Future Research Directions in Asthma. An NHLBI Working Group Report.

Abstract:

:Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the NHLBI convened a group of extramural investigators for an Asthma Research Strategic Planning workshop on September 18-19, 2014, to accelerate discoveries and their translation to patients. The workshop focused on (1) in utero and early-life origins of asthma, (2) the use of phenotypes and endotypes to classify disease, (3) defining disease modification, (4) disease management, and (5) implementation research. This report summarizes the workshop and produces recommendations to guide future research in asthma.

authors

Levy BD,Noel PJ,Freemer MM,Cloutier MM,Georas SN,Jarjour NN,Ober C,Woodruff PG,Barnes KC,Bender BG,Camargo CA Jr,Chupp GL,Denlinger LC,Fahy JV,Fitzpatrick AM,Fuhlbrigge A,Gaston BM,Hartert TV,Kolls JK,Lynch SV,Moo

doi

10.1164/rccm.201505-0963WS

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

1366-72

issue

11

eissn

1073-449X

issn

1535-4970

journal_volume

192

pub_type

杂志文章,评审
  • Cigarette smoking is associated with subclinical parenchymal lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA)-lung study.

    abstract:RATIONALE:Cigarette smoking is a risk factor for diffuse parenchymal lung disease. Risk factors for subclinical parenchymal lung disease have not been described. OBJECTIVES:To determine if cigarette smoking is associated with subclinical parenchymal lung disease, as measured by spirometric restriction and regions of h...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200812-1966OC

    authors: Lederer DJ,Enright PL,Kawut SM,Hoffman EA,Hunninghake G,van Beek EJ,Austin JH,Jiang R,Lovasi GS,Barr RG

    更新日期:2009-09-01 00:00:00

  • Quality of life in allergic rhinitis and asthma. A population-based study of young adults.

    abstract::Quality of life has been found to be impaired both in patients with asthma and in patients with allergic rhinitis, but the relative burden of these diseases has not been investigated. We analyzed answers to the SF-36 questionnaire from 850 subjects recruited in two French centers participating in the European Communit...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.162.4.9912033

    authors: Leynaert B,Neukirch C,Liard R,Bousquet J,Neukirch F

    更新日期:2000-10-01 00:00:00

  • Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation.

    abstract:RATIONALE:5-Hydroxytryptamine (5-HT) is involved in the pathogenesis of allergic airway inflammation (AAI). It is unclear, however, how 5-HT contributes to AAI and whether this depends on tryptophan hydroxylase (TPH) 1, the critical enzyme for peripheral 5-HT synthesis. OBJECTIVES:To elucidate the role of TPH1 and the...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201208-1440OC

    authors: Dürk T,Duerschmied D,Müller T,Grimm M,Reuter S,Vieira RP,Ayata K,Cicko S,Sorichter S,Walther DJ,Virchow JC,Taube C,Idzko M

    更新日期:2013-03-01 00:00:00

  • Association between glycemic state and lung function: the Framingham Heart Study.

    abstract::Diabetes mellitus has been inconsistently associated with a reduced level of pulmonary function. To elucidate this association further, we analyzed the relationship of diabetes and of fasting blood glucose to the level of pulmonary function assessed by spirometry in the 3,254 members of the Framingham Offspring Cohort...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.2203022

    authors: Walter RE,Beiser A,Givelber RJ,O'Connor GT,Gottlieb DJ

    更新日期:2003-03-15 00:00:00

  • Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease.

    abstract:RATIONALE:There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum. OBJECTIVES:To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD an...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1164/rccm.201008-1220OC

    authors: Sin DD,Miller BE,Duvoix A,Man SF,Zhang X,Silverman EK,Connett JE,Anthonisen NA,Wise RA,Tashkin D,Celli BR,Edwards LD,Locantore N,Macnee W,Tal-Singer R,Lomas DA,ECLIPSE Investigators.

    更新日期:2011-05-01 00:00:00

  • Interaction of HLA phenotype and exposure intensity in sensitization to complex platinum salts.

    abstract::The development of sensitization to inhaled allergens is determined by the interaction of multiple genetic and environmental influences. Occupational sensitization to low-molecular-weight chemicals allows a specific immunological response to an inhaled hapten to be studied in a well-defined population with characteriz...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.160.2.9807065

    authors: Newman Taylor AJ,Cullinan P,Lympany PA,Harris JM,Dowdeswell RJ,du Bois RM

    更新日期:1999-08-01 00:00:00

  • Decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smoking.

    abstract::Asthma in adults may be associated with chronic airflow obstruction, possibly resulting from airway disease in early life and/or a greater rate of decline in lung function in adult life compared with those with asthma. Treatment and cigarette smoking may also influence the rate of decline of lung function. The aim of ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200402-230OC

    authors: James AL,Palmer LJ,Kicic E,Maxwell PS,Lagan SE,Ryan GF,Musk AW

    更新日期:2005-01-15 00:00:00

  • Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.

    abstract:RATIONALE:Serum chitinases may be novel biomarkers of airway inflammation and remodeling, but less is known about factors regulating their levels. OBJECTIVES:To examine serum chitotriosidase activity and YKL-40 levels in patients with asthma and chronic obstructive pulmonary disease (COPD) and evaluate clinically rele...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201504-0760OC

    authors: James AJ,Reinius LE,Verhoek M,Gomes A,Kupczyk M,Hammar U,Ono J,Ohta S,Izuhara K,Bel E,Kere J,Söderhäll C,Dahlén B,Boot RG,Dahlén SE,BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway

    更新日期:2016-01-15 00:00:00

  • Use of the child health questionnaire in a sample of moderate and low-income inner-city children with asthma.

    abstract::The Child Health Questionnaire (CHQ-PF50) is one of several recent efforts to gauge pediatric, health-related quality of life from the patient's (or parent's) perspective. Although tested extensively with healthy children, more information is needed about CHQ performance among children with chronic conditions such as ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.162.4.2001067

    authors: Asmussen L,Olson LM,Grant EN,Landgraf JM,Fagan J,Weiss KB

    更新日期:2000-10-01 00:00:00

  • The impact of genomic changes on treatment of lung cancer.

    abstract::The remarkable success of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in patients with EGFR mutations and ALK rearrangements, respectively, introduced the era of targeted therapy in advanced non-small cell lung cancer (NSCLC), shifting treatment from platinum...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1164/rccm.201305-0843PP

    authors: Cardarella S,Johnson BE

    更新日期:2013-10-01 00:00:00

  • Airway inflammation in childhood asthma.

    abstract::Airway pathology has been extensively investigated in adulthood asthma, whereas only few studies examined bronchial biopsies in childhood asthma. To evaluate the airway pathology in children with asthma, we analyzed bronchial biopsies obtained from 23 children undergoing bronchoscopy for clinical indications other tha...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200305-650OC

    authors: Barbato A,Turato G,Baraldo S,Bazzan E,Calabrese F,Tura M,Zuin R,Beghe B,Maestrelli P,Fabbri LM,Saetta M

    更新日期:2003-10-01 00:00:00

  • Effects of ONO-1078, a peptide leukotriene antagonist, on endotoxin-induced acute lung injury.

    abstract::The role of lipoxygenase metabolites in the pathogenesis of endotoxin (LPS)-induced lung injury remains to be clarified. We investigated the contribution of peptide leukotrienes to LPS-induced acute lung injury using a potent antagonist, ONO-1078 (ONO). Experimental groups consisted of a saline group (n = 10), an LPS ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.150.5.7952560

    authors: Ishizaka A,Hasegawa N,Sakamaki F,Tasaka S,Nakamura H,Kishikawa K,Yamada A,Obata T,Sayama K,Urano T

    更新日期:1994-11-01 00:00:00

  • Transpulmonary systemic fat embolism. Studies in mongrel dogs after cemented arthroplasty.

    abstract::We investigated the source of intravascular fat in systemic organs (brain, heart, and kidney) after massive pulmonary fat embolism during cemented arthroplasty. We used a bilateral cemented arthroplasty (BCA) in anesthetized mongrel dogs that simulates a cemented total-hip replacement procedure. We hypothesized that d...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.150.5.7952570

    authors: Byrick RJ,Mullen JB,Mazer CD,Guest CB

    更新日期:1994-11-01 00:00:00

  • Tracheal gas insufflation: catheter effectiveness determined by expiratory flush volume.

    abstract::Used adjunctively during mechanical ventilation, tracheal gas insufflation (TGI) improves CO2 elimination, principally by decreasing effective anatomic dead space. Continuing lung deflation at end- expiration raises the end-expiratory C02 concentration within the proximal airway, and could theoretically reduce the eff...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.153.6.8665040

    authors: Ravenscraft SA,Shapiro RS,Nahum A,Burke WC,Adams AB,Nakos G,Marini JJ

    更新日期:1996-06-01 00:00:00

  • Beryllium sensitization progresses to chronic beryllium disease: a longitudinal study of disease risk.

    abstract::The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify both beryllium sensitization and chronic beryllium disease. Approximately 50% of individuals with beryllium sensitization have chronic beryllium disease at the time of their initial clinical evaluation; however, the rate of p...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200402-190OC

    authors: Newman LS,Mroz MM,Balkissoon R,Maier LA

    更新日期:2005-01-01 00:00:00

  • Relaxation is impaired in the diaphragm muscle of the cardiomyopathic Syrian hamster.

    abstract::Relaxation was examined in diaphragm muscle strips of cardiomyopathic Syrian hamsters and control hamsters. Isotonic lengthening velocity and isometric tension decay were analyzed over the load continuum in response to twitch. For each load level (P), we measured the maximum extent of shortening (deltaL), the peak len...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.155.5.9154860

    authors: Coirault C,Chemla D,Pourny JC,Lambert F,Riou B,Lecarpentier Y

    更新日期:1997-05-01 00:00:00

  • A randomized controlled trial of intravenous montelukast in acute asthma.

    abstract::Many patients with acute asthma do not respond adequately to currently accepted therapy, including oxygen, beta-agonists, and corticosteroids. Leukotriene receptor antagonists such as montelukast have demonstrated efficacy in chronic asthma, but their efficacy in acute asthma is unknown. In this randomized, double-bli...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1164/rccm.200208-802OC

    authors: Camargo CA Jr,Smithline HA,Malice MP,Green SA,Reiss TF

    更新日期:2003-02-15 00:00:00

  • Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype.

    abstract:RATIONALE:The relationship between clinical phenotype of childhood primary ciliary dyskinesia (PCD) and ultrastructural defects and genotype is poorly defined. OBJECTIVES:To delineate clinical features of childhood PCD and their associations with ultrastructural defects and genotype. METHODS:A total of 118 participan...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1164/rccm.201409-1672OC

    authors: Davis SD,Ferkol TW,Rosenfeld M,Lee HS,Dell SD,Sagel SD,Milla C,Zariwala MA,Pittman JE,Shapiro AJ,Carson JL,Krischer JP,Hazucha MJ,Cooper ML,Knowles MR,Leigh MW

    更新日期:2015-02-01 00:00:00

  • Associations of Nasopharyngeal Metabolome and Microbiome with Severity among Infants with Bronchiolitis. A Multiomic Analysis.

    abstract:RATIONALE:Bronchiolitis is the most common lower respiratory infection in infants; however, it remains unclear which infants with bronchiolitis will develop severe illness. In addition, although emerging evidence indicates associations of the upper-airway microbiome with bronchiolitis severity, little is known about th...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1164/rccm.201701-0071OC

    authors: Stewart CJ,Mansbach JM,Wong MC,Ajami NJ,Petrosino JF,Camargo CA Jr,Hasegawa K

    更新日期:2017-10-01 00:00:00

  • Sepsis and Cancer: An Interplay of Friends and Foes.

    abstract::Sepsis and cancer share a number of pathophysiological features, and both result from the inability of the host's immune system to cope with the initial insult (tissue invasion by pathogens and malignant cell transformation, respectively). The common coexistence of both disorders and the profound related alterations i...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1164/rccm.202004-1116TR

    authors: Mirouse A,Vigneron C,Llitjos JF,Chiche JD,Mira JP,Mokart D,Azoulay E,Pène F

    更新日期:2020-12-15 00:00:00

  • Human respiratory syncytial virus produces prolonged alterations of neural control in airways of developing ferrets.

    abstract::A dysfunction of pathways that normally cause contraction or relaxation of airways has been proposed to explain heightened levels of responsiveness produced by various insults to the airway. For example, we previously reported (4) that infection of cotton rats with the human respiratory syncytial virus (HRSV) leads to...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.157.5.9705026

    authors: Colasurdo GN,Hemming VG,Prince GA,Gelfand AS,Loader JE,Larsen GL

    更新日期:1998-05-01 00:00:00

  • Correlates of the "don't know" response to questions about snoring.

    abstract::Many persons say that they "don't know" whether they snore. The purpose of this study was to investigate the prevalence and correlates of such responses in an elderly population. Subjects were 1715 members (1,155 men, 560 women) of a previously defined cohort (Western Group Collaborative Study) followed prospectively ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.160.6.9807082

    authors: Bliwise DL,Swan GE,Carmelli D,La Rue A

    更新日期:1999-12-01 00:00:00

  • High prevalence of pulmonary tuberculosis and inadequate case finding in rural western Kenya.

    abstract:RATIONALE:Limited information exists on the prevalence of tuberculosis and adequacy of case finding in African populations with high rates of HIV. OBJECTIVES:To estimate the prevalence of bacteriologically confirmed pulmonary tuberculosis (PTB) and the fraction attributable to HIV, and to evaluate case detection. MET...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201008-1269OC

    authors: van't Hoog AH,Laserson KF,Githui WA,Meme HK,Agaya JA,Odeny LO,Muchiri BG,Marston BJ,DeCock KM,Borgdorff MW

    更新日期:2011-05-01 00:00:00

  • Effect of fibrous glass on rat pleural mesothelium. Histopathologic observations.

    abstract::Female Fisher 344 rats (n = 25) were inoculated intrapleurally with a single 20-mg dose of (JM-100) fibrous glass. The mean length (2.2 microns) and width (0.15 microns) of the fibrous glass particles was within respirable range. Following inoculation, the rats were killed at timed intervals ranging from 2 to 430 d fr...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.150.2.8049840

    authors: Fraire AE,Greenberg SD,Spjut HJ,Roggli VL,Dodson RF,Cartwright J,Williams G,Baker S

    更新日期:1994-08-01 00:00:00

  • Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome.

    abstract:RATIONALE:E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped e-liquids are unknown. OBJECTIVES:To determine the effects of chronic vaping on pulmonary epithelia. METHODS:We performed research bronchoscopies on h...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201710-2033OC

    authors: Ghosh A,Coakley RC,Mascenik T,Rowell TR,Davis ES,Rogers K,Webster MJ,Dang H,Herring LE,Sassano MF,Livraghi-Butrico A,Van Buren SK,Graves LM,Herman MA,Randell SH,Alexis NE,Tarran R

    更新日期:2018-07-01 00:00:00

  • Basal expression of bone morphogenetic protein receptor is reduced in mild asthma.

    abstract:RATIONALE:Despite increasing recognition of bone morphogenetic protein (BMP) signaling in tissue remodeling, the expression pattern of ligands and signaling pathways remain undefined in the asthmatic airway. OBJECTIVES:To determine expression of BMP ligands (BMP-2, BMP-4, and BMP-7) and type I and type II receptors (A...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1164/rccm.200709-1376OC

    authors: Kariyawasam HH,Xanthou G,Barkans J,Aizen M,Kay AB,Robinson DS

    更新日期:2008-05-15 00:00:00

  • Platelets Regulate Pulmonary Inflammation and Tissue Destruction in Tuberculosis.

    abstract:RATIONALE:Platelets may interact with the immune system in tuberculosis (TB) to regulate human inflammatory responses that lead to morbidity and spread of infection. OBJECTIVES:To identify a functional role of platelets in the innate inflammatory and matrix-degrading response in TB. METHODS:Markers of platelet activa...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201710-2102OC

    authors: Fox KA,Kirwan DE,Whittington AM,Krishnan N,Robertson BD,Gilman RH,López JW,Singh S,Porter JC,Friedland JS

    更新日期:2018-07-15 00:00:00

  • Anti-inflammatory cytokine release by alveolar macrophages in pulmonary sarcoidosis.

    abstract::Sarcoidosis is a systemic, granulomatous disorder with a high rate of spontaneous remission indicating the presence of antiinflammatory mechanisms. Antiinflammatory mediators such as interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) should be able to induce spontaneous remission of sarcoidosis. By ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章

    doi:10.1164/ajrccm.154.3.8810610

    authors: Zissel G,Homolka J,Schlaak J,Schlaak M,Müller-Quernheim J

    更新日期:1996-09-01 00:00:00

  • Allergenic activity of a major grass pollen allergen is elevated in the presence of nasal secretion.

    abstract::Phl p5 is a major allergen of timothy grass and causes rhinitis and bronchial asthma in nearly all patients allergic to grass pollen. The biochemical processing of this molecule by the nasal mucosa at its first encounter and possible changes of its biologic activity are unknown. Two isoforms of the allergen were expre...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.157.4.9709040

    authors: Bufe A,Gehlhar K,Schramm G,Schlaak M,Becker WM

    更新日期:1998-04-01 00:00:00

  • Effect of dobutamine on oxygen consumption and gastric mucosal pH in septic patients.

    abstract::Decreases in gastric mucosal pH (pHi) are associated with splanchnic hypoxia in animals and with increased mortality in patients. In the present study we measured changes in gastric pHi with a tonometer in septic patients after a short-term infusion of dobutamine. These changes were compared with concurrent alteration...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.150.2.8049810

    authors: Gutierrez G,Clark C,Brown SD,Price K,Ortiz L,Nelson C

    更新日期:1994-08-01 00:00:00