当前位置： SCI文献检索 > AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE期刊下所有文献 > Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence.

Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence.

Abstract：

RATIONALE:The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson, Arizona, we previously described four phenotypes based on the occurrence of wheezing lower respiratory illnesses before age 3 yr and active wheeze at age 6 yr: never wheezers (n = 425), transient early wheezers (n = 164), persistent wheezers (n = 113), and late-onset wheezers (n = 124). OBJECTIVE:We sought to determine the prognosis for these phenotypes, with reference to lung function and symptoms, through adolescence. METHODS:Current wheeze was assessed by questionnaire, lung function was measured by conventional spirometry, and atopy was determined by skin prick tests. RESULTS:The prevalence of atopy and wheeze by age 16 yr was similar for never and transient wheezers and for persistent and late-onset wheezers. Both transient early, and persistent wheezers had significantly lower FEF(25-75) (-259 ml/s, p < 0.001, and -260 ml/s, p = 0.001, respectively), FEV1 (-75 ml, p = 0.02, and -87 ml, p = 0.03, respectively), and FEV1:FVC ratio (-1.9%, p = 0.002, and -2.5%, p = 0.001, respectively) through age 16 yr compared with never wheezers. Late-onset wheezers had levels of lung function similar to those of never wheezers through age 16 yr. There was no significant change in lung function among subjects with any of the four phenotypes, relative to their peers, from age 6 to 16 yr. CONCLUSION:Patterns of wheezing prevalence and levels of lung function are established by age 6 yr and do not appear to change significantly by age 16 yr in children who start having asthma-like symptoms during the preschool years.

journal_name

Am J Respir Crit Care Med

journal_title

American journal of respiratory and critical care medicine

authors

Morgan WJ,Stern DA,Sherrill DL,Guerra S,Holberg CJ,Guilbert TW,Taussig LM,Wright AL,Martinez FD

doi

10.1164/rccm.200504-525OC

keywords:

subject

Has Abstract

pub_date

2005-11-15 00:00:00

pages

1253-8

issue

eissn

1073-449X

issn

1535-4970

pii

200504-525OC

journal_volume

172

pub_type

杂志文章

在线工具

Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence.