A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.

abstract：:Rationale: Chronic obstructive pulmonary disease (COPD) has been associated with numerous genetic variants, yet the extent to which its genetic risk is mediated by variation in lung structure remains unknown.Objectives: To characterize associations between a genetic risk score (GRS) associated with COPD susceptibility...

journal_title：American journal of respiratory and critical care medicine

authors： Oelsner EC,Ortega VE,Smith BM,Nguyen JN,Manichaikul AW,Hoffman EA,Guo X,Taylor KD,Woodruff PG,Couper DJ,Hansel NN,Martinez FJ,Paine R 3rd,Han MK,Cooper C,Dransfield MT,Criner G,Krishnan JA,Bowler R,Bleecker ER,Pet

更新日期：2019-09-15 00:00:00

abstract：:To determine whether the diagnostic yield of transbronchial needle aspiration (TBNA) improves over time and to obtain insights about factors influencing its performance, we reviewed our experience during a 3-yr period. After serial multifaceted educational interventions directed toward bronchoscopists and their techni...

journal_title：American journal of respiratory and critical care medicine

authors： Haponik EF,Cappellari JO,Chin R,Adair NE,Lykens M,Alford PT,Bowton DL

更新日期：1995-06-01 00:00:00

abstract：:The role of nutritional status in the prognosis of subjects with severe chronic obstructive pulmonary disease was studied in a cohort of Canadian men and women followed for 3 to 5 yr. A total of 348 subjects who were recruited for a study of negative pressure ventilation were evaluated for lung function and body weigh...

journal_title：American journal of respiratory and critical care medicine

authors： Gray-Donald K,Gibbons L,Shapiro SH,Macklem PT,Martin JG

更新日期：1996-03-01 00:00:00

abstract：:A nonvolitional test to assess diaphragm strength in neonates has not been previously described. Our aim was to assess the feasibility of cervical (CMS) and anterior (AMS) magnetic stimulation of the phrenic nerves in neonates. Double circular stimulating coils (90-mm) were used. For CMS, one coil was placed over the ...

journal_title：American journal of respiratory and critical care medicine

authors： Rafferty GF,Greenough A,Dimitriou G,Kavadia V,Laubscher B,Polkey MI,Harris ML,Moxham J

更新日期：2000-12-01 00:00:00

abstract：:The expression of renin-angiotensin system components and the elevation of angiotensin-converting enzyme (ACE) in a number of fibrotic lung diseases suggests angiotensin II (AII) could play a role in the pathogenesis of pulmonary fibrosis. However, the effect of AII on lung fibroblasts has not previously been assessed...

journal_title：American journal of respiratory and critical care medicine

authors： Marshall RP,McAnulty RJ,Laurent GJ

更新日期：2000-06-01 00:00:00

abstract：:Patients with severe chronic obstructive pulmonary disease (COPD) do not use the sternocleidomastoid muscles when breathing at rest, but have a greater than normal neural drive to the rib-cage inspiratory muscles, the abdominal muscles, and the diaphragm. Yet the increased activation of the abdominal muscles and diaph...

journal_title：American journal of respiratory and critical care medicine

authors： Estenne M,Derom E,De Troyer A

更新日期：1998-08-01 00:00:00

abstract：RATIONALE:The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma. OBJECTIVES:To identify novel asthma phenotypes using an unsupervised hierarchical clu...

journal_title：American journal of respiratory and critical care medicine

authors： Moore WC,Meyers DA,Wenzel SE,Teague WG,Li H,Li X,D'Agostino R Jr,Castro M,Curran-Everett D,Fitzpatrick AM,Gaston B,Jarjour NN,Sorkness R,Calhoun WJ,Chung KF,Comhair SA,Dweik RA,Israel E,Peters SP,Busse WW,Erzurum

更新日期：2010-02-15 00:00:00

abstract：:The etiology of sleep disruption in patients in intensive care units (ICUs) is poorly understood, but is thought to be related to environmental stimuli, especially noise. We sampled 203 patients (121 males and 82 females) from different ICUs (cardiac [CCU], cardiac stepdown [CICU], medical [MICU], and surgical [SICU])...

journal_title：American journal of respiratory and critical care medicine

authors： Freedman NS,Kotzer N,Schwab RJ

更新日期：1999-04-01 00:00:00

abstract：RATIONALE:Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. OBJECTIVES:We sought to identify donor, recipient, and perioperative risk factors for PGD. METHODS:We performed a 10-center p...

journal_title：American journal of respiratory and critical care medicine

authors： Diamond JM,Lee JC,Kawut SM,Shah RJ,Localio AR,Bellamy SL,Lederer DJ,Cantu E,Kohl BA,Lama VN,Bhorade SM,Crespo M,Demissie E,Sonett J,Wille K,Orens J,Shah AS,Weinacker A,Arcasoy S,Shah PD,Wilkes DS,Ware LB,Palme

更新日期：2013-03-01 00:00:00

abstract：:Stenotrophomonas maltophilia is a gram-negative bacterium that has been cultured with increasing prevalence from the sputum of patients with cystic fibrosis (CF). We conducted a cohort study, using the Cystic Fibrosis Foundation Registry, to assess the effect of S. maltophilia on survival. We studied all patients in t...

journal_title：American journal of respiratory and critical care medicine

authors： Goss CH,Otto K,Aitken ML,Rubenfeld GD

更新日期：2002-08-01 00:00:00

abstract：:Female Fisher 344 rats (n = 25) were inoculated intrapleurally with a single 20-mg dose of (JM-100) fibrous glass. The mean length (2.2 microns) and width (0.15 microns) of the fibrous glass particles was within respirable range. Following inoculation, the rats were killed at timed intervals ranging from 2 to 430 d fr...

journal_title：American journal of respiratory and critical care medicine

authors： Fraire AE,Greenberg SD,Spjut HJ,Roggli VL,Dodson RF,Cartwright J,Williams G,Baker S

更新日期：1994-08-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), also called basigin, is present in the lung during development, but its expression in normal adult lung is minimal. Increases of EMMPRIN have been found in various forms of experimental lung injury. To determine whether EMMPRIN might be involved in alveolar inj...

journal_title：American journal of respiratory and critical care medicine

authors： Betsuyaku T,Tanino M,Nagai K,Nasuhara Y,Nishimura M,Senior RM

更新日期：2003-07-15 00:00:00

abstract：RATIONALE:Although it is widely assumed that the incidence of childhood respiratory allergies to common aeroallergens is directly related to allergen exposure in early life, few longitudinal studies have investigated this issue, and available data are scarce and mainly limited to high-risk groups. OBJECTIVES:To assess...

journal_title：American journal of respiratory and critical care medicine

authors： Torrent M,Sunyer J,Garcia R,Harris J,Iturriaga MV,Puig C,Vall O,Anto JM,Newman Taylor AJ,Cullinan P

更新日期：2007-09-01 00:00:00

abstract：:Four hundred forty-one subjects 34 to 69 yr of age were recruited from a random sample of the community. The sample was biased in favor of men, snorers, and subjects with subjective sleep complaints. They answered a questionnaire and were monitored in their homes for sleep-disordered breathing (SDB). This report conce...

journal_title：American journal of respiratory and critical care medicine

authors： Olson LG,King MT,Hensley MJ,Saunders NA

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Mast cells have important roles in innate immunity and tissue remodeling but have remained poorly studied in inflammatory airway diseases like chronic obstructive pulmonary disease (COPD). OBJECTIVES:To perform a detailed histological characterization of human lung mast cell populations at different severiti...

journal_title：American journal of respiratory and critical care medicine

authors： Andersson CK,Mori M,Bjermer L,Löfdahl CG,Erjefält JS

更新日期：2010-02-01 00:00:00

abstract：:The purpose of the present study is twofold: to evaluate alterations in total phospholipid content and individual phospholipid classes of the surfactant, and to detect markers of inflammatory reaction in bronchoalveolar lavage (BAL) from patients with hydrostatic pulmonary edema (HPE). Mechanically ventilated patients...

journal_title：American journal of respiratory and critical care medicine

authors： Nakos G,Pneumatikos J,Tsangaris I,Tellis C,Lekka M

更新日期：1997-03-01 00:00:00

abstract：:T cells in the airways are considered to play a key role in orchestrating the inflammatory response of asthma through the elaboration of specific cytokines. Using flow cytometry we have investigated the T-cell response of sensitized asthmatic airways 6 h after local allergen provocation. Twelve subjects with atopic as...

journal_title：American journal of respiratory and critical care medicine

authors： Gratziou C,Carroll M,Montefort S,Teran L,Howarth PH,Holgate ST

更新日期：1996-02-01 00:00:00

abstract：:Mechanical ventilation may promote overdistension-induced pulmonary lesions in patients with acute respiratory distress syndrome (ARDS). The static pressure-volume (P-V) curve of the respiratory system can be used to determine the lung volume and corresponding static airway pressure at which lung compliance begins to ...

journal_title：American journal of respiratory and critical care medicine

authors： Roupie E,Dambrosio M,Servillo G,Mentec H,el Atrous S,Beydon L,Brun-Buisson C,Lemaire F,Brochard L

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:The vast majority of children around the world undergoing adenotonsillectomy for obstructive sleep apnea-hypopnea syndrome (OSA) are not objectively diagnosed by nocturnal polysomnography because of access availability and cost issues. Automated analysis of nocturnal oximetry (nSpO2), which is readily and glo...

journal_title：American journal of respiratory and critical care medicine

authors： Hornero R,Kheirandish-Gozal L,Gutiérrez-Tobal GC,Philby MF,Alonso-Álvarez ML,Álvarez D,Dayyat EA,Xu Z,Huang YS,Tamae Kakazu M,Li AM,Van Eyck A,Brockmann PE,Ehsan Z,Simakajornboon N,Kaditis AG,Vaquerizo-Villar F,Crespo S

更新日期：2017-12-15 00:00:00

abstract：RATIONALE:The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown. OBJECTIVES:To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi J,Hang JQ,Mehta AJ,Zhang HX,Dai HL,Su L,Eisen EA,Christiani DC

更新日期：2010-07-15 00:00:00

abstract：:This Executive Summary of the Global Strategy for the Diagnosis, Management, and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 report focuses primarily on the revised and novel parts of the document. The most significant changes include: (1) the assessment of chronic obstructiv...

journal_title：American journal of respiratory and critical care medicine

authors： Vogelmeier CF,Criner GJ,Martinez FJ,Anzueto A,Barnes PJ,Bourbeau J,Celli BR,Chen R,Decramer M,Fabbri LM,Frith P,Halpin DM,López Varela MV,Nishimura M,Roche N,Rodriguez-Roisin R,Sin DD,Singh D,Stockley R,Vestbo J,W

更新日期：2017-03-01 00:00:00

abstract：RATIONALE:Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of renal endothelial cell injury) associated with hypoxemia. OBJECTIVES:To determine whether (1) cigarette smoke (CS)-induced pulmonary and renal endothelial cell injury explains the association between albumin...

journal_title：American journal of respiratory and critical care medicine

authors： Polverino F,Laucho-Contreras ME,Petersen H,Bijol V,Sholl LM,Choi ME,Divo M,Pinto-Plata V,Chetta A,Tesfaigzi Y,Celli BR,Owen CA

更新日期：2017-06-01 00:00:00

abstract：:Segmental bronchoprovocation (SBP) with allergen was used in an attempt to study eosinophils recruited to the airway 24 h after challenge. Unexpectedly, in the first four patients, neutrophils (rather than eosinophils) were recruited in the bronchoalveolar lavage (BAL) fluids, and we hypothesized that the allergen ext...

journal_title：American journal of respiratory and critical care medicine

authors： Hunt LW,Gleich GJ,Ohnishi T,Weiler DA,Mansfield ES,Kita H,Sur S

更新日期：1994-06-01 00:00:00

abstract：:We review recent advances in the use of corticosteroids (CS) in pediatric lung disease. CS are frequently used, systemically or by inhalation. Their mechanisms of action in pulmonary diseases are ill defined. CS exert direct inhibitory effects on many inflammatory cells through genomic mechanisms. There is a time lag ...

journal_title：American journal of respiratory and critical care medicine

authors： de Benedictis FM,Bush A

更新日期：2012-01-01 00:00:00

abstract：RATIONALE:Immediate graft performance after lung transplantation is associated with short- and long-term clinical outcomes. However, the biologic mechanism that determines outcomes is not fully understood. OBJECTIVES:To investigate the impact of cell death signals at 24 and 48 hours after lung transplantation on short...

journal_title：American journal of respiratory and critical care medicine

authors： Hashimoto K,Besla R,Zamel R,Juvet S,Kim H,Azad S,Waddell TK,Cypel M,Liu M,Keshavjee S

更新日期：2016-07-01 00:00:00

abstract：:A 21-yr-old man with multiple pulmonary AV fistulae presented with moderate hypoxemia with chronic hyperventilation, which continued even after sufficient oxygenation by 100% O2 inhalation. The infusion of aminophylline, an adenosine receptor blocker, not only increased PaCO2 from 35 to 39 mm Hg but also depressed the...

journal_title：American journal of respiratory and critical care medicine

authors： Kobayashi S,Nishimura M,Nasuhara Y,Miyamoto K,Kawakami Y

更新日期：1994-12-01 00:00:00

abstract：:A protective role for dietary antioxidants in asthma has been proposed. However, epidemiological evidence to implicate antioxidant vitamins is weak, and data on the role of flavonoid-rich foods and antioxidant trace elements are lacking. We carried out a population-based case-control study in South London, UK, to inve...

journal_title：American journal of respiratory and critical care medicine

authors： Shaheen SO,Sterne JA,Thompson RL,Songhurst CE,Margetts BM,Burney PG

更新日期：2001-11-15 00:00:00

abstract：:The plasma level of fibrinogen is felt to be an independent risk factor for vascular events. Obstructive sleep apnea (OSA) has a high prevalence in patients with stroke and may also be an independent risk factor. The aim of our study was to determine the association between OSA and plasma levels of fibrinogen in patie...

journal_title：American journal of respiratory and critical care medicine

authors： Wessendorf TE,Thilmann AF,Wang YM,Schreiber A,Konietzko N,Teschler H

更新日期：2000-12-01 00:00:00

abstract：RATIONALE:Protein kinase C zeta (PKCζ) has been reported to act as a tumor suppressor. Deletion of PKCζ in experimental cancer models has been shown to increase tumor growth. However, the mechanisms of PKCζ down-regulation in cancerous cells have not been previously described. OBJECTIVES:To determine the molecular mec...

journal_title：American journal of respiratory and critical care medicine

authors： Queisser MA,Dada LA,Deiss-Yehiely N,Angulo M,Zhou G,Kouri FM,Knab LM,Liu J,Stegh AH,DeCamp MM,Budinger GR,Chandel NS,Ciechanover A,Iwai K,Sznajder JI

更新日期：2014-09-15 00:00:00

abstract：:We evaluated positron emission tomographic imaging of pulmonary transgene expression, using an enhanced mutant herpes simplex virus-1 thymidine kinase as the reporter gene, in the lungs of normal rats. Sixteen rats were studied 3 days after an intratracheal administration of 5 x 10(9) to 1 x 10(11) viral particles of ...

journal_title：American journal of respiratory and critical care medicine

authors： Richard JC,Zhou Z,Ponde DE,Dence CS,Factor P,Reynolds PN,Luker GD,Sharma V,Ferkol T,Piwnica-Worms D,Schuster DP

更新日期：2003-05-01 00:00:00