Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients.

abstract：:Exposure to fine airborne particulate matter (PM(2.5)) is associated with cardiovascular events and mortality in older and cardiac patients. Potential physiologic effects of in-vehicle, roadside, and ambient PM(2.5) were investigated in young, healthy, nonsmoking, male North Carolina Highway Patrol troopers. Nine troo...

journal_title：American journal of respiratory and critical care medicine

authors： Riediker M,Cascio WE,Griggs TR,Herbst MC,Bromberg PA,Neas L,Williams RW,Devlin RB

更新日期：2004-04-15 00:00:00

abstract：RATIONALE:E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped e-liquids are unknown. OBJECTIVES:To determine the effects of chronic vaping on pulmonary epithelia. METHODS:We performed research bronchoscopies on h...

journal_title：American journal of respiratory and critical care medicine

authors： Ghosh A,Coakley RC,Mascenik T,Rowell TR,Davis ES,Rogers K,Webster MJ,Dang H,Herring LE,Sassano MF,Livraghi-Butrico A,Van Buren SK,Graves LM,Herman MA,Randell SH,Alexis NE,Tarran R

更新日期：2018-07-01 00:00:00

abstract：:In mechanically ventilated patients, pressure and flow tracings can be used to assess respiratory pump muscle activity or rest. When the ventilation is delivered through an endotracheal tube, the respiratory system can be considered a one-compartment model, and activation of the respiratory muscles results in deformat...

journal_title：American journal of respiratory and critical care medicine

authors： Jounieaux V,Parreira VF,Delguste P,Aubert G,Rodenstein DO

更新日期：1997-06-01 00:00:00

abstract：:Studies have shown evidence of significant parent-offspring and sibling correlation in FEV1, but familial aggregation of decline of FEV1 over time has not been reported. Our study population comprised 392 families enrolled in the Tucson Epidemiological Study of Airway Obstructive Diseases. Subjects were older than 18 ...

journal_title：American journal of respiratory and critical care medicine

authors： Kurzius-Spencer M,Sherrill DL,Holberg CJ,Martinez FD,Lebowitz MD

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors. OBJECTIVES:First, to compare the diagnostic performance of the TST and a form of in vitro IFN-gamma release assay (IFNGRA) in the c...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson ST,Williams AJ,Brown JR,Newton SM,Simsova M,Nicol MP,Sebo P,Levin M,Wilkinson RJ,Wilkinson KA

更新日期：2006-05-01 00:00:00

abstract：:Pulmonary emphysema and periodontal disease are each characterized by the uncontrolled proteolysis of connective tissue proteins by proteinases derived from human neutrophils. Although these diseases would not appear to be related in terms of the initial insult to individual tissues, the ultimate result in each diseas...

journal_title：American journal of respiratory and critical care medicine

authors： Travis J,Pike R,Imamura T,Potempa J

更新日期：1994-12-01 00:00:00

abstract：:We enrolled nine allergic subjects in a double blind, placebo-controlled study to examine the effect of premedication with 0.6 mg of atropine on nasal antigen challenge. The challenge consisted of unilaterally stimulating the nasal septum with diluent followed by three increasing doses of antigen and recording respons...

journal_title：American journal of respiratory and critical care medicine

authors： Baroody FM,Ford S,Lichtenstein LM,Kagey-Sobotka A,Naclerio RM

更新日期：1994-06-01 00:00:00

abstract：:The severity of asthma can be graded from mild intermittent to severe persistent. Airway inflammation is a feature of persistent asthma. We compared several markers of inflammation in mucosal biopsies and bronchoalveolar lavage fluid (BAL fluid) from 12 healthy control subjects, 24 patients with intermittent asthma, a...

journal_title：American journal of respiratory and critical care medicine

authors： Vignola AM,Chanez P,Campbell AM,Souques F,Lebel B,Enander I,Bousquet J

更新日期：1998-02-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease that persists even during adequate therapy and asymptomatic episodes. We questioned whether "silent" chronic allergen exposure can induce and maintain airway inflammation and whether this still occurs during regular treatment with inhaled steroids. Twenty-six patients with hous...

journal_title：American journal of respiratory and critical care medicine

authors： de Kluijver J,Evertse CE,Schrumpf JA,van der Veen H,Zwinderman AH,Hiemstra PS,Rabe KF,Sterk PJ

更新日期：2002-08-01 00:00:00

abstract：:The gender-and race-specific effects of asthma/wheeze on pulmonary function level and annual growth velocity were studied in a cohort of 10,792 white and 944 black children 6 to 18 yr of age, examined annually between 1974 and 1989 in six U.S. cities. In comparison with white boys who never reported asthma or wheeze, ...

journal_title：American journal of respiratory and critical care medicine

authors： Gold DR,Wypij D,Wang X,Speizer FE,Pugh M,Ware JH,Ferris BG Jr,Dockery DW

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:Chronic infection with Pseudomonas aeruginosa is associated with an increased exacerbation frequency, a more rapid decline in lung function, and increased mortality in patients with bronchiectasis. OBJECTIVES:To perform a randomized placebo-controlled study assessing the efficacy and safety of inhaled colist...

journal_title：American journal of respiratory and critical care medicine

authors： Haworth CS,Foweraker JE,Wilkinson P,Kenyon RF,Bilton D

更新日期：2014-04-15 00:00:00

abstract：:Rationale: Limited information is available on racial/ethnic differences in pulmonary arterial hypertension (PAH).Objectives: Determine effects of race/ethnicity and ancestry on mortality and disease outcomes in diverse patients with PAH.Methods: Patients with Group 1 PAH were included from two national registries wit...

journal_title：American journal of respiratory and critical care medicine

authors： Karnes JH,Wiener HW,Schwantes-An TH,Natarajan B,Sweatt AJ,Chaturvedi A,Arora A,Batai K,Nair V,Steiner HE,Giles JB,Yu J,Hosseini M,Pauciulo MW,Lutz KA,Coleman AW,Feldman J,Vanderpool R,Tang H,Garcia JGN,Yuan JX,K

更新日期：2020-06-01 00:00:00

abstract：:We have studied intrasubject variability with respect to counts of immunostained inflammatory cells in snap frozen endobronchial biopsies from a group of patients with clinically mild to moderate stable asthma. Fiberoptic bronchoscopy was used to obtain endobronchial biopsies from the upper and lower lobes in 12 volun...

journal_title：American journal of respiratory and critical care medicine

authors： Richmond I,Booth H,Ward C,Walters EH

更新日期：1996-03-01 00:00:00

abstract：RATIONALE:Limited information exists on the prevalence of tuberculosis and adequacy of case finding in African populations with high rates of HIV. OBJECTIVES:To estimate the prevalence of bacteriologically confirmed pulmonary tuberculosis (PTB) and the fraction attributable to HIV, and to evaluate case detection. MET...

journal_title：American journal of respiratory and critical care medicine

authors： van't Hoog AH,Laserson KF,Githui WA,Meme HK,Agaya JA,Odeny LO,Muchiri BG,Marston BJ,DeCock KM,Borgdorff MW

更新日期：2011-05-01 00:00:00

abstract：:Allergen inhalation challenge is associated with increases in eosinophil number and activation, and provides a useful model for investigating airway inflammation in asthma. Limited information, however, is available on the effect of allergen challenge on cytokines regulating eosinophil function. We investigated allerg...

journal_title：American journal of respiratory and critical care medicine

authors： Woolley KL,Adelroth E,Woolley MJ,Ellis R,Jordana M,O'Byrne PM

更新日期：1995-06-01 00:00:00

abstract：:In a previous study of older pulp and paper workers in Berlin, New Hampshire, decrements in spirometry results associated with accidental exposures to high levels of irritant gases depended on cumulative levels of pulp mill exposure and cigarette smoking. Many of those subjects were older and retired. A new study was ...

journal_title：American journal of respiratory and critical care medicine

authors： Henneberger PK,Lax MB,Ferris BG Jr

更新日期：1996-01-01 00:00:00

abstract：:Decreases in gastric mucosal pH (pHi) are associated with splanchnic hypoxia in animals and with increased mortality in patients. In the present study we measured changes in gastric pHi with a tonometer in septic patients after a short-term infusion of dobutamine. These changes were compared with concurrent alteration...

journal_title：American journal of respiratory and critical care medicine

authors： Gutierrez G,Clark C,Brown SD,Price K,Ortiz L,Nelson C

更新日期：1994-08-01 00:00:00

abstract：:Epidemiological data indicate that living or working in a moldy building is associated with increased risk of respiratory symptoms and disease related to inflammatory reactions, but biochemical evidence linking cause and effect is still scarce. The staff working in a mold-contaminated school, and a reference group wit...

journal_title：American journal of respiratory and critical care medicine

authors： Hirvonen MR,Ruotsalainen M,Roponen M,Hyvärinen A,Husman T,Kosma VM,Komulainen H,Savolainen K,Nevalainen A

更新日期：1999-12-01 00:00:00

abstract：:We tested the hypothesis that continuous positive airway pressure (CPAP) use and outcomes can be improved by an autotitrating CPAP device in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) who require higher CPAP (10 cm H2O or more). In this multisite randomized single-blind cross-over study, 44 patien...

journal_title：American journal of respiratory and critical care medicine

authors： Massie CA,McArdle N,Hart RW,Schmidt-Nowara WW,Lankford A,Hudgel DW,Gordon N,Douglas NJ

更新日期：2003-01-01 00:00:00

abstract：RATIONALE:The causal direction between asthma and lung function deficit is unknown, but important for the focus of preventive measures and research into the origins of asthma. OBJECTIVES:To analyze the interaction between lung function development and asthma from birth to 7 years of age. METHODS:The Copenhagen Prospe...

journal_title：American journal of respiratory and critical care medicine

authors： Bisgaard H,Jensen SM,Bønnelykke K

更新日期：2012-06-01 00:00:00

abstract：:Currently the diagnosis of chronic obstructive pulmonary disease (COPD) requires the demonstration of airflow limitation, defined as a post-bronchodilator FEV1/FVC <0.7, a measurement that remains methodologically robust and widely available. FEV1 is one of the most powerful predictors of clinically relevant outcomes ...

journal_title：American journal of respiratory and critical care medicine

authors： Han MK,Agusti A,Celli BR,Criner GJ,Halpin DMG,Roche N,Papi A,Stockley RA,Wedzicha J,Vogelmeier CF

更新日期：2020-11-19 00:00:00

abstract：:In unilateral lung injury, application of global positive end-expiratory pressure (PEEP) may cause overdistension of normal alveoli and redistribution of blood flow to diseased lung areas, thereby worsening oxygenation. We hypothesized that selective application of tracheal gas insufflation (TGI) will recruit the inju...

journal_title：American journal of respiratory and critical care medicine

authors： Blanch L,Van der Kloot TE,Youngblood AM,Murias G,Naveira A,Adams AB,Romero PV,Nahum A

更新日期：2001-08-15 00:00:00

abstract：:In order to examine the dose-dependence of the airway response to animal allergens we performed environmental challenges on 17 workers with documented IgE-mediated allergic reactions to laboratory rats. The 1-h environmental challenges were conducted in a vivarium during cage cleaning (high-allergen challenge), quiet ...

journal_title：American journal of respiratory and critical care medicine

authors： Eggleston PA,Ansari AA,Adkinson NF Jr,Wood RA

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Ipsilateral recurrence rates of spontaneous pneumothorax after video-assisted thoracoscopic surgery are higher than rates after open thoracotomy. OBJECTIVES:This study was conducted to determine whether additional minocycline pleurodesis would be effective in diminishing recurrence after video-assisted thora...

journal_title：American journal of respiratory and critical care medicine

authors： Chen JS,Hsu HH,Chen RJ,Kuo SW,Huang PM,Tsai PR,Lee JM,Lee YC

更新日期：2006-03-01 00:00:00

abstract：:The frequency and determinants of exogenous reinfection and of endogenous reactivation of tuberculosis in patients previously treated are poorly understood. In Gran Canaria Island, Spain, between 1991 and 1996, 962 tuberculosis cases were confirmed by culture. Drug susceptibility testing was performed on available bac...

journal_title：American journal of respiratory and critical care medicine

authors： Caminero JA,Pena MJ,Campos-Herrero MI,Rodríguez JC,Afonso O,Martin C,Pavón JM,Torres MJ,Burgos M,Cabrera P,Small PM,Enarson DA

更新日期：2001-03-01 00:00:00

abstract：:Although abnormalities of alveolar fibrin turnover have been reported to play a role in the development of idiopathic pulmonary fibrosis (IPF), the pathophysiological relevance remains unclear. We therefore investigated the localization of tissue factor (TF) and fibrin deposition in patients with IPF using immunohisto...

journal_title：American journal of respiratory and critical care medicine

authors： Imokawa S,Sato A,Hayakawa H,Kotani M,Urano T,Takada A

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:Nitric oxide (NO), synthesized by NOSs (NO synthases), plays a role in the development of pulmonary hypertension (PH). However, the role of NO/NOSs in bone marrow (BM) cells in PH remains elusive. OBJECTIVES:To determine the role of NOSs in BM cells in PH. METHODS:Experiments were performed on 36 patients w...

journal_title：American journal of respiratory and critical care medicine

authors： Ogoshi T,Tsutsui M,Kido T,Sakanashi M,Naito K,Oda K,Ishimoto H,Yamada S,Wang KY,Toyohira Y,Izumi H,Masuzaki H,Shimokawa H,Yanagihara N,Yatera K,Mukae H

更新日期：2018-07-15 00:00:00

abstract：RATIONALE:As of April 2015, participants in the Danish Lung Cancer Screening Trial had been followed for at least 5 years since their last screening. OBJECTIVES:Mortality, causes of death, and lung cancer findings are reported to explore the effect of computed tomography (CT) screening. METHODS:A total of 4,104 parti...

journal_title：American journal of respiratory and critical care medicine

authors： Wille MM,Dirksen A,Ashraf H,Saghir Z,Bach KS,Brodersen J,Clementsen PF,Hansen H,Larsen KR,Mortensen J,Rasmussen JF,Seersholm N,Skov BG,Thomsen LH,Tønnesen P,Pedersen JH

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:The effect of graft ischemic time on early graft function and long-term survival of patients who underwent lung transplantation remains controversial. Consequently, graft ischemic time has not been incorporated in the decision-making process at the time of graft acceptance. OBJECTIVES:To investigate the rela...

journal_title：American journal of respiratory and critical care medicine

authors： Thabut G,Mal H,Cerrina J,Dartevelle P,Dromer C,Velly JF,Stern M,Loirat P,Lesèche G,Bertocchi M,Mornex JF,Haloun A,Despins P,Pison C,Blin D,Reynaud-Gaubert M

更新日期：2005-04-01 00:00:00

abstract：RATIONALE:An increasing number of persons, exposed to high altitude for leisure, sport, or work, may suffer from severe high-altitude illness. OBJECTIVES:To assess, in a large cohort of subjects, the association between physiological parameters and the risk of altitude illness and their discrimination ability in a ris...

journal_title：American journal of respiratory and critical care medicine

authors： Richalet JP,Larmignat P,Poitrine E,Letournel M,Canouï-Poitrine F

更新日期：2012-01-15 00:00:00