; as a res...

journal_title：American journal of respiratory and critical care medicine

authors： Sands SA,Edwards BA,Kelly VJ,Skuza EM,Davidson MR,Wilkinson MH,Berger PJ

更新日期：2010-10-01 00:00:00

abstract：:The factors that lead to increased production of specific IgG subclasses are still largely unknown. Recent studies suggest that increased IgG4 responses may be related to prolonged antigen exposure. We present data showing that increased IgG4 responses are found under conditions of chronic exposure to Aspergillus fumi...

journal_title：American journal of respiratory and critical care medicine

authors： Tomee JF,Dubois AE,Koëter GH,Beaumont F,van der Werf TS,Kauffman HF

更新日期：1996-06-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a generally fatal disorder with a reported median survival of 3 to 6 yr. This has been based on relatively few studies with diagnoses inconsistently confirmed by adequate lung biopsy. Retrospective analysis of 104 patients with IPF who had open lung biopsy (OLB) at Mayo Medical C...

journal_title：American journal of respiratory and critical care medicine

authors： Bjoraker JA,Ryu JH,Edwin MK,Myers JL,Tazelaar HD,Schroeder DR,Offord KP

更新日期：1998-01-01 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. The prevalence of HP is higher than recognized, especially its chronic form. Mechanisms of disease are still incompletely known. Strategies to im...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JN,Ortega HG,Reynolds HY,Cormier YF,Fan LL,Franks TJ,Kreiss K,Kunkel S,Lynch D,Quirce S,Rose C,Schleimer RP,Schuyler MR,Selman M,Trout D,Yoshizawa Y

更新日期：2005-04-01 00:00:00

abstract：:The etiology of sleep disruption in patients in intensive care units (ICUs) is poorly understood, but is thought to be related to environmental stimuli, especially noise. We sampled 203 patients (121 males and 82 females) from different ICUs (cardiac [CCU], cardiac stepdown [CICU], medical [MICU], and surgical [SICU])...

journal_title：American journal of respiratory and critical care medicine

authors： Freedman NS,Kotzer N,Schwab RJ

更新日期：1999-04-01 00:00:00

abstract：RATIONALE:Reactivation tuberculosis (TB) occurs as a result of reactivation of latent TB infection (LTBI), and was reported to occur in the United States at a rate of 0.10 to 0.16 cases per 100 person-years in the 1950s; it has not been measured since. OBJECTIVES:To calculate the rate of reactivation TB in a U.S. comm...

journal_title：American journal of respiratory and critical care medicine

authors： Horsburgh CR Jr,O'Donnell M,Chamblee S,Moreland JL,Johnson J,Marsh BJ,Narita M,Johnson LS,von Reyn CF

更新日期：2010-08-01 00:00:00

abstract：:Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the N...

journal_title：American journal of respiratory and critical care medicine

authors： Levy BD,Noel PJ,Freemer MM,Cloutier MM,Georas SN,Jarjour NN,Ober C,Woodruff PG,Barnes KC,Bender BG,Camargo CA Jr,Chupp GL,Denlinger LC,Fahy JV,Fitzpatrick AM,Fuhlbrigge A,Gaston BM,Hartert TV,Kolls JK,Lynch SV,Moo

更新日期：2015-12-01 00:00:00

abstract：:Chronic beryllium disease (CBD) provides a model system in which to evaluate the antigen-stimulated, cell-mediated, immune response that leads to granulomatous lung disease. We hypothesized that beryllium salts would stimulate bronchoalveolar lavage (BAL) cell release of tumor necrosis factor-alpha (TNF-alpha) and lnt...

journal_title：American journal of respiratory and critical care medicine

authors： Tinkle SS,Newman LS

更新日期：1997-12-01 00:00:00

abstract：RATIONALE:Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a multicomponent disease with systemic consequences and effects on quality of life. Single measures such as lung function provide a limited reflection of how the disease affects patients. Composite measures have the potential to accoun...

journal_title：American journal of respiratory and critical care medicine

authors： Jones RC,Donaldson GC,Chavannes NH,Kida K,Dickson-Spillmann M,Harding S,Wedzicha JA,Price D,Hyland ME

更新日期：2009-12-15 00:00:00

abstract：RATIONALE:In the absence of a surgical lung biopsy, patients diagnosed with idiopathic pulmonary fibrosis (IPF) in clinical practice could participate in the INPULSIS trials of nintedanib if they had honeycombing and/or traction bronchiectasis plus reticulation, without atypical features of usual interstitial pneumonia...

journal_title：American journal of respiratory and critical care medicine

authors： Raghu G,Wells AU,Nicholson AG,Richeldi L,Flaherty KR,Le Maulf F,Stowasser S,Schlenker-Herceg R,Hansell DM

更新日期：2017-01-01 00:00:00

abstract：RATIONALE:Recent cohort studies in chronic obstructive pulmonary disease (COPD) have questioned the validity of previously reported associations between inhaled corticosteroids (ICS) and reductions in mortality and rehospitalization in observational studies. Using time-dependent versions of statistical survival models,...

journal_title：American journal of respiratory and critical care medicine

authors： Kiri VA,Pride NB,Soriano JB,Vestbo J

更新日期：2005-08-15 00:00:00

abstract：RATIONALE:There is growing evidence that resident cells, such as fibroblasts and epithelial cells, can drive the persistent accumulation of dendritic cells (DCs) in chronically inflamed tissue, leading to the organization and the maintenance of ectopic lymphoid aggregates. This phenomenon, occurring through a chemokine...

journal_title：American journal of respiratory and critical care medicine

authors： Marchal-Sommé J,Uzunhan Y,Marchand-Adam S,Kambouchner M,Valeyre D,Crestani B,Soler P

更新日期：2007-11-15 00:00:00

abstract：:To elucidate which cells are synthesizing tenascin in usual interstitial pneumonia (UIP) we have analyzed thoracoscopic or open lung biopsies from 30 patients with UIP by mRNA in situ hybridization, using (35)S-labeled tenascin RNA probes. The phenotype of the cells expressing tenascin mRNA was confirmed by immunohist...

journal_title：American journal of respiratory and critical care medicine

authors： Pääkkö P,Kaarteenaho-Wiik R,Pöllänen R,Soini Y

更新日期：2000-03-01 00:00:00

abstract：:Theophylline is well-established in the management of asthma, and there is some evidence of an antiinflammatory effect in asthma. It is not known whether theophylline affects inflammatory markers such as sputum eosinophils and exhaled nitric oxide (NO) in patients with mild asthma not receiving inhaled steroid therapy...

journal_title：American journal of respiratory and critical care medicine

authors： Lim S,Tomita K,Caramori G,Jatakanon A,Oliver B,Keller A,Adcock I,Chung KF,Barnes PJ

更新日期：2001-07-15 00:00:00

abstract：:This Executive Summary of the Global Strategy for the Diagnosis, Management, and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 report focuses primarily on the revised and novel parts of the document. The most significant changes include: (1) the assessment of chronic obstructiv...

journal_title：American journal of respiratory and critical care medicine

authors： Vogelmeier CF,Criner GJ,Martinez FJ,Anzueto A,Barnes PJ,Bourbeau J,Celli BR,Chen R,Decramer M,Fabbri LM,Frith P,Halpin DM,López Varela MV,Nishimura M,Roche N,Rodriguez-Roisin R,Sin DD,Singh D,Stockley R,Vestbo J,W

更新日期：2017-03-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is a highly prevalent disorder in children, in which enlarged adenotonsillar tissues (AT) play a major pathophysiologic role. Mechanisms leading to the proliferation and hypertrophy of AT in children who subsequently develop OSA remain unknown, and surgical extirpation of AT is a...

journal_title：American journal of respiratory and critical care medicine

authors： Khalyfa A,Gharib SA,Kim J,Dayyat E,Snow AB,Bhattacharjee R,Kheirandish-Gozal L,Goldman JL,Gozal D

更新日期：2010-05-15 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), also called basigin, is present in the lung during development, but its expression in normal adult lung is minimal. Increases of EMMPRIN have been found in various forms of experimental lung injury. To determine whether EMMPRIN might be involved in alveolar inj...

journal_title：American journal of respiratory and critical care medicine

authors： Betsuyaku T,Tanino M,Nagai K,Nasuhara Y,Nishimura M,Senior RM

更新日期：2003-07-15 00:00:00

abstract：:Pulmonary hypertension associated with congestive heart failure carries a risk of right ventricular failure after cardiac transplantation. Few data, however, are available on the hemodynamic behavior of the pulmonary circulation in these patients. We therefore studied mean pulmonary artery pressure minus left atrial p...

journal_title：American journal of respiratory and critical care medicine

authors： Naeije R,Lipski A,Abramowicz M,Lejeune P,Mélot C,Antoine M,De Smet JM,Leclerc JL,Primo G

更新日期：1994-04-01 00:00:00

abstract：RATIONALE:Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM). OBJECTIVES:To relate ASM hypertrophy, ASM hyperplasia, and deposition of ECM to the severity and duration of asthma. METHODS:Airways from ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Elliot JG,Jones RL,Carroll ML,Mauad T,Bai TR,Abramson MJ,McKay KO,Green FH

更新日期：2012-05-15 00:00:00

abstract：RATIONALE:The rapid diagnosis of pulmonary tuberculosis (TB) is difficult when acid fast bacilli (AFB) cannot be detected in sputum smears. OBJECTIVES:Following a proof of principle study, we examined in routine clinical practice whether individuals with sputum AFB smear-negative TB can be discriminated from those wit...

journal_title：American journal of respiratory and critical care medicine

authors： Jafari C,Thijsen S,Sotgiu G,Goletti D,Domínguez Benítez JA,Losi M,Eberhardt R,Kirsten D,Kalsdorf B,Bossink A,Latorre I,Migliori GB,Strassburg A,Winteroll S,Greinert U,Richeldi L,Ernst M,Lange C,Tuberculosis Network Eu

更新日期：2009-10-01 00:00:00

abstract：RATIONALE:Improved understanding of the lung microbiome in HIV-infected individuals could lead to better strategies for diagnosis, therapy, and prophylaxis of HIV-associated pneumonias. Differences in the oral and lung microbiomes in HIV-infected and HIV-uninfected individuals are not well defined. Whether highly activ...

journal_title：American journal of respiratory and critical care medicine

authors： Beck JM,Schloss PD,Venkataraman A,Twigg H 3rd,Jablonski KA,Bushman FD,Campbell TB,Charlson ES,Collman RG,Crothers K,Curtis JL,Drews KL,Flores SC,Fontenot AP,Foulkes MA,Frank I,Ghedin E,Huang L,Lynch SV,Morris A,Pa

更新日期：2015-12-01 00:00:00