The effect of biomass burning on respiratory symptoms and lung function in rural Mexican women.

abstract：RATIONALE:There are few follow-up studies on long-term cardiopulmonary function after pulmonary endarterectomy (PEA), the operation of choice for chronic thromboembolic pulmonary hypertension (CTEPH). OBJECTIVES:To prospectively evaluate long-term outcome of patients with CTEPH treated with PEA. METHODS:Between 1994 ...

journal_title：American journal of respiratory and critical care medicine

authors： Corsico AG,D'Armini AM,Cerveri I,Klersy C,Ansaldo E,Niniano R,Gatto E,Monterosso C,Morsolini M,Nicolardi S,Tramontin C,Pozzi E,Viganò M

更新日期：2008-08-15 00:00:00

abstract：RATIONALE:The mechanism by which acute allograft rejection leads to chronic rejection remains poorly understood despite its common occurrence. Exosomes, membrane vesicles released from cells within the lung allograft, contain a diverse array of biomolecules that closely reflect the biologic state of the cell and tissue...

journal_title：American journal of respiratory and critical care medicine

authors： Gregson AL,Hoji A,Injean P,Poynter ST,Briones C,Palchevskiy V,Weigt SS,Shino MY,Derhovanessian A,Sayah D,Saggar R,Ross D,Ardehali A,Lynch JP 3rd,Belperio JA

更新日期：2015-12-15 00:00:00

abstract：:There have been four types of drug treatment of asthma that have been used over the past 100 years. Belladonna alkaloids, derived from the thorn-apple plant were used in 1905, and chemically synthesized entities in this class are still in use today. Western medicine began to use adrenergic stimulants approximately 100...

journal_title：American journal of respiratory and critical care medicine

authors： Chu EK,Drazen JM

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:In the normal lung, breathing and deep inspirations potently antagonize bronchoconstriction, but in the asthmatic lung this salutary effect is substantially attenuated or even reversed. To explain these findings, the prevailing hypothesis focuses on contracting airway smooth muscle and posits a nonlinear dyna...

journal_title：American journal of respiratory and critical care medicine

authors： Lavoie TL,Krishnan R,Siegel HR,Maston ED,Fredberg JJ,Solway J,Dowell ML

更新日期：2012-08-01 00:00:00

abstract：:To elucidate which cells are synthesizing tenascin in usual interstitial pneumonia (UIP) we have analyzed thoracoscopic or open lung biopsies from 30 patients with UIP by mRNA in situ hybridization, using (35)S-labeled tenascin RNA probes. The phenotype of the cells expressing tenascin mRNA was confirmed by immunohist...

journal_title：American journal of respiratory and critical care medicine

authors： Pääkkö P,Kaarteenaho-Wiik R,Pöllänen R,Soini Y

更新日期：2000-03-01 00:00:00

abstract：:Glucocorticoids (GC) are the most effective anti-inflammatory drugs used in asthma. By a process called trans-activation, they increase the transcription of genes involved in either beneficial processes or certain side effects. Through trans-repression, they inhibit the transcription factors nuclear factor kappa B (NF...

journal_title：American journal of respiratory and critical care medicine

authors： Jaffuel D,Demoly P,Gougat C,Balaguer P,Mautino G,Godard P,Bousquet J,Mathieu M

更新日期：2000-07-01 00:00:00

abstract：:The predisposing factors and complications of unplanned extubation (UEX) in mechanically ventilated adult patients are not well recognized. We designed a prospective multicenter observational study to identify risk factors and describe the complications of UEX. We followed 426 ventilated patients over a 2-mo period. C...

journal_title：American journal of respiratory and critical care medicine

authors： Boulain T

更新日期：1998-04-01 00:00:00

abstract：:The cells and proteases that mediate cigarette smoke-induced emphysema are controversial, with evidence favoring either neutrophils and neutrophil-derived serine proteases or macrophages and macrophage-derived metalloproteases as the important effectors. We recently reported that both macrophage metalloelastase (MMP-1...

journal_title：American journal of respiratory and critical care medicine

authors： Churg A,Wang RD,Tai H,Wang X,Xie C,Dai J,Shapiro SD,Wright JL

更新日期：2003-04-15 00:00:00

abstract：:Lung transplant (LTx) recipients have a low peak work rate, peak oxygen consumption (V O2peak), and early lactate threshold on incremental exercise. We hypothesized that LTx recipients have reduced oxidative function and altered fiber type proportion in peripheral skeletal muscle. Seven stable LTx recipients and seven...

journal_title：American journal of respiratory and critical care medicine

authors： Wang XN,Williams TJ,McKenna MJ,Li JL,Fraser SF,Side EA,Snell GI,Walters EH,Carey MF

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:Statin use has been linked to improved lung health in asthma and chronic obstructive pulmonary disease. We hypothesize that statins inhibit allergic airway inflammation and reduce airway hyperreactivity via a mevalonate-dependent mechanism. OBJECTIVES:To determine whether simvastatin attenuates airway inflam...

journal_title：American journal of respiratory and critical care medicine

authors： Zeki AA,Franzi L,Last J,Kenyon NJ

更新日期：2009-10-15 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), also called basigin, is present in the lung during development, but its expression in normal adult lung is minimal. Increases of EMMPRIN have been found in various forms of experimental lung injury. To determine whether EMMPRIN might be involved in alveolar inj...

journal_title：American journal of respiratory and critical care medicine

authors： Betsuyaku T,Tanino M,Nagai K,Nasuhara Y,Nishimura M,Senior RM

更新日期：2003-07-15 00:00:00

abstract：RATIONALE:Although it is widely assumed that the incidence of childhood respiratory allergies to common aeroallergens is directly related to allergen exposure in early life, few longitudinal studies have investigated this issue, and available data are scarce and mainly limited to high-risk groups. OBJECTIVES:To assess...

journal_title：American journal of respiratory and critical care medicine

authors： Torrent M,Sunyer J,Garcia R,Harris J,Iturriaga MV,Puig C,Vall O,Anto JM,Newman Taylor AJ,Cullinan P

更新日期：2007-09-01 00:00:00

abstract：:We determined if pulmonary peptidoleukotrienes contribute to the pathogenesis of chronic lung disease of extreme prematurity (CLD) by measuring urinary leukotriene E4 (uLTE4). Study patients had a birth weight < 1000 g and were about 28 d old when they were classified as normal control subjects (n = 8) or as having CL...

journal_title：American journal of respiratory and critical care medicine

authors： Davidson D,Drafta D,Wilkens BA

更新日期：1995-03-01 00:00:00

abstract：:Several epidemiologic studies have demonstrated a consistent association between levels of particulate matter (PM) in the ambient air with increases in cardiovascular and respiratory mortality and morbidity. Diesel exhaust (DE), in addition to generating other pollutants, is a major contributor to PM pollution in most...

journal_title：American journal of respiratory and critical care medicine

authors： Salvi S,Blomberg A,Rudell B,Kelly F,Sandström T,Holgate ST,Frew A

更新日期：1999-03-01 00:00:00

abstract：:Mycoplasma pulmonis infection in rats causes a chronic inflammatory airway disease. Along with extensive remodeling of the airway mucosa, lymphocytic infiltrates, angiogenesis, and mucosal thickening, there is an abnormal sensitivity of the blood vessels to mediators that evoke "neurogenic inflammation". As a result, ...

journal_title：American journal of respiratory and critical care medicine

authors： Bowden JJ,Schoeb TR,Lindsey JR,McDonald DM

更新日期：1994-11-01 00:00:00

abstract：:Decision analysis was used to compare three alternative strategies for a 6-mo course of treatment for tuberculosis: directly observed drug therapy (DOT), self-administered fixed-dose combination drug therapy, and self-administered conventional individual drug therapy. Estimates of effectiveness were obtained from the ...

journal_title：American journal of respiratory and critical care medicine

authors： Moore RD,Chaulk CP,Griffiths R,Cavalcante S,Chaisson RE

更新日期：1996-10-01 00:00:00

abstract：:The present studies were designed to assess the pattern of activity and the frequency of activation of the neck muscles in patients with chronic obstructive pulmonary disease (COPD). Using concentric needle electrodes, we thus recorded the electromyograms of the scalene, sternocleidomastoid, and trapezius muscles duri...

journal_title：American journal of respiratory and critical care medicine

authors： De Troyer A,Peche R,Yernault JC,Estenne M

更新日期：1994-07-01 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) represents an immunologic reaction of the pulmonary parenchyma to an inhaled agent. Since tumor necrosis factor (TNF)-alpha is thought to be involved in the pathogenesis of HP, and polymorphisms in the TNF genes have been associated with variations in the production of TNF-alpha, we i...

journal_title：American journal of respiratory and critical care medicine

authors： Schaaf BM,Seitzer U,Pravica V,Aries SP,Zabel P

更新日期：2001-02-01 00:00:00

abstract：:Reduced bronchodilatation in response to deep inspiration (DI) has been demonstrated in asthmatics. We have previously shown that inhibition of DI for 10 min or more during methacholine inhalation increases airway narrowing in normals. We tested the hypothesis that inhibition of DIs during methacholine inhalation in a...

journal_title：American journal of respiratory and critical care medicine

authors： King GG,Moore BJ,Seow CY,Paré PD

更新日期：2001-07-15 00:00:00

abstract：:This study investigated the clinico-pathologic correlation of tumor angiogenesis in non-small-cell lung cancers. Formalin-fixed, paraffin-embedded surgical specimens of 55 consecutive patients with primary non-small-cell lung cancers were examined. Included were 26 squamous cell carcinomas and 29 adenocarcinomas. Twen...

journal_title：American journal of respiratory and critical care medicine

authors： Yuan A,Yang PC,Yu CJ,Lee YC,Yao YT,Chen CL,Lee LN,Kuo SH,Luh KT

更新日期：1995-12-01 00:00:00

abstract：:The aim of this study was to determine the effects of maturation on crossbridge properties and myosin isoform composition in hamster diaphragm muscle. Diaphragm strips were obtained at postnatal Days 1 and 8 and in adults (10 to 12 wk). Peak isometric tension and maximum unloaded shortening velocity (Vmax) increased w...

journal_title：American journal of respiratory and critical care medicine

authors： Coirault C,Lambert F,Joseph T,Blanc FX,Chemla D,Lecarpentier Y

更新日期：1997-09-01 00:00:00

abstract：RATIONALE:In a high-tuberculosis (TB) incidence area of Cape Town, South Africa, there is a very high rate of unexplained recurrent TB. The incidence of new bacteriologically confirmed disease in the area is 313 per 100,000 individuals. OBJECTIVE:To estimate the rate of recurrent TB attributable to reinfection after s...

journal_title：American journal of respiratory and critical care medicine

authors： Verver S,Warren RM,Beyers N,Richardson M,van der Spuy GD,Borgdorff MW,Enarson DA,Behr MA,van Helden PD

更新日期：2005-06-15 00:00:00

abstract：:A noninvasive means of detecting airway secretions in ventilator-dependent patients is desirable because endotracheal suctioning can result in life-threatening complications. In a patient who had copious secretions, we observed a sawtooth pattern on his flow-volume curve that disappeared after suctioning. Accordingly,...

journal_title：American journal of respiratory and critical care medicine

authors： Jubran A,Tobin MJ

更新日期：1994-09-01 00:00:00

abstract：:There is intriguing evidence suggesting pathophysiologic relationships among dyspnea, hyperventilation, and panic anxiety. The symptoms of panic attacks and pulmonary disease overlap, so that panic anxiety can reflect underlying cardiopulmonary disease and dyspnea can reflect an underlying anxiety disorder. The pathog...

journal_title：American journal of respiratory and critical care medicine

authors： Smoller JW,Pollack MH,Otto MW,Rosenbaum JF,Kradin RL

更新日期：1996-07-01 00:00:00

abstract：RATIONALE:Although interferon (IFN)-gamma release assays are approved for the diagnosis of latent tuberculosis infection (LTBI), limited data exist regarding their performance in HIV infection. OBJECTIVES:To compare tuberculin skin test (TST) results to the commercial IFN-gamma release assay QuantiFERON-TB Gold In-Tub...

journal_title：American journal of respiratory and critical care medicine

authors： Luetkemeyer AF,Charlebois ED,Flores LL,Bangsberg DR,Deeks SG,Martin JN,Havlir DV

更新日期：2007-04-01 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM), a disease that occurs primarily in women, is characterized by cystic lung lesions causing respiratory failure, which may require lung transplantation. Lung diffusion (DLCO) and/or FEV1 are decreased, but frequently not in parallel with each other. Because cardiopulmonary exercise testin...

journal_title：American journal of respiratory and critical care medicine

authors： Taveira-DaSilva AM,Stylianou MP,Hedin CJ,Kristof AS,Avila NA,Rabel A,Travis WD,Moss J

更新日期：2003-12-15 00:00:00

abstract：:The potential role of nitric oxide synthase-2 (NOS2) in acute lung injury (ALI) has gained increasing attention. This study evaluates the effects of hypoxia, an important feature of ALI, on NOS2 expression in a rat model of ALI caused by exposure to hypoxia and LPS. Exposure to hypoxia alone had no effect on the expre...

journal_title：American journal of respiratory and critical care medicine

authors： Agorreta J,Garayoa M,Montuenga LM,Zulueta JJ

更新日期：2003-08-01 00:00:00

abstract：:Rationale: Decisions in medicine are made on the basis of knowledge and reasoning, often in shared conversations with patients and families in consideration of clinical practice guideline recommendations, individual preferences, and individual goals. Observational studies can provide valuable knowledge to inform guide...

journal_title：American journal of respiratory and critical care medicine

authors： Gershon AS,Lindenauer PK,Wilson KC,Rose L,Walkey AJ,Sadatsafavi M,Anstrom KJ,Au DH,Bender BG,Brookhart MA,Dweik RA,Han MK,Joo MJ,Lavergne V,Mehta AB,Miravitlles M,Mularski RA,Roche N,Oren E,Riekert KA,Schoenberg N

更新日期：2021-01-01 00:00:00

abstract：RATIONALE:Breathing supplemental oxygen reduces breathlessness during exercise in patients with chronic obstructive pulmonary disease (COPD). Replacing nitrogen with helium reduces expiratory flow resistance and may improve lung emptying. Combining these treatments should be independently effective. OBJECTIVES:Study t...

journal_title：American journal of respiratory and critical care medicine

authors： Laude EA,Duffy NC,Baveystock C,Dougill B,Campbell MJ,Lawson R,Jones PW,Calverley PM

更新日期：2006-04-15 00:00:00

abstract：RATIONALE:Severe asthma is a major public health issue throughout the world. Increased bronchial smooth muscle (BSM) mass, a characteristic feature of airway remodeling in severe asthma, is associated with resistance to high-intensity treatment and poor prognosis. In vitro, the Ca(2+)-channel blocker gallopamil decreas...

journal_title：American journal of respiratory and critical care medicine

authors： Girodet PO,Dournes G,Thumerel M,Begueret H,Dos Santos P,Ozier A,Dupin I,Trian T,Montaudon M,Laurent F,Marthan R,Berger P

更新日期：2015-04-15 00:00:00