Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia.

abstract：INTRODUCTION:Proteinases with a disintegrin and a metalloproteinase domain (ADAMs) have not been well studied in COPD. We investigated whether ADAM9 is linked to COPD in humans and mice. METHODS:ADAM9 blood and lung levels were measured in COPD patients versus controls, and air- versus cigarette smoke (CS)-exposed wil...

journal_title：American journal of respiratory and critical care medicine

authors： Wang X,Polverino F,Rojas-Quintero J,Zhang D,Sánchez J,Yambayev I,Lindqvist E,Virtala R,Djukanovic R,Davies DE,Wilson S,O'Donnell R,Cunoosamy D,Hazon P,Higham A,Singh D,Olsson H,Owen CA

更新日期：2018-06-04 00:00:00

abstract：:In many countries the majority of patients with asthma are now treated with inhaled beta 2-agonists as required and regular inhaled steroids. Compliance with asthma medication is poor, particularly for inhaled steroids, which do not give immediate relief of symptoms. An inhaler combining a beta 2-agonist and a steroid...

journal_title：American journal of respiratory and critical care medicine

authors： Barnes PJ,O'Connor BJ

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:Characteristics of and survival estimates for recipients of lung retransplantation in the modern era are unknown. OBJECTIVES:To compare lung retransplant patients in the modern era with historical retransplant patients, to compare retransplant patients with initial transplant patients in the modern era, and ...

journal_title：American journal of respiratory and critical care medicine

authors： Kawut SM,Lederer DJ,Keshavjee S,Wilt JS,Daly T,D'Ovidio F,Sonett JR,Arcasoy SM,Barr ML

更新日期：2008-01-01 00:00:00

abstract：RATIONALE:Defining the biogeography of bacterial populations in human body habitats is a high priority for understanding microbial-host relationships in health and disease. The healthy lung was traditionally considered sterile, but this notion has been challenged by emerging molecular approaches that enable comprehensi...

journal_title：American journal of respiratory and critical care medicine

authors： Charlson ES,Bittinger K,Haas AR,Fitzgerald AS,Frank I,Yadav A,Bushman FD,Collman RG

更新日期：2011-10-15 00:00:00

abstract：:Silicosis is characterized by fibrosing nodular lesions that may eventually develop into progressive massive fibrosis (PMF). Cytokines (interleukin-1beta [IL-1beta], tumor necrosis factor-alpha [TNF-alpha] and growth factors insulin-like growth factor-1 [IGF-1] platelet-derived growth factor [PDGF]) have been implicat...

journal_title：American journal of respiratory and critical care medicine

authors： Jagirdar J,Begin R,Dufresne A,Goswami S,Lee TC,Rom WN

更新日期：1996-10-01 00:00:00

abstract：:During exercise, children with congenital central hypoventilation syndrome (CCHS) demonstrate coupling of VE to exercise load, despite the absence of a VE response to changes in FICO2. To assess the effect of movement on VE, we studied six CCHS patients and six matched controls during passive motion in a motor-driven ...

journal_title：American journal of respiratory and critical care medicine

authors： Gozal D,Marcus CL,Ward SL,Keens TG

更新日期：1996-02-01 00:00:00

abstract：RATIONALE:17β-Estradiol (E2) attenuates hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension (HPH) through an unknown mechanism that may involve estrogen receptors (ER) or E2 conversion to catecholestradiols and methoxyestradiols with previously unrecognized effects on cardiopulmonary vascular remodeli...

journal_title：American journal of respiratory and critical care medicine

authors： Lahm T,Albrecht M,Fisher AJ,Selej M,Patel NG,Brown JA,Justice MJ,Brown MB,Van Demark M,Trulock KM,Dieudonne D,Reddy JG,Presson RG,Petrache I

更新日期：2012-05-01 00:00:00

abstract：:The aim of this study was to determine the effects of maturation on crossbridge properties and myosin isoform composition in hamster diaphragm muscle. Diaphragm strips were obtained at postnatal Days 1 and 8 and in adults (10 to 12 wk). Peak isometric tension and maximum unloaded shortening velocity (Vmax) increased w...

journal_title：American journal of respiratory and critical care medicine

authors： Coirault C,Lambert F,Joseph T,Blanc FX,Chemla D,Lecarpentier Y

更新日期：1997-09-01 00:00:00

abstract：:We assessed the influence of current indoor levels of fungi, house dust mite allergen (Der p 1), and cat allergen (Fel d 1) on sensitization and asthma in adults. A total of 485 adults answered a questionnaire and had skin prick tests and lung function tests. Dust and air samples were collected from their bedrooms. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Dharmage S,Bailey M,Raven J,Mitakakis T,Cheng A,Guest D,Rolland J,Forbes A,Thien F,Abramson M,Walters EH

更新日期：2001-07-01 00:00:00

abstract：:Dysfunction of the muscles of ambulation contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Men with COPD have high prevalence of low testosterone levels, which may contribute to muscle weakness. We determined effects of testosterone supplementation (100 mg of testosterone enanthate i...

journal_title：American journal of respiratory and critical care medicine

authors： Casaburi R,Bhasin S,Cosentino L,Porszasz J,Somfay A,Lewis MI,Fournier M,Storer TW

更新日期：2004-10-15 00:00:00

abstract：:Heart failure is associated with Cheyne-Stokes breathing, which fragments patients' sleep. Correction of respiratory disturbance may reduce sleep fragmentation and excessive daytime sleepiness. This randomized prospective parallel trial assesses whether nocturnal-assist servoventilation improves daytime sleepiness com...

journal_title：American journal of respiratory and critical care medicine

authors： Pepperell JC,Maskell NA,Jones DR,Langford-Wiley BA,Crosthwaite N,Stradling JR,Davies RJ

更新日期：2003-11-01 00:00:00

abstract：RATIONALE:Numerous studies have been published on the new Mycobacterium tuberculosis (MTB)-specific IFN-gamma release assays. However, their prognostic value for progression from latent tuberculosis infection (LTBI) to active TB has yet to be established. OBJECTIVES:To compare the QuantiFERON-TB Gold In-Tube assay (QF...

journal_title：American journal of respiratory and critical care medicine

authors： Diel R,Loddenkemper R,Meywald-Walter K,Niemann S,Nienhaus A

更新日期：2008-05-15 00:00:00

abstract：:Although skeletal muscle abnormalities have been described in association with human immunodeficiency virus (HIV), the effects of HIV infection on respiratory muscle function have not been well characterized. We hypothesized that HIV+ individuals may develop respiratory muscle weakness and that respiratory muscle dysf...

journal_title：American journal of respiratory and critical care medicine

authors： Schulz L,Nagaraja HN,Rague N,Drake J,Diaz PT

更新日期：1997-03-01 00:00:00

abstract：RATIONALE:Obesity, especially truncal obesity, is a risk factor for asthma incidence, prevalence, and severity. Chitinase 3-like-1 (Chi3l1) is an evolutionarily conserved moiety that plays a critical role in antipathogen and Th2 responses. However, the mechanisms that underlie the association between asthma and obesity...

journal_title：American journal of respiratory and critical care medicine

authors： Ahangari F,Sood A,Ma B,Takyar S,Schuyler M,Qualls C,Dela Cruz CS,Chupp GL,Lee CG,Elias JA

更新日期：2015-04-01 00:00:00

abstract：:Pulmonary emphysema and periodontal disease are each characterized by the uncontrolled proteolysis of connective tissue proteins by proteinases derived from human neutrophils. Although these diseases would not appear to be related in terms of the initial insult to individual tissues, the ultimate result in each diseas...

journal_title：American journal of respiratory and critical care medicine

authors： Travis J,Pike R,Imamura T,Potempa J

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:Noncommunicable diseases are major causes of morbidity and mortality in sub-Saharan Africa (sSA). Valid burden of disease estimates are lacking for noncommunicable lung disease in sSA. OBJECTIVES:We performed a community-based survey to determine the prevalence of chronic lung disease among adults 18 years o...

journal_title：American journal of respiratory and critical care medicine

authors： Meghji J,Nadeau G,Davis KJ,Wang D,Nyirenda MJ,Gordon SB,Mortimer K

更新日期：2016-07-01 00:00:00

abstract：:The relationship of sleep-disordered breathing (SOB) to neuropsychological deficits was investigated with cross-sectional data from the Wisconsin Sleep Cohort Study, a population-based study of the natural history of SDB. A sample of 841 employed men and women ages 30 to 60 yr was studied by overnight polysomnography ...

journal_title：American journal of respiratory and critical care medicine

authors： Kim HC,Young T,Matthews CG,Weber SM,Woodward AR,Palta M

更新日期：1997-12-01 00:00:00

abstract：:Although sleep-disordered breathing (SDB) has been shown to be very prevalent in the elderly, little has been done to examine differences between the elderly of different racial groups. It has been well documented that SDB often results in hypertension and that hypertension is more common in African-Americans than in ...

journal_title：American journal of respiratory and critical care medicine

authors： Ancoli-Israel S,Klauber MR,Stepnowsky C,Estline E,Chinn A,Fell R

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:There is growing evidence that resident cells, such as fibroblasts and epithelial cells, can drive the persistent accumulation of dendritic cells (DCs) in chronically inflamed tissue, leading to the organization and the maintenance of ectopic lymphoid aggregates. This phenomenon, occurring through a chemokine...

journal_title：American journal of respiratory and critical care medicine

authors： Marchal-Sommé J,Uzunhan Y,Marchand-Adam S,Kambouchner M,Valeyre D,Crestani B,Soler P

更新日期：2007-11-15 00:00:00

abstract：RATIONALE:The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major challenge due to lack of effective drug therapy or accurate indicators for disease progression. Fibrocytes are circulating mesenchymal cell progenitors that are involved in tissue repair and fibrosis. OBJECTIVES:To test the hypoth...

journal_title：American journal of respiratory and critical care medicine

authors： Moeller A,Gilpin SE,Ask K,Cox G,Cook D,Gauldie J,Margetts PJ,Farkas L,Dobranowski J,Boylan C,O'Byrne PM,Strieter RM,Kolb M

更新日期：2009-04-01 00:00:00

abstract：:The aim of this study was to evaluate the effect of two body positions (supine and semirecumbency) on the dynamics of gastroesophageal reflux (GER) in 15 patients requiring mechanical ventilation and having a nasogastric tube in place. Samples of gastric contents, pharyngeal and bronchial secretions, and blood were ob...

journal_title：American journal of respiratory and critical care medicine

authors： Orozco-Levi M,Torres A,Ferrer M,Piera C,el-Ebiary M,de la Bellacasa JP,Rodriguez-Roisin R

更新日期：1995-10-01 00:00:00

abstract：:Diseases of the respiratory tract are among the leading causes of death in the world population. Increasing evidence points to a key role of the innate immune system with its pattern recognition receptors (PRRs) in both infectious and noninfectious lung diseases, which include pneumonia, chronic obstructive pulmonary ...

journal_title：American journal of respiratory and critical care medicine

authors： Opitz B,van Laak V,Eitel J,Suttorp N

更新日期：2010-06-15 00:00:00

abstract：:Despite extensive research into the etiology and treatment of severe sepsis, little is known about its epidemiology in children. We sought to determine the age- and sex-adjusted incidence, outcome, and associated hospital costs of severe sepsis in United States children using 1995 hospital discharge and population dat...

journal_title：American journal of respiratory and critical care medicine

authors： Watson RS,Carcillo JA,Linde-Zwirble WT,Clermont G,Lidicker J,Angus DC

更新日期：2003-03-01 00:00:00

abstract：:The aim of this study was to assess positive end-expiratory pressure (PEEP)-induced lung overdistension and alveolar recruitment in six patients with acute lung injury (ALI) using a computed tomographic (CT) scan method. Lung overdistension was first determined in six healthy volunteers in whom CT sections were obtain...

journal_title：American journal of respiratory and critical care medicine

authors： Vieira SR,Puybasset L,Richecoeur J,Lu Q,Cluzel P,Gusman PB,Coriat P,Rouby JJ

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Systemic steroids are the standard treatment for bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) despite their poor efficacy and disabling side effects. OBJECTIVES:To evaluate the effectiveness and tolerance of budesonide/formoterol as an alternative tr...

journal_title：American journal of respiratory and critical care medicine

authors： Bergeron A,Chevret S,Chagnon K,Godet C,Bergot E,Peffault de Latour R,Dominique S,de Revel T,Juvin K,Maillard N,Reman O,Contentin N,Robin M,Buzyn A,Socié G,Tazi A

更新日期：2015-06-01 00:00:00

abstract：RATIONALE:Endobronchial ultrasound (EBUS) and electromagnetic navigation bronchoscopy (ENB) have increased the diagnostic yield of bronchoscopic diagnosis of peripheral lung lesions. However, the role of combining these modalities to overcome each individual technique's limitations and, consequently, to further increas...

journal_title：American journal of respiratory and critical care medicine

authors： Eberhardt R,Anantham D,Ernst A,Feller-Kopman D,Herth F

更新日期：2007-07-01 00:00:00

abstract：:Ventilation was measured in 31 difficult-to-wean patients while pressure support (PS) was reduced by 5 cm H2O every 20 min. Weaning had to be aborted in 14 of 31 patients (Group F) because they met predefined distress criteria. The remaining 17 patients who were able to complete the "weaning test" (Group S) had larger...

journal_title：American journal of respiratory and critical care medicine

authors： Stroetz RW,Hubmayr RD

更新日期：1995-09-01 00:00:00

abstract：:Little is known about the structural response of the diaphragm to controlled mechanical ventilation. We examined effects of this intervention on muscle mass, myosin heavy chain isoforms, and contractile function in the rat diaphragm. Animals were mechanically ventilated for up to 4 days, and comparisons were made with...

journal_title：American journal of respiratory and critical care medicine

authors： Yang L,Luo J,Bourdon J,Lin MC,Gottfried SB,Petrof BJ

更新日期：2002-10-15 00:00:00

abstract：:Humans exhibit an acute inflammatory response in the lungs after controlled laboratory exposure to ozone. The present study was designed to test whether biomarkers of inflammation are detectable in humans exposed to ozone and associated copollutants under natural conditions outdoors. Bronchoscopy with bronchoalveolar ...

journal_title：American journal of respiratory and critical care medicine

authors： Kinney PL,Nilsen DM,Lippmann M,Brescia M,Gordon T,McGovern T,El-Fawal H,Devlin RB,Rom WN

更新日期：1996-11-01 00:00:00

abstract：:Collections of sputum from 105 patients with newly diagnosed pulmonary tuberculosis were made before and at 1 and 2 d after the start of chemotherapy with isoniazid (INH) alone given to groups of patients in doses of 600 mg, 300 mg, 150 mg, 75 mg, 37.5 mg, 18.75 mg, and 9 mg daily, as well as from an untreated group. ...

journal_title：American journal of respiratory and critical care medicine

authors： Donald PR,Sirgel FA,Botha FJ,Seifart HI,Parkin DP,Vandenplas ML,Van de Wal BW,Maritz JS,Mitchison DA

更新日期：1997-09-01 00:00:00