Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release.

abstract：:Vitamin D receptor (VDR) polymorphisms have been associated with several immune-related diseases, and VDR and vitamin D itself modulate T cell differentiation. VDR maps to chromosome 12q, near a region commonly linked to asthma. We evaluated VDR as part of a 12q positional candidate survey, and in response to observat...

journal_title：American journal of respiratory and critical care medicine

authors： Raby BA,Lazarus R,Silverman EK,Lake S,Lange C,Wjst M,Weiss ST

更新日期：2004-11-15 00:00:00

abstract：RATIONALE:The prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease. Recent studies suggest that vitamin D deficiency is associated with reduced lung function. The relationship between vitamin D deficiency and lung fu...

journal_title：American journal of respiratory and critical care medicine

authors： Zosky GR,Berry LJ,Elliot JG,James AL,Gorman S,Hart PH

更新日期：2011-05-15 00:00:00

abstract：:Epidemiological data indicate that living or working in a moldy building is associated with increased risk of respiratory symptoms and disease related to inflammatory reactions, but biochemical evidence linking cause and effect is still scarce. The staff working in a mold-contaminated school, and a reference group wit...

journal_title：American journal of respiratory and critical care medicine

authors： Hirvonen MR,Ruotsalainen M,Roponen M,Hyvärinen A,Husman T,Kosma VM,Komulainen H,Savolainen K,Nevalainen A

更新日期：1999-12-01 00:00:00

abstract：:The low-affinity IgG Fc receptor, FcgammaRIIB, displays inhibitory potential in experimental models such as autoimmune diseases. However, whether this receptor is involved in the onset of allergic diseases remains unknown. This study examines the role of FcgammaRIIB in the initiation of allergic rhinitis in mice. Repe...

journal_title：American journal of respiratory and critical care medicine

authors： Watanabe T,Okano M,Hattori H,Yoshino T,Ohno N,Ohta N,Sugata Y,Orita Y,Takai T,Nishizaki K

更新日期：2004-01-01 00:00:00

abstract：RATIONALE:Statin use has been linked to improved lung health in asthma and chronic obstructive pulmonary disease. We hypothesize that statins inhibit allergic airway inflammation and reduce airway hyperreactivity via a mevalonate-dependent mechanism. OBJECTIVES:To determine whether simvastatin attenuates airway inflam...

journal_title：American journal of respiratory and critical care medicine

authors： Zeki AA,Franzi L,Last J,Kenyon NJ

更新日期：2009-10-15 00:00:00

abstract：RATIONALE:HIV-tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an immunopathological reaction to mycobacterial antigens induced by antiretroviral therapy. Prednisone reduces morbidity in TB-IRIS, but the mechanisms are unclear. OBJECTIVES:To determine the effect of prednisone on the inf...

journal_title：American journal of respiratory and critical care medicine

authors： Meintjes G,Skolimowska KH,Wilkinson KA,Matthews K,Tadokera R,Conesa-Botella A,Seldon R,Rangaka MX,Rebe K,Pepper DJ,Morroni C,Colebunders R,Maartens G,Wilkinson RJ

更新日期：2012-08-15 00:00:00

abstract：:In order to examine the dose-dependence of the airway response to animal allergens we performed environmental challenges on 17 workers with documented IgE-mediated allergic reactions to laboratory rats. The 1-h environmental challenges were conducted in a vivarium during cage cleaning (high-allergen challenge), quiet ...

journal_title：American journal of respiratory and critical care medicine

authors： Eggleston PA,Ansari AA,Adkinson NF Jr,Wood RA

更新日期：1995-03-01 00:00:00

abstract：:The mechanisms of exertional dyspnea relief in response to supplemental oxygen (O2) in chronic airflow limitation (CAL) are not precisely known and are likely multifactorial. To explore factors contributing to the relief of dyspnea after oxygen administration, 11 patients with severe CAL (FEV1.0 = 39 +/- 3% predicted,...

journal_title：American journal of respiratory and critical care medicine

authors： O'Donnell DE,Bain DJ,Webb KA

更新日期：1997-02-01 00:00:00

abstract：:Noninvasive and invasive diagnostic techniques have been shown to achieve comparable performances in the evaluation of suspected ventilator-associated pneumonia (VAP). We studied the impact of both approaches on outcome in a prospective, open, and randomized study in three intensive care units (ICUs) of a 1,000-bed te...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Torres A,Ewig S,Marcos MA,Alcón A,Lledó R,Asenjo MA,Maldonaldo A

更新日期：2000-07-01 00:00:00

abstract：:State-dependent changes in upper airway caliber were studied with magnetic resonance imaging (MRI) techniques. We hypothesized that changes in airway caliber during sleep in normal subjects would result from positional and dimensional changes in upper airway soft-tissue structures, including the lateral pharyngeal wal...

journal_title：American journal of respiratory and critical care medicine

authors： Trudo FJ,Gefter WB,Welch KC,Gupta KB,Maislin G,Schwab RJ

更新日期：1998-10-01 00:00:00

abstract：:Allergen inhalation challenge is associated with increases in eosinophil number and activation, and provides a useful model for investigating airway inflammation in asthma. Limited information, however, is available on the effect of allergen challenge on cytokines regulating eosinophil function. We investigated allerg...

journal_title：American journal of respiratory and critical care medicine

authors： Woolley KL,Adelroth E,Woolley MJ,Ellis R,Jordana M,O'Byrne PM

更新日期：1995-06-01 00:00:00

abstract：RATIONALE:In a pulmonary process characterized by spatially heterogeneous loss of aeration, the impairment of gas exchange is expected to depend on the regional distribution of perfusion relative to that of aeration. OBJECTIVES:To investigate how regional aeration, shunt, and perfusion are interrelated at different le...

journal_title：American journal of respiratory and critical care medicine

authors： Musch G,Bellani G,Vidal Melo MF,Harris RS,Winkler T,Schroeder T,Venegas JG

更新日期：2008-02-01 00:00:00

abstract：:Bronchial dehiscence after lung transplantation is difficult to treat and associated with high mortality. We describe our experience using self-expanding metallic stents to treat post-lung transplant bronchial dehiscence. From January 1995 to June 2004, 189 single and 118 double lung transplants were performed in our ...

journal_title：American journal of respiratory and critical care medicine

authors： Mughal MM,Gildea TR,Murthy S,Pettersson G,DeCamp M,Mehta AC

更新日期：2005-09-15 00:00:00

abstract：:Previous studies have shown that the allergic late airway response (LR) is dependent on the leukotriene (LT) pathway in Brown Norway (BN) rats. In this same model, interleukin-2 (IL-2) has been shown to increase allergic airway responses without increasing LT production. This study examined the relationship between th...

journal_title：American journal of respiratory and critical care medicine

authors： Nag S,Lamkhioued B,Renzi PM

更新日期：2002-06-01 00:00:00

abstract：RATIONALE:Oxygen is commonly administered after extubation. Although several devices are available, data about their clinical efficacy are scarce. OBJECTIVES:To compare the effects of the Venturi mask and the nasal high-flow (NHF) therapy on PaO2/FiO2SET ratio after extubation. Secondary endpoints were to assess effec...

journal_title：American journal of respiratory and critical care medicine

authors： Maggiore SM,Idone FA,Vaschetto R,Festa R,Cataldo A,Antonicelli F,Montini L,De Gaetano A,Navalesi P,Antonelli M

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:High-dose isoniazid is recommended in short-course regimens for multidrug-resistant TB (MDR-TB). The optimal dose of isoniazid and its individual contribution to efficacy against TB strains with inhA or katG mutations are unknown. OBJECTIVE:Define the optimal dose of isoniazid for patients with isoniazid-res...

journal_title：American journal of respiratory and critical care medicine

authors： Dooley KE,Miyahara S,von Groote-Bidlingmaier F,Sun X,Hafner R,Rosenkranz SL,Ignatius EH,Nuermberger EL,Moran L,Donahue K,Swindells S,Vanker N,Diacon AH,A5312 Study Team.

更新日期：2020-01-16 00:00:00

abstract：:The impact of methicillin resistance on morbidity and mortality of patients suffering from severe Staphylococcus aureus infections remains highly controversial. We analyzed a retrospective cohort of 97 patients with methicillin-susceptible and 74 patients with methicillin-resistant Staphylococcus aureus ventilator-ass...

journal_title：American journal of respiratory and critical care medicine

authors： Combes A,Luyt CE,Fagon JY,Wollf M,Trouillet JL,Gibert C,Chastre J,PNEUMA Trial Group.

更新日期：2004-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is associated with significant morbidity and mortality despite aggressive therapy. Thirty-eight patients with biopsy-proven IPF were studied to identify pretreatment features that could be used to predict short-term improvement in pulmonary function and improved longer term survival...

journal_title：American journal of respiratory and critical care medicine

authors： Gay SE,Kazerooni EA,Toews GB,Lynch JP 3rd,Gross BH,Cascade PN,Spizarny DL,Flint A,Schork MA,Whyte RI,Popovich J,Hyzy R,Martinez FJ

更新日期：1998-04-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that is influenced by both genetic and environmental factors. For many years, knowledge of the genetic basis of COPD was limited to Mendelian syndromes, such as alpha-1 antitrypsin deficiency and cutis laxa, caused by rare genetic variant...

journal_title：American journal of respiratory and critical care medicine

authors： Ragland MF,Benway CJ,Lutz SM,Bowler RP,Hecker J,Hokanson JE,Crapo JD,Castaldi PJ,DeMeo DL,Hersh CP,Hobbs BD,Lange C,Beaty TH,Cho MH,Silverman EK

更新日期：2019-09-15 00:00:00

abstract：RATIONALE:The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma. OBJECTIVES:To identify novel asthma phenotypes using an unsupervised hierarchical clu...

journal_title：American journal of respiratory and critical care medicine

authors： Moore WC,Meyers DA,Wenzel SE,Teague WG,Li H,Li X,D'Agostino R Jr,Castro M,Curran-Everett D,Fitzpatrick AM,Gaston B,Jarjour NN,Sorkness R,Calhoun WJ,Chung KF,Comhair SA,Dweik RA,Israel E,Peters SP,Busse WW,Erzurum

更新日期：2010-02-15 00:00:00

abstract：:To determine the factors contributing to tuberculosis incidence in the U.S.-born and foreign-born populations in San Francisco, California, and to assess the effectiveness of tuberculosis control efforts in these populations, we performed a population-based molecular epidemiologic study using 367 patients with strains...

journal_title：American journal of respiratory and critical care medicine

authors： Chin DP,DeRiemer K,Small PM,de Leon AP,Steinhart R,Schecter GF,Daley CL,Moss AR,Paz EA,Jasmer RM,Agasino CB,Hopewell PC

更新日期：1998-12-01 00:00:00

abstract：:In anaphylactic shock (AS), the relative effects of the autacoids including histamine, prostaglandins, and leukotrienes on causing cardiovascular collapse and the extent to which receptor blocking agents and pathway inhibitors may prevent this collapse are not clear. In a ragweed model of anaphylaxis, we examined whet...

journal_title：American journal of respiratory and critical care medicine

authors： Chrusch C,Sharma S,Unruh H,Bautista E,Duke K,Becker A,Kepron W,Mink SN

更新日期：1999-10-01 00:00:00

abstract：RATIONALE:Epidemiologic studies have shown that, in atopic children, wheezing is more likely to persist into adulthood, eventually becoming asthma, whereas it appears to resolve by adolescence in nonatopic children. OBJECTIVES:To investigate whether among children with multitrigger wheeze responsive to bronchodilators...

journal_title：American journal of respiratory and critical care medicine

authors： Turato G,Barbato A,Baraldo S,Zanin ME,Bazzan E,Lokar-Oliani K,Calabrese F,Panizzolo C,Snijders D,Maestrelli P,Zuin R,Fabbri LM,Saetta M

更新日期：2008-09-01 00:00:00

abstract：RATIONALE:Conversion from a negative to positive QuantiFERON-TB test is indicative of Mycobacterium tuberculosis (Mtb) infection, which predisposes individuals to tuberculosis disease. Interpretation of serial tests is confounded by immunological and technical variability. OBJECTIVES:To improve the consistency of seri...

journal_title：American journal of respiratory and critical care medicine

authors： Nemes E,Rozot V,Geldenhuys H,Bilek N,Mabwe S,Abrahams D,Makhethe L,Erasmus M,Keyser A,Toefy A,Cloete Y,Ratangee F,Blauenfeldt T,Ruhwald M,Walzl G,Smith B,Loxton AG,Hanekom WA,Andrews JR,Lempicki MD,Ellis R,Ginsb

更新日期：2017-09-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that was recently shown to exhibit bronchoconstrictive properties in vitro. In asthmatic patients, the expression of ET-1 peptide was also shown to be increased in endobronchial biopsies. Thus, we postulated that ET-1 could be higher in subjects with nocturnal...

journal_title：American journal of respiratory and critical care medicine

authors： Kraft M,Beam WR,Wenzel SE,Zamora MR,O'Brien RF,Martin RJ

更新日期：1994-04-01 00:00:00

abstract：:Controversy exists regarding the clinical utility of pleural fluid pH, lactate dehydrogenase (LDH), and glucose for identifying complicated parapneumonic effusions that require drainage. In this report, we performed a meta-analysis of pertinent studies, using receiver operating characteristic (ROC) techniques, to asse...

journal_title：American journal of respiratory and critical care medicine

authors： Heffner JE,Brown LK,Barbieri C,DeLeo JM

更新日期：1995-06-01 00:00:00

abstract：:This study was carried out to determine if the bronchoconstrictive effect of cigarette smoke (CS) is enhanced when airway hyperresponsiveness is induced by ovalbumin (Ova) sensitization, and if so, whether an increase in endogenously released tachykinins is involved. The bronchoconstrictive effects of an acute CS inha...

journal_title：American journal of respiratory and critical care medicine

authors： Wu ZX,Zhou D,Chen G,Lee LY

更新日期：2000-01-01 00:00:00

abstract：:Lone cryptogenic fibrosing alveolitis (CFA) is a progressive interstitial lung disease, with a median survival of 3 to 6 yr from the onset of dyspnea. CFA can be subdivided into prognostically significant histopathologic patterns, including nonspecific interstitial pneumonia (NSIP). We reviewed 78 patients with a clin...

journal_title：American journal of respiratory and critical care medicine

authors： Nicholson AG,Colby TV,du Bois RM,Hansell DM,Wells AU

更新日期：2000-12-01 00:00:00

abstract：:A major cause of morbidity and mortality following lung transplantation is posttransplant lymphoproliferative disease (PTLD). In a retrospective cohort analysis of pediatric patients, we evaluated the risk factors associated with PTLD in 128 first-time lung transplant recipients from 1990 to 1997. The greatest risk fa...

journal_title：American journal of respiratory and critical care medicine

authors： Cohen AH,Sweet SC,Mendeloff E,Mallory GB Jr,Huddleston CB,Kraus M,Kelly M,Hayashi R,DeBaun MR

更新日期：2000-04-01 00:00:00

abstract：:Acute exacerbation of idiopathic pulmonary fibrosis has been defined as an acute, clinically significant, respiratory deterioration of unidentifiable cause. The objective of this international working group report on acute exacerbation of idiopathic pulmonary fibrosis was to provide a comprehensive update on the topic...

journal_title：American journal of respiratory and critical care medicine

authors： Collard HR,Ryerson CJ,Corte TJ,Jenkins G,Kondoh Y,Lederer DJ,Lee JS,Maher TM,Wells AU,Antoniou KM,Behr J,Brown KK,Cottin V,Flaherty KR,Fukuoka J,Hansell DM,Johkoh T,Kaminski N,Kim DS,Kolb M,Lynch DA,Myers JL,R

更新日期：2016-08-01 00:00:00