Derivation and validation of a prognostic model for pulmonary embolism.

abstract：:Calculation of diurnal peak expiratory flow (PEF) variability using values before and after bronchodilator is no longer possible for many asthmatic patients because they now use beta-agonists "as needed" for symptoms rather than regularly. This study assesses the usefulness of a number of alternative PEF indices as ma...

journal_title：American journal of respiratory and critical care medicine

authors： Reddel HK,Salome CM,Peat JK,Woolcock AJ

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:There is consensus on the need to address social determinants of tuberculosis (TB) to achieve TB control, but evidence based on interventions is lacking. OBJECTIVES:We reanalyzed data from the sociomedical experiment performed at the Papworth Village Settlement in England, where the impact of stable employme...

journal_title：American journal of respiratory and critical care medicine

authors： Bhargava A,Pai M,Bhargava M,Marais BJ,Menzies D

更新日期：2012-09-01 00:00:00

abstract：:Patients with impaired pulmonary function are at increased risk for the development of postoperative complications. Recently exercise testing and predicted postoperative (ppo) function have gained increasing importance in the evaluation of lung resection candidates. We prospectively evaluated an algorithm for the preo...

journal_title：American journal of respiratory and critical care medicine

authors： Wyser C,Stulz P,Solèr M,Tamm M,Müller-Brand J,Habicht J,Perruchoud AP,Bolliger CT

更新日期：1999-05-01 00:00:00

abstract：RATIONALE:Nasal polyps (NPs) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. However, the mechanisms underlying NP retention of plasma proteins in their submucosa remain unclear. OBJECTIVES:We hypothesized that formation of a fibrin mesh retains plasma protei...

journal_title：American journal of respiratory and critical care medicine

authors： Takabayashi T,Kato A,Peters AT,Hulse KE,Suh LA,Carter R,Norton J,Grammer LC,Cho SH,Tan BK,Chandra RK,Conley DB,Kern RC,Fujieda S,Schleimer RP

更新日期：2013-01-01 00:00:00

abstract：:In animal models of endotoxemia, sepsis is associated with the accumulation of leukocytes and altered microvascular perfusion. In order to test the hypothesis that bacterial sepsis upregulates leukocyte-endothelial adhesion, we used intravital microscopy to examine the flow behavior of leukocytes in the postcapillary ...

journal_title：American journal of respiratory and critical care medicine

authors： Piper RD,Pitt-Hyde ML,Anderson LA,Sibbald WJ,Potter RF

更新日期：1998-01-01 00:00:00

abstract：:Previous study of adrenergic control of the tracheal vasculature in rats (1) demonstrated that beta-adrenergic blockade heightened arteriolar and large venular contractile responses to norepinephrine, a nonselective alpha-adrenergic agonist. The present study was undertaken to confirm the presence of functional beta-a...

journal_title：American journal of respiratory and critical care medicine

authors： Corboz MR,Ballard ST,Inglis SK,Taylor AE

更新日期：1996-03-01 00:00:00

abstract：:Genes for the chemokine receptors CCR5 and CCR2 are characterized by polymorphisms resulting in a nonfunctional receptor expression. Ligands for CCR2 and CCR5 (chemokines monocyte chemotactic protein-1 [MCP-1] and RANTES) are implicated in the pathogenesis of sarcoidosis. We have, therefore, analyzed polymorphisms of ...

journal_title：American journal of respiratory and critical care medicine

authors： Petrek M,Drábek J,Kolek V,Zlámal J,Welsh KI,Bunce M,Weigl E,Du Bois R

更新日期：2000-09-01 00:00:00

abstract：:Exposure to fine airborne particulate matter (PM(2.5)) is associated with cardiovascular events and mortality in older and cardiac patients. Potential physiologic effects of in-vehicle, roadside, and ambient PM(2.5) were investigated in young, healthy, nonsmoking, male North Carolina Highway Patrol troopers. Nine troo...

journal_title：American journal of respiratory and critical care medicine

authors： Riediker M,Cascio WE,Griggs TR,Herbst MC,Bromberg PA,Neas L,Williams RW,Devlin RB

更新日期：2004-04-15 00:00:00

abstract：RATIONALE:IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. OBJECTIVES:The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting reports in the literature. These earlier st...

journal_title：American journal of respiratory and critical care medicine

authors： Kearley J,Erjefalt JS,Andersson C,Benjamin E,Jones CP,Robichaud A,Pegorier S,Brewah Y,Burwell TJ,Bjermer L,Kiener PA,Kolbeck R,Lloyd CM,Coyle AJ,Humbles AA

更新日期：2011-04-01 00:00:00

abstract：:Genetic factors are likely to contribute to the variable presentation of community-acquired pneumonia (CAP). The purpose of this prospective cohort study was to determine whether the LTalpha+250 (TNFbeta+250) and TNFalpha-308 gene polymorphisms are associated with different presentations of CAP. Septic shock (SS) was ...

journal_title：American journal of respiratory and critical care medicine

authors： Waterer GW,Quasney MW,Cantor RM,Wunderink RG

更新日期：2001-06-01 00:00:00

abstract：:Rationale: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be explored.Objectives: To elucidate the role of TYKRIL (tyrosine kinase receptor-inducing lncRNA) as a regulator of p53/ PDGFRβ (platelet-derive...

journal_title：American journal of respiratory and critical care medicine

authors： Zehendner CM,Valasarajan C,Werner A,Boeckel JN,Bischoff FC,John D,Weirick T,Glaser SF,Rossbach O,Jaé N,Demolli S,Khassafi F,Yuan K,de Jesus Perez VA,Michalik KM,Chen W,Seeger W,Guenther A,Wasnick RM,Uchida S,Zeihe

更新日期：2020-11-15 00:00:00

abstract：:DNA fingerprinting of Mycobacterium tuberculosis is used to study the epidemiology of tuberculosis, but the specificity of the widely used IS6110 technique has not been validated. Isolates from Denver, Colorado from December 1988 through June 1994 were fingerprinted with the IS6110 technique. Available records were re...

journal_title：American journal of respiratory and critical care medicine

authors： Burman WJ,Reves RR,Hawkes AP,Rietmeijer CA,Yang Z,el-Hajj H,Bates JH,Cave MD

更新日期：1997-03-01 00:00:00

abstract：RATIONALE:Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community. OBJECTIVES:To determine whether lung transplant recipients can be chronically infected by rhinovirus and the potential clinical impact. METHODS:We first ide...

journal_title：American journal of respiratory and critical care medicine

authors： Kaiser L,Aubert JD,Pache JC,Deffernez C,Rochat T,Garbino J,Wunderli W,Meylan P,Yerly S,Perrin L,Letovanec I,Nicod L,Tapparel C,Soccal PM

更新日期：2006-12-15 00:00:00

abstract：:The aim of the study was to determine whether closing pressures or vascular distensibility can be used to describe liver venous hemodynamics when right atrial pressure is raised. The study was performed using a vascularly isolated pig liver preparation that allowed the independent control of portal vein and hepatic ar...

journal_title：American journal of respiratory and critical care medicine

authors： Brienza N,Ayuse T,O'Donnell CP,Permutt S,Robotham JL

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:S. aureus is the most common respiratory pathogen isolated from patients with cystic fibrosis (CF) in the US. While modes of acquisition and genetic adaptation have been described for Pseudomonas aeruginosa, resulting in improved diagnosis and treatment, these features remain more poorly defined for S. aureus...

journal_title：American journal of respiratory and critical care medicine

authors： Long DR,Wolter DJ,Lee M,Precit M,McLean K,Holmes E,Penewit K,Waalkes A,Hoffman LR,Salipante SJ

更新日期：2020-12-09 00:00:00

abstract：:The effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase activity, was evaluated in a rat model of laryngeal injury induced by endotracheal intubation for 1 h. At 1 h after extubation, the laryngeal damage was characterized by areas of mucosal necrosis, submucosal edema, swelling of subglottic glan...

journal_title：American journal of respiratory and critical care medicine

authors： Stern Y,Salzman A,Cotton RT,Zingarelli B

更新日期：1999-11-01 00:00:00

abstract：:This study describes the natural history of atopic and wheezy disorders from birth to adult life in a cohort at risk of atopy. One hundred subjects born in Poole, England, were selected at birth in 1976 on the basis that at least one parent was atopic. Subjects were examined annually in the preschool years, and at the...

journal_title：American journal of respiratory and critical care medicine

authors： Rhodes HL,Thomas P,Sporik R,Holgate ST,Cogswell JJ

更新日期：2002-01-15 00:00:00

abstract：RATIONALE:Allergic asthma is characterized by reversible airway obstruction, lung inflammation, and airway hyperresponsiveness (AHR). Previous studies using leukotriene B(4) (LTB(4)) receptor 1-deficient mice and adoptive transfer experiments have suggested that LTB(4) plays a role in lung inflammation and AHR. OBJECT...

journal_title：American journal of respiratory and critical care medicine

authors： Rao NL,Riley JP,Banie H,Xue X,Sun B,Crawford S,Lundeen KA,Yu F,Karlsson L,Fourie AM,Dunford PJ

更新日期：2010-05-01 00:00:00

abstract：RATIONALE:There is a need to develop novel noninvasive imaging biomarkers that help to evaluate antiinflammatory asthma treatments. OBJECTIVES:To investigate whether the extent of the segmental lung edema measured noninvasively using turbo-inversion recovery-magnitude magnetic resonance imaging (TIRM MRI) corresponds ...

journal_title：American journal of respiratory and critical care medicine

authors： Vogel-Claussen J,Renne J,Hinrichs J,Schönfeld C,Gutberlet M,Schaumann F,Winkler C,Faulenbach C,Krug N,Wacker FK,Hohlfeld JM

更新日期：2014-03-15 00:00:00

abstract：:Silicosis is characterized by fibrosing nodular lesions that may eventually develop into progressive massive fibrosis (PMF). Cytokines (interleukin-1beta [IL-1beta], tumor necrosis factor-alpha [TNF-alpha] and growth factors insulin-like growth factor-1 [IGF-1] platelet-derived growth factor [PDGF]) have been implicat...

journal_title：American journal of respiratory and critical care medicine

authors： Jagirdar J,Begin R,Dufresne A,Goswami S,Lee TC,Rom WN

更新日期：1996-10-01 00:00:00

abstract：RATIONALE:The sympathetic nervous system has been reported to be activated in pulmonary arterial hypertension (PAH). OBJECTIVES:We investigated the prognostic significance of muscle sympathetic nervous system activity (MSNA) in PAH. METHODS:Thirty-two patients with PAH were included in the study and underwent a measu...

journal_title：American journal of respiratory and critical care medicine

authors： Ciarka A,Doan V,Velez-Roa S,Naeije R,van de Borne P

更新日期：2010-06-01 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR nuclear hormone receptor family, but the role of PPAR-β/δ in sepsis is unknown. OBJECTIVES:We investigated the role of PPAR-β/δ in murine models of LPS-induced organ injury and dysfunction and cecal ligat...

journal_title：American journal of respiratory and critical care medicine

authors： Kapoor A,Shintani Y,Collino M,Osuchowski MF,Busch D,Patel NS,Sepodes B,Castiglia S,Fantozzi R,Bishop-Bailey D,Mota-Filipe H,Yaqoob MM,Suzuki K,Bahrami S,Desvergne B,Mitchell JA,Thiemermann C

更新日期：2010-12-15 00:00:00

abstract：:Because inflammation stimulates the expression of inducible nitric oxide (NO) synthase (iNOS) with an associated increased local NO production, we hypothesized that patients with pneumonia would have increased excretion of NO into their airways. To test this hypothesis, NO was measured in the exhaled air and from the ...

journal_title：American journal of respiratory and critical care medicine

authors： Adrie C,Monchi M,Dinh-Xuan AT,Dall'Ava-Santucci J,Dhainaut JF,Pinsky MR

更新日期：2001-04-01 00:00:00

abstract：RATIONALE:Corticosteroids are the antiinflammatory treatment of choice in asthma. Treatment guidelines are mainly symptom-driven but symptoms are not closely related to airway inflammation. The fraction of nitric oxide in exhaled air (FENO) is a marker of airway inflammation in asthma. OBJECTIVE:We evaluated whether t...

journal_title：American journal of respiratory and critical care medicine

authors： Pijnenburg MW,Bakker EM,Hop WC,De Jongste JC

更新日期：2005-10-01 00:00:00

abstract：:We used various ovalbumin sensitization and challenge protocols to determine the importance of the route of allergen administration and the genetic background in modulating the physiologic, inflammatory, and immunologic features characteristic of allergen-induced asthma. In BALB/c mice, induction of maximal airway hyp...

journal_title：American journal of respiratory and critical care medicine

authors： Zhang Y,Lamm WJ,Albert RK,Chi EY,Henderson WR Jr,Lewis DB

更新日期：1997-02-01 00:00:00

abstract：:To examine the differential properties of mucous glycoproteins, we produced hypertrophic and metaplastic changes in goblet cells of rat nasal epithelium by intranasal instillation of ovalbumin (OVA) in OVA-sensitized rats, and by intranasal lipopolysaccharide (LPS) instillation. The epithelial mucosubstance was quanti...

journal_title：American journal of respiratory and critical care medicine

authors： Shimizu T,Hirano H,Shimizu S,Kishioka C,Sakakura Y,Majima Y

更新日期：2001-09-15 00:00:00

abstract：:To compare the effectiveness of information delivered to family members of critically ill patients by junior and senior physicians, we performed a prospective randomized multicenter trial in 11 French intensive care units. Patients (n = 220) were allocated at random to having their family members receive information b...

journal_title：American journal of respiratory and critical care medicine

authors： Moreau D,Goldgran-Toledano D,Alberti C,Jourdain M,Adrie C,Annane D,Garrouste-Orgeas M,Lefrant JY,Papazian L,Quinio P,Pochard F,Azoulay E

更新日期：2004-02-15 00:00:00

abstract：RATIONALE:Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids. This has been linked to a reduction of histone deacetylase-2 as a result of oxidative stress and is reversed by theophylline. OBJECTIVES:To determine the role of phosphoinositide-3-kinase-delta (PI3K-δ) on the...

journal_title：American journal of respiratory and critical care medicine

authors： To Y,Ito K,Kizawa Y,Failla M,Ito M,Kusama T,Elliott WM,Hogg JC,Adcock IM,Barnes PJ

更新日期：2010-10-01 00:00:00

abstract：RATIONALE:Statin use has been linked to improved lung health in asthma and chronic obstructive pulmonary disease. We hypothesize that statins inhibit allergic airway inflammation and reduce airway hyperreactivity via a mevalonate-dependent mechanism. OBJECTIVES:To determine whether simvastatin attenuates airway inflam...

journal_title：American journal of respiratory and critical care medicine

authors： Zeki AA,Franzi L,Last J,Kenyon NJ

更新日期：2009-10-15 00:00:00

abstract：:We examined endotoxin exposure and wheezing episodes during the first year of life in a birth cohort of 499 infants with one or both parents having a history of asthma or allergy. We measured endotoxin in settled dust from the baby's bed, bedroom floor, family room, and kitchen floor within the first 3 mo after birth....

journal_title：American journal of respiratory and critical care medicine

authors： Park JH,Gold DR,Spiegelman DL,Burge HA,Milton DK

更新日期：2001-02-01 00:00:00