Abstract:
:The purpose of the present study is twofold: to evaluate alterations in total phospholipid content and individual phospholipid classes of the surfactant, and to detect markers of inflammatory reaction in bronchoalveolar lavage (BAL) from patients with hydrostatic pulmonary edema (HPE). Mechanically ventilated patients with HPE (Group 1) were compared with mechanically ventilated patients without cardiopulmonary disease (Group 2), considered as the control group. Group 3, including patients with high-permeability pulmonary edema, was used for further comparison. BAL was obtained and immediately cooled at 4 degrees C. Total proteins, albumin, and platelet-activating factor--acetylhydrolase (PAF-AcH) were measured. Total lipids were extracted and analyzed after thin-layer chromatographic separation. PAF was determined with bioassay. Total BAL proteins and albumin were found significantly higher in patients with HPE compared with control, but were lower compared with adult respiratory distress syndrome (ARDS). PAF was elevated in patients with HPE and ARDS, whereas in the control group it was actually in nondetectable levels. PAF was significantly higher in ARDS than in HPE patients. BAL neutrophils concentration was higher in HPE compared with control, but lower compared with ARDS. There was an inverse correlation between PAF-AcH and PAF. Quantitative reduction of total BAL phospholipids (PL) and qualititative deficiency was observed in both patients with HPE and ARDS. The findings of this study suggest that there is evidence of inflammation in the airspaces of patients with HPE.
journal_name
Am J Respir Crit Care Medauthors
Nakos G,Pneumatikos J,Tsangaris I,Tellis C,Lekka Mdoi
10.1164/ajrccm.155.3.9117030subject
Has Abstractpub_date
1997-03-01 00:00:00pages
945-51issue
3eissn
1073-449Xissn
1535-4970journal_volume
155pub_type
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journal_title:American journal of respiratory and critical care medicine
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journal_title:American journal of respiratory and critical care medicine
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2000-04-01 00:00:00
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更新日期:2009-08-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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abstract:BACKGROUND:Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults; however, whether mild OSA has significant neurocognitive and cardiovascular complications is uncertain. OBJECTIVES:The specific goals of this Research Statement are to appraise the evidence regarding whether long-term adverse neuro...
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2002-12-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1164/rccm.200412-1743PP
更新日期:2005-11-01 00:00:00