Effect of laparotomy on clearance and cytokine induction in Staphylococcus aureus infected lungs.

abstract：:We investigated the source of intravascular fat in systemic organs (brain, heart, and kidney) after massive pulmonary fat embolism during cemented arthroplasty. We used a bilateral cemented arthroplasty (BCA) in anesthetized mongrel dogs that simulates a cemented total-hip replacement procedure. We hypothesized that d...

journal_title：American journal of respiratory and critical care medicine

authors： Byrick RJ,Mullen JB,Mazer CD,Guest CB

更新日期：1994-11-01 00:00:00

abstract：:We used various ovalbumin sensitization and challenge protocols to determine the importance of the route of allergen administration and the genetic background in modulating the physiologic, inflammatory, and immunologic features characteristic of allergen-induced asthma. In BALB/c mice, induction of maximal airway hyp...

journal_title：American journal of respiratory and critical care medicine

authors： Zhang Y,Lamm WJ,Albert RK,Chi EY,Henderson WR Jr,Lewis DB

更新日期：1997-02-01 00:00:00

abstract：RATIONALE:Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD). OBJECTIVES:To examine whether these medications might be associated with an excess risk of pneumonia. METHODS:We conducted a nested case-control study within a cohort of patients with COPD from Que...

journal_title：American journal of respiratory and critical care medicine

authors： Ernst P,Gonzalez AV,Brassard P,Suissa S

更新日期：2007-07-15 00:00:00

abstract：:Impaired lung epithelial Na(+) channel (ENaC) activity at the time of birth results in respiratory distress. To investigate potential mechanisms, the ontogeny and cellular distribution of the alphaENaC subunit mRNA expression was studied in normal, immature, and abnormal (hypoplastic) human fetal lungs using nonradioi...

journal_title：American journal of respiratory and critical care medicine

authors： Smith DE,Otulakowski G,Yeger H,Post M,Cutz E,O'Brodovich HM

更新日期：2000-04-01 00:00:00

abstract：:The demand for intensivists is increasing around the world, not only to meet the needs of a growing aging population, but also to fill positions in the intensive care unit now occupied by other specialists, since there is compelling evidence that the presence of critical care practitioners improves patient outcomes. N...

journal_title：American journal of respiratory and critical care medicine

authors： Estenssoro E,Valente Barbas CS,Briva A

更新日期：2013-01-15 00:00:00

abstract：RATIONALE:Sarcoidosis is known as a disease with high heterogeneity in clinical severity and inflammatory activity. On the basis of radiologic criteria, John Guyette Scadding developed a classification system, which is widely used, but is insufficient for clinical decision making. Therefore, biomarkers and genetic mark...

journal_title：American journal of respiratory and critical care medicine

authors： Prasse A,Katic C,Germann M,Buchwald A,Zissel G,Müller-Quernheim J

更新日期：2008-02-01 00:00:00

abstract：:The aim of this prospective study was to detect subjects in the general population with objective signs of chronic obstructive pulmonary disease (COPD) or asthma at an early stage. This was done by means of a two-stage protocol involving screening and a subsequent 2-yr monitoring of all subjects with positive results ...

journal_title：American journal of respiratory and critical care medicine

authors： van den Boom G,van Schayck CP,van Möllen MP,Tirimanna PR,den Otter JJ,van Grunsven PM,Buitendijk MJ,van Herwaarden CL,van Weel C

更新日期：1998-12-01 00:00:00

abstract：RATIONALE:HIV-1-induced interstitial pneumonitis (IP) is a serious complication of HIV-1 infection, characterized by inflammation and cellular infiltration in lungs, often leading to respiratory failure and death. The barrier function of the pulmonary endothelium is caused in part by tight junction (TJ) proteins, such ...

journal_title：American journal of respiratory and critical care medicine

authors： Li H,Singh S,Potula R,Persidsky Y,Kanmogne GD

更新日期：2014-07-01 00:00:00

abstract：:Fibrosing alveolitis may occur alone (CFA) or in association with systemic sclerosis (FASSc). FASSc was recently shown to have a prognostic advantage over CFA. Because interleukin-8 (IL-8) is likely to be a major determinant of neutrophil alveolitis, we evaluated IL-8 expression in patients with CFA and FASSc and comp...

journal_title：American journal of respiratory and critical care medicine

authors： Southcott AM,Jones KP,Li D,Majumdar S,Cambrey AD,Pantelidis P,Black CM,Laurent GJ,Davies BH,Jeffery PK

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:Patients with acute lung injury have impaired function of the lung surfactant system. Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation and have suggested that treatment of patients with severe d...

journal_title：American journal of respiratory and critical care medicine

authors： Spragg RG,Taut FJ,Lewis JF,Schenk P,Ruppert C,Dean N,Krell K,Karabinis A,Günther A

更新日期：2011-04-15 00:00:00

abstract：:To investigate repair mechanisms in bleomycin-induced pulmonary fibrosis, we used mice deficient in gamma-glutamyl transpeptidase (GGT-/-), a key enzyme in glutathione (GSH) and cysteine metabolism. Seventy-two hours after bleomycin (0.03 U/g), GGT-/- mice displayed a different inflammatory response to wild-type mice ...

journal_title：American journal of respiratory and critical care medicine

authors： Pardo A,Ruiz V,Arreola JL,Ramírez R,Cisneros-Lira J,Gaxiola M,Barrios R,Kala SV,Lieberman MW,Selman M

更新日期：2003-03-15 00:00:00

abstract：RATIONALE:Th2 cytokines play an important role in allergic diseases. These cytokines activate signal transduction pathways, including Janus kinase/signal transducer and activator of transcription (STAT) signaling. Although the suppressor of cytokine signaling (SOCS) family protein, a negative regulator of the Janus kin...

journal_title：American journal of respiratory and critical care medicine

authors： Fukuyama S,Nakano T,Matsumoto T,Oliver BG,Burgess JK,Moriwaki A,Tanaka K,Kubo M,Hoshino T,Tanaka H,McKenzie AN,Matsumoto K,Aizawa H,Nakanishi Y,Yoshimura A,Black JL,Inoue H

更新日期：2009-06-01 00:00:00

abstract：:We examined endotoxin exposure and wheezing episodes during the first year of life in a birth cohort of 499 infants with one or both parents having a history of asthma or allergy. We measured endotoxin in settled dust from the baby's bed, bedroom floor, family room, and kitchen floor within the first 3 mo after birth....

journal_title：American journal of respiratory and critical care medicine

authors： Park JH,Gold DR,Spiegelman DL,Burge HA,Milton DK

更新日期：2001-02-01 00:00:00

abstract：:Airway remodeling may lead to irreversible loss of lung function in asthma. The impact of childhood asthma, airway responsiveness, atopy, and smoking on airway remodeling was investigated in a birth cohort studied longitudinally to age 26. A low postbronchodilator ratio of forced exhaled volume in 1 second (FEV1) to v...

journal_title：American journal of respiratory and critical care medicine

authors： Rasmussen F,Taylor DR,Flannery EM,Cowan JO,Greene JM,Herbison GP,Sears MR

更新日期：2002-06-01 00:00:00

abstract：:Nanoparticle-based drug delivery systems have considerable potential for treatment of tuberculosis (TB). The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility ...

journal_title：American journal of respiratory and critical care medicine

authors： Gelperina S,Kisich K,Iseman MD,Heifets L

更新日期：2005-12-15 00:00:00

abstract：:Previous studies have shown an increased number of inflammatory cells and, in particular, CD8+ve cells in the airways of smokers with chronic obstructive pulmonary disease (COPD). In this study we investigated whether a similar inflammatory process is also present in the lungs, and particularly in lung parenchyma and ...

journal_title：American journal of respiratory and critical care medicine

authors： Saetta M,Baraldo S,Corbino L,Turato G,Braccioni F,Rea F,Cavallesco G,Tropeano G,Mapp CE,Maestrelli P,Ciaccia A,Fabbri LM

更新日期：1999-08-01 00:00:00

abstract：RATIONALE:The sympathetic nervous system has been reported to be activated in pulmonary arterial hypertension (PAH). OBJECTIVES:We investigated the prognostic significance of muscle sympathetic nervous system activity (MSNA) in PAH. METHODS:Thirty-two patients with PAH were included in the study and underwent a measu...

journal_title：American journal of respiratory and critical care medicine

authors： Ciarka A,Doan V,Velez-Roa S,Naeije R,van de Borne P

更新日期：2010-06-01 00:00:00

abstract：RATIONALE:Chronic hypoxia induces pulmonary vascular remodeling, pulmonary hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms driving these responses. Hypoxia-inducible factor-1α (HIF-1α) is a master regulator of transcription in hypoxic cells, up-regulating genes involved in ...

journal_title：American journal of respiratory and critical care medicine

authors： Ball MK,Waypa GB,Mungai PT,Nielsen JM,Czech L,Dudley VJ,Beussink L,Dettman RW,Berkelhamer SK,Steinhorn RH,Shah SJ,Schumacker PT

更新日期：2014-02-01 00:00:00

abstract：:Patients with pulmonary Mycobacterium avium complex (MAC) infection occasionally have neither past histories of pulmonary diseases nor underlying immunodeficiency conditions. Therefore, we hypothesized that MAC may be linked with a disease-susceptibility gene and determined human leukocyte-associated antigens (HLA) in...

journal_title：American journal of respiratory and critical care medicine

authors： Takahashi M,Ishizaka A,Nakamura H,Kobayashi K,Nakamura M,Namiki M,Sekita T,Okajima S

更新日期：2000-07-01 00:00:00

abstract：RATIONALE:The majority of previous studies investigating asthma genetics have focused on cohorts with stable disease and have not defined mechanisms important during acute asthma. CD14 and CC16 each play a key role in biologically important inflammatory pathways and the gene of each has a functional promoter-region pol...

journal_title：American journal of respiratory and critical care medicine

authors： Martin AC,Laing IA,Khoo SK,Zhang G,Rueter K,Teoh L,Taheri S,Hayden CM,Geelhoed GC,Goldblatt J,LeSouëf PN

更新日期：2006-03-15 00:00:00

abstract：:Collapsibility of the active pharynx, where active contraction of the upper airway muscles is evident, was previously reported to be higher in children with obstructive sleep apnea (OSA) than in those with primary snoring during sleep. Contribution of neuromuscular and anatomic factors to the increased collapsibility,...

journal_title：American journal of respiratory and critical care medicine

authors： Isono S,Shimada A,Utsugi M,Konno A,Nishino T

更新日期：1998-04-01 00:00:00

abstract：:The role of lipoxygenase metabolites in the pathogenesis of endotoxin (LPS)-induced lung injury remains to be clarified. We investigated the contribution of peptide leukotrienes to LPS-induced acute lung injury using a potent antagonist, ONO-1078 (ONO). Experimental groups consisted of a saline group (n = 10), an LPS ...

journal_title：American journal of respiratory and critical care medicine

authors： Ishizaka A,Hasegawa N,Sakamaki F,Tasaka S,Nakamura H,Kishikawa K,Yamada A,Obata T,Sayama K,Urano T

更新日期：1994-11-01 00:00:00

abstract：:We prospectively investigated the mechanism of airflow limitation before and after targeted emphysematous resection in 12 consecutively studied adult patients 68 +/- 4 yr of age (mean +/- SD) with very severe COPD undergoing bilateral thoracoscopic stapling techniques. Lung function, static lung elastic recoil, and ai...

journal_title：American journal of respiratory and critical care medicine

authors： Gelb AF,Zamel N,McKenna RJ Jr,Brenner M

更新日期：1996-10-01 00:00:00

abstract：RATIONALE:Although intensive care units (ICUs) were created for patients with life-threatening illnesses, the ICU environment generates a high risk of iatrogenic events. Identifying medical errors (MEs) that serve as indicators for iatrogenic risk is crucial for purposes of reporting and prevention. OBJECTIVES:We desc...

journal_title：American journal of respiratory and critical care medicine

authors： Garrouste-Orgeas M,Timsit JF,Vesin A,Schwebel C,Arnodo P,Lefrant JY,Souweine B,Tabah A,Charpentier J,Gontier O,Fieux F,Mourvillier B,Troché G,Reignier J,Dumay MF,Azoulay E,Reignier B,Carlet J,Soufir L,OUTCOMEREA Stu

更新日期：2010-01-15 00:00:00

abstract：RATIONALE:Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM). OBJECTIVES:To relate ASM hypertrophy, ASM hyperplasia, and deposition of ECM to the severity and duration of asthma. METHODS:Airways from ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Elliot JG,Jones RL,Carroll ML,Mauad T,Bai TR,Abramson MJ,McKay KO,Green FH

更新日期：2012-05-15 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a generally fatal disorder with a reported median survival of 3 to 6 yr. This has been based on relatively few studies with diagnoses inconsistently confirmed by adequate lung biopsy. Retrospective analysis of 104 patients with IPF who had open lung biopsy (OLB) at Mayo Medical C...

journal_title：American journal of respiratory and critical care medicine

authors： Bjoraker JA,Ryu JH,Edwin MK,Myers JL,Tazelaar HD,Schroeder DR,Offord KP

更新日期：1998-01-01 00:00:00

abstract：:Nebulized aerosols are commonly used to deliver drugs into the lungs of patients with cystic fibrosis (CF). The aim of this study was to assess the effectiveness of pressure-support (PS) ventilation in increasing aerosol deposition within the lungs of children with CF. An in vitro study demonstrated the feasibility of...

journal_title：American journal of respiratory and critical care medicine

authors： Fauroux B,Itti E,Pigeot J,Isabey D,Meignan M,Ferry G,Lofaso F,Willemot JM,Clément A,Harf A

更新日期：2000-12-01 00:00:00

abstract：:Salbutamol inhibits neutropenia, increased airway resistance, and gas exchange abnormalities provoked by platelet-activating factor (PAF) challenge in normal persons. To further explore the intriguing dissociation between spirometric abnormalities and gas exchange defects shown in patients with asthma, we investigated...

journal_title：American journal of respiratory and critical care medicine

authors： Díaz O,Barberà JA,Marrades R,Chung KF,Roca J,Rodriguez-Roisin R

更新日期：1997-07-01 00:00:00

abstract：:The nasal mucosal is the first site of contact with inhaled antigens. However, the nature of local immune responses and the role of nasal-associated lymphoid tissue (NALT) in those responses have rarely been studied. To characterize the cells involved in mucosally derived immune responses, NALT and Peyer's patch (PP) ...

journal_title：American journal of respiratory and critical care medicine

authors： Heritage PL,Underdown BJ,Arsenault AL,Snider DP,McDermott MR

更新日期：1997-10-01 00:00:00

abstract：:The remarkable success of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in patients with EGFR mutations and ALK rearrangements, respectively, introduced the era of targeted therapy in advanced non-small cell lung cancer (NSCLC), shifting treatment from platinum...

journal_title：American journal of respiratory and critical care medicine

authors： Cardarella S,Johnson BE

更新日期：2013-10-01 00:00:00