Suplatast tosilate inhibits late response and airway inflammation in sensitized guinea pigs.

abstract：RATIONALE:IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. OBJECTIVES:The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting reports in the literature. These earlier st...

journal_title：American journal of respiratory and critical care medicine

authors： Kearley J,Erjefalt JS,Andersson C,Benjamin E,Jones CP,Robichaud A,Pegorier S,Brewah Y,Burwell TJ,Bjermer L,Kiener PA,Kolbeck R,Lloyd CM,Coyle AJ,Humbles AA

更新日期：2011-04-01 00:00:00

abstract：:Sarcoidosis is a systemic granulomatous disease of unknown etiology that primarily affects the lungs. The etiology remains unclear; however, environmental, genetic, ethnic, and familial factors probably modify expression of the disease. As an example, African Americans are at greater risk of mortality and morbidity th...

journal_title：American journal of respiratory and critical care medicine

authors： Martin WJ 2nd,Iannuzzi MC,Gail DB,Peavy HH

更新日期：2004-09-01 00:00:00

abstract：:Serum concentrations of neuron-specific enolase (NSE) were measured in 135 patients with benign pulmonary diseases who also underwent a clinical, laboratory, and radiologic evaluation. Eleven percent of the patients as a whole and 27.3% of those who were tuberculous had abnormal serum levels of NSE. Significant differ...

journal_title：American journal of respiratory and critical care medicine

authors： Collazos J,Esteban C,Fernández A,Genollá J

更新日期：1994-07-01 00:00:00

abstract：:Many patients who develop incapacitating illness have not expressed clear treatment preferences. Therefore, surrogate decision makers are asked to make judgments about what treatment pathway is most consistent with the patient's values. Surrogates often struggle with such decisions. The difficulty arises because answe...

journal_title：American journal of respiratory and critical care medicine

authors： Scheunemann LP,Arnold RM,White DB

更新日期：2012-09-15 00:00:00

abstract：RATIONALE:Allergic asthma is characterized by reversible airway obstruction, lung inflammation, and airway hyperresponsiveness (AHR). Previous studies using leukotriene B(4) (LTB(4)) receptor 1-deficient mice and adoptive transfer experiments have suggested that LTB(4) plays a role in lung inflammation and AHR. OBJECT...

journal_title：American journal of respiratory and critical care medicine

authors： Rao NL,Riley JP,Banie H,Xue X,Sun B,Crawford S,Lundeen KA,Yu F,Karlsson L,Fourie AM,Dunford PJ

更新日期：2010-05-01 00:00:00

abstract：RATIONALE:The serial computed tomography findings and prognosis of the acute exacerbation of idiopathic pulmonary fibrosis (IPF) are not yet well defined in a larger number of cases. OBJECTIVES:To evaluate the parenchymal abnormalities and prognosis using high-resolution computed tomography (HRCT) in acute exacerbatio...

journal_title：American journal of respiratory and critical care medicine

authors： Akira M,Kozuka T,Yamamoto S,Sakatani M

更新日期：2008-08-15 00:00:00

abstract：:We derived reference values for slow vital capacity (VC) and flow-volume curve indexes (FVC, FEV(1), and flows) from the 1,185 tracings provided by 1,039 "normal" subjects who participated in one or both cross-sectional surveys of the Po River Delta study in 1980-1982 and in 1988-1991. Definition of "normal" was based...

journal_title：American journal of respiratory and critical care medicine

authors： Pistelli F,Bottai M,Viegi G,Di Pede F,Carrozzi L,Baldacci S,Pedreschi M,Giuntini C

更新日期：2000-03-01 00:00:00

abstract：RATIONALE:Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. OBJECTIVES:We defined the burden of life-threatening (O(2) saturation [O(2) sat] ≤ ...

journal_title：American journal of respiratory and critical care medicine

authors： Ferolla FM,Hijano DR,Acosta PL,Rodríguez A,Dueñas K,Sancilio A,Barboza E,Caría A,Gago GF,Almeida RE,Castro L,Pozzolo C,Martínez MV,Grimaldi LA,Rebec B,Calvo M,Henrichsen J,Nocito C,González M,Barbero G,Losada JV,

更新日期：2013-05-01 00:00:00

abstract：:Two distinct types of tumor necrosis factor receptors (TNF-R) have been identified (TNF-R55 and TNF-R75). Both TNF-R also exist in soluble forms (TNF-sR), resulting from the release of the extracellular domains (TNF-sR55 and TNF-sR75). TNF-sR may play an important role in vivo as they can bind to TNF alpha and prevent...

journal_title：American journal of respiratory and critical care medicine

authors： Humbert M,Roux-Lombard P,Cerrina J,Magnan A,Simonneau G,Dartevelle P,Galanaud P,Dayer JM,Emilie D

更新日期：1994-06-01 00:00:00

abstract：:Bronchoalveolar lavage (BAL) is increasingly used in the pediatric age group. However, normal values for BAL fluid (BALF) constituents are lacking. As part of an investigation to define reference values in children, we studied lymphocyte surface markers of BALF in 28 children 3 to 16 yr of age without bronchopulmonary...

journal_title：American journal of respiratory and critical care medicine

authors： Ratjen F,Bredendiek M,Zheng L,Brendel M,Costabel U

更新日期：1995-07-01 00:00:00

abstract：:The currently recommended prehospital treatment for carbon monoxide (CO) poisoning is administration of 100% O(2). We have shown in dogs that normocapnic hyperpnea with O(2) further accelerates CO elimination. The purpose of this study was to examine the relation between minute ventilation (V E) and the rate of elimin...

journal_title：American journal of respiratory and critical care medicine

authors： Takeuchi A,Vesely A,Rucker J,Sommer LZ,Tesler J,Lavine E,Slutsky AS,Maleck WH,Volgyesi G,Fedorko L,Iscoe S,Fisher JA

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:Drug-resistant tuberculosis transmission in hospitals threatens staff and patient health. Surgical face masks used by patients with tuberculosis (TB) are believed to reduce transmission but have not been rigorously tested. OBJECTIVES:We sought to quantify the efficacy of surgical face masks when worn by pati...

journal_title：American journal of respiratory and critical care medicine

authors： Dharmadhikari AS,Mphahlele M,Stoltz A,Venter K,Mathebula R,Masotla T,Lubbe W,Pagano M,First M,Jensen PA,van der Walt M,Nardell EA

更新日期：2012-05-15 00:00:00

abstract：:The period covered by this update can be considered as the most exciting period in idiopathic pulmonary fibrosis (IPF) research. It started with the identification of genetic variants that are associated with IPF in the majority of patients and continued with discovery of molecular and genetic biomarkers that predict ...

journal_title：American journal of respiratory and critical care medicine

authors： Rosas IO,Kaminski N

更新日期：2015-02-01 00:00:00

abstract：:There have been four types of drug treatment of asthma that have been used over the past 100 years. Belladonna alkaloids, derived from the thorn-apple plant were used in 1905, and chemically synthesized entities in this class are still in use today. Western medicine began to use adrenergic stimulants approximately 100...

journal_title：American journal of respiratory and critical care medicine

authors： Chu EK,Drazen JM

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Although intensive care units (ICUs) were created for patients with life-threatening illnesses, the ICU environment generates a high risk of iatrogenic events. Identifying medical errors (MEs) that serve as indicators for iatrogenic risk is crucial for purposes of reporting and prevention. OBJECTIVES:We desc...

journal_title：American journal of respiratory and critical care medicine

authors： Garrouste-Orgeas M,Timsit JF,Vesin A,Schwebel C,Arnodo P,Lefrant JY,Souweine B,Tabah A,Charpentier J,Gontier O,Fieux F,Mourvillier B,Troché G,Reignier J,Dumay MF,Azoulay E,Reignier B,Carlet J,Soufir L,OUTCOMEREA Stu

更新日期：2010-01-15 00:00:00

abstract：RATIONALE:Epidemiological studies in older individuals have found an association between the use of angiotensin-converting enzyme (ACE) inhibition (ACE-I) therapy and preserved locomotor muscle mass, strength, and walking speed. ACE-I therapy might therefore have a role in the context of pulmonary rehabilitation (PR). ...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis KJ,Meyrick VM,Mehta B,Haji GS,Li K,Montgomery H,Man WD,Polkey MI,Hopkinson NS

更新日期：2016-12-01 00:00:00

abstract：:A 21-yr-old man with multiple pulmonary AV fistulae presented with moderate hypoxemia with chronic hyperventilation, which continued even after sufficient oxygenation by 100% O2 inhalation. The infusion of aminophylline, an adenosine receptor blocker, not only increased PaCO2 from 35 to 39 mm Hg but also depressed the...

journal_title：American journal of respiratory and critical care medicine

authors： Kobayashi S,Nishimura M,Nasuhara Y,Miyamoto K,Kawakami Y

更新日期：1994-12-01 00:00:00

abstract：:Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha released from alveolar macrophages (AM) in pulmonary tuberculosis (TB) are important in host defense against mycobacterial infection. Nitric oxide (NO) production is enhanced in AM of TB patients. We examined whether NO was implicated in (IL)-1beta and TNF-a...

journal_title：American journal of respiratory and critical care medicine

authors： Kuo HP,Wang CH,Huang KS,Lin HC,Yu CT,Liu CY,Lu LC

更新日期：2000-01-01 00:00:00

abstract：RATIONALE:Long-term intermittent hypoxia (LTIH) exposure in adult mice, modeling oxygenation patterns of moderate-severe obstructive sleep apnea, results in lasting hypersomnolence and is associated with nitration and oxidation injuries in many brain regions, including wake-active regions. OBJECTIVES:We sought to dete...

journal_title：American journal of respiratory and critical care medicine

authors： Zhan G,Fenik P,Pratico D,Veasey SC

更新日期：2005-06-15 00:00:00

abstract：RATIONALE:The effects of prenatal cigarette smoke (CS) exposure and hypoxemia on cardiorespiratory control have been investigated in full-term infants. However, few data are available in preterm infants, who form a particularly vulnerable population, with developmentally immature cardiorespiratory control. OBJECTIVES:...

journal_title：American journal of respiratory and critical care medicine

authors： Schneider J,Mitchell I,Singhal N,Kirk V,Hasan SU

更新日期：2008-09-01 00:00:00

abstract：:POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare variant of plasma cell dyscrasia with multiple systemic manifestations. We followed the progress of 20 patients with POEMS syndrome in our institution over a 10-yr period. Pulmonary hypertension (PH) was ob...

journal_title：American journal of respiratory and critical care medicine

authors： Lesprit P,Godeau B,Authier FJ,Soubrier M,Zuber M,Larroche C,Viard JP,Wechsler B,Gherardi R

更新日期：1998-03-01 00:00:00

abstract：RATIONALE:Patients with obstructive sleep apnea (OSA) adapt to the anatomical vulnerability of their upper airway by generating increased activity in upper airway-dilating muscles during wakefulness. Norepinephrine (NE) and serotonin (5-HT) mediate, through α₁-adrenergic and 5-HT₂A receptors, a wake-related excitatory ...

journal_title：American journal of respiratory and critical care medicine

authors： Rukhadze I,Fenik VB,Benincasa KE,Price A,Kubin L

更新日期：2010-11-15 00:00:00

abstract：:Measurement of respiratory compliance is advocated for assessing the severity of acute respiratory failure (ARF). Recently, the administration of an automated constant flow of 15 L/min was proposed as a method easier to implement at the bedside than supersyringe or inspiratory occlusions methods. However, pressure-vol...

journal_title：American journal of respiratory and critical care medicine

authors： Lu Q,Vieira SR,Richecoeur J,Puybasset L,Kalfon P,Coriat P,Rouby JJ

更新日期：1999-01-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) has been associated with kidney function loss, which may be related to changes in the renin-angiotensin system (RAS). OBJECTIVES:We sought to determine the effect of continuous positive airway pressure (CPAP) of patients with OSA on renal hemodynamics at baseline and in response...

journal_title：American journal of respiratory and critical care medicine

authors： Nicholl DD,Hanly PJ,Poulin MJ,Handley GB,Hemmelgarn BR,Sola DY,Ahmed SB

更新日期：2014-09-01 00:00:00

abstract：RATIONALE:Th2 cytokines play an important role in allergic diseases. These cytokines activate signal transduction pathways, including Janus kinase/signal transducer and activator of transcription (STAT) signaling. Although the suppressor of cytokine signaling (SOCS) family protein, a negative regulator of the Janus kin...

journal_title：American journal of respiratory and critical care medicine

authors： Fukuyama S,Nakano T,Matsumoto T,Oliver BG,Burgess JK,Moriwaki A,Tanaka K,Kubo M,Hoshino T,Tanaka H,McKenzie AN,Matsumoto K,Aizawa H,Nakanishi Y,Yoshimura A,Black JL,Inoue H

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Measurements of upper airway size and shape are important in investigating the pathophysiology of obstructive sleep apnea (OSA) and in devising, applying, and determining the effectiveness of treatment modalities. We describe an endoscopic optical technique (anatomic optical coherence tomography, aOCT) that ...

journal_title：American journal of respiratory and critical care medicine

authors： Armstrong JJ,Leigh MS,Sampson DD,Walsh JH,Hillman DR,Eastwood PR

更新日期：2006-01-15 00:00:00

abstract：RATIONALE:Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Among others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known. OBJECTIVES:To identify additional risk loci for sarcoidosis and its acute and chronic subforms, we a...

journal_title：American journal of respiratory and critical care medicine

authors： Fischer A,Schmid B,Ellinghaus D,Nothnagel M,Gaede KI,Schürmann M,Lipinski S,Rosenstiel P,Zissel G,Höhne K,Petrek M,Kolek V,Pabst S,Grohé C,Grunewald J,Ronninger M,Eklund A,Padyukov L,Gieger C,Wichmann HE,Nebel A,

更新日期：2012-11-01 00:00:00

abstract：RATIONALE:Platelets are essential for pulmonary leukocyte recruitment, airway hyperresponsiveness, and bronchial remodeling in animals with allergic inflammation and can be found in bronchoalveolar lavage of sensitized animals. No studies, however, have explored the direct migration of platelets to lungs. OBJECTIVES:T...

journal_title：American journal of respiratory and critical care medicine

authors： Pitchford SC,Momi S,Baglioni S,Casali L,Giannini S,Rossi R,Page CP,Gresele P

更新日期：2008-03-15 00:00:00

abstract：RATIONALE:The around-the-clock presence of an in-house attending critical care physician (24/7 coverage) is purported to be associated with improved outcomes among high-risk children with critical illness. OBJECTIVES:To evaluate the association of 24/7 in-house coverage with outcomes in children with critical illness....

journal_title：American journal of respiratory and critical care medicine

authors： Gupta P,Rettiganti M,Rice TB,Wetzel RC

更新日期：2016-12-15 00:00:00

abstract：:Rationale: The management of indeterminate pulmonary nodules (IPNs) remains challenging, resulting in invasive procedures and delays in diagnosis and treatment. Strategies to decrease the rate of unnecessary invasive procedures and optimize surveillance regimens are needed.Objectives: To develop and validate a deep le...

journal_title：American journal of respiratory and critical care medicine

authors： Massion PP,Antic S,Ather S,Arteta C,Brabec J,Chen H,Declerck J,Dufek D,Hickes W,Kadir T,Kunst J,Landman BA,Munden RF,Novotny P,Peschl H,Pickup LC,Santos C,Smith GT,Talwar A,Gleeson F

更新日期：2020-07-15 00:00:00