Tumor angiogenesis correlates with histologic type and metastasis in non-small-cell lung cancer.

abstract：RATIONALE:Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM). OBJECTIVES:To relate ASM hypertrophy, ASM hyperplasia, and deposition of ECM to the severity and duration of asthma. METHODS:Airways from ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Elliot JG,Jones RL,Carroll ML,Mauad T,Bai TR,Abramson MJ,McKay KO,Green FH

更新日期：2012-05-15 00:00:00

abstract：RATIONALE:Data on hemoptysis of unknown origin (i.e., "cryptogenic") are scarce and the outcome of patients affected is controversial. OBJECTIVES:To describe the clinical spectrum and course of patients with cryptogenic hemoptysis, as well as pathologic findings when surgery is performed. METHODS:A cohort of 81 patie...

journal_title：American journal of respiratory and critical care medicine

authors： Savale L,Parrot A,Khalil A,Antoine M,Théodore J,Carette MF,Mayaud C,Fartoukh M

更新日期：2007-06-01 00:00:00

abstract：:The lobar and cephalocaudal distribution of aerated and nonaerated lung and of PEEP-induced alveolar recruitment is unknown in acute lung injury (ALI). Dimensions of the lungs and volumes of aerated and nonaerated parts of each pulmonary lobe were measured using a computerized tomographic quantitative analysis and com...

journal_title：American journal of respiratory and critical care medicine

authors： Puybasset L,Cluzel P,Chao N,Slutsky AS,Coriat P,Rouby JJ

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Neutrophils are key players in chronic obstructive pulmonary disease (COPD), and increased numbers of neutrophils are present in sputum and lung tissue of patients with COPD. Interestingly, immunoglobulin free light chains (IgLC) are able to prolong the life of neutrophils; therefore, IgLC may contribute to t...

journal_title：American journal of respiratory and critical care medicine

authors： Braber S,Thio M,Blokhuis BR,Henricks PA,Koelink PJ,Groot Kormelink T,Bezemer GF,Kerstjens HA,Postma DS,Garssen J,Kraneveld AD,Redegeld FA,Folkerts G

更新日期：2012-04-15 00:00:00

abstract：:Despite extensive research into the etiology and treatment of severe sepsis, little is known about its epidemiology in children. We sought to determine the age- and sex-adjusted incidence, outcome, and associated hospital costs of severe sepsis in United States children using 1995 hospital discharge and population dat...

journal_title：American journal of respiratory and critical care medicine

authors： Watson RS,Carcillo JA,Linde-Zwirble WT,Clermont G,Lidicker J,Angus DC

更新日期：2003-03-01 00:00:00

abstract：:The potential role of atypical bacterial infection in the pathogenesis of asthma is a subject of continuing debate. There is an increasing body of literature concerning the association between the atypical bacteria Chlamydophila pneumoniae and Mycoplasma pneumoniae and asthma pathogenesis; however, many studies invest...

journal_title：American journal of respiratory and critical care medicine

authors： Johnston SL,Martin RJ

更新日期：2005-11-01 00:00:00

abstract：:Retrospective studies have suggested that combination antibiotic therapy for severe bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a prospective, multicenter, international observational study of 844 adult patients with bacteremia due to Streptococcus pneumoniae. The effect of combin...

journal_title：American journal of respiratory and critical care medicine

authors： Baddour LM,Yu VL,Klugman KP,Feldman C,Ortqvist A,Rello J,Morris AJ,Luna CM,Snydman DR,Ko WC,Chedid MB,Hui DS,Andremont A,Chiou CC,International Pneumococcal Study Group.

更新日期：2004-08-15 00:00:00

abstract：:To investigate whether the magnitude of blood flow contributes to ventilator-induced lung injury, 14 sets of isolated rabbit lungs were randomized for perfusion at either 300 (Group A: n = 7) or 900 ml/ min (Group B: n = 7) while ventilated with 30 cm H2O peak static pressure. Control lungs (Group C: n = 7) were venti...

journal_title：American journal of respiratory and critical care medicine

authors： Broccard AF,Hotchkiss JR,Kuwayama N,Olson DA,Jamal S,Wangensteen DO,Marini JJ

更新日期：1998-06-01 00:00:00

abstract：:A variety of substances including human meconium have been found to affect adversely the surface tension-lowering activity of pulmonary surfactants, and this effect may be important in the pathogenesis of a number of human diseases. To find whether inactivation of surfactant could be prevented or reduced by nonionic p...

journal_title：American journal of respiratory and critical care medicine

authors： William Taeusch H,Lu KW,Goerke J,Clements JA

更新日期：1999-05-01 00:00:00

abstract：:Sepsis is the most common cause of death in patients in the intensive care unit. Genome-wide gene expression analysis can provide insights into the molecular alterations of sepsis. Total mRNA was extracted from the livers of 6 uninfected control mice and 60 septic mice after infusion of either live Escherichia coli or...

journal_title：American journal of respiratory and critical care medicine

authors： Yu SL,Chen HW,Yang PC,Peck K,Tsai MH,Chen JJ,Lin FY

更新日期：2004-05-15 00:00:00

abstract：:Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particles (DEPs) are prothrombotic. Here, we investigated the time course and the mechanisms. At 1, 6, and 24 hours after instillation ...

journal_title：American journal of respiratory and critical care medicine

authors： Nemmar A,Nemery B,Hoet PH,Vermylen J,Hoylaerts MF

更新日期：2003-12-01 00:00:00

abstract：:We aimed to elucidate the relationships between pleural (Ppl), esophageal (Pes), and superimposed gravitational pressures in acute lung injury, and to understand the mechanisms of recruitment and derecruitment. In six dogs with oleic acid respiratory failure, we measured Pes and Ppl in the uppermost, middle, and most ...

journal_title：American journal of respiratory and critical care medicine

authors： Pelosi P,Goldner M,McKibben A,Adams A,Eccher G,Caironi P,Losappio S,Gattinoni L,Marini JJ

更新日期：2001-07-01 00:00:00

abstract：:Although transbronchial lung biopsy (TBBx) is widely acknowledged as the "gold standard" for diagnosis of acute rejection, controversy exists regarding the need to perform follow-up procedures. Over a 5-yr period, we performed 1,142 TBBx of which 173 were follow-up TBBx in 99 patients with pulmonary allograft rejectio...

journal_title：American journal of respiratory and critical care medicine

authors： Aboyoun CL,Tamm M,Chhajed PN,Hopkins P,Malouf MA,Rainer S,Glanville AR

更新日期：2001-08-01 00:00:00

abstract：:Chronic beryllium disease (CBD) provides a model system in which to evaluate the antigen-stimulated, cell-mediated, immune response that leads to granulomatous lung disease. We hypothesized that beryllium salts would stimulate bronchoalveolar lavage (BAL) cell release of tumor necrosis factor-alpha (TNF-alpha) and lnt...

journal_title：American journal of respiratory and critical care medicine

authors： Tinkle SS,Newman LS

更新日期：1997-12-01 00:00:00

abstract：RATIONALE:The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma. OBJECTIVES:To identify novel asthma phenotypes using an unsupervised hierarchical clu...

journal_title：American journal of respiratory and critical care medicine

authors： Moore WC,Meyers DA,Wenzel SE,Teague WG,Li H,Li X,D'Agostino R Jr,Castro M,Curran-Everett D,Fitzpatrick AM,Gaston B,Jarjour NN,Sorkness R,Calhoun WJ,Chung KF,Comhair SA,Dweik RA,Israel E,Peters SP,Busse WW,Erzurum

更新日期：2010-02-15 00:00:00

abstract：RATIONALE:S. aureus is the most common respiratory pathogen isolated from patients with cystic fibrosis (CF) in the US. While modes of acquisition and genetic adaptation have been described for Pseudomonas aeruginosa, resulting in improved diagnosis and treatment, these features remain more poorly defined for S. aureus...

journal_title：American journal of respiratory and critical care medicine

authors： Long DR,Wolter DJ,Lee M,Precit M,McLean K,Holmes E,Penewit K,Waalkes A,Hoffman LR,Salipante SJ

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:The clinical utility of bronchoalveolar lavage fluid (BAL) cell analysis for the diagnosis and management of patients with interstitial lung disease (ILD) has been a subject of debate and controversy. The American Thoracic Society (ATS) sponsored a committee of international experts to examine all relevant l...

journal_title：American journal of respiratory and critical care medicine

authors： Meyer KC,Raghu G,Baughman RP,Brown KK,Costabel U,du Bois RM,Drent M,Haslam PL,Kim DS,Nagai S,Rottoli P,Saltini C,Selman M,Strange C,Wood B,American Thoracic Society Committee on BAL in Interstitial Lung Disease.

更新日期：2012-05-01 00:00:00

abstract：:Rationale: The bHLH (basic helix-loop-helix) transcription factor TWIST1 (Twist-related protein 1) controls cell proliferation and differentiation in tissue development and disease processes. Recently, endothelial TWIST1 has been linked to pulmonary hypertension (PH) and endothelial-to-mesenchymal transition, yet the ...

journal_title：American journal of respiratory and critical care medicine

authors： Fan Y,Gu X,Zhang J,Sinn K,Klepetko W,Wu N,Foris V,Solymosi P,Kwapiszewska G,Kuebler WM

更新日期：2020-11-01 00:00:00

abstract：:Exaggerated airway narrowing in response to bronchoconstricting stimuli is a characteristic feature of asthmatic subjects. It is unknown whether the site of airway narrowing differs in asthmatic subjects from that observed in normal subjects. Increased airway wall thickness has been suggested as a contributing cause f...

journal_title：American journal of respiratory and critical care medicine

authors： Okazawa M,Müller N,McNamara AE,Child S,Verburgt L,Paré PD

更新日期：1996-11-01 00:00:00

abstract：:At the time of diagnosis, many sarcoidosis patients have no clinical indication for corticosteroid therapy, and prognostic parameters predicting deterioration are missing. In the present study, we investigated parameters derived from bronchoalveolar lavage (BAL) and serum in 77 patients with recently diagnosed sarcoid...

journal_title：American journal of respiratory and critical care medicine

authors： Ziegenhagen MW,Benner UK,Zissel G,Zabel P,Schlaak M,Müller-Quernheim J

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:Our understanding of how airway remodeling affects regional airway elastic properties is limited due to technical difficulties in quantitatively measuring dynamic, in vivo airway dimensions. Such knowledge could help elucidate mechanisms of excessive airway narrowing. OBJECTIVES:To use anatomical optical coh...

journal_title：American journal of respiratory and critical care medicine

authors： Williamson JP,McLaughlin RA,Noffsinger WJ,James AL,Baker VA,Curatolo A,Armstrong JJ,Regli A,Shepherd KL,Marks GB,Sampson DD,Hillman DR,Eastwood PR

更新日期：2011-03-01 00:00:00

abstract：:Pulmonary tuberculosis, one of the granulomatous diseases, has few serological markers for its activity. Recently, an increased serum level of vascular endothelial growth factor (VEGF) was detected in patients with Crohn's disease, also a granulomatous disease. We hypothesized that VEGF might be associated with the pa...

journal_title：American journal of respiratory and critical care medicine

authors： Matsuyama W,Hashiguchi T,Matsumuro K,Iwami F,Hirotsu Y,Kawabata M,Arimura K,Osame M

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs. OBJECTIVES:To determine whether whole blood gene expression signatures reflect inflamm...

journal_title：American journal of respiratory and critical care medicine

authors： Koth LL,Solberg OD,Peng JC,Bhakta NR,Nguyen CP,Woodruff PG

更新日期：2011-11-15 00:00:00

abstract：:The present study was undertaken to determine if a synthetic peptide, KLLLLKLLLLKLLLLKLLLLK (KL4), in which K = lysine and L = leucine, in an aqueous dispersion of phospholipids (DPPC and POPG), would expand pulmonary alveoli and improve gas exchange in premature human infants with respiratory distress syndrome (RDS)....

journal_title：American journal of respiratory and critical care medicine

authors： Cochrane CG,Revak SD,Merritt TA,Heldt GP,Hallman M,Cunningham MD,Easa D,Pramanik A,Edwards DK,Alberts MS

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Amplification of distal 3q is the most common genomic aberration in squamous lung cancer (SQC). SQC develops in a multistage progression from normal bronchial epithelium through dysplasia to invasive disease. Identifying the key driver events in the early pathogenesis of SQC will facilitate the search for pre...

journal_title：American journal of respiratory and critical care medicine

authors： McCaughan F,Pole JC,Bankier AT,Konfortov BA,Carroll B,Falzon M,Rabbitts TH,George PJ,Dear PH,Rabbitts PH

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The use of biomass as a cooking fuel is commonplace in developing countries and has been associated with chronic bronchitis and obstructive airway disease. METHODS:A cross-sectional survey was done in the village of Solis, close to Mexico City. Lifelong nonsmoking women 38 yr of age or older (n=841) complet...

journal_title：American journal of respiratory and critical care medicine

authors： Regalado J,Pérez-Padilla R,Sansores R,Páramo Ramirez JI,Brauer M,Paré P,Vedal S

更新日期：2006-10-15 00:00:00

abstract：RATIONALE:Patients with obstructive sleep apnea (OSA) adapt to the anatomical vulnerability of their upper airway by generating increased activity in upper airway-dilating muscles during wakefulness. Norepinephrine (NE) and serotonin (5-HT) mediate, through α₁-adrenergic and 5-HT₂A receptors, a wake-related excitatory ...

journal_title：American journal of respiratory and critical care medicine

authors： Rukhadze I,Fenik VB,Benincasa KE,Price A,Kubin L

更新日期：2010-11-15 00:00:00

abstract：:We evaluated positron emission tomographic imaging of pulmonary transgene expression, using an enhanced mutant herpes simplex virus-1 thymidine kinase as the reporter gene, in the lungs of normal rats. Sixteen rats were studied 3 days after an intratracheal administration of 5 x 10(9) to 1 x 10(11) viral particles of ...

journal_title：American journal of respiratory and critical care medicine

authors： Richard JC,Zhou Z,Ponde DE,Dence CS,Factor P,Reynolds PN,Luker GD,Sharma V,Ferkol T,Piwnica-Worms D,Schuster DP

更新日期：2003-05-01 00:00:00

abstract：RATIONALE:Genetic alterations on 8p22 have been implicated in multiple cancers, including lung cancer. In this region, genetic variants of the class A scavenger receptor (SR-A) gene have been associated with prostate cancer risk and have been highlighted as a potential susceptibility gene of cancer. OBJECTIVES:To dete...

journal_title：American journal of respiratory and critical care medicine

authors： Ben J,Jin G,Zhang Y,Ma B,Bai H,Chen J,Zhang H,Gong Q,Zhou X,Zhang H,Qian L,Zhu X,Li X,Yang Q,Hu Z,Xu Y,Shen H,Chen Q

更新日期：2012-10-15 00:00:00

abstract：:Asthma in children and young adults is strongly associated with immediate hypersensitivity to indoor allergens, notably those derived from the house dust mite. In addition, outdoor air pollution is considered to aggravate existing asthma. We investigated the prevalence of asthma and the pattern of allergen sensitizati...

journal_title：American journal of respiratory and critical care medicine

authors： Sporik R,Ingram JM,Price W,Sussman JH,Honsinger RW,Platts-Mills TA

更新日期：1995-05-01 00:00:00