Transforming growth factor-beta (TGF-beta) in silicosis.

abstract：RATIONALE:Although intensive care units (ICUs) were created for patients with life-threatening illnesses, the ICU environment generates a high risk of iatrogenic events. Identifying medical errors (MEs) that serve as indicators for iatrogenic risk is crucial for purposes of reporting and prevention. OBJECTIVES:We desc...

journal_title：American journal of respiratory and critical care medicine

authors： Garrouste-Orgeas M,Timsit JF,Vesin A,Schwebel C,Arnodo P,Lefrant JY,Souweine B,Tabah A,Charpentier J,Gontier O,Fieux F,Mourvillier B,Troché G,Reignier J,Dumay MF,Azoulay E,Reignier B,Carlet J,Soufir L,OUTCOMEREA Stu

更新日期：2010-01-15 00:00:00

abstract：BACKGROUND:The clinical utility of bronchoalveolar lavage fluid (BAL) cell analysis for the diagnosis and management of patients with interstitial lung disease (ILD) has been a subject of debate and controversy. The American Thoracic Society (ATS) sponsored a committee of international experts to examine all relevant l...

journal_title：American journal of respiratory and critical care medicine

authors： Meyer KC,Raghu G,Baughman RP,Brown KK,Costabel U,du Bois RM,Drent M,Haslam PL,Kim DS,Nagai S,Rottoli P,Saltini C,Selman M,Strange C,Wood B,American Thoracic Society Committee on BAL in Interstitial Lung Disease.

更新日期：2012-05-01 00:00:00

abstract：:In animal models of endotoxemia, sepsis is associated with the accumulation of leukocytes and altered microvascular perfusion. In order to test the hypothesis that bacterial sepsis upregulates leukocyte-endothelial adhesion, we used intravital microscopy to examine the flow behavior of leukocytes in the postcapillary ...

journal_title：American journal of respiratory and critical care medicine

authors： Piper RD,Pitt-Hyde ML,Anderson LA,Sibbald WJ,Potter RF

更新日期：1998-01-01 00:00:00

abstract：:We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma pathogenesis. Compatible with a central role for eosinophils and mast cells in asthma, sputum of asthmatic subjects c...

journal_title：American journal of respiratory and critical care medicine

authors： Louis R,Shute J,Biagi S,Stanciu L,Marrelli F,Tenor H,Hidi R,Djukanović R

更新日期：1997-02-01 00:00:00

abstract：:Although considerable evidence indicates a role for CD4(+) T lymphocytes (T cells) in airway inflammation, little data exist regarding the mechanisms underlying the induction and regulation of CD4(+) T cell reactivity to lung-specific antigens. To dissect the immunologic and molecular mechanisms of CD4(+) T cell dysre...

journal_title：American journal of respiratory and critical care medicine

authors： Bruder D,Westendorf AM,Geffers R,Gruber AD,Gereke M,Enelow RI,Buer J

更新日期：2004-12-01 00:00:00

abstract：:The lungs of newborn rats exposed to 60% oxygen for 14 days develop an injury that shares morphologic similarities to human bronchopulmonary dysplasia (BPD). Neutrophil influx into the lung, as part of an inflammatory response, may play a pivotal role in the development of BPD. A neutrophil chemokine, cytokine-induced...

journal_title：American journal of respiratory and critical care medicine

authors： Yi M,Jankov RP,Belcastro R,Humes D,Copland I,Shek S,Sweezey NB,Post M,Albertine KH,Auten RL,Tanswell AK

更新日期：2004-12-01 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：American journal of respiratory and critical care medicine

authors： Kanwar BA

更新日期：2020-10-07 00:00:00

abstract：:A study was done to compare the efficacy and safety of the coprescription of salmeterol 50 microgram twice daily or 100 microgram twice daily with beclomethasone dipropionate (BDP) 500 micrograms twice daily (SALM 50 and SALM 100) with BDP 1,000 microgram twice daily (BDP 1,000) in patients with asthma not controlled ...

journal_title：American journal of respiratory and critical care medicine

authors： Woolcock A,Lundback B,Ringdal N,Jacques LA

更新日期：1996-05-01 00:00:00

abstract：:Ventilatory responses to peripheral chemoreceptor stimuli are absent in patients with Prader-Willi syndrome (PWS) during wakefulness. Because arousal from sleep after rapidly developing hypoxia may require intact peripheral chemoreceptor function, we hypothesized that blunted hypoxic arousal responses during sleep Sta...

journal_title：American journal of respiratory and critical care medicine

authors： Arens R,Gozal D,Burrell BC,Bailey SL,Bautista DB,Keens TG,Ward SL

更新日期：1996-01-01 00:00:00

abstract：:We have recently demonstrated the development of systemic hypertension in a canine model of obstructive sleep apnea (OSA), but the underlying physiological mechanisms were not identified. Therefore, the purpose of this study was to examine the effect of OSA on arterial baroreceptor control of heart rate (HR) in this c...

journal_title：American journal of respiratory and critical care medicine

authors： Brooks D,Horner RL,Floras JS,Kozar LF,Render-Teixeira CL,Phillipson EA

更新日期：1999-04-01 00:00:00

abstract：:CD14 influences postnatal switching of T helper cell responses. CD14 C-159T has been associated with altered CD14 and IgE levels in cross-sectional studies. Identifying whether associations vary with age requires data from children of the same age followed longitudinally over many years. In this study, an unselected p...

journal_title：American journal of respiratory and critical care medicine

authors： O'Donnell AR,Toelle BG,Marks GB,Hayden CM,Laing IA,Peat JK,Goldblatt J,Le Souëf PN

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：RATIONALE:The relative contribution of body proportion and social exposures to ethnic differences in lung function has not previously been reported in the United Kingdom. OBJECTIVES:To examine ethnic differences in lung function in relation to anthropometry and social and psychosocial factors in early adolescence. ME...

journal_title：American journal of respiratory and critical care medicine

authors： Whitrow MJ,Harding S

更新日期：2008-06-01 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR nuclear hormone receptor family, but the role of PPAR-β/δ in sepsis is unknown. OBJECTIVES:We investigated the role of PPAR-β/δ in murine models of LPS-induced organ injury and dysfunction and cecal ligat...

journal_title：American journal of respiratory and critical care medicine

authors： Kapoor A,Shintani Y,Collino M,Osuchowski MF,Busch D,Patel NS,Sepodes B,Castiglia S,Fantozzi R,Bishop-Bailey D,Mota-Filipe H,Yaqoob MM,Suzuki K,Bahrami S,Desvergne B,Mitchell JA,Thiemermann C

更新日期：2010-12-15 00:00:00

abstract：:We examined the efficacy and the acceptance of an oral device (SnorEx) causing a forward displacement of the tongue for the treatment of sleep-disordered breathing (SDB). Twenty-three consecutive subjects with SDB were investigated. Noncompliance (NC) of use of the oral appliance was observed in 74% (17 of 23) of the ...

journal_title：American journal of respiratory and critical care medicine

authors： Schönhofer B,Stoohs RA,Rager H,Wenzel M,Wenzel G,Köhler D

更新日期：1997-02-01 00:00:00

abstract：:Snoring and sleeping apnea are reportedly associated with morbidity. We used home monitoring (MESAM IV) to measure snoring and sleep apnea in 294 men aged 40 to 65 yr from the volunteer register of the Busselton (Australia) Health Survey. In this group, 81% snored for more than 10% of the night and 22% for more than h...

journal_title：American journal of respiratory and critical care medicine

authors： Bearpark H,Elliott L,Grunstein R,Cullen S,Schneider H,Althaus W,Sullivan C

更新日期：1995-05-01 00:00:00

abstract：:Smoking is the major risk factor for chronic respiratory symptoms, but dietary factors may also play a role. Most studies of diet and lung disease have been cross-sectional and conducted in populations with a Western-style diet. We analyzed the relation between dietary intake at baseline and new onset of cough with ph...

journal_title：American journal of respiratory and critical care medicine

authors： Butler LM,Koh WP,Lee HP,Yu MC,London SJ

更新日期：2004-08-01 00:00:00

abstract：:This is a study of the reliability of peak expiratory flow (PEF) monitoring using a portable computerized peak flow meter, the VMX Mini-log, in 17 subjects referred for suspected occupational asthma. Subjects were requested to monitor their PEF six times daily using the VMX Mini-Log for 2 wk at work and at least 10 d ...

journal_title：American journal of respiratory and critical care medicine

authors： Quirce S,Contreras G,Dybuncio A,Chan-Yeung M

更新日期：1995-09-01 00:00:00

abstract：:We examined the influence of gender on the polysomnographic features of obstructive sleep apnea (OSA) in a retrospective study of 830 patients with OSA diagnosed by overnight polysomnography (PSG). The severity of OSA was determined from the apnea- hypopnea index (AHI) for total sleep time (AHI(TST)), and was classifi...

journal_title：American journal of respiratory and critical care medicine

authors： O'Connor C,Thornley KS,Hanly PJ

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:Tezacaftor (formerly VX-661) is an investigational small molecule that improves processing and trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in vitro, and improves CFTR function alone and in combination with ivacaftor. OBJECTIVES:To evaluate the safety and efficacy of tezacaft...

journal_title：American journal of respiratory and critical care medicine

authors： Donaldson SH,Pilewski JM,Griese M,Cooke J,Viswanathan L,Tullis E,Davies JC,Lekstrom-Himes JA,Wang LT,VX11-661-101 Study Group.

更新日期：2018-01-15 00:00:00

abstract：:Prior data indicate positive effects of long-term exercise interventions for cognitive functioning among patients with chronic obstructive pulmonary disease (COPD), but no prior studies have examined acute effects of individual bouts of exercise among patients with COPD. This study evaluated acute effects of exercise ...

journal_title：American journal of respiratory and critical care medicine

authors： Emery CF,Honn VJ,Frid DJ,Lebowitz KR,Diaz PT

更新日期：2001-11-01 00:00:00

abstract：RATIONALE:During acute lung injury (ALI) the macrophage pool expands markedly as inflammatory monocytes migrate from the circulation to the airspaces. As inflammation resolves, macrophage numbers return to preinjury levels and normal tissue structure and function are restored. OBJECTIVES:To determine the fate of resid...

journal_title：American journal of respiratory and critical care medicine

authors： Janssen WJ,Barthel L,Muldrow A,Oberley-Deegan RE,Kearns MT,Jakubzick C,Henson PM

更新日期：2011-09-01 00:00:00

abstract：:Phosphatidylglycerol (PG) and phosphatidylinositol (PI) are anionic phospholipids (APLs) present in lung surfactant of virtually all species studied, although their specific contribution to function is unknown. This study examines how APLs influence surfactant monolayer stability and adsorption under static and dynami...

journal_title：American journal of respiratory and critical care medicine

authors： Ingenito EP,Mora R,Mark L

更新日期：2000-03-01 00:00:00

abstract：RATIONALE:Cigarette smoke is the major risk factor in the development of chronic obstructive pulmonary disease (COPD). Lipidomics is a novel and emerging research field that may provide new insights in the origins of chronic inflammatory diseases, such as COPD. OBJECTIVES:To investigate whether expression of the sputu...

journal_title：American journal of respiratory and critical care medicine

authors： Telenga ED,Hoffmann RF,Ruben t'Kindt,Hoonhorst SJ,Willemse BW,van Oosterhout AJ,Heijink IH,van den Berge M,Jorge L,Sandra P,Postma DS,Sandra K,ten Hacken NH

更新日期：2014-07-15 00:00:00

abstract：:During exercise, children with congenital central hypoventilation syndrome (CCHS) demonstrate coupling of VE to exercise load, despite the absence of a VE response to changes in FICO2. To assess the effect of movement on VE, we studied six CCHS patients and six matched controls during passive motion in a motor-driven ...

journal_title：American journal of respiratory and critical care medicine

authors： Gozal D,Marcus CL,Ward SL,Keens TG

更新日期：1996-02-01 00:00:00

abstract：:The aim of this study was to determine the effects of maturation on crossbridge properties and myosin isoform composition in hamster diaphragm muscle. Diaphragm strips were obtained at postnatal Days 1 and 8 and in adults (10 to 12 wk). Peak isometric tension and maximum unloaded shortening velocity (Vmax) increased w...

journal_title：American journal of respiratory and critical care medicine

authors： Coirault C,Lambert F,Joseph T,Blanc FX,Chemla D,Lecarpentier Y

更新日期：1997-09-01 00:00:00

abstract：RATIONALE:The rate of progression of most interstitial lung diseases (ILD) is unpredictable. Fibrocytes are circulating bone marrow-derived cells that have been implicated in the pathogenesis of lung fibrosis. Hermansky-Pudlak syndrome (HPS), a genetic cause of ILD in early adulthood, allows for study of biomarkers of ...

journal_title：American journal of respiratory and critical care medicine

authors： Trimble A,Gochuico BR,Markello TC,Fischer R,Gahl WA,Lee JK,Kim Y,Burdick MD,Strieter RM,Mehrad B

更新日期：2014-12-15 00:00:00

abstract：BACKGROUND:Current classification of pulmonary hypertension (PH) is based on a relatively simple combination of patient characteristics and hemodynamics. This limits customization of treatment, and lacks the clarity of a more granular identification based on individual patient phenotypes. Rapid advances in mechanistic ...

journal_title：American journal of respiratory and critical care medicine

authors： Dweik RA,Rounds S,Erzurum SC,Archer S,Fagan K,Hassoun PM,Hill NS,Humbert M,Kawut SM,Krowka M,Michelakis E,Morrell NW,Stenmark K,Tuder RM,Newman J,ATS Committee on Pulmonary Hypertension Phenotypes.

更新日期：2014-02-01 00:00:00

abstract：:In complex diseases of genetic etiology such as asthma and atopy, it is difficult to differentiate causes of disease from consequences, and quantitate the importance of such causative factors. We examined possible risk factors for the development of wheezing and bronchial hyperresponsiveness in a cotwin-control study ...

journal_title：American journal of respiratory and critical care medicine

authors： Duffy DL,Mitchell CA,Martin NG

更新日期：1998-03-01 00:00:00

abstract：:Sepsis and cancer share a number of pathophysiological features, and both result from the inability of the host's immune system to cope with the initial insult (tissue invasion by pathogens and malignant cell transformation, respectively). The common coexistence of both disorders and the profound related alterations i...

journal_title：American journal of respiratory and critical care medicine

authors： Mirouse A,Vigneron C,Llitjos JF,Chiche JD,Mira JP,Mokart D,Azoulay E,Pène F

更新日期：2020-12-15 00:00:00