Elevated urinary leukotriene E4 in chronic lung disease of extreme prematurity.

abstract：:We used three-dimensional reconstructions obtained with spiral computed tomography to measure total diaphragm surface area (Adi), and the surface area of the dome (Ado) and of the zone of apposition (Aap) of the diaphragm in nine patients with single-lung transplantation (SLT) for emphysema and nine normal subjects ma...

journal_title：American journal of respiratory and critical care medicine

authors： Cassart M,Verbandt Y,de Francquen P,Gevenois PA,Estenne M

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:The perception of dyspnea and pain show many similarities. Initial imaging studies suggested an important role of the insular cortex for the perception of both sensations. However, little is known about the cortical processing of dyspnea. OBJECTIVES:This study investigated the influence of lesions of the ins...

journal_title：American journal of respiratory and critical care medicine

authors： Schön D,Rosenkranz M,Regelsberger J,Dahme B,Büchel C,von Leupoldt A

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:Tezacaftor (formerly VX-661) is an investigational small molecule that improves processing and trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in vitro, and improves CFTR function alone and in combination with ivacaftor. OBJECTIVES:To evaluate the safety and efficacy of tezacaft...

journal_title：American journal of respiratory and critical care medicine

authors： Donaldson SH,Pilewski JM,Griese M,Cooke J,Viswanathan L,Tullis E,Davies JC,Lekstrom-Himes JA,Wang LT,VX11-661-101 Study Group.

更新日期：2018-01-15 00:00:00

abstract：RATIONALE:Although commonly used as the primary outcome measure of clinical trials in pulmonary arterial hypertension (PAH), the minimal important difference (MID) of the 6-minute walk test (6MWT) has not been well defined for this population of patients. OBJECTIVES:To estimate the MID in the 6MWT in patients with PAH...

journal_title：American journal of respiratory and critical care medicine

authors： Mathai SC,Puhan MA,Lam D,Wise RA

更新日期：2012-09-01 00:00:00

abstract：:To investigate repair mechanisms in bleomycin-induced pulmonary fibrosis, we used mice deficient in gamma-glutamyl transpeptidase (GGT-/-), a key enzyme in glutathione (GSH) and cysteine metabolism. Seventy-two hours after bleomycin (0.03 U/g), GGT-/- mice displayed a different inflammatory response to wild-type mice ...

journal_title：American journal of respiratory and critical care medicine

authors： Pardo A,Ruiz V,Arreola JL,Ramírez R,Cisneros-Lira J,Gaxiola M,Barrios R,Kala SV,Lieberman MW,Selman M

更新日期：2003-03-15 00:00:00

abstract：:Neutrophil adherence to tumor necrosis factor-alpha (TNF-alpha)-treated human pulmonary microvascular endothelial cells (PMECs) induces cytoskeletal changes in endothelial cells that require intercellular adhesion molecule-1 (ICAM-1)-dependent signaling events. This study determined whether similar changes occurred in...

journal_title：American journal of respiratory and critical care medicine

authors： Wang Q,Pfeiffer GR 2nd,Stevens T,Doerschuk CM

更新日期：2002-09-15 00:00:00

abstract：RATIONALE:The inadequacy of effector T-cell response in containment of tubercle bacilli is believed to result in the development of disseminated forms of tuberculosis (TB), such as miliary tuberculosis (MTB). Regulatory T cells (Treg) plausibly play a critical role in the immunopathogenesis of disseminated TB by suppre...

journal_title：American journal of respiratory and critical care medicine

authors： Sharma PK,Saha PK,Singh A,Sharma SK,Ghosh B,Mitra DK

更新日期：2009-06-01 00:00:00

abstract：:Although numerous reports have described the improvement in PAO2 in patients in the prone position, the underlying mechanism has yet to be determined. Some authors have suggested this phenomenon may be related to an increase in functional residual capacity (FRC); however, no previous studies have described positional ...

journal_title：American journal of respiratory and critical care medicine

authors： Numa AH,Hammer J,Newth CJ

更新日期：1997-10-01 00:00:00

abstract：:alpha-Tocopherol is a potent antioxidant that effectively protects biological membranes against oxidative injury through coordination with ascorbic acid. Because propofol has a phenolic structure similar to that of alpha-tocopherol, this intravenous anesthetic may also have similar antioxidant activity. To test this h...

journal_title：American journal of respiratory and critical care medicine

authors： Tsuchiya M,Asada A,Kasahara E,Sato EF,Shindo M,Inoue M

更新日期：2002-01-01 00:00:00

abstract：RATIONALE:Density-based morphometric studies have demonstrated decreased capillary density in infants with bronchopulmonary dysplasia (BPD) and in BPD-like animal models, leading to the prevailing view that microvascular development is disrupted in BPD. OBJECTIVE:To perform a comprehensive analysis of the early and la...

journal_title：American journal of respiratory and critical care medicine

authors： De Paepe ME,Mao Q,Powell J,Rubin SE,DeKoninck P,Appel N,Dixon M,Gundogan F

更新日期：2006-01-15 00:00:00

abstract：RATIONALE:Activins are members of the transforming growth factor-beta superfamily thought to be involved in repair processes after tissue injury. OBJECTIVES:The aim of this study was to clarify whether activin and its antagonist, follistatin, played a significant role in lung injury and fibrosis. METHODS AND RESULTS:...

journal_title：American journal of respiratory and critical care medicine

authors： Aoki F,Kurabayashi M,Hasegawa Y,Kojima I

更新日期：2005-09-15 00:00:00

abstract：RATIONALE:The relation between birth weight and respiratory symptoms and asthma in children remains unclear. Previous studies focused on a relation at separate ages. A longitudinal analysis may lead to a better understanding. OBJECTIVES:To estimate the effect of birth weight on the development and course of respirator...

journal_title：American journal of respiratory and critical care medicine

authors： Caudri D,Wijga A,Gehring U,Smit HA,Brunekreef B,Kerkhof M,Hoekstra M,Gerritsen J,de Jongste JC

更新日期：2007-05-15 00:00:00

abstract：RATIONALE:Acute lung injury (ALI) acts as a complex genetic trait, yet its genetic risk factors remain incompletely understood. Large-scale genotyping has not previously been reported for ALI. OBJECTIVES:To identify ALI risk variants after major trauma using a large-scale candidate gene approach. METHODS:We performed...

journal_title：American journal of respiratory and critical care medicine

authors： Meyer NJ,Li M,Feng R,Bradfield J,Gallop R,Bellamy S,Fuchs BD,Lanken PN,Albelda SM,Rushefski M,Aplenc R,Abramova H,Atochina-Vasserman EN,Beers MF,Calfee CS,Cohen MJ,Pittet JF,Christiani DC,O'Keefe GE,Ware LB,May AK

更新日期：2011-05-15 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：:We investigated airway responsiveness to mannitol, a new hyperosmolar challenge, in persons hyperresponsive to airway drying. We studied 36 asthmatic subjects, 18 to 40 yr of age, responsive to exercise (n = 23) and eucapnic hyperventilation (n = 28) defined by a 10% fall in FEV1. Fifteen subjects performed both chall...

journal_title：American journal of respiratory and critical care medicine

authors： Brannan JD,Koskela H,Anderson SD,Chew N

更新日期：1998-10-01 00:00:00

abstract：:This study examines hemodialysis clearances of isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and ethambutol (EMB). Seven chronic hemodialysis patients were studied. Six were given single oral doses (INH 300 mg, RIF 600 mg, PZA 1000 mg, and EMB 25 mg/kg) 2 h before hemodialysis (Cobe Centrysystem 3 hemodialysis ...

journal_title：American journal of respiratory and critical care medicine

authors： Malone RS,Fish DN,Spiegel DM,Childs JM,Peloquin CA

更新日期：1999-05-01 00:00:00

abstract：:The impact of methicillin resistance on morbidity and mortality of patients suffering from severe Staphylococcus aureus infections remains highly controversial. We analyzed a retrospective cohort of 97 patients with methicillin-susceptible and 74 patients with methicillin-resistant Staphylococcus aureus ventilator-ass...

journal_title：American journal of respiratory and critical care medicine

authors： Combes A,Luyt CE,Fagon JY,Wollf M,Trouillet JL,Gibert C,Chastre J,PNEUMA Trial Group.

更新日期：2004-10-01 00:00:00

abstract：:Long-term cognitive impairment is common among ICU survivors, but its natural history remains unclear. In this systematic review, we report the frequency of cognitive impairment in ICU survivors across various time points after ICU discharge that were extracted from 46 of the 3,350 screened records. Prior studies used...

journal_title：American journal of respiratory and critical care medicine

authors： Honarmand K,Lalli RS,Priestap F,Chen JL,McIntyre CW,Owen AM,Slessarev M

更新日期：2020-07-15 00:00:00

abstract：:To study whether the individual inflammatory response to ozone was reproducible, dose-dependent, and time-dependent, we performed two exposures to 250 ppb ozone, one to 125 ppb and one to filtered air, each for 3 h of intermittent exercise and separated by at least 1 wk. Twenty-one healthy and 15 asthmatic subjects pa...

journal_title：American journal of respiratory and critical care medicine

authors： Holz O,Jörres RA,Timm P,Mücke M,Richter K,Koschyk S,Magnussen H

更新日期：1999-03-01 00:00:00

abstract：:A study was done to compare the efficacy and safety of the coprescription of salmeterol 50 microgram twice daily or 100 microgram twice daily with beclomethasone dipropionate (BDP) 500 micrograms twice daily (SALM 50 and SALM 100) with BDP 1,000 microgram twice daily (BDP 1,000) in patients with asthma not controlled ...

journal_title：American journal of respiratory and critical care medicine

authors： Woolcock A,Lundback B,Ringdal N,Jacques LA

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:Although intensive care units (ICUs) were created for patients with life-threatening illnesses, the ICU environment generates a high risk of iatrogenic events. Identifying medical errors (MEs) that serve as indicators for iatrogenic risk is crucial for purposes of reporting and prevention. OBJECTIVES:We desc...

journal_title：American journal of respiratory and critical care medicine

authors： Garrouste-Orgeas M,Timsit JF,Vesin A,Schwebel C,Arnodo P,Lefrant JY,Souweine B,Tabah A,Charpentier J,Gontier O,Fieux F,Mourvillier B,Troché G,Reignier J,Dumay MF,Azoulay E,Reignier B,Carlet J,Soufir L,OUTCOMEREA Stu

更新日期：2010-01-15 00:00:00

abstract：RATIONALE:Tissue injury and repair involve highly conserved processes governed by mechanisms that can be co-opted in tumors. We hypothesized that soluble factors released during the repair response to lung injury would promote orthotopic tumor growth. OBJECTIVES:To determine whether lung injury promoted growth of orth...

journal_title：American journal of respiratory and critical care medicine

authors： Arenberg D,Luckhardt TR,Carskadon S,Zhao L,Amin MA,Koch AE

更新日期：2010-10-15 00:00:00

abstract：:The pathophysiology of impaired exercise tolerance in patients with cystic fibrosis (CF) is not completely understood. The objective of this study was to compare exercise ability (at clinical and cellular levels) and resting energy expenditure in female athletes with CF compared with matched control subjects. Sixteen ...

journal_title：American journal of respiratory and critical care medicine

authors： Selvadurai HC,Allen J,Sachinwalla T,Macauley J,Blimkie CJ,Van Asperen PP

更新日期：2003-12-15 00:00:00

abstract：RATIONALE:Donor mesenchymal stromal/stem cell (MSC) expansion and fibrotic differentiation is associated with development of bronchiolitis obliterans syndrome (BOS) in human lung allografts. However, the regulators of fibrotic differentiation of these resident mesenchymal cells are not well understood. OBJECTIVES:This...

journal_title：American journal of respiratory and critical care medicine

authors： Walker NM,Badri LN,Wadhwa A,Wettlaufer S,Peters-Golden M,Lama VN

更新日期：2012-01-01 00:00:00

abstract：:Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components, and several candidate genes have been reported to be linked to atopy in Caucasian populations. We conducted a study of linkage between asthma and markers on chromosomes 5q31-q33 and 11q13 in 68 Japa...

journal_title：American journal of respiratory and critical care medicine

authors： Noguchi E,Shibasaki M,Arinami T,Takeda K,Maki T,Miyamoto T,Kawashima T,Kobayashi K,Hamaguchi H

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:Previous studies have demonstrated a high prevalence of sleep apnea (SA) in patients with chronic heart failure (HF), which is associated with higher rates of morbidity, mortality, and health care use. OBJECTIVES:To investigate the reported incidence, treatment, outcomes, and economic cost of SA in new-onset...

journal_title：American journal of respiratory and critical care medicine

authors： Javaheri S,Caref EB,Chen E,Tong KB,Abraham WT

更新日期：2011-02-15 00:00:00

abstract：RATIONALE:Amplification of distal 3q is the most common genomic aberration in squamous lung cancer (SQC). SQC develops in a multistage progression from normal bronchial epithelium through dysplasia to invasive disease. Identifying the key driver events in the early pathogenesis of SQC will facilitate the search for pre...

journal_title：American journal of respiratory and critical care medicine

authors： McCaughan F,Pole JC,Bankier AT,Konfortov BA,Carroll B,Falzon M,Rabbitts TH,George PJ,Dear PH,Rabbitts PH

更新日期：2010-07-01 00:00:00

abstract：RATIONALE:A loss of function mutation in the cystic fibrosis transmembrane conductance regulator gene is believed to be an independent risk factor for bone disease in patients with cystic fibrosis. OBJECTIVES:The objective of this work was to use congenic mice as a preclinical model to examine the bone phenotype of Cf...

journal_title：American journal of respiratory and critical care medicine

authors： Haston CK,Li W,Li A,Lafleur M,Henderson JE

更新日期：2008-02-01 00:00:00

abstract：:Many patients with acute asthma do not respond adequately to currently accepted therapy, including oxygen, beta-agonists, and corticosteroids. Leukotriene receptor antagonists such as montelukast have demonstrated efficacy in chronic asthma, but their efficacy in acute asthma is unknown. In this randomized, double-bli...

journal_title：American journal of respiratory and critical care medicine

authors： Camargo CA Jr,Smithline HA,Malice MP,Green SA,Reiss TF

更新日期：2003-02-15 00:00:00

abstract：:There have been four types of drug treatment of asthma that have been used over the past 100 years. Belladonna alkaloids, derived from the thorn-apple plant were used in 1905, and chemically synthesized entities in this class are still in use today. Western medicine began to use adrenergic stimulants approximately 100...

journal_title：American journal of respiratory and critical care medicine

authors： Chu EK,Drazen JM

更新日期：2005-06-01 00:00:00