Abstract:
:Platelets are an important, albeit generally underappreciated, component of the inflammatory cascade. Platelets are known to contribute to inflammation in atherosclerosis, stroke, and asthma. They produce a large number of proinflammatory lipid mediators and cytokines, and play a vital role in recruitment of leukocytes into inflamed tissue. We review the role of platelets in inflammation, how they assist in the recruitment of leukocytes into lung tissue in asthma, and evidence of their dysfunction in cystic fibrosis (CF). Platelet dysfunction in CF could contribute to pulmonary inflammation and tissue destruction. We hypothesize that platelet activation is important in CF lung disease and suggest research avenues that might help elucidate the role of activated platelets in CF.
journal_name
Am J Respir Crit Care Medauthors
O'Sullivan BP,Michelson ADdoi
10.1164/rccm.200508-1243PPkeywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
483-90issue
5eissn
1073-449Xissn
1535-4970pii
200508-1243PPjournal_volume
173pub_type
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