Sleep-disordered breathing and neuropsychological deficits. A population-based study.

abstract：:Cyclophosphamide-induced lung toxicity may be difficult to recognize because of the presence of confounding variables such as concomitant use of other cytotoxic drugs, opportunistic infections, diffuse pulmonary malignancy, radiation pneumonitis, and oxygen toxicity. The purpose of this retrospective analysis was to i...

journal_title：American journal of respiratory and critical care medicine

authors： Malik SW,Myers JL,DeRemee RA,Specks U

更新日期：1996-12-01 00:00:00

abstract：RATIONALE:Platelets may interact with the immune system in tuberculosis (TB) to regulate human inflammatory responses that lead to morbidity and spread of infection. OBJECTIVES:To identify a functional role of platelets in the innate inflammatory and matrix-degrading response in TB. METHODS:Markers of platelet activa...

journal_title：American journal of respiratory and critical care medicine

authors： Fox KA,Kirwan DE,Whittington AM,Krishnan N,Robertson BD,Gilman RH,López JW,Singh S,Porter JC,Friedland JS

更新日期：2018-07-15 00:00:00

abstract：:Reduced bronchodilatation in response to deep inspiration (DI) has been demonstrated in asthmatics. We have previously shown that inhibition of DI for 10 min or more during methacholine inhalation increases airway narrowing in normals. We tested the hypothesis that inhibition of DIs during methacholine inhalation in a...

journal_title：American journal of respiratory and critical care medicine

authors： King GG,Moore BJ,Seow CY,Paré PD

更新日期：2001-07-15 00:00:00

abstract：RATIONALE:Genetic alterations on 8p22 have been implicated in multiple cancers, including lung cancer. In this region, genetic variants of the class A scavenger receptor (SR-A) gene have been associated with prostate cancer risk and have been highlighted as a potential susceptibility gene of cancer. OBJECTIVES:To dete...

journal_title：American journal of respiratory and critical care medicine

authors： Ben J,Jin G,Zhang Y,Ma B,Bai H,Chen J,Zhang H,Gong Q,Zhou X,Zhang H,Qian L,Zhu X,Li X,Yang Q,Hu Z,Xu Y,Shen H,Chen Q

更新日期：2012-10-15 00:00:00

abstract：:Microscopic examination of tissue sections of mycobacterial lesions frequently results in few or no bacilli seen, even if the lesions appear active histologically. This might be due to the effects of the fixative fluid and/or organic solvent, both of which are conventionally used to make tissue sections for histopatho...

journal_title：American journal of respiratory and critical care medicine

authors： Fukunaga H,Murakami T,Gondo T,Sugi K,Ishihara T

更新日期：2002-10-01 00:00:00

abstract：:Damage to the airway epithelium is one prominent feature of chronic asthma. Corticosteroids induce apoptosis in inflammatory cells, which in part explains their ability to suppress airway inflammation. However, corticosteroid therapy does not necessarily reverse epithelial damage. We hypothesized that corticosteroids ...

journal_title：American journal of respiratory and critical care medicine

authors： Dorscheid DR,Wojcik KR,Sun S,Marroquin B,White SR

更新日期：2001-11-15 00:00:00

abstract：RATIONALE:Our understanding of how airway remodeling affects regional airway elastic properties is limited due to technical difficulties in quantitatively measuring dynamic, in vivo airway dimensions. Such knowledge could help elucidate mechanisms of excessive airway narrowing. OBJECTIVES:To use anatomical optical coh...

journal_title：American journal of respiratory and critical care medicine

authors： Williamson JP,McLaughlin RA,Noffsinger WJ,James AL,Baker VA,Curatolo A,Armstrong JJ,Regli A,Shepherd KL,Marks GB,Sampson DD,Hillman DR,Eastwood PR

更新日期：2011-03-01 00:00:00

abstract：:The use of noninvasive methods of monitoring airway inflammation, such as exhaled nitric oxide (eNO) and induced sputum, has been shown to improve asthma monitoring and optimize treatment in adult patients with asthma. There is a lack of comparable data in children. Forty children with stable asthma eligible for inhal...

journal_title：American journal of respiratory and critical care medicine

authors： Zacharasiewicz A,Wilson N,Lex C,Erin EM,Li AM,Hansel T,Khan M,Bush A

更新日期：2005-05-15 00:00:00

abstract：:The relationships between mite and cat allergen levels in the home, skin test reactivity, and severity of asthma were explored in 120 asthmatic subjects, 57 in Vancouver and 63 in Winnipeg. Patients in the two cities were similar in age, gender distribution, and severity of asthma. Skin tests were performed using 13 c...

journal_title：American journal of respiratory and critical care medicine

authors： Chan-Yeung M,Manfreda J,Dimich-Ward H,Lam J,Ferguson A,Warren P,Simons E,Broder I,Chapman M,Platts-Mills T

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:Staphylococcus aureus is a major pathogen complicating postsurgical care. OBJECTIVES:To test the effect of sterile laparotomy (LAP) on pulmonary clearance of S. aureus in a murine model. METHODS:Control and LAP mice were infected intranasally with 10(8) cfu of S. aureus. Microbial clearance, pulmonary leuko...

journal_title：American journal of respiratory and critical care medicine

authors： Olszewski MA,Falkowski NR,Surana R,Sonstein J,Hartman A,Moore BB,Huffnagle GB,Toews GB

更新日期：2007-11-01 00:00:00

abstract：RATIONALE:Asthma treatment might improve when inhaled steroids are titrated on airway inflammation. Fractional exhaled nitric oxide (FeNO0.05), a marker of eosinophilic airway inflammation, can be measured at home. OBJECTIVES:We assessed daily FeNO0.05 telemonitoring in the management of childhood asthma. METHODS:Chi...

journal_title：American journal of respiratory and critical care medicine

authors： de Jongste JC,Carraro S,Hop WC,CHARISM Study Group.,Baraldi E

更新日期：2009-01-15 00:00:00

abstract：:The hereditary thrombophilias are a group of inherited conditions that predispose to thrombosis. Heritable deficiencies of the endogenous anticoagulants protein C, protein S, and antithrombin have been recognized for some years, but their prevalence, even among patients with familial thrombosis, is low. The recent dis...

journal_title：American journal of respiratory and critical care medicine

authors： Murin S,Marelich GP,Arroliga AC,Matthay RA

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Although intensive care units (ICUs) were created for patients with life-threatening illnesses, the ICU environment generates a high risk of iatrogenic events. Identifying medical errors (MEs) that serve as indicators for iatrogenic risk is crucial for purposes of reporting and prevention. OBJECTIVES:We desc...

journal_title：American journal of respiratory and critical care medicine

authors： Garrouste-Orgeas M,Timsit JF,Vesin A,Schwebel C,Arnodo P,Lefrant JY,Souweine B,Tabah A,Charpentier J,Gontier O,Fieux F,Mourvillier B,Troché G,Reignier J,Dumay MF,Azoulay E,Reignier B,Carlet J,Soufir L,OUTCOMEREA Stu

更新日期：2010-01-15 00:00:00

abstract：:Asthma in children and young adults is strongly associated with immediate hypersensitivity to indoor allergens, notably those derived from the house dust mite. In addition, outdoor air pollution is considered to aggravate existing asthma. We investigated the prevalence of asthma and the pattern of allergen sensitizati...

journal_title：American journal of respiratory and critical care medicine

authors： Sporik R,Ingram JM,Price W,Sussman JH,Honsinger RW,Platts-Mills TA

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:Smoking is the largest contributor to lung cancer risk, and those who continue to smoke after diagnosis have a worse survival. Screening for lung cancer with low-dose computed tomography (LDCT) reduces mortality in high-risk individuals. Smoking cessation is an essential component of a high-quality screening ...

journal_title：American journal of respiratory and critical care medicine

authors： Tanner NT,Kanodra NM,Gebregziabher M,Payne E,Halbert CH,Warren GW,Egede LE,Silvestri GA

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. The pleiotropic cytokine tumor necrosis factor-alpha is essential to control tuberculosis infection, and various tumor necrosis factor family members and their respecti...

journal_title：American journal of respiratory and critical care medicine

authors： Möller M,Flachsbart F,Till A,Thye T,Horstmann RD,Meyer CG,Osei I,van Helden PD,Hoal EG,Schreiber S,Nebel A,Franke A

更新日期：2010-02-15 00:00:00

abstract：RATIONALE:Sublingual allergen-specific immunotherapy is gaining popularity for treatment of allergic diseases, but underlying immunological mechanisms are unresolved. OBJECTIVES:To perform detailed immunological investigation of sublingual house dust mite (HDM) immunotherapy. METHODS:A 12-month randomized double-blin...

journal_title：American journal of respiratory and critical care medicine

authors： O'Hehir RE,Gardner LM,de Leon MP,Hales BJ,Biondo M,Douglass JA,Rolland JM,Sandrini A

更新日期：2009-11-15 00:00:00

abstract：:Burkholderia gladioli has been reported as colonizing the airways of patients with cystic fibrosis (CF) but has not previously been associated with adverse outcome. We describe six patients with CF in whom the same strain of B. gladioli, on the basis of ribotyping and biochemical characteristics, was grown in their sp...

journal_title：American journal of respiratory and critical care medicine

authors： Wilsher ML,Kolbe J,Morris AJ,Welch DF

更新日期：1997-04-01 00:00:00

abstract：:Although there is abundant clinical evidence of asthmatic responses to indoor aeroallergens, the symptomatic impacts of other common indoor air pollutants from gas stoves, fireplaces, and environmental tobacco smoke have been less well characterized. These combustion sources produce a complex mixture of pollutants, ma...

journal_title：American journal of respiratory and critical care medicine

authors： Ostro BD,Lipsett MJ,Mann JK,Wiener MB,Selner J

更新日期：1994-06-01 00:00:00

abstract：:We investigated the source of intravascular fat in systemic organs (brain, heart, and kidney) after massive pulmonary fat embolism during cemented arthroplasty. We used a bilateral cemented arthroplasty (BCA) in anesthetized mongrel dogs that simulates a cemented total-hip replacement procedure. We hypothesized that d...

journal_title：American journal of respiratory and critical care medicine

authors： Byrick RJ,Mullen JB,Mazer CD,Guest CB

更新日期：1994-11-01 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR nuclear hormone receptor family, but the role of PPAR-β/δ in sepsis is unknown. OBJECTIVES:We investigated the role of PPAR-β/δ in murine models of LPS-induced organ injury and dysfunction and cecal ligat...

journal_title：American journal of respiratory and critical care medicine

authors： Kapoor A,Shintani Y,Collino M,Osuchowski MF,Busch D,Patel NS,Sepodes B,Castiglia S,Fantozzi R,Bishop-Bailey D,Mota-Filipe H,Yaqoob MM,Suzuki K,Bahrami S,Desvergne B,Mitchell JA,Thiemermann C

更新日期：2010-12-15 00:00:00

abstract：RATIONALE:Although intermittent, three-times-weekly therapy is recommended for the initial treatment of noncavitary nodular bronchiectatic Mycobacterium avium complex (MAC) lung disease, supporting data are limited. OBJECTIVES:To evaluate the clinical efficacy of intermittent therapy compared with daily therapy for no...

journal_title：American journal of respiratory and critical care medicine

authors： Jeong BH,Jeon K,Park HY,Kim SY,Lee KS,Huh HJ,Ki CS,Lee NY,Shin SJ,Daley CL,Koh WJ

更新日期：2015-01-01 00:00:00

abstract：RATIONALE:From the late 1970s to the early 1990s, studies found that mortality rates for pulmonary fibrosis were increasing. Recent data for mortality from pulmonary fibrosis are unavailable. OBJECTIVES:We sought to determine mortality rates for pulmonary fibrosis in the United States from 1992 through 2003. METHODS:...

journal_title：American journal of respiratory and critical care medicine

authors： Olson AL,Swigris JJ,Lezotte DC,Norris JM,Wilson CG,Brown KK

更新日期：2007-08-01 00:00:00

abstract：:Bronchial hyperresponsiveness (BHR), the increased sensitivity to a wide variety of stimuli that narrow the airways, is a central abnormality in patients with asthma, and is frequently observed in patients with chronic obstructive pulmonary disease. In the study of the underlying mechanisms of BHR, various animal mode...

journal_title：American journal of respiratory and critical care medicine

authors： Rabe KF

更新日期：1998-11-01 00:00:00

abstract：:The mechanism responsible for diminished exercise performance in cystic fibrosis (CF) is not clear. We hypothesized that reduced muscle size, rather than an intrinsic muscle defect, was the primary factor in such diminished exercise performance. Twenty-two subjects with CF (14 females and eight males, aged 6.5 to 17.7...

journal_title：American journal of respiratory and critical care medicine

authors： Moser C,Tirakitsoontorn P,Nussbaum E,Newcomb R,Cooper DM

更新日期：2000-11-01 00:00:00

abstract：:The virulence of Pseudomonas aeruginosa is partly controlled by the las quorum-sensing system. A rat model of acute pneumonia was used to investigate the pathophysiological impact of this system by comparing the virulence of the wild-type virulent laboratory strain PAO1 with that of its lasR-deleted mutant PAOR. In co...

journal_title：American journal of respiratory and critical care medicine

authors： Lesprit P,Faurisson F,Join-Lambert O,Roudot-Thoraval F,Foglino M,Vissuzaine C,Carbon C

更新日期：2003-06-01 00:00:00

abstract：:The predisposing factors and complications of unplanned extubation (UEX) in mechanically ventilated adult patients are not well recognized. We designed a prospective multicenter observational study to identify risk factors and describe the complications of UEX. We followed 426 ventilated patients over a 2-mo period. C...

journal_title：American journal of respiratory and critical care medicine

authors： Boulain T

更新日期：1998-04-01 00:00:00

abstract：RATIONALE:Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD). OBJECTIVES:To examine whether these medications might be associated with an excess risk of pneumonia. METHODS:We conducted a nested case-control study within a cohort of patients with COPD from Que...

journal_title：American journal of respiratory and critical care medicine

authors： Ernst P,Gonzalez AV,Brassard P,Suissa S

更新日期：2007-07-15 00:00:00

abstract：:To gain insight into the source of exhaled nitric oxide (NO) in normal humans, we examined the effects of respiratory pattern on the concentration of NO in exhaled air while subjects were wearing a noseclip and then under endotracheal intubation, using a specially designed gas sampling system to separate exhaled air i...

journal_title：American journal of respiratory and critical care medicine

authors： Tsujino I,Miyamoto K,Nishimura M,Shinano H,Makita H,Saito S,Nakano T,Kawakami Y

更新日期：1996-11-01 00:00:00

abstract：:Exogenous surfactant therapy is not standard in the acute respiratory distress syndrome (ARDS) because of a lack of proven benefit. Nonuniform surfactant distribution after either bolus or aerosol administration may be an important factor limiting response. In a previous study of acute lung injury, we demonstrated tha...

journal_title：American journal of respiratory and critical care medicine

authors： Balaraman V,Meister J,Ku TL,Sood SL,Tam E,Killeen J,Uyehara CF,Egan E,Easa D

更新日期：1998-07-01 00:00:00