Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease.

abstract：:We hypothesized that ischemia/reperfusion (I/R) injury of the liver during normotensive gram-negative bacteremic sepsis alters the kinetics of circulating endotoxin, tumor necrosis factor-alpha (TNF-alpha), and coinduced mediators, thereby exacerbating sepsis-induced lung inflammation. Liver and lung dysfunction were ...

journal_title：American journal of respiratory and critical care medicine

authors： Matuschak GM,Henry KA,Johanns CA,Lechner AJ

更新日期：2001-03-01 00:00:00

abstract：RATIONALE:Severe asthma is a major public health issue throughout the world. Increased bronchial smooth muscle (BSM) mass, a characteristic feature of airway remodeling in severe asthma, is associated with resistance to high-intensity treatment and poor prognosis. In vitro, the Ca(2+)-channel blocker gallopamil decreas...

journal_title：American journal of respiratory and critical care medicine

authors： Girodet PO,Dournes G,Thumerel M,Begueret H,Dos Santos P,Ozier A,Dupin I,Trian T,Montaudon M,Laurent F,Marthan R,Berger P

更新日期：2015-04-15 00:00:00

abstract：:The potential role of atypical bacterial infection in the pathogenesis of asthma is a subject of continuing debate. There is an increasing body of literature concerning the association between the atypical bacteria Chlamydophila pneumoniae and Mycoplasma pneumoniae and asthma pathogenesis; however, many studies invest...

journal_title：American journal of respiratory and critical care medicine

authors： Johnston SL,Martin RJ

更新日期：2005-11-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a syndrome of chronic wasting, in part associated with a chronic inflammatory response. The aim of this study was to investigate cross-sectionally and prospectively the potential role of leptin in relation to systemic inflammation in the regulation of the energy balance ...

journal_title：American journal of respiratory and critical care medicine

authors： Schols AM,Creutzberg EC,Buurman WA,Campfield LA,Saris WH,Wouters EF

更新日期：1999-10-01 00:00:00

abstract：RATIONALE:Childhood sleep-disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience s...

journal_title：American journal of respiratory and critical care medicine

authors： Tamanyan K,Walter LM,Weichard A,Davey MJ,Nixon GM,Biggs SN,Horne RSC

更新日期：2018-06-01 00:00:00

abstract：:The bactericidal activities of several once-weekly rifapentine (P)-containing combination regimens against Mycobacterium tuberculosis, and their ability to prevent the selection of rifampin (R)-resistant mutants, were compared with those of the standard six-times-weekly regimen consisting of R, isoniazid (H), and pyra...

journal_title：American journal of respiratory and critical care medicine

authors： Grosset J,Lounis N,Truffot-Pernot C,O'Brien RJ,Raviglione MC,Ji B

更新日期：1998-05-01 00:00:00

abstract：RATIONALE:Increasing epithelial repair and regeneration may hasten resolution of lung injury in patients with the acute respiratory distress syndrome (ARDS). In animal models of ARDS, keratinocyte growth factor (KGF) reduces injury and increases epithelial proliferation and repair. The effect of KGF in the human alveol...

journal_title：American journal of respiratory and critical care medicine

authors： Shyamsundar M,McAuley DF,Ingram RJ,Gibson DS,O'Kane D,McKeown ST,Edwards A,Taggart C,Elborn JS,Calfee CS,Matthay MA,O'Kane CM

更新日期：2014-06-15 00:00:00

abstract：:Airway pathology has been extensively investigated in adulthood asthma, whereas only few studies examined bronchial biopsies in childhood asthma. To evaluate the airway pathology in children with asthma, we analyzed bronchial biopsies obtained from 23 children undergoing bronchoscopy for clinical indications other tha...

journal_title：American journal of respiratory and critical care medicine

authors： Barbato A,Turato G,Baraldo S,Bazzan E,Calabrese F,Tura M,Zuin R,Beghe B,Maestrelli P,Fabbri LM,Saetta M

更新日期：2003-10-01 00:00:00

abstract：RATIONALE:An objective and simple prognostic model for patients with pulmonary embolism could be helpful in guiding initial intensity of treatment. OBJECTIVES:To develop a clinical prediction rule that accurately classifies patients with pulmonary embolism into categories of increasing risk of mortality and other adve...

journal_title：American journal of respiratory and critical care medicine

authors： Aujesky D,Obrosky DS,Stone RA,Auble TE,Perrier A,Cornuz J,Roy PM,Fine MJ

更新日期：2005-10-15 00:00:00

abstract：:Noninflammatory structural alterations, variously referred to as airway remodeling, are well documented in the asthmatic airway. However, the pathogenesis of these alterations, the importance of airway remodeling in generating the asthma phenotype, and the natural history of airway remodeling responses have not been a...

journal_title：American journal of respiratory and critical care medicine

authors： Zhu Z,Lee CG,Zheng T,Chupp G,Wang J,Homer RJ,Noble PW,Hamid Q,Elias JA

更新日期：2001-11-15 00:00:00

abstract：:The interleukin-1 cluster on human chromosome 2q12-2q14 harbors various promising candidate genes for asthma and other inflammatory diseases. We conducted a systematic association study with single-nucleotide polymorphisms (SNPs) located in candidate genes situated in this cluster. Single-marker, two-locus and three-l...

journal_title：American journal of respiratory and critical care medicine

authors： Gohlke H,Illig T,Bahnweg M,Klopp N,André E,Altmüller J,Herbon N,Werner M,Knapp M,Pescollderungg L,Boner A,Malerba G,Pignatti PF,Wjst M

更新日期：2004-06-01 00:00:00

abstract：:Historically, infections caused by Mycobacterium tuberculosis have been treated simultaneously with isoniazid and rifampin. As a consequence of this combined therapy, strains resistant only to rifampin were rarely recovered. However, recently there has been an increasing number of reports describing HIV-positive patie...

journal_title：American journal of respiratory and critical care medicine

authors： Lutfey M,Della-Latta P,Kapur V,Palumbo LA,Gurner D,Stotzky G,Brudney K,Dobkin J,Moss A,Musser JM,Kreiswirth BN

更新日期：1996-02-01 00:00:00

abstract：:Gold-induced pulmonary disease is difficult to diagnose, especially, in the case in which interstitial pneumonia appears in the course of gold therapy for rheumatoid arthritis. We analyzed the literature to define the clinical features and prognosis of gold-induced pulmonary disease, and to identify those features tha...

journal_title：American journal of respiratory and critical care medicine

authors： Tomioka R,King TE Jr

更新日期：1997-03-01 00:00:00

abstract：INTRODUCTION:Proteinases with a disintegrin and a metalloproteinase domain (ADAMs) have not been well studied in COPD. We investigated whether ADAM9 is linked to COPD in humans and mice. METHODS:ADAM9 blood and lung levels were measured in COPD patients versus controls, and air- versus cigarette smoke (CS)-exposed wil...

journal_title：American journal of respiratory and critical care medicine

authors： Wang X,Polverino F,Rojas-Quintero J,Zhang D,Sánchez J,Yambayev I,Lindqvist E,Virtala R,Djukanovic R,Davies DE,Wilson S,O'Donnell R,Cunoosamy D,Hazon P,Higham A,Singh D,Olsson H,Owen CA

更新日期：2018-06-04 00:00:00

abstract：:Clinicians are frequently faced with patients in whom the radiographic resolution of community-acquired pneumonia seems delayed. Previous studies of radiographic resolution of the disease have yielded conflicting results. We prospectively assessed the radiographic resolution of pneumonia in 81 non-immuno-compromised p...

journal_title：American journal of respiratory and critical care medicine

authors： Mittl RL Jr,Schwab RJ,Duchin JS,Goin JE,Albeida SM,Miller WT

更新日期：1994-03-01 00:00:00

abstract：RATIONALE:Data on hemoptysis of unknown origin (i.e., "cryptogenic") are scarce and the outcome of patients affected is controversial. OBJECTIVES:To describe the clinical spectrum and course of patients with cryptogenic hemoptysis, as well as pathologic findings when surgery is performed. METHODS:A cohort of 81 patie...

journal_title：American journal of respiratory and critical care medicine

authors： Savale L,Parrot A,Khalil A,Antoine M,Théodore J,Carette MF,Mayaud C,Fartoukh M

更新日期：2007-06-01 00:00:00

abstract：RATIONALE:During acute lung injury (ALI) the macrophage pool expands markedly as inflammatory monocytes migrate from the circulation to the airspaces. As inflammation resolves, macrophage numbers return to preinjury levels and normal tissue structure and function are restored. OBJECTIVES:To determine the fate of resid...

journal_title：American journal of respiratory and critical care medicine

authors： Janssen WJ,Barthel L,Muldrow A,Oberley-Deegan RE,Kearns MT,Jakubzick C,Henson PM

更新日期：2011-09-01 00:00:00

abstract：RATIONALE:HIV-tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an immunopathological reaction to mycobacterial antigens induced by antiretroviral therapy. Prednisone reduces morbidity in TB-IRIS, but the mechanisms are unclear. OBJECTIVES:To determine the effect of prednisone on the inf...

journal_title：American journal of respiratory and critical care medicine

authors： Meintjes G,Skolimowska KH,Wilkinson KA,Matthews K,Tadokera R,Conesa-Botella A,Seldon R,Rangaka MX,Rebe K,Pepper DJ,Morroni C,Colebunders R,Maartens G,Wilkinson RJ

更新日期：2012-08-15 00:00:00

abstract：:Early experience suggests that lung volume reduction surgery improves exercise tolerance as measured by the 6-min walk distance in patients with emphysema. To identify the physiologic mechanism(s) by which lung volume reduction surgery improved exercise, we performed progressive cardiopulmonary exercise testing, inclu...

journal_title：American journal of respiratory and critical care medicine

authors： Benditt JO,Lewis S,Wood DE,Klima L,Albert RK

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:The impact of asthma on chronic lung function deficits is well known. However, there has been little study of ethnic differences in these asthma-associated deficits. OBJECTIVES:To examine whether there are ethnic differences in the effects of asthma on children's lung function. METHODS:We evaluated the impa...

journal_title：American journal of respiratory and critical care medicine

authors： Zhang Y,McConnell R,Gilliland F,Berhane K

更新日期：2011-03-01 00:00:00

abstract：:Cigarette smoking causes the development of chronic bronchitis and chronic obstructive pulmonary disease. We hypothesized that exposure to cigarette smoke might initiate release of inflammatory mediators by bronchial epithelial cells. To evaluate this, the effect of cigarette smoke extract (CSE) on IL-8 release from c...

journal_title：American journal of respiratory and critical care medicine

authors： Mio T,Romberger DJ,Thompson AB,Robbins RA,Heires A,Rennard SI

更新日期：1997-05-01 00:00:00

abstract：RATIONALE:Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a multicomponent disease with systemic consequences and effects on quality of life. Single measures such as lung function provide a limited reflection of how the disease affects patients. Composite measures have the potential to accoun...

journal_title：American journal of respiratory and critical care medicine

authors： Jones RC,Donaldson GC,Chavannes NH,Kida K,Dickson-Spillmann M,Harding S,Wedzicha JA,Price D,Hyland ME

更新日期：2009-12-15 00:00:00

abstract：:Alveolar epithelial type II cells (AET2) respond with exocytosis of surfactant containing lamellar bodies to stimulation with mechanical stretch and secretagogues, a process that is fundamental for maintaining alveolar stability and lung gas exchange. In the present study in cultured rat AET2, we employed botulinum C2...

journal_title：American journal of respiratory and critical care medicine

authors： Rose F,Kürth-Landwehr C,Sibelius U,Reuner KH,Aktories K,Seeger W,Grimminger F

更新日期：1999-01-01 00:00:00

abstract：RATIONALE:Encephalitis caused by anti-N-methyl-d-aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis. There are limited data on intensive care unit (ICU) management of these patients. OBJECTIVES:To identify prognostic factors of good neurologic outcome in patients admitted to an ...

journal_title：American journal of respiratory and critical care medicine

authors： de Montmollin E,Demeret S,Brulé N,Conrad M,Dailler F,Lerolle N,Navellou JC,Schwebel C,Alves M,Cour M,Engrand N,Tonnelier JM,Maury E,Ruckly S,Picard G,Rogemond V,Magalhaes É,Sharshar T,Timsit JF,Honnorat J,Sonnevil

更新日期：2017-02-15 00:00:00

abstract：RATIONALE:Because of high mortality, end-of-life care is an important component of intensive care. OBJECTIVES:We evaluated the effectiveness of a quality-improvement intervention to improve intensive care unit (ICU) end-of-life care. METHODS:We conducted a cluster-randomized trial randomizing 12 hospitals. The interv...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis JR,Nielsen EL,Treece PD,Downey L,Dotolo D,Shannon SE,Back AL,Rubenfeld GD,Engelberg RA

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:Th2 cytokines play an important role in allergic diseases. These cytokines activate signal transduction pathways, including Janus kinase/signal transducer and activator of transcription (STAT) signaling. Although the suppressor of cytokine signaling (SOCS) family protein, a negative regulator of the Janus kin...

journal_title：American journal of respiratory and critical care medicine

authors： Fukuyama S,Nakano T,Matsumoto T,Oliver BG,Burgess JK,Moriwaki A,Tanaka K,Kubo M,Hoshino T,Tanaka H,McKenzie AN,Matsumoto K,Aizawa H,Nakanishi Y,Yoshimura A,Black JL,Inoue H

更新日期：2009-06-01 00:00:00

abstract：:Acute exacerbation of idiopathic pulmonary fibrosis has been defined as an acute, clinically significant, respiratory deterioration of unidentifiable cause. The objective of this international working group report on acute exacerbation of idiopathic pulmonary fibrosis was to provide a comprehensive update on the topic...

journal_title：American journal of respiratory and critical care medicine

authors： Collard HR,Ryerson CJ,Corte TJ,Jenkins G,Kondoh Y,Lederer DJ,Lee JS,Maher TM,Wells AU,Antoniou KM,Behr J,Brown KK,Cottin V,Flaherty KR,Fukuoka J,Hansell DM,Johkoh T,Kaminski N,Kim DS,Kolb M,Lynch DA,Myers JL,R

更新日期：2016-08-01 00:00:00

abstract：RATIONALE:Chronic infection with Pseudomonas aeruginosa is associated with an increased exacerbation frequency, a more rapid decline in lung function, and increased mortality in patients with bronchiectasis. OBJECTIVES:To perform a randomized placebo-controlled study assessing the efficacy and safety of inhaled colist...

journal_title：American journal of respiratory and critical care medicine

authors： Haworth CS,Foweraker JE,Wilkinson P,Kenyon RF,Bilton D

更新日期：2014-04-15 00:00:00

abstract：RATIONALE:Ventilation-perfusion scintigraphy is highly sensitive for pulmonary embolism (PE), but its clinical usefulness is limited by its nondiagnostic rate. Objective analysis of single photon emission computed tomography (SPECT) three-dimensional scintigraphy may improve its diagnostic performance compared with sub...

journal_title：American journal of respiratory and critical care medicine

authors： Harris B,Bailey D,Miles S,Bailey E,Rogers K,Roach P,Thomas P,Hensley M,King GG

更新日期：2007-06-01 00:00:00

abstract：RATIONALE:The acute respiratory distress syndrome is a significant cause of morbidity and mortality in critically ill patients. Angiopoietin-1 (Ang-1), a ligand for the endothelial Tie2 receptor, is an endothelial survival and vascular stabilization factor that reduces endothelial permeability and inhibits leukocyte-en...

journal_title：American journal of respiratory and critical care medicine

authors： McCarter SD,Mei SH,Lai PF,Zhang QW,Parker CH,Suen RS,Hood RD,Zhao YD,Deng Y,Han RN,Dumont DJ,Stewart DJ

更新日期：2007-05-15 00:00:00