High concentrations of keratinocyte growth factor in airways of premature infants predicted absence of bronchopulmonary dysplasia.

abstract：:Fibrosing alveolitis may occur alone (CFA) or in association with systemic sclerosis (FASSc). FASSc was recently shown to have a prognostic advantage over CFA. Because interleukin-8 (IL-8) is likely to be a major determinant of neutrophil alveolitis, we evaluated IL-8 expression in patients with CFA and FASSc and comp...

journal_title：American journal of respiratory and critical care medicine

authors： Southcott AM,Jones KP,Li D,Majumdar S,Cambrey AD,Pantelidis P,Black CM,Laurent GJ,Davies BH,Jeffery PK

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:Few studies have examined associations between exposure to air pollution and childhood lung function after implementation of strict air quality regulations in the 1990s. OBJECTIVES:To assess traffic-related pollution exposure and childhood lung function. METHODS:We geocoded addresses for 614 mother-child pa...

journal_title：American journal of respiratory and critical care medicine

authors： Rice MB,Rifas-Shiman SL,Litonjua AA,Oken E,Gillman MW,Kloog I,Luttmann-Gibson H,Zanobetti A,Coull BA,Schwartz J,Koutrakis P,Mittleman MA,Gold DR

更新日期：2016-04-15 00:00:00

abstract：:Respiratory system compliance (Crs) in infants with cystic fibrosis (CF) has been reported as decreased or not different compared with healthy control subjects; however, the reported measurements of Crs were "quasi-static" or by the single-breath occlusion technique, with all measurements limited to tidal lung volume,...

journal_title：American journal of respiratory and critical care medicine

authors： Tepper RS,Weist A,Williams-Nkomo T,Kisling J

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:Studies in patients and experimental animals provide compelling evidence of the involvement of the major thrombin receptor, proteinase-activated receptor-1 (PAR(1)), and the potent chemokine, chemokine (CC motif) ligand-2 (CCL2)/monocyte chemotactic protein-1, in the pathogenesis of idiopathic pulmonary fibro...

journal_title：American journal of respiratory and critical care medicine

authors： Mercer PF,Johns RH,Scotton CJ,Krupiczojc MA,Königshoff M,Howell DC,McAnulty RJ,Das A,Thorley AJ,Tetley TD,Eickelberg O,Chambers RC

更新日期：2009-03-01 00:00:00

abstract：:To examine the differential properties of mucous glycoproteins, we produced hypertrophic and metaplastic changes in goblet cells of rat nasal epithelium by intranasal instillation of ovalbumin (OVA) in OVA-sensitized rats, and by intranasal lipopolysaccharide (LPS) instillation. The epithelial mucosubstance was quanti...

journal_title：American journal of respiratory and critical care medicine

authors： Shimizu T,Hirano H,Shimizu S,Kishioka C,Sakakura Y,Majima Y

更新日期：2001-09-15 00:00:00

abstract：:Burkholderia gladioli has been reported as colonizing the airways of patients with cystic fibrosis (CF) but has not previously been associated with adverse outcome. We describe six patients with CF in whom the same strain of B. gladioli, on the basis of ribotyping and biochemical characteristics, was grown in their sp...

journal_title：American journal of respiratory and critical care medicine

authors： Wilsher ML,Kolbe J,Morris AJ,Welch DF

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:The majority of patients with sarcoidosis resolve their condition; however 5-10% of patients with sarcoidosis develop pulmonary fibrosis with poor prognosis. Prostaglandin-endoperoxide synthase 2 (PTGS2) is a key regulatory enzyme in the synthesis of the antifibrotic agent prostaglandin E(2) and is reduced in...

journal_title：American journal of respiratory and critical care medicine

authors： Hill MR,Papafili A,Booth H,Lawson P,Hubner M,Beynon H,Read C,Lindahl G,Marshall RP,McAnulty RJ,Laurent GJ

更新日期：2006-10-15 00:00:00

abstract：:CC-chemokine receptor 3 (CCR3)-stimulating chemokines are likely to have important in vivo roles in the regulation of eosinophil, basophil, and potentially helper T cell type 2 and mast cell recruitment. We have developed techniques to investigate the actions of eotaxin and other chemokines on multiple leukocyte popul...

journal_title：American journal of respiratory and critical care medicine

authors： Bryan SA,Jose PJ,Topping JR,Wilhelm R,Soderberg C,Kertesz D,Barnes PJ,Williams TJ,Hansel TT,Sabroe I

更新日期：2002-06-15 00:00:00

abstract：:It has long been known that there are cyclic changes in arterial pressure during mechanical ventilation. They are caused by cyclic changes in both the right and left ventricular stroke output, occurring in opposite phases. As a result, arterial pulse pressure is increased during inspiration and decreased during expira...

journal_title：American journal of respiratory and critical care medicine

authors： Vieillard-Baron A,Chergui K,Augarde R,Prin S,Page B,Beauchet A,Jardin F

更新日期：2003-09-15 00:00:00

abstract：RATIONALE:Occupational exposure to beryllium (Be) can result in chronic granulomatous inflammation characterized by the presence of Be-specific CD4+ T cells. Studies show that oxidative stress plays a role in the pathogenesis of chronic inflammatory disorders. OBJECTIVES:We hypothesized that Be-induced oxidative stres...

journal_title：American journal of respiratory and critical care medicine

authors： Dobis DR,Sawyer RT,Gillespie MM,Huang J,Newman LS,Maier LA,Day BJ

更新日期：2008-05-01 00:00:00

abstract：:Lung cancer is a significant disease with survival rates remaining poor despite numerous therapeutic advances during the last 30 years. Understanding lung cancer pathogenesis through murine modeling may improve future human therapies, and new data indicate that mutations within different endogenous stem cells situated...

journal_title：American journal of respiratory and critical care medicine

authors： Giangreco A,Groot KR,Janes SM

更新日期：2007-03-15 00:00:00

abstract：:Little is known about the structural response of the diaphragm to controlled mechanical ventilation. We examined effects of this intervention on muscle mass, myosin heavy chain isoforms, and contractile function in the rat diaphragm. Animals were mechanically ventilated for up to 4 days, and comparisons were made with...

journal_title：American journal of respiratory and critical care medicine

authors： Yang L,Luo J,Bourdon J,Lin MC,Gottfried SB,Petrof BJ

更新日期：2002-10-15 00:00:00

abstract：:Sepsis and cancer share a number of pathophysiological features, and both result from the inability of the host's immune system to cope with the initial insult (tissue invasion by pathogens and malignant cell transformation, respectively). The common coexistence of both disorders and the profound related alterations i...

journal_title：American journal of respiratory and critical care medicine

authors： Mirouse A,Vigneron C,Llitjos JF,Chiche JD,Mira JP,Mokart D,Azoulay E,Pène F

更新日期：2020-12-15 00:00:00

abstract：RATIONALE:Dyspnea is the impairing cardinal symptom of asthma but its accurate perception is also crucial for timely initiation of treatment. However, the underlying brain mechanisms of perceived dyspnea in patients with asthma are unknown. OBJECTIVES:To study brain mechanisms of dyspnea in asthma. METHODS:By using f...

journal_title：American journal of respiratory and critical care medicine

authors： von Leupoldt A,Sommer T,Kegat S,Eippert F,Baumann HJ,Klose H,Dahme B,Büchel C

更新日期：2009-08-01 00:00:00

abstract：:Based on serial lung function measurements performed in 142 children (68 males; 74 females) with cystic fibrosis (CF), prospectively evaluated over an age range of 6 to 20 years, we attempted to determine whether the lung clearance index (LCI) as a measure of ventilation inhomogeneities could be a discriminating facto...

journal_title：American journal of respiratory and critical care medicine

authors： Kraemer R,Blum A,Schibler A,Ammann RA,Gallati S

更新日期：2005-02-15 00:00:00

abstract：:Two patients receiving low dose methotrexate, one with rheumatoid arthritis and the other with pityriasis rubra pilaris, developed disseminated histoplasmosis and Mycobacterium avium intracellulare pneumonia, respectively. Twenty-three cases of opportunistic infection in patients receiving low dose methotrexate have b...

journal_title：American journal of respiratory and critical care medicine

authors： LeMense GP,Sahn SA

更新日期：1994-07-01 00:00:00

abstract：:Asthma and chronic bronchitis are inflammatory diseases with extracellular matrix (ECM) remodeling and collagen deposition. Collagen homeostasis is controlled by metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). We evaluated MMP and TIMP balance in induced sputum of 10 control, 31 untreate...

journal_title：American journal of respiratory and critical care medicine

authors： Vignola AM,Riccobono L,Mirabella A,Profita M,Chanez P,Bellia V,Mautino G,D'accardi P,Bousquet J,Bonsignore G

更新日期：1998-12-01 00:00:00

abstract：:Bronchial dehiscence after lung transplantation is difficult to treat and associated with high mortality. We describe our experience using self-expanding metallic stents to treat post-lung transplant bronchial dehiscence. From January 1995 to June 2004, 189 single and 118 double lung transplants were performed in our ...

journal_title：American journal of respiratory and critical care medicine

authors： Mughal MM,Gildea TR,Murthy S,Pettersson G,DeCamp M,Mehta AC

更新日期：2005-09-15 00:00:00

abstract：RATIONALE:Platelets are essential for pulmonary leukocyte recruitment, airway hyperresponsiveness, and bronchial remodeling in animals with allergic inflammation and can be found in bronchoalveolar lavage of sensitized animals. No studies, however, have explored the direct migration of platelets to lungs. OBJECTIVES:T...

journal_title：American journal of respiratory and critical care medicine

authors： Pitchford SC,Momi S,Baglioni S,Casali L,Giannini S,Rossi R,Page CP,Gresele P

更新日期：2008-03-15 00:00:00

abstract：RATIONALE:Daily azithromycin decreases acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but long-term side effects are unknown. OBJECTIVES:To identify the types of exacerbations most likely to be reduced and clinical subgroups most likely to benefit from azithromycin, 250 mg daily, added to usual...

journal_title：American journal of respiratory and critical care medicine

authors： Han MK,Tayob N,Murray S,Dransfield MT,Washko G,Scanlon PD,Criner GJ,Casaburi R,Connett J,Lazarus SC,Albert R,Woodruff P,Martinez FJ

更新日期：2014-06-15 00:00:00

abstract：RATIONALE:Diaphragm atrophy and dysfunction have been reported in humans during mechanical ventilation, but the prevalence, causes, and functional impact of changes in diaphragm thickness during routine mechanical ventilation for critically ill patients are unknown. OBJECTIVES:To describe the evolution of diaphragm th...

journal_title：American journal of respiratory and critical care medicine

authors： Goligher EC,Fan E,Herridge MS,Murray A,Vorona S,Brace D,Rittayamai N,Lanys A,Tomlinson G,Singh JM,Bolz SS,Rubenfeld GD,Kavanagh BP,Brochard LJ,Ferguson ND

更新日期：2015-11-01 00:00:00

abstract：:Until recently it was thought that age greater than 35 yr was the main risk factor for the development of drug-induced hepatitis (DIH) in patients receiving antituberculosis therapy. We conducted a study to determine whether infection with either the hepatitis C virus or the human immunodeficiency virus (HIV) were sig...

journal_title：American journal of respiratory and critical care medicine

authors： Ungo JR,Jones D,Ashkin D,Hollender ES,Bernstein D,Albanese AP,Pitchenik AE

更新日期：1998-06-01 00:00:00

abstract：RATIONALE:There are few follow-up studies on long-term cardiopulmonary function after pulmonary endarterectomy (PEA), the operation of choice for chronic thromboembolic pulmonary hypertension (CTEPH). OBJECTIVES:To prospectively evaluate long-term outcome of patients with CTEPH treated with PEA. METHODS:Between 1994 ...

journal_title：American journal of respiratory and critical care medicine

authors： Corsico AG,D'Armini AM,Cerveri I,Klersy C,Ansaldo E,Niniano R,Gatto E,Monterosso C,Morsolini M,Nicolardi S,Tramontin C,Pozzi E,Viganò M

更新日期：2008-08-15 00:00:00

abstract：:We tested the hypothesis that in advanced pulmonary fibrosis, edema is redistributed away from the relatively noncompliant interstitium and predominantly floods alveoli. Severe left lung fibrosis was produced in six dogs with radiation and intratracheal bleomycin and, 24 mo later, hydrostatic edema was induced by infu...

journal_title：American journal of respiratory and critical care medicine

authors： Zwikler MP,Iancu D,Michel RP

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:Numerous studies have been published on the new Mycobacterium tuberculosis (MTB)-specific IFN-gamma release assays. However, their prognostic value for progression from latent tuberculosis infection (LTBI) to active TB has yet to be established. OBJECTIVES:To compare the QuantiFERON-TB Gold In-Tube assay (QF...

journal_title：American journal of respiratory and critical care medicine

authors： Diel R,Loddenkemper R,Meywald-Walter K,Niemann S,Nienhaus A

更新日期：2008-05-15 00:00:00

abstract：:The management of children with drug-resistant tuberculosis (DR-TB) is challenging, and it is likely that in many places, the roll-out of molecular diagnostic testing will lead to more children being diagnosed. There is a limited evidence base to guide optimal treatment and follow-up in the pediatric population; in ex...

journal_title：American journal of respiratory and critical care medicine

authors： Seddon JA,Furin JJ,Gale M,Del Castillo Barrientos H,Hurtado RM,Amanullah F,Ford N,Starke JR,Schaaf HS,Sentinel Project on Pediatric Drug-Resistant Tuberculosis.

更新日期：2012-11-15 00:00:00

abstract：:Arousal is believed to be needed for upper airway opening in obstructive hypopneas-apneas, without compelling evidence to support this notion. The association may be incidental. I studied the temporal relation between arousal and opening and impact of arousal on flow response at opening in 82 patients (apnea-hypopnea ...

journal_title：American journal of respiratory and critical care medicine

authors： Younes M

更新日期：2004-03-01 00:00:00

abstract：:Surfactant protein B (SP-B) is one of the essential constituents of the alveolar surfactant system, presenting mainly in the form of SP-B dimer. The measurement of this molecule in biologic samples has been hampered by its extreme hydrophobicity and intimate association with surfactant lipids. We developed a solid-pha...

journal_title：American journal of respiratory and critical care medicine

authors： Krämer HJ,Schmidt R,Günther A,Becker G,Suzuki Y,Seeger W

更新日期：1995-11-01 00:00:00

abstract：:This study was carried out to determine if the bronchoconstrictive effect of cigarette smoke (CS) is enhanced when airway hyperresponsiveness is induced by ovalbumin (Ova) sensitization, and if so, whether an increase in endogenously released tachykinins is involved. The bronchoconstrictive effects of an acute CS inha...

journal_title：American journal of respiratory and critical care medicine

authors： Wu ZX,Zhou D,Chen G,Lee LY

更新日期：2000-01-01 00:00:00

abstract：:Neutrophil adherence to tumor necrosis factor-alpha (TNF-alpha)-treated human pulmonary microvascular endothelial cells (PMECs) induces cytoskeletal changes in endothelial cells that require intercellular adhesion molecule-1 (ICAM-1)-dependent signaling events. This study determined whether similar changes occurred in...

journal_title：American journal of respiratory and critical care medicine

authors： Wang Q,Pfeiffer GR 2nd,Stevens T,Doerschuk CM

更新日期：2002-09-15 00:00:00