当前位置： SCI文献检索 > AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE期刊下所有文献 > Antituberculosis drug-induced hepatotoxicity. The role of hepatitis C virus and the human immunodeficiency virus.

Antituberculosis drug-induced hepatotoxicity. The role of hepatitis C virus and the human immunodeficiency virus.

Abstract：

:Until recently it was thought that age greater than 35 yr was the main risk factor for the development of drug-induced hepatitis (DIH) in patients receiving antituberculosis therapy. We conducted a study to determine whether infection with either the hepatitis C virus or the human immunodeficiency virus (HIV) were significant risk factors for the development of DIH in patients receiving antituberculosis therapy. Our study consisted of two parts. In the first part, 134 consecutive patients admitted for the treatment of tuberculosis (TB) were followed for the development of DIH. All of these patients were also screened for the presence of hepatitis C and HIV. In the second part of the study, those patients who were hepatitis C positive and who developed DIH on repeated reintroduction of the anti-TB drugs were offered a liver biopsy. If active inflammation, which may be suggestive of hepatitis C infection, was present on the biopsy specimen, treatment with alpha-interferon was begun and the anti-TB drugs were subsequently reintroduced. During the 18 mo of the study, 22 patients developed DIH. The relative risk of developing DIH if the patient was hepatitis C or HIV positive was fivefold and fourfold, respectively (p < 0.05). If a patient was coinfected with both hepatitis C and HIV the relative risk of developing DIH was increased 14.4-fold (p < 0.002). In the treatment part, four patients were treated with alpha-interferon, and all were able to undergo the reintroduction of anti-TB therapy without reoccurrence of DIH. Infection with hepatitis C and HIV are independent and additive risk factors for the development of DIH during TB therapy. The treatment of hepatitis C with alpha-interferon may allow the reintroduction of anti-TB agents in those who previously developed DIH when exposed to these drugs.

journal_name

Am J Respir Crit Care Med

journal_title

American journal of respiratory and critical care medicine

authors

Ungo JR,Jones D,Ashkin D,Hollender ES,Bernstein D,Albanese AP,Pitchenik AE

doi

10.1164/ajrccm.157.6.9711039

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

1871-6

issue

6 Pt 1

eissn

1073-449X

issn

1535-4970

journal_volume

157

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE文献大全
  • Age Effects on Cerebral Oxygenation and Behavior in Children with Sleep-disordered Breathing.

    abstract：RATIONALE:Childhood sleep-disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience s...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201709-1825OC

    authors： Tamanyan K,Walter LM,Weichard A,Davey MJ,Nixon GM,Biggs SN,Horne RSC

    更新日期：2018-06-01 00:00:00

  • Platelets Regulate Pulmonary Inflammation and Tissue Destruction in Tuberculosis.

    abstract：RATIONALE:Platelets may interact with the immune system in tuberculosis (TB) to regulate human inflammatory responses that lead to morbidity and spread of infection. OBJECTIVES:To identify a functional role of platelets in the innate inflammatory and matrix-degrading response in TB. METHODS:Markers of platelet activa...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201710-2102OC

    authors： Fox KA,Kirwan DE,Whittington AM,Krishnan N,Robertson BD,Gilman RH,López JW,Singh S,Porter JC,Friedland JS

    更新日期：2018-07-15 00:00:00

  • Effect of dobutamine on oxygen consumption and gastric mucosal pH in septic patients.

    abstract：:Decreases in gastric mucosal pH (pHi) are associated with splanchnic hypoxia in animals and with increased mortality in patients. In the present study we measured changes in gastric pHi with a tonometer in septic patients after a short-term infusion of dobutamine. These changes were compared with concurrent alteration...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.150.2.8049810

    authors： Gutierrez G,Clark C,Brown SD,Price K,Ortiz L,Nelson C

    更新日期：1994-08-01 00:00:00

  • Attenuation of obstructive sleep apnea by compression stockings in subjects with venous insufficiency.

    abstract：RATIONALE:Fluid accumulation in the legs and its overnight redistribution into the neck appears to play a causative role in obstructive sleep apnea (OSA) in sedentary men. Chronic venous insufficiency (CVI) promotes fluid accumulation in the legs that can be counteracted by compression stockings. OBJECTIVES:To test th...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1164/rccm.201102-0350OC

    authors： Redolfi S,Arnulf I,Pottier M,Lajou J,Koskas I,Bradley TD,Similowski T

    更新日期：2011-11-01 00:00:00

  • Topographic basis of bimodal ventilation-perfusion distributions during bronchoconstriction in sheep.

    abstract：:The distribution of ventilation-perfusion (VA/Q) ratios during bronchoconstriction measured with the multiple inert gases elimination technique is frequently bimodal. However, the topographic basis and the cause of that bimodality remain unknown. In this article, regional VA/Q is quantified by three-dimensional positr...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200409-1296OC

    authors： Melo MF,Harris RS,Layfield JD,Venegas JG

    更新日期：2005-04-01 00:00:00

  • Junior versus senior physicians for informing families of intensive care unit patients.

    abstract：:To compare the effectiveness of information delivered to family members of critically ill patients by junior and senior physicians, we performed a prospective randomized multicenter trial in 11 French intensive care units. Patients (n = 220) were allocated at random to having their family members receive information b...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1164/rccm.200305-645OC

    authors： Moreau D,Goldgran-Toledano D,Alberti C,Jourdain M,Adrie C,Annane D,Garrouste-Orgeas M,Lefrant JY,Papazian L,Quinio P,Pochard F,Azoulay E

    更新日期：2004-02-15 00:00:00

  • Superior vena cava syndrome. Rapid histologic diagnosis by ultrasound-guided transthoracic needle aspiration biopsy.

    abstract：:We prospectively analyzed the diagnostic yield and safety of ultrasound (US)-guided transthoracic needle aspiration biopsy in the histologic diagnosis of 40 patients with superior vena cava (SVC) syndrome. During a 4-yr period, 40 patients with SVC obstruction were admitted to National Taiwan University Hospital. Of t...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.149.3.8118650

    authors： Ko JC,Yang PC,Yuan A,Chang DB,Yu CJ,Wu HD,Lee LN,Kuo SH,Luh KT

    更新日期：1994-03-01 00:00:00

  • Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis?

    abstract：:The potential role of atypical bacterial infection in the pathogenesis of asthma is a subject of continuing debate. There is an increasing body of literature concerning the association between the atypical bacteria Chlamydophila pneumoniae and Mycoplasma pneumoniae and asthma pathogenesis; however, many studies invest...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,评审

    doi：10.1164/rccm.200412-1743PP

    authors： Johnston SL,Martin RJ

    更新日期：2005-11-01 00:00:00

  • Comparison of murine nasal-associated lymphoid tissue and Peyer's patches.

    abstract：:The nasal mucosal is the first site of contact with inhaled antigens. However, the nature of local immune responses and the role of nasal-associated lymphoid tissue (NALT) in those responses have rarely been studied. To characterize the cells involved in mucosally derived immune responses, NALT and Peyer's patch (PP) ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.156.4.97-03017

    authors： Heritage PL,Underdown BJ,Arsenault AL,Snider DP,McDermott MR

    更新日期：1997-10-01 00:00:00

  • Impaired airway function and wheezing in infancy: the influence of maternal smoking and a genetic predisposition to asthma.

    abstract：:This prospective community-based study of infants born in inner London was undertaken to examine the association between premorbid airway function and subsequent wheezing in the first year of life and to explore the influence on this association of a family history of asthma and maternal smoking during pregnancy. Heal...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.159.2.9712029

    authors： Dezateux C,Stocks J,Dundas I,Fletcher ME

    更新日期：1999-02-01 00:00:00

  • Tumor angiogenesis correlates with histologic type and metastasis in non-small-cell lung cancer.

    abstract：:This study investigated the clinico-pathologic correlation of tumor angiogenesis in non-small-cell lung cancers. Formalin-fixed, paraffin-embedded surgical specimens of 55 consecutive patients with primary non-small-cell lung cancers were examined. Included were 26 squamous cell carcinomas and 29 adenocarcinomas. Twen...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.152.6.8520790

    authors： Yuan A,Yang PC,Yu CJ,Lee YC,Yao YT,Chen CL,Lee LN,Kuo SH,Luh KT

    更新日期：1995-12-01 00:00:00

  • Cryptogenic hemoptysis: from a benign to a life-threatening pathologic vascular condition.

    abstract：RATIONALE:Data on hemoptysis of unknown origin (i.e., "cryptogenic") are scarce and the outcome of patients affected is controversial. OBJECTIVES:To describe the clinical spectrum and course of patients with cryptogenic hemoptysis, as well as pathologic findings when surgery is performed. METHODS:A cohort of 81 patie...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200609-1362OC

    authors： Savale L,Parrot A,Khalil A,Antoine M,Théodore J,Carette MF,Mayaud C,Fartoukh M

    更新日期：2007-06-01 00:00:00

  • The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease.

    abstract：RATIONALE:Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD). OBJECTIVES:To determine the effect of inhaled corticosteroids with or without long-acting beta(2)-adrenergic agonist on systemic biomarkers of inflammation. METHODS:W...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1164/rccm.200709-1356OC

    authors： Sin DD,Man SF,Marciniuk DD,Ford G,FitzGerald M,Wong E,York E,Mainra RR,Ramesh W,Melenka LS,Wilde E,Cowie RL,Williams D,Gan WQ,Rousseau R,ABC (Advair, Biomarkers in COPD) Investigators.

    更新日期：2008-06-01 00:00:00

  • Reduction in All-Cause Mortality with Fluticasone Furoate/Umeclidinium/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease.

    abstract：:Rationale: The IMPACT (Informing the Pathway of Chronic Obstructive Pulmonary Disease Treatment) trial demonstrated a significant reduction in all-cause mortality (ACM) risk with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus UMEC/VI in patients with chronic obstructive pulmonary disease (COPD) at ris...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1164/rccm.201911-2207OC

    authors： Lipson DA,Crim C,Criner GJ,Day NC,Dransfield MT,Halpin DMG,Han MK,Jones CE,Kilbride S,Lange P,Lomas DA,Lettis S,Manchester P,Martin N,Midwinter D,Morris A,Pascoe SJ,Singh D,Wise RA,Martinez FJ

    更新日期：2020-06-15 00:00:00

  • Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis.

    abstract：RATIONALE:Systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) portends worse outcome than other forms of PAH. Vasoconstrictive and vascular remodeling actions of endothelin (ET) 1 and angiotensin (Ang) II via endothelin receptor type A (ETAR) and Ang receptor type-1 (AT1R) activation are implicate...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201403-0442OC

    authors： Becker MO,Kill A,Kutsche M,Guenther J,Rose A,Tabeling C,Witzenrath M,Kühl AA,Heidecke H,Ghofrani HA,Tiede H,Schermuly RT,Nickel N,Hoeper MM,Lukitsch I,Gollasch M,Kuebler WM,Bock S,Burmester GR,Dragun D,Riemekasten

    更新日期：2014-10-01 00:00:00

  • Incorporating Coexisting Chronic Illness into Decisions about Patient Selection for Lung Cancer Screening. An Official American Thoracic Society Research Statement.

    abstract：BACKGROUND:Lung cancer screening (LCS) has the potential to reduce the risk of lung cancer death in healthy individuals, but the impact of coexisting chronic illnesses on LCS outcomes has not been well defined. Consideration of the complex relationship between baseline risk of lung cancer, treatment-related harms, and ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201805-0986ST

    authors： Rivera MP,Tanner NT,Silvestri GA,Detterbeck FC,Tammemägi MC,Young RP,Slatore CG,Caverly TJ,Boyd CM,Braithwaite D,Fathi JT,Gould MK,Iaccarino JM,Malkoski SP,Mazzone PJ,Tanoue LT,Schoenborn NL,Zulueta JJ,Wiener RS,Ame

    更新日期：2018-07-15 00:00:00

  • Leukocyte activation and flow behavior in rat skeletal muscle in sepsis.

    abstract：:In animal models of endotoxemia, sepsis is associated with the accumulation of leukocytes and altered microvascular perfusion. In order to test the hypothesis that bacterial sepsis upregulates leukocyte-endothelial adhesion, we used intravital microscopy to examine the flow behavior of leukocytes in the postcapillary ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.157.1.9609012

    authors： Piper RD,Pitt-Hyde ML,Anderson LA,Sibbald WJ,Potter RF

    更新日期：1998-01-01 00:00:00

  • The effect of size and age of subject on airway responsiveness in children.

    abstract：:Methodologies used to assess airway responsiveness (AR) in children administer the same dosage schedule to all children despite the great range in the size of subjects. The aim of this study was to examine the hypothesis that the level of AR is size dependent within same-age cohorts and between different ages. Among a...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.152.2.7633710

    authors： Le Souëf PN,Sears MR,Sherrill D

    更新日期：1995-08-01 00:00:00

  • Detection of Pediatric Pulmonary Arterial Hypertension by School Electrocardiography Mass Screening.

    abstract：:Rationale: To detect pulmonary arterial hypertension (PAH) at any early stage is a promising approach to optimize the outcome. Objectives: To investigate the impact of school ECG-based screening on detecting idiopathic or heritable (I/H)-PAH in the general pediatric population. Methods: This was a nationwide survey of...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201802-0375OC

    authors： Sawada H,Mitani Y,Nakayama T,Fukushima H,Kogaki S,Igarashi T,Ichida F,Ono Y,Nakanishi T,Doi S,Ishikawa S,Matsushima M,Yamada O,Saji T

    更新日期：2019-06-01 00:00:00

  • Future Research Directions in Asthma. An NHLBI Working Group Report.

    abstract：:Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the N...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,评审

    doi：10.1164/rccm.201505-0963WS

    authors： Levy BD,Noel PJ,Freemer MM,Cloutier MM,Georas SN,Jarjour NN,Ober C,Woodruff PG,Barnes KC,Bender BG,Camargo CA Jr,Chupp GL,Denlinger LC,Fahy JV,Fitzpatrick AM,Fuhlbrigge A,Gaston BM,Hartert TV,Kolls JK,Lynch SV,Moo

    更新日期：2015-12-01 00:00:00

  • Increased serum level of vascular endothelial growth factor in pulmonary tuberculosis.

    abstract：:Pulmonary tuberculosis, one of the granulomatous diseases, has few serological markers for its activity. Recently, an increased serum level of vascular endothelial growth factor (VEGF) was detected in patients with Crohn's disease, also a granulomatous disease. We hypothesized that VEGF might be associated with the pa...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.162.3.9911010

    authors： Matsuyama W,Hashiguchi T,Matsumuro K,Iwami F,Hirotsu Y,Kawabata M,Arimura K,Osame M

    更新日期：2000-09-01 00:00:00

  • In-home air pollution is linked to respiratory morbidity in former smokers with chronic obstructive pulmonary disease.

    abstract：RATIONALE:The effect of indoor air pollutants on respiratory morbidity among patients with chronic obstructive pulmonary disease (COPD) in developed countries is uncertain. OBJECTIVES:The first longitudinal study to investigate the independent effects of indoor particulate matter (PM) and nitrogen dioxide (NO(2)) conc...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201211-1987OC

    authors： Hansel NN,McCormack MC,Belli AJ,Matsui EC,Peng RD,Aloe C,Paulin L,Williams DL,Diette GB,Breysse PN

    更新日期：2013-05-15 00:00:00

  • Use of a long-acting inhaled beta2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease.

    abstract：:Chronic obstructive pulmonary disease (COPD) is a condition in which continuous bronchodilation may have clinical advantages. This study evaluated salmeterol, a beta-agonist bronchodilator with a duration of action substantially longer than that of short-acting beta-agonists, compared with ipratropium, an anticholiner...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1164/ajrccm.163.5.9903053

    authors： Rennard SI,Anderson W,ZuWallack R,Broughton J,Bailey W,Friedman M,Wisniewski M,Rickard K

    更新日期：2001-04-01 00:00:00

  • Segregation analysis of physician-diagnosed asthma in Hispanic and non-Hispanic white families. A recessive component?

    abstract：:The inheritance of asthma, evident from its high family concordance, is not well understood. To investigate whether asthma may be inherited through a major gene with two alleles, segregation analyses were conducted in 3,369 individuals from 906 nuclear families enrolled, without selection, in a longitudinal study of r...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.154.1.8680670

    authors： Holberg CJ,Elston RC,Halonen M,Wright AL,Taussig LM,Morgan WJ,Martinez FD

    更新日期：1996-07-01 00:00:00

  • Tracheal microvascular responses to beta-adrenergic stimulation in anesthetized rats.

    abstract：:Previous study of adrenergic control of the tracheal vasculature in rats (1) demonstrated that beta-adrenergic blockade heightened arteriolar and large venular contractile responses to norepinephrine, a nonselective alpha-adrenergic agonist. The present study was undertaken to confirm the presence of functional beta-a...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.153.3.8630550

    authors： Corboz MR,Ballard ST,Inglis SK,Taylor AE

    更新日期：1996-03-01 00:00:00

  • Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing.

    abstract：RATIONALE:The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors. OBJECTIVES:First, to compare the diagnostic performance of the TST and a form of in vitro IFN-gamma release assay (IFNGRA) in the c...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200509-1526OC

    authors： Anderson ST,Williams AJ,Brown JR,Newton SM,Simsova M,Nicol MP,Sebo P,Levin M,Wilkinson RJ,Wilkinson KA

    更新日期：2006-05-01 00:00:00

  • Untargeted lipidomic analysis in chronic obstructive pulmonary disease. Uncovering sphingolipids.

    abstract：RATIONALE:Cigarette smoke is the major risk factor in the development of chronic obstructive pulmonary disease (COPD). Lipidomics is a novel and emerging research field that may provide new insights in the origins of chronic inflammatory diseases, such as COPD. OBJECTIVES:To investigate whether expression of the sputu...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201312-2210OC

    authors： Telenga ED,Hoffmann RF,Ruben t'Kindt,Hoonhorst SJ,Willemse BW,van Oosterhout AJ,Heijink IH,van den Berge M,Jorge L,Sandra P,Postma DS,Sandra K,ten Hacken NH

    更新日期：2014-07-15 00:00:00

  • Effect of Obstructive Sleep Apnea Treatment on Renal Function in Patients with Cardiovascular Disease.

    abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. OBJECTIVES:To determine the effects of continuous positive airway pressure (CPAP) on renal function in subjects with coexisting OSA and cardiovascular dise...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1164/rccm.201703-0603OC

    authors： Loffler KA,Heeley E,Freed R,Anderson CS,Brockway B,Corbett A,Chang CL,Douglas JA,Ferrier K,Graham N,Hamilton GS,Hlavac M,McArdle N,McLachlan J,Mukherjee S,Naughton MT,Thien F,Young A,Grunstein RR,Palmer LJ,Woodman

    更新日期：2017-12-01 00:00:00

  • Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia.

    abstract：:Retrospective studies have suggested that combination antibiotic therapy for severe bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a prospective, multicenter, international observational study of 844 adult patients with bacteremia due to Streptococcus pneumoniae. The effect of combin...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1164/rccm.200311-1578OC

    authors： Baddour LM,Yu VL,Klugman KP,Feldman C,Ortqvist A,Rello J,Morris AJ,Luna CM,Snydman DR,Ko WC,Chedid MB,Hui DS,Andremont A,Chiou CC,International Pneumococcal Study Group.

    更新日期：2004-08-15 00:00:00

  • The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5.

    abstract：:While signal transducer and activator of transcription protein 6 (STAT6) is important in interleukin-4 (IL-4)-induced commitment of CD4(+) T cells to the T helper cell, type 2 (Th2) phenotype and IgE isotype switching in B cells, its role in other IL-4-mediated events and their impact upon the allergic response is les...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.160.4.9809065

    authors： Tomkinson A,Kanehiro A,Rabinovitch N,Joetham A,Cieslewicz G,Gelfand EW

    更新日期：1999-10-01 00:00:00