Evidence of a critical period of airway instability during central apneas in preterm infants.

abstract：:Because interleukin 8 (IL-8) is a potent neutrophil chemotactic and activating cytokine, we investigated IL-8 production in relation to neutrophil migration and elastase release in the human lung during unilateral community-acquired pneumonia (CAP). In 17 patients, the local response in the involved lung was compared ...

journal_title：American journal of respiratory and critical care medicine

authors： Boutten A,Dehoux MS,Seta N,Ostinelli J,Venembre P,Crestani B,Dombret MC,Durand G,Aubier M

更新日期：1996-01-01 00:00:00

abstract：:The mechanism responsible for diminished exercise performance in cystic fibrosis (CF) is not clear. We hypothesized that reduced muscle size, rather than an intrinsic muscle defect, was the primary factor in such diminished exercise performance. Twenty-two subjects with CF (14 females and eight males, aged 6.5 to 17.7...

journal_title：American journal of respiratory and critical care medicine

authors： Moser C,Tirakitsoontorn P,Nussbaum E,Newcomb R,Cooper DM

更新日期：2000-11-01 00:00:00

abstract：:Airway hyperresponsiveness in asthma has been attributed to impaired ability of deep inspiration (DI) to stretch airway smooth muscle. We have retested this hypothesis by comparing the responses to methacholine of 10 asthmatic and 10 control subjects. After each dose subjects breathed tidally without deep inspiration ...

journal_title：American journal of respiratory and critical care medicine

authors： Burns GP,Gibson GJ

更新日期：1998-07-01 00:00:00

abstract：:A 21-yr-old man with multiple pulmonary AV fistulae presented with moderate hypoxemia with chronic hyperventilation, which continued even after sufficient oxygenation by 100% O2 inhalation. The infusion of aminophylline, an adenosine receptor blocker, not only increased PaCO2 from 35 to 39 mm Hg but also depressed the...

journal_title：American journal of respiratory and critical care medicine

authors： Kobayashi S,Nishimura M,Nasuhara Y,Miyamoto K,Kawakami Y

更新日期：1994-12-01 00:00:00

abstract：:Despite several codes of research ethics, the issuance of comprehensive rules regarding informed consent by governmental agencies, and numerous writings on the subject of informed consent, many commentators still question the quality of the informed consent process in clinical research. A major concern is that investi...

journal_title：American journal of respiratory and critical care medicine

authors： Silverman HJ

更新日期：1996-09-01 00:00:00

abstract：RATIONALE:Although research supports a sleep-disordered breathing and atrial fibrillation association, prospective data examining sleep-disordered breathing predicting incident atrial fibrillation are lacking. OBJECTIVES:To investigate sleep-disordered breathing indices as predictors of incident atrial fibrillation. ...

journal_title：American journal of respiratory and critical care medicine

authors： May AM,Blackwell T,Stone PH,Stone KL,Cawthon PM,Sauer WH,Varosy PD,Redline S,Mehra R,MrOS Sleep (Outcomes of Sleep Disorders in Older Men) Study Group.

更新日期：2016-04-01 00:00:00

abstract：:During dynamic hyperinflation, the ventilatory pump is facing increased demand because it must overcome the intrinsic positive end-expiratory pressure (PEEPi) and decreased capacity since it must operate at a dynamically increased end-expiratory lung volume (EELV). The aim of this study was to evaluate the relative pr...

journal_title：American journal of respiratory and critical care medicine

authors： Yan S,Kayser B

更新日期：1997-08-01 00:00:00

abstract：:Early experience suggests that lung volume reduction surgery improves exercise tolerance as measured by the 6-min walk distance in patients with emphysema. To identify the physiologic mechanism(s) by which lung volume reduction surgery improved exercise, we performed progressive cardiopulmonary exercise testing, inclu...

journal_title：American journal of respiratory and critical care medicine

authors： Benditt JO,Lewis S,Wood DE,Klima L,Albert RK

更新日期：1997-08-01 00:00:00

abstract：:Previous study of adrenergic control of the tracheal vasculature in rats (1) demonstrated that beta-adrenergic blockade heightened arteriolar and large venular contractile responses to norepinephrine, a nonselective alpha-adrenergic agonist. The present study was undertaken to confirm the presence of functional beta-a...

journal_title：American journal of respiratory and critical care medicine

authors： Corboz MR,Ballard ST,Inglis SK,Taylor AE

更新日期：1996-03-01 00:00:00

abstract：RATIONALE:Mechanical ventilation is known to induce ventilator-induced diaphragm dysfunction. Patients submitted to mechanical ventilation often receive massive doses of corticosteroids that may cause further deterioration of diaphragm function. OBJECTIVES:To examine whether the combination of 24 hours of controlled m...

journal_title：American journal of respiratory and critical care medicine

authors： Maes K,Testelmans D,Cadot P,Deruisseau K,Powers SK,Decramer M,Gayan-Ramirez G

更新日期：2008-12-15 00:00:00

abstract：:Obstructive sleep apnea (OSA) is traditionally diagnosed using overnight polysomnography. Decision rules may provide an alternative to polysomnography. A consecutive series of patients referred to a tertiary sleep center underwent prospective evaluation with the upper airway physical examination protocol, followed by ...

journal_title：American journal of respiratory and critical care medicine

authors： Tsai WH,Remmers JE,Brant R,Flemons WW,Davies J,Macarthur C

更新日期：2003-05-15 00:00:00

abstract：RATIONALE:Limited information exists on the prevalence of tuberculosis and adequacy of case finding in African populations with high rates of HIV. OBJECTIVES:To estimate the prevalence of bacteriologically confirmed pulmonary tuberculosis (PTB) and the fraction attributable to HIV, and to evaluate case detection. MET...

journal_title：American journal of respiratory and critical care medicine

authors： van't Hoog AH,Laserson KF,Githui WA,Meme HK,Agaya JA,Odeny LO,Muchiri BG,Marston BJ,DeCock KM,Borgdorff MW

更新日期：2011-05-01 00:00:00

abstract：:Rapid and selective recruitment of neutrophils into the airspace in response to LPS facilitates the clearance of bacterial pathogens. However, neutrophil infiltration can also participate in the development and progression of environmental airway disease. Previous data have revealed that Toll-like receptor 4 (tlr4) is...

journal_title：American journal of respiratory and critical care medicine

authors： Hollingsworth JW,Chen BJ,Brass DM,Berman K,Gunn MD,Cook DN,Schwartz DA

更新日期：2005-04-15 00:00:00

abstract：RATIONALE:Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a multicomponent disease with systemic consequences and effects on quality of life. Single measures such as lung function provide a limited reflection of how the disease affects patients. Composite measures have the potential to accoun...

journal_title：American journal of respiratory and critical care medicine

authors： Jones RC,Donaldson GC,Chavannes NH,Kida K,Dickson-Spillmann M,Harding S,Wedzicha JA,Price D,Hyland ME

更新日期：2009-12-15 00:00:00

abstract：:In many countries the majority of patients with asthma are now treated with inhaled beta 2-agonists as required and regular inhaled steroids. Compliance with asthma medication is poor, particularly for inhaled steroids, which do not give immediate relief of symptoms. An inhaler combining a beta 2-agonist and a steroid...

journal_title：American journal of respiratory and critical care medicine

authors： Barnes PJ,O'Connor BJ

更新日期：1995-04-01 00:00:00

abstract：:Although abnormalities of alveolar fibrin turnover have been reported to play a role in the development of idiopathic pulmonary fibrosis (IPF), the pathophysiological relevance remains unclear. We therefore investigated the localization of tissue factor (TF) and fibrin deposition in patients with IPF using immunohisto...

journal_title：American journal of respiratory and critical care medicine

authors： Imokawa S,Sato A,Hayakawa H,Kotani M,Urano T,Takada A

更新日期：1997-08-01 00:00:00

abstract：:POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare variant of plasma cell dyscrasia with multiple systemic manifestations. We followed the progress of 20 patients with POEMS syndrome in our institution over a 10-yr period. Pulmonary hypertension (PH) was ob...

journal_title：American journal of respiratory and critical care medicine

authors： Lesprit P,Godeau B,Authier FJ,Soubrier M,Zuber M,Larroche C,Viard JP,Wechsler B,Gherardi R

更新日期：1998-03-01 00:00:00

abstract：RATIONALE:Density-based morphometric studies have demonstrated decreased capillary density in infants with bronchopulmonary dysplasia (BPD) and in BPD-like animal models, leading to the prevailing view that microvascular development is disrupted in BPD. OBJECTIVE:To perform a comprehensive analysis of the early and la...

journal_title：American journal of respiratory and critical care medicine

authors： De Paepe ME,Mao Q,Powell J,Rubin SE,DeKoninck P,Appel N,Dixon M,Gundogan F

更新日期：2006-01-15 00:00:00

abstract：RATIONALE:The effects of prenatal cigarette smoke (CS) exposure and hypoxemia on cardiorespiratory control have been investigated in full-term infants. However, few data are available in preterm infants, who form a particularly vulnerable population, with developmentally immature cardiorespiratory control. OBJECTIVES:...

journal_title：American journal of respiratory and critical care medicine

authors： Schneider J,Mitchell I,Singhal N,Kirk V,Hasan SU

更新日期：2008-09-01 00:00:00

abstract：RATIONALE:Innate immune responses marked by increases in tumor necrosis factor (TNF)-α have been associated with asthma but whether such alterations are evident before symptoms is not yet clear. OBJECTIVES:To determine if prevalence of childhood asthma or asthma-related traits is predicted by perinatal innate immune s...

journal_title：American journal of respiratory and critical care medicine

authors： Halonen M,Lohman IC,Stern DA,Ellis WL,Rothers J,Wright AL

更新日期：2013-07-01 00:00:00

abstract：:The purpose of the present study is twofold: to evaluate alterations in total phospholipid content and individual phospholipid classes of the surfactant, and to detect markers of inflammatory reaction in bronchoalveolar lavage (BAL) from patients with hydrostatic pulmonary edema (HPE). Mechanically ventilated patients...

journal_title：American journal of respiratory and critical care medicine

authors： Nakos G,Pneumatikos J,Tsangaris I,Tellis C,Lekka M

更新日期：1997-03-01 00:00:00

abstract：RATIONALE:Platelets are essential for pulmonary leukocyte recruitment, airway hyperresponsiveness, and bronchial remodeling in animals with allergic inflammation and can be found in bronchoalveolar lavage of sensitized animals. No studies, however, have explored the direct migration of platelets to lungs. OBJECTIVES:T...

journal_title：American journal of respiratory and critical care medicine

authors： Pitchford SC,Momi S,Baglioni S,Casali L,Giannini S,Rossi R,Page CP,Gresele P

更新日期：2008-03-15 00:00:00

abstract：RATIONALE:Poor adherence is common in difficult-to-control asthma. Distinguishing patients with difficult-to-control asthma who respond to inhaled corticosteroids (ICS) from refractory asthma is an important clinical challenge. OBJECTIVES:Suppression of fractional exhaled nitric oxide (FeNO) with directly observed ICS...

journal_title：American journal of respiratory and critical care medicine

authors： Heaney LG,Busby J,Bradding P,Chaudhuri R,Mansur AH,Niven R,Pavord ID,Lindsay JT,Costello RW,Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

更新日期：2019-02-15 00:00:00

abstract：:Increased pharyngeal collapsibility and abnormal anatomic structures have been postulated to contribute to the pathophysiology of obstructive sleep apnea (OSA) syndrome. It is unclear whether the abnormal craniofacial and soft tissue features may affect the pharyngeal collapsibility and contribute to the apnea density...

journal_title：American journal of respiratory and critical care medicine

authors： Sforza E,Bacon W,Weiss T,Thibault A,Petiau C,Krieger J

更新日期：2000-02-01 00:00:00

abstract：RATIONALE:Severe sepsis and septic shock are leading causes of intensive care unit (ICU) admission, morbidity, and mortality. The effect of compliance with sepsis management guidelines on outcomes is unclear. OBJECTIVES:To assess the effect on mortality of compliance with a severe sepsis and septic shock management bu...

journal_title：American journal of respiratory and critical care medicine

authors： Miller RR 3rd,Dong L,Nelson NC,Brown SM,Kuttler KG,Probst DR,Allen TL,Clemmer TP,Intermountain Healthcare Intensive Medicine Clinical Program.

更新日期：2013-07-01 00:00:00

abstract：:We tested the hypothesis that in advanced pulmonary fibrosis, edema is redistributed away from the relatively noncompliant interstitium and predominantly floods alveoli. Severe left lung fibrosis was produced in six dogs with radiation and intratracheal bleomycin and, 24 mo later, hydrostatic edema was induced by infu...

journal_title：American journal of respiratory and critical care medicine

authors： Zwikler MP,Iancu D,Michel RP

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:There is growing evidence that resident cells, such as fibroblasts and epithelial cells, can drive the persistent accumulation of dendritic cells (DCs) in chronically inflamed tissue, leading to the organization and the maintenance of ectopic lymphoid aggregates. This phenomenon, occurring through a chemokine...

journal_title：American journal of respiratory and critical care medicine

authors： Marchal-Sommé J,Uzunhan Y,Marchand-Adam S,Kambouchner M,Valeyre D,Crestani B,Soler P

更新日期：2007-11-15 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：:Premature lungs are highly susceptible to lung injuries, leading to bronchopulmonary dysplasia (BPD). Keratinocyte growth factor (KGF) is produced by the developing lung and may reduce the risk of BPD by preventing injury to the lung epithelium and enhancing its repair. To determine whether KGF concentrations in the a...

journal_title：American journal of respiratory and critical care medicine

authors： Danan C,Franco ML,Jarreau PH,Dassieu G,Chailley-Heu B,Bourbon J,Delacourt C

更新日期：2002-05-15 00:00:00

abstract：RATIONALE:Cigarette smoke is the major risk factor in the development of chronic obstructive pulmonary disease (COPD). Lipidomics is a novel and emerging research field that may provide new insights in the origins of chronic inflammatory diseases, such as COPD. OBJECTIVES:To investigate whether expression of the sputu...

journal_title：American journal of respiratory and critical care medicine

authors： Telenga ED,Hoffmann RF,Ruben t'Kindt,Hoonhorst SJ,Willemse BW,van Oosterhout AJ,Heijink IH,van den Berge M,Jorge L,Sandra P,Postma DS,Sandra K,ten Hacken NH

更新日期：2014-07-15 00:00:00