Hyponatremia predicts right heart failure and poor survival in pulmonary arterial hypertension.

abstract：:Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with primary pulmonary hypertension (PPH) has been speculative. Mutations in the bone morphogenetic protein recepto...

journal_title：American journal of respiratory and critical care medicine

authors： Runo JR,Vnencak-Jones CL,Prince M,Loyd JE,Wheeler L,Robbins IM,Lane KB,Newman JH,Johnson J,Nichols WC,Phillips JA 3rd

更新日期：2003-03-15 00:00:00

abstract：RATIONALE:IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. OBJECTIVES:The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting reports in the literature. These earlier st...

journal_title：American journal of respiratory and critical care medicine

authors： Kearley J,Erjefalt JS,Andersson C,Benjamin E,Jones CP,Robichaud A,Pegorier S,Brewah Y,Burwell TJ,Bjermer L,Kiener PA,Kolbeck R,Lloyd CM,Coyle AJ,Humbles AA

更新日期：2011-04-01 00:00:00

abstract：RATIONALE:Idiopathic pulmonary fibrosis (IPF) is caused by alterations in expression of proteins involved in multiple pathways, including matrix deposition, inflammation, injury, and repair. OBJECTIVES:To understand the pathogenic changes in lung protein expression in IPF and to evaluate apolipoprotein (Apo) A-I as a ...

journal_title：American journal of respiratory and critical care medicine

authors： Kim TH,Lee YH,Kim KH,Lee SH,Cha JY,Shin EK,Jung S,Jang AS,Park SW,Uh ST,Kim YH,Park JS,Sin HG,Youm W,Koh ES,Cho SY,Paik YK,Rhim TY,Park CS

更新日期：2010-09-01 00:00:00

abstract：:The last century experienced remarkable advances in the classification, diagnosis, and understanding of the pathogenesis of the interstitial lung diseases. Technological advances, particularly physiologic testing, lung imaging studies, bronchoalveolar lavage, surgical lung biopsy, and histopathologic assessment, impro...

journal_title：American journal of respiratory and critical care medicine

authors： King TE Jr

更新日期：2005-08-01 00:00:00

abstract：RATIONALE:IL-4 and IL-13 share many biological functions important in the development of allergic airway inflammation and are implicated in the pathogenesis of asthma. AMG 317 is a fully human monoclonal antibody to IL-4Ralpha that blocks both IL-4 and IL-13 pathways. OBJECTIVES:To evaluate efficacy and safety of AMG ...

journal_title：American journal of respiratory and critical care medicine

authors： Corren J,Busse W,Meltzer EO,Mansfield L,Bensch G,Fahrenholz J,Wenzel SE,Chon Y,Dunn M,Weng HH,Lin SL

更新日期：2010-04-15 00:00:00

abstract：:Most randomized trials in critical care report no mortality benefit; this may reflect competing pathogenic mechanisms, patient heterogeneity, or true ineffectiveness of interventions. We hypothesize that in acute respiratory distress syndrome (ARDS), randomizing only those patients who show a favorable physiological r...

journal_title：American journal of respiratory and critical care medicine

authors： Goligher EC,Kavanagh BP,Rubenfeld GD,Ferguson ND

更新日期：2015-12-15 00:00:00

abstract：:Rationale: Chronic cough is characterized by frequent urges to cough and a heightened sensitivity to inhaled irritants. Airway sensory nerves trigger cough. We hypothesized that sensory nerve density is increased in chronic cough, which may contribute to excessive and persistent coughing.Objectives: To measure airway ...

journal_title：American journal of respiratory and critical care medicine

authors： Shapiro CO,Proskocil BJ,Oppegard LJ,Blum ED,Kappel NL,Chang CH,Fryer AD,Jacoby DB,Costello RW,Drake MG

更新日期：2021-02-01 00:00:00

abstract：:The clinical significance of minimal acute rejection (grade A1) in lung transplant recipients is unknown. We prospectively analyzed 1,159 transbronchial lung biopsies in 184 patients. Two hundred seventy-nine biopsies in 128 participants confirmed A1 histology at a mean postoperative day of 229 +/- 340. Sixty four of ...

journal_title：American journal of respiratory and critical care medicine

authors： Hopkins PM,Aboyoun CL,Chhajed PN,Malouf MA,Plit ML,Rainer SP,Glanville AR

更新日期：2004-11-01 00:00:00

abstract：RATIONALE:The effects of high positive end-expiratory pressure (PEEP) strictly depend on lung recruitability, which varies widely during acute respiratory distress syndrome (ARDS). Unfortunately, increasing PEEP may lead to opposing effects on two main factors potentially worsening the lung injury, that is, alveolar st...

journal_title：American journal of respiratory and critical care medicine

authors： Caironi P,Cressoni M,Chiumello D,Ranieri M,Quintel M,Russo SG,Cornejo R,Bugedo G,Carlesso E,Russo R,Caspani L,Gattinoni L

更新日期：2010-03-15 00:00:00

abstract：:The influx of neutrophils into the lung is a sentinel event in LPS-induced acute lung inflammation. Previous studies have shown that systemic inhibition of p38 decreases LPS-induced neutrophil influx into the alveolar space but has no effect on pulmonary parenchymal neutrophil accumulation or on microvascular leak, in...

journal_title：American journal of respiratory and critical care medicine

authors： Arndt PG,Young SK,Lieber JG,Fessler MB,Nick JA,Worthen GS

更新日期：2005-05-01 00:00:00

abstract：:Secretory leukocyte protease inhibitor (SLPI) and elafin are structurally similar, low-molecular-weight antiproteases produced in the lung. We have developed a simple method for distinguishing the antiprotease activities of SLPI and elafin in lung lavage fluid from those of alpha 1-antitrypsin (alpha 1-AT) that is bas...

journal_title：American journal of respiratory and critical care medicine

authors： Nadziejko C,Finkelstein I,Balmes JR

更新日期：1995-11-01 00:00:00

abstract：RATIONALE:Lung cancer screening using computed tomography (CT) is effective in detecting lung cancer in early stages. Concerns regarding false-positive rates and unnecessary invasive procedures have been raised. OBJECTIVE:To study the efficiency of a lung cancer protocol using spiral CT and F-18-fluorodeoxyglucose pos...

journal_title：American journal of respiratory and critical care medicine

authors： Bastarrika G,García-Velloso MJ,Lozano MD,Montes U,Torre W,Spiteri N,Campo A,Seijo L,Alcaide AB,Pueyo J,Cano D,Vivas I,Cosín O,Domínguez P,Serra P,Richter JA,Montuenga L,Zulueta JJ

更新日期：2005-06-15 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is characterized by an extensive alveolar capillary leak, permitting contact between intra-alveolar factors and the endothelium. To investigate whether factors contained in the alveolar milieu induce cell death in human lung microvascular endothelial cells, we exposed these c...

journal_title：American journal of respiratory and critical care medicine

authors： Hamacher J,Lucas R,Lijnen HR,Buschke S,Dunant Y,Wendel A,Grau GE,Suter PM,Ricou B

更新日期：2002-09-01 00:00:00

abstract：:It is controversial whether mutations in cystic fibrosis transmembrane conductance regulator intrinsically dysregulate inflammation. We characterized passage 2 human tracheobronchial epithelial cell cultures morphologically and physiologically and determined whether cytokine production or nuclear factor-kappaB activat...

journal_title：American journal of respiratory and critical care medicine

authors： Becker MN,Sauer MS,Muhlebach MS,Hirsh AJ,Wu Q,Verghese MW,Randell SH

更新日期：2004-03-01 00:00:00

abstract：:Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components, and several candidate genes have been reported to be linked to atopy in Caucasian populations. We conducted a study of linkage between asthma and markers on chromosomes 5q31-q33 and 11q13 in 68 Japa...

journal_title：American journal of respiratory and critical care medicine

authors： Noguchi E,Shibasaki M,Arinami T,Takeda K,Maki T,Miyamoto T,Kawashima T,Kobayashi K,Hamaguchi H

更新日期：1997-11-01 00:00:00

abstract：:Although the incidence of pulmonary hypertension is higher in female patients, numerous experimental studies have demonstrated better outcome in female animals, exacerbation of the disease after ovariectomy, and a strong protective effect of estrogen: a phenomenon known as the "estrogen paradox" of pulmonary hypertens...

journal_title：American journal of respiratory and critical care medicine

authors： Umar S,Rabinovitch M,Eghbali M

更新日期：2012-07-15 00:00:00

abstract：:Bronchoalveolar lavage (BAL) is increasingly used in the pediatric age group. However, normal values for BAL fluid (BALF) constituents are lacking. As part of an investigation to define reference values in children, we studied lymphocyte surface markers of BALF in 28 children 3 to 16 yr of age without bronchopulmonary...

journal_title：American journal of respiratory and critical care medicine

authors： Ratjen F,Bredendiek M,Zheng L,Brendel M,Costabel U

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:The airway surface liquid, the thin layer of liquid covering the airways, is essential for mucociliary clearance and as a barrier against microbial and other noxious agents. Proteins secreted into the airway surface liquid by epithelial and nonepithelial cells may be important in innate immunity and to improv...

journal_title：American journal of respiratory and critical care medicine

authors： Candiano G,Bruschi M,Pedemonte N,Caci E,Liberatori S,Bini L,Pellegrini C,Viganò M,O'Connor BJ,Lee TH,Galietta LJ,Zegarra-Moran O

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:Pulmonary hypertension (PH) is a life-threatening disease, characterized by vascular remodeling and vasoconstriction. Evidence suggests that oxidative stress may contribute to the pathogenesis and/or development of PH. OBJECTIVES:In the present study, we examined whether intratracheal gene transfer of human ...

journal_title：American journal of respiratory and critical care medicine

authors： Kamezaki F,Tasaki H,Yamashita K,Tsutsui M,Koide S,Nakata S,Tanimoto A,Okazaki M,Sasaguri Y,Adachi T,Otsuji Y

更新日期：2008-01-15 00:00:00

abstract：:Induced sputum using hypertonic saline (HS) is a useful research tool to study airway inflammation (AI). HS provocation testing can also be used to measure airway hyperresponsiveness (AHR). A combined HS challenge and sputum induction procedure has been developed to permit assessment of AI and AHR in a single test. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Jones PD,Hankin R,Simpson J,Gibson PG,Henry RL

更新日期：2001-10-01 00:00:00

abstract：:The number of alveoli is a key structural determinant of lung architecture. A design-based stereologic approach was used for the direct and unbiased estimation of alveolar number in the human lung. The principle is based on two-dimensional topology in three-dimensional space and is free of assumptions on the shape, si...

journal_title：American journal of respiratory and critical care medicine

authors： Ochs M,Nyengaard JR,Jung A,Knudsen L,Voigt M,Wahlers T,Richter J,Gundersen HJ

更新日期：2004-01-01 00:00:00

abstract：:There is a subgroup of cigarette smokers who are more susceptible than others to the deleterious effects of cigarette smoke and to chronic airflow obstruction. The study of histopathologic and physiologic differences between these "susceptible" smokers and "resistant" smokers, who do not develop clinically significant...

journal_title：American journal of respiratory and critical care medicine

authors： Aguayo SM

更新日期：1994-06-01 00:00:00

abstract：:Pulmonary infections are a significant cause of morbidity and mortality in patients with alcohol abuse and human immunodeficiency virus (HIV) infection, two immunocompromising conditions that frequently coexist. This study examined the separate and combined effects of in vivo lentiviral infection and in vitro alcohol ...

journal_title：American journal of respiratory and critical care medicine

authors： Stoltz DA,Nelson S,Kolls JK,Zhang P,Bohm RP Jr,Murphey-Corb M,Bagby GJ

更新日期：2000-01-01 00:00:00

abstract：:Although abnormalities of alveolar fibrin turnover have been reported to play a role in the development of idiopathic pulmonary fibrosis (IPF), the pathophysiological relevance remains unclear. We therefore investigated the localization of tissue factor (TF) and fibrin deposition in patients with IPF using immunohisto...

journal_title：American journal of respiratory and critical care medicine

authors： Imokawa S,Sato A,Hayakawa H,Kotani M,Urano T,Takada A

更新日期：1997-08-01 00:00:00

abstract：:Pulmonary hypertension is a life-threatening complication of sickle cell disease. L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. This deficiency may play a role in pulmonary hypertension. The enzyme arginase hydrolyzes arginine...

journal_title：American journal of respiratory and critical care medicine

authors： Morris CR,Morris SM Jr,Hagar W,Van Warmerdam J,Claster S,Kepka-Lenhart D,Machado L,Kuypers FA,Vichinsky EP

更新日期：2003-07-01 00:00:00

abstract：RATIONALE:The mechanism by which acute allograft rejection leads to chronic rejection remains poorly understood despite its common occurrence. Exosomes, membrane vesicles released from cells within the lung allograft, contain a diverse array of biomolecules that closely reflect the biologic state of the cell and tissue...

journal_title：American journal of respiratory and critical care medicine

authors： Gregson AL,Hoji A,Injean P,Poynter ST,Briones C,Palchevskiy V,Weigt SS,Shino MY,Derhovanessian A,Sayah D,Saggar R,Ross D,Ardehali A,Lynch JP 3rd,Belperio JA

更新日期：2015-12-15 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：American journal of respiratory and critical care medicine

authors： Kanwar BA

更新日期：2020-10-07 00:00:00

abstract：RATIONALE:Intensive care unit (ICU) nurses work in a demanding environment where they are repetitively exposed to traumatic situations and stressful events. The psychological effects on nurses as a result of working in the ICU are relatively unknown. OBJECTIVE:To determine whether there is an increased prevalence of p...

journal_title：American journal of respiratory and critical care medicine

authors： Mealer ML,Shelton A,Berg B,Rothbaum B,Moss M

更新日期：2007-04-01 00:00:00

abstract：:We sought to describe pulmonary fibrosis mortality in the United States from 1979 through 1991 by analyzing death certificate reports compiled by the National Center for Health Statistics. Of the 26,866,600 people who died during the study period, 107,292 had a diagnosis of pulmonary fibrosis listed on their death cer...

journal_title：American journal of respiratory and critical care medicine

authors： Mannino DM,Etzel RA,Parrish RG

更新日期：1996-05-01 00:00:00

abstract：:Characterization of chemokine expression patterns in virus-infected epithelial cells provides important clues to the pathophysiology of such infections. The aim of this study was to determine the chemokine response pattern of respiratory epithelium when infected with respiratory syncytial virus (RSV). Macrophage infla...

journal_title：American journal of respiratory and critical care medicine

authors： Harrison AM,Bonville CA,Rosenberg HF,Domachowske JB

更新日期：1999-06-01 00:00:00