Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity.

abstract：:Quality of life has been found to be impaired both in patients with asthma and in patients with allergic rhinitis, but the relative burden of these diseases has not been investigated. We analyzed answers to the SF-36 questionnaire from 850 subjects recruited in two French centers participating in the European Communit...

journal_title：American journal of respiratory and critical care medicine

authors： Leynaert B,Neukirch C,Liard R,Bousquet J,Neukirch F

更新日期：2000-10-01 00:00:00

abstract：:To quantify changes in tissue oxygenation of pathologic lungs, we applied a novel method using near-infrared spectroscopy (NIRs). In in vitro experiments, we assayed the effect of photon scattering on the absorption spectra of an in vitro system simulating structures of lung, which consists of test tube containing air...

journal_title：American journal of respiratory and critical care medicine

authors： Noriyuki T,Ohdan H,Yoshioka S,Miyata Y,Asahara T,Dohi K

更新日期：1997-11-01 00:00:00

abstract：:This study aimed to estimate exposure-response relationships for mesothelioma and environmental exposure to crocidolite. All 4,659 former residents of Wittenoom, Western Australia (WA) who lived there between 1943 and 1993 for at least 1 mo and were not directly employed in the crocidolite industry, were followed-up t...

journal_title：American journal of respiratory and critical care medicine

authors： Hansen J,de Klerk NH,Musk AW,Hobbs MS

更新日期：1998-01-01 00:00:00

abstract：RATIONALE:Epidemiological studies in older individuals have found an association between the use of angiotensin-converting enzyme (ACE) inhibition (ACE-I) therapy and preserved locomotor muscle mass, strength, and walking speed. ACE-I therapy might therefore have a role in the context of pulmonary rehabilitation (PR). ...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis KJ,Meyrick VM,Mehta B,Haji GS,Li K,Montgomery H,Man WD,Polkey MI,Hopkinson NS

更新日期：2016-12-01 00:00:00

abstract：:Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-l...

journal_title：American journal of respiratory and critical care medicine

authors： Shahar E,Whitney CW,Redline S,Lee ET,Newman AB,Nieto FJ,O'Connor GT,Boland LL,Schwartz JE,Samet JM

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:Platelets may interact with the immune system in tuberculosis (TB) to regulate human inflammatory responses that lead to morbidity and spread of infection. OBJECTIVES:To identify a functional role of platelets in the innate inflammatory and matrix-degrading response in TB. METHODS:Markers of platelet activa...

journal_title：American journal of respiratory and critical care medicine

authors： Fox KA,Kirwan DE,Whittington AM,Krishnan N,Robertson BD,Gilman RH,López JW,Singh S,Porter JC,Friedland JS

更新日期：2018-07-15 00:00:00

abstract：RATIONALE:Although research supports a sleep-disordered breathing and atrial fibrillation association, prospective data examining sleep-disordered breathing predicting incident atrial fibrillation are lacking. OBJECTIVES:To investigate sleep-disordered breathing indices as predictors of incident atrial fibrillation. ...

journal_title：American journal of respiratory and critical care medicine

authors： May AM,Blackwell T,Stone PH,Stone KL,Cawthon PM,Sauer WH,Varosy PD,Redline S,Mehra R,MrOS Sleep (Outcomes of Sleep Disorders in Older Men) Study Group.

更新日期：2016-04-01 00:00:00

abstract：:Not all asthma can be adequately controlled, despite the use of high-dose inhaled corticosteroids. Because cysteinyl-leukotrienes (Cys-LT) have been implicated in the pathogenesis of asthma, we hypothesized that the leukotriene receptor antagonist zafirlukast, in combination with high-doses of inhaled corticosteroids,...

journal_title：American journal of respiratory and critical care medicine

authors： Virchow JC Jr,Prasse A,Naya I,Summerton L,Harris A

更新日期：2000-08-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the major pathogen responsible for acute bronchiolitis in infancy. However, evaluation of the relative importance of rhinovirus or multiple viral infections has been hampered by the lack of sensitive diagnostic methodologies. Therefore, in this study we used the reverse transcripti...

journal_title：American journal of respiratory and critical care medicine

authors： Papadopoulos NG,Moustaki M,Tsolia M,Bossios A,Astra E,Prezerakou A,Gourgiotis D,Kafetzis D

更新日期：2002-05-01 00:00:00

abstract：:The severity of asthma can be graded from mild intermittent to severe persistent. Airway inflammation is a feature of persistent asthma. We compared several markers of inflammation in mucosal biopsies and bronchoalveolar lavage fluid (BAL fluid) from 12 healthy control subjects, 24 patients with intermittent asthma, a...

journal_title：American journal of respiratory and critical care medicine

authors： Vignola AM,Chanez P,Campbell AM,Souques F,Lebel B,Enander I,Bousquet J

更新日期：1998-02-01 00:00:00

abstract：RATIONALE:Little is known about human club cells, dome-shaped cells with dense cytoplasmic granules and microvilli that represent the major secretory cells of the human small airways (at least sixth-generation bronchi). OBJECTIVES:To define the ontogeny and biology of the human small airway epithelium club cell. METH...

journal_title：American journal of respiratory and critical care medicine

authors： Zuo WL,Shenoy SA,Li S,O'Beirne SL,Strulovici-Barel Y,Leopold PL,Wang G,Staudt MR,Walters MS,Mason C,Kaner RJ,Mezey JG,Crystal RG

更新日期：2018-12-01 00:00:00

abstract：:Hepatopulmonary syndrome (HPS) is characterized by intrapulmonary vascular dilatations and an increased alveoloarterial oxygen difference (AaPO(2)). These abnormalities are related to augmented pulmonary nitric oxide (NO) production, dependent primarily on increases in the expression and activity of inducible NO-synth...

journal_title：American journal of respiratory and critical care medicine

authors： Rabiller A,Nunes H,Lebrec D,Tazi KA,Wartski M,Dulmet E,Libert JM,Mougeot C,Moreau R,Mazmanian M,Humbert M,Hervé P

更新日期：2002-08-15 00:00:00

abstract：RATIONALE:Airway remodeling is an important feature of chronic asthma that causes irreversible airflow obstruction. Although asthma is considered to be a Th2 disease, the role of T-bet and GATA-3, the key transcription factors for differentiation toward Th1 and Th2 cells, in the pathogenesis of airway remodeling is poo...

journal_title：American journal of respiratory and critical care medicine

authors： Kiwamoto T,Ishii Y,Morishima Y,Yoh K,Maeda A,Ishizaki K,Iizuka T,Hegab AE,Matsuno Y,Homma S,Nomura A,Sakamoto T,Takahashi S,Sekizawa K

更新日期：2006-07-15 00:00:00

abstract：:To investigate the mechanisms underlying ventilator-dependence in patients with chronic obstructive pulmonary disease (COPD), and to assess the effects of the combination of positive end-expiratory pressure (PEEP) and pressure-support ventilation (PSV) on inspiratory muscle effort, we investigated respiratory mechanic...

journal_title：American journal of respiratory and critical care medicine

authors： Appendini L,Purro A,Patessio A,Zanaboni S,Carone M,Spada E,Donner CF,Rossi A

更新日期：1996-11-01 00:00:00

abstract：RATIONALE:The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major challenge due to lack of effective drug therapy or accurate indicators for disease progression. Fibrocytes are circulating mesenchymal cell progenitors that are involved in tissue repair and fibrosis. OBJECTIVES:To test the hypoth...

journal_title：American journal of respiratory and critical care medicine

authors： Moeller A,Gilpin SE,Ask K,Cox G,Cook D,Gauldie J,Margetts PJ,Farkas L,Dobranowski J,Boylan C,O'Byrne PM,Strieter RM,Kolb M

更新日期：2009-04-01 00:00:00

abstract：:To determine the relative contribution of ectopic calcitonin (CT) production versus nonectopic secretion of CT in patients with small cell lung cancer (SCLC), serum and urine immunoreactive CT (iCT) levels of 86 different subjects were measured by radioimmunoassay (RIA) using two polyclonal antisera (Ab3b and Ab4). Th...

journal_title：American journal of respiratory and critical care medicine

authors： Kelley MJ,Becker KL,Rushin JM,Venzon D,Phelps R,Ihde DC,Bliss DP Jr,Melby K,Snider RH,Johnson BE

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:Pure oxygen causes more oxidative stress than room air in resuscitation of asphyctic neonates, and consequently could be associated with increased tissue damage. OBJECTIVES:To compare damage caused to heart and kidneys on reoxygenation in severely asphyctic term neonates resuscitated with room air (RAR) or 1...

journal_title：American journal of respiratory and critical care medicine

authors： Vento M,Sastre J,Asensi MA,Viña J

更新日期：2005-12-01 00:00:00

abstract：:We tested the hypothesis that in advanced pulmonary fibrosis, edema is redistributed away from the relatively noncompliant interstitium and predominantly floods alveoli. Severe left lung fibrosis was produced in six dogs with radiation and intratracheal bleomycin and, 24 mo later, hydrostatic edema was induced by infu...

journal_title：American journal of respiratory and critical care medicine

authors： Zwikler MP,Iancu D,Michel RP

更新日期：1994-05-01 00:00:00

abstract：:Diseases of the respiratory tract are among the leading causes of death in the world population. Increasing evidence points to a key role of the innate immune system with its pattern recognition receptors (PRRs) in both infectious and noninfectious lung diseases, which include pneumonia, chronic obstructive pulmonary ...

journal_title：American journal of respiratory and critical care medicine

authors： Opitz B,van Laak V,Eitel J,Suttorp N

更新日期：2010-06-15 00:00:00

abstract：:A protective role for dietary antioxidants in asthma has been proposed. However, epidemiological evidence to implicate antioxidant vitamins is weak, and data on the role of flavonoid-rich foods and antioxidant trace elements are lacking. We carried out a population-based case-control study in South London, UK, to inve...

journal_title：American journal of respiratory and critical care medicine

authors： Shaheen SO,Sterne JA,Thompson RL,Songhurst CE,Margetts BM,Burney PG

更新日期：2001-11-15 00:00:00

abstract：:Experimental and epidemiological evidence supports the hypothesis that exposure to mycobacteria has the potential to suppress the development of asthma and/or atopy and there are reports in the Chinese medical literature of repeated vaccination with inactivated BCG being effective in the management of asthma. Forty-th...

journal_title：American journal of respiratory and critical care medicine

authors： Shirtcliffe PM,Easthope SE,Cheng S,Weatherall M,Tan PL,Le Gros G,Beasley R

更新日期：2001-05-01 00:00:00

abstract：:Methodologies used to assess airway responsiveness (AR) in children administer the same dosage schedule to all children despite the great range in the size of subjects. The aim of this study was to examine the hypothesis that the level of AR is size dependent within same-age cohorts and between different ages. Among a...

journal_title：American journal of respiratory and critical care medicine

authors： Le Souëf PN,Sears MR,Sherrill D

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Patients of Hispanic origin with cystic fibrosis (CF) are the largest growing minority, representing 8.5% of patients with CF in the United States. No national survival analysis of this group has ever been undertaken. OBJECTIVES:We aimed to determine whether Hispanic ethnicity within the CF population is ass...

journal_title：American journal of respiratory and critical care medicine

authors： Rho J,Ahn C,Gao A,Sawicki GS,Keller A,Jain R

更新日期：2018-10-15 00:00:00

abstract：:Prior data indicate positive effects of long-term exercise interventions for cognitive functioning among patients with chronic obstructive pulmonary disease (COPD), but no prior studies have examined acute effects of individual bouts of exercise among patients with COPD. This study evaluated acute effects of exercise ...

journal_title：American journal of respiratory and critical care medicine

authors： Emery CF,Honn VJ,Frid DJ,Lebowitz KR,Diaz PT

更新日期：2001-11-01 00:00:00

abstract：:We determined if pulmonary peptidoleukotrienes contribute to the pathogenesis of chronic lung disease of extreme prematurity (CLD) by measuring urinary leukotriene E4 (uLTE4). Study patients had a birth weight < 1000 g and were about 28 d old when they were classified as normal control subjects (n = 8) or as having CL...

journal_title：American journal of respiratory and critical care medicine

authors： Davidson D,Drafta D,Wilkens BA

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Data regarding the influence of ambient air pollution on infant bronchiolitis are few. OBJECTIVES:We evaluated the impact of several air pollutants and their sources on infant bronchiolitis. METHODS:Infants in the Georgia Air Basin of British Columbia with an inpatient or outpatient clinical encounter for b...

journal_title：American journal of respiratory and critical care medicine

authors： Karr CJ,Demers PA,Koehoorn MW,Lencar CC,Tamburic L,Brauer M

更新日期：2009-11-15 00:00:00

abstract：:Several epidemiologic studies have demonstrated a consistent association between levels of particulate matter (PM) in the ambient air with increases in cardiovascular and respiratory mortality and morbidity. Diesel exhaust (DE), in addition to generating other pollutants, is a major contributor to PM pollution in most...

journal_title：American journal of respiratory and critical care medicine

authors： Salvi S,Blomberg A,Rudell B,Kelly F,Sandström T,Holgate ST,Frew A

更新日期：1999-03-01 00:00:00

abstract：:Segmental bronchoprovocation (SBP) with allergen was used in an attempt to study eosinophils recruited to the airway 24 h after challenge. Unexpectedly, in the first four patients, neutrophils (rather than eosinophils) were recruited in the bronchoalveolar lavage (BAL) fluids, and we hypothesized that the allergen ext...

journal_title：American journal of respiratory and critical care medicine

authors： Hunt LW,Gleich GJ,Ohnishi T,Weiler DA,Mansfield ES,Kita H,Sur S

更新日期：1994-06-01 00:00:00

abstract：RATIONALE:Lung allografts are prone to reperfusion injury and acute rejection, which, in addition to infiltrating lymphocytes, are accompanied by neutrophil infiltration and neutrophil-associated oxidative stress. Indoleamine 2,3-dioxygenase (IDO) is a unique cytosolic enzyme that possesses T-cell-suppressive and antio...

journal_title：American journal of respiratory and critical care medicine

authors： Liu H,Liu L,Fletcher BS,Visner GA

更新日期：2006-03-01 00:00:00

abstract：:Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of lung hyperinflation as measured by the inspiratory capacity-to-total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pul...

journal_title：American journal of respiratory and critical care medicine

authors： Casanova C,Cote C,de Torres JP,Aguirre-Jaime A,Marin JM,Pinto-Plata V,Celli BR

更新日期：2005-03-15 00:00:00