Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against laryngeal injury in rats.

abstract：:The nasal mucosal is the first site of contact with inhaled antigens. However, the nature of local immune responses and the role of nasal-associated lymphoid tissue (NALT) in those responses have rarely been studied. To characterize the cells involved in mucosally derived immune responses, NALT and Peyer's patch (PP) ...

journal_title：American journal of respiratory and critical care medicine

authors： Heritage PL,Underdown BJ,Arsenault AL,Snider DP,McDermott MR

更新日期：1997-10-01 00:00:00

abstract：:The purpose of this study was to evaluate the physiologic responses to endurance training in patients with moderate to severe airflow obstruction by specifically looking at changes in skeletal muscle enzymatic activities. Eleven patients (age = 65 +/- 7 yr, mean +/- SD, FEV1 = 36 +/- 11% of predicted value, range = 24...

journal_title：American journal of respiratory and critical care medicine

authors： Maltais F,LeBlanc P,Simard C,Jobin J,Bérubé C,Bruneau J,Carrier L,Belleau R

更新日期：1996-08-01 00:00:00

abstract：:The cysteinyl leukotrienes (CysLTs) are important mediators of human asthma. Pharmacologic and clinical studies show that the CysLTs exert most of their bronchoconstrictive and proinflammatory effects through activation of a putative, 7-transmembrane domain, G-protein-coupled receptor, the CysLT1 receptor. The initial...

journal_title：American journal of respiratory and critical care medicine

authors： Figueroa DJ,Breyer RM,Defoe SK,Kargman S,Daugherty BL,Waldburger K,Liu Q,Clements M,Zeng Z,O'Neill GP,Jones TR,Lynch KR,Austin CP,Evans JF

更新日期：2001-01-01 00:00:00

abstract：:Allergen-induced bronchoconstriction involves mast cell activation. Tryptase is a mast cell serine protease that is released during this process, but little is known about the action of tryptase in the airway. The purpose of this study was to determine: (1) if aerosolized tryptase causes bronchoconstriction, and (2) t...

journal_title：American journal of respiratory and critical care medicine

authors： Molinari JF,Scuri M,Moore WR,Clark J,Tanaka R,Abraham WM

更新日期：1996-09-01 00:00:00

abstract：RATIONALE:Although research supports a sleep-disordered breathing and atrial fibrillation association, prospective data examining sleep-disordered breathing predicting incident atrial fibrillation are lacking. OBJECTIVES:To investigate sleep-disordered breathing indices as predictors of incident atrial fibrillation. ...

journal_title：American journal of respiratory and critical care medicine

authors： May AM,Blackwell T,Stone PH,Stone KL,Cawthon PM,Sauer WH,Varosy PD,Redline S,Mehra R,MrOS Sleep (Outcomes of Sleep Disorders in Older Men) Study Group.

更新日期：2016-04-01 00:00:00

abstract：:The aim of this study was to clarify the influence of gastroesophageal reflux (GER) on cough threshold in patients with digestive symptoms but free from respiratory involvement. Of 57 consecutive subjects referred for 24-h esophageal pH monitoring because of digestive reflux symptoms, 29 patients free from respiratory...

journal_title：American journal of respiratory and critical care medicine

authors： Ferrari M,Olivieri M,Sembenini C,Benini L,Zuccali V,Bardelli E,Bovo P,Cavallini G,Vantini I,Lo Cascio V

更新日期：1995-02-01 00:00:00

abstract：:Phl p5 is a major allergen of timothy grass and causes rhinitis and bronchial asthma in nearly all patients allergic to grass pollen. The biochemical processing of this molecule by the nasal mucosa at its first encounter and possible changes of its biologic activity are unknown. Two isoforms of the allergen were expre...

journal_title：American journal of respiratory and critical care medicine

authors： Bufe A,Gehlhar K,Schramm G,Schlaak M,Becker WM

更新日期：1998-04-01 00:00:00

abstract：:Antimicrobial stewardship involves a multifaceted approach that strives to combat the emergence of resistance, improve clinical outcomes, and control costs by improving antimicrobial use. Therefore, stewardship is of great importance and relevance in the intensive care unit. Clinical decision support systems, biomarke...

journal_title：American journal of respiratory and critical care medicine

authors： Lawrence KL,Kollef MH

更新日期：2009-03-15 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening, interstitial lung disease of unknown etiology. The median survival of patients with IPF is only 2 to 3 years, yet some patients live much longer. Respiratory failure resulting from disease progression is the most frequent cause of death. To date w...

journal_title：American journal of respiratory and critical care medicine

authors： Ley B,Collard HR,King TE Jr

更新日期：2011-02-15 00:00:00

abstract：RATIONALE:Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation caused by a combination of airways disease (bronchiolitis) and parenchymal destruction (emphysema), whose relative proportion varies from patient to patient. OBJECTIVES:To explore and contrast the molecular pathogenes...

journal_title：American journal of respiratory and critical care medicine

authors： Faner R,Cruz T,Casserras T,López-Giraldo A,Noell G,Coca I,Tal-Singer R,Miller B,Rodriguez-Roisin R,Spira A,Kalko SG,Agustí A

更新日期：2016-06-01 00:00:00

abstract：:During Operation Everest III (Comex '97), to assess the consequences of altitude-induced hypoxia, eight volunteers were decompressed in a hypobaric chamber, with a decompression profile simulating the climb of Mount Everest. Cardiac function was assessed using a combination of M-mode and two-dimensional echocardiograp...

journal_title：American journal of respiratory and critical care medicine

authors： Boussuges A,Molenat F,Burnet H,Cauchy E,Gardette B,Sainty JM,Jammes Y,Richalet JP

更新日期：2000-01-01 00:00:00

abstract：:A noninvasive method to characterize inflammation and infection in the airways of nonexpectorating children with cystic fibrosis (CF) is needed for clinical and research purposes. Accordingly, we performed sputum inductions by administering 3% saline to 11 healthy control children and 20 children with CF, composed of ...

journal_title：American journal of respiratory and critical care medicine

authors： Sagel SD,Kapsner R,Osberg I,Sontag MK,Accurso FJ

更新日期：2001-10-15 00:00:00

abstract：:Four hundred forty-one subjects 34 to 69 yr of age were recruited from a random sample of the community. The sample was biased in favor of men, snorers, and subjects with subjective sleep complaints. They answered a questionnaire and were monitored in their homes for sleep-disordered breathing (SDB). This report conce...

journal_title：American journal of respiratory and critical care medicine

authors： Olson LG,King MT,Hensley MJ,Saunders NA

更新日期：1995-08-01 00:00:00

abstract：:Two patients receiving low dose methotrexate, one with rheumatoid arthritis and the other with pityriasis rubra pilaris, developed disseminated histoplasmosis and Mycobacterium avium intracellulare pneumonia, respectively. Twenty-three cases of opportunistic infection in patients receiving low dose methotrexate have b...

journal_title：American journal of respiratory and critical care medicine

authors： LeMense GP,Sahn SA

更新日期：1994-07-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is a highly prevalent disorder in children, in which enlarged adenotonsillar tissues (AT) play a major pathophysiologic role. Mechanisms leading to the proliferation and hypertrophy of AT in children who subsequently develop OSA remain unknown, and surgical extirpation of AT is a...

journal_title：American journal of respiratory and critical care medicine

authors： Khalyfa A,Gharib SA,Kim J,Dayyat E,Snow AB,Bhattacharjee R,Kheirandish-Gozal L,Goldman JL,Gozal D

更新日期：2010-05-15 00:00:00

abstract：RATIONALE:The prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease. Recent studies suggest that vitamin D deficiency is associated with reduced lung function. The relationship between vitamin D deficiency and lung fu...

journal_title：American journal of respiratory and critical care medicine

authors： Zosky GR,Berry LJ,Elliot JG,James AL,Gorman S,Hart PH

更新日期：2011-05-15 00:00:00

abstract：:In order to assess the usefulness of sputum analysis in studying plasma-protein exudation and local secretion of proteins in the airways, we measured specific proteins in the sputum sol phase (SSP) and sputum gel phase (SGP) from patients with stable asthma or chronic obstructive pulmonary disease (COPD). Protein leve...

journal_title：American journal of respiratory and critical care medicine

authors： Schoonbrood DF,Lutter R,Habets FJ,Roos CM,Jansen HM,Out TA

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:The American Thoracic Society/European Respiratory Society International Consensus Classification panel identified the clinical entity idiopathic nonspecific interstitial pneumonia (NSIP) as a provisional diagnosis and recommended further study. OBJECTIVES:We hypothesized that idiopathic NSIP is an autoimmun...

journal_title：American journal of respiratory and critical care medicine

authors： Kinder BW,Collard HR,Koth L,Daikh DI,Wolters PJ,Elicker B,Jones KD,King TE Jr

更新日期：2007-10-01 00:00:00

abstract：RATIONALE:Immunophenotypes of antiviral responses, and their relationship with asthma, allergy, and lower respiratory tract infections, are poorly understood. OBJECTIVES:We characterized multiple cytokine responses of peripheral blood mononuclear cells to rhinovirus stimulation, and their relationship with clinical ou...

journal_title：American journal of respiratory and critical care medicine

authors： Custovic A,Belgrave D,Lin L,Bakhsoliani E,Telcian AG,Solari R,Murray CS,Walton RP,Curtin J,Edwards MR,Simpson A,Rattray M,Johnston SL

更新日期：2018-05-15 00:00:00

abstract：:The purpose of the study was to examine risk factors for nosocomial pneumonia in the surgical and medical/respiratory intensive care unit (ICU) populations. In a public teaching hospital, all cases of nosocomial pneumonia in the surgical and medical/respiratory ICUs (n = 20, respectively) were identified by prospectiv...

journal_title：American journal of respiratory and critical care medicine

authors： Cunnion KM,Weber DJ,Broadhead WE,Hanson LC,Pieper CF,Rutala WA

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Hyponatremia is associated with decompensated heart failure and poor prognosis in patients with left ventricular systolic dysfunction. OBJECTIVES:We sought to determine if hyponatremia is associated with right heart failure and worse prognosis in patients with pulmonary arterial hypertension (PAH). METHODS:...

journal_title：American journal of respiratory and critical care medicine

authors： Forfia PR,Mathai SC,Fisher MR,Housten-Harris T,Hemnes AR,Champion HC,Girgis RE,Hassoun PM

更新日期：2008-06-15 00:00:00

abstract：:Positive pressure ventilation with large VTs has been shown to cause release of cytokines, including macrophage inflammatory protein-2 (MIP-2), a functional equivalent of human interleukin-8. The mechanisms regulating ventilation-induced cytokine production are unclear. Based on our previous in vitro model of lung cel...

journal_title：American journal of respiratory and critical care medicine

authors： Li LF,Yu L,Quinn DA

更新日期：2004-02-15 00:00:00

abstract：:A continuously mixed series of microbial communities inhabits various points of the respiratory tract, with community composition determined by distance from colonization sources, colonization rates, and extinction rates. Ecology and evolution theory developed in the context of biogeography is relevant to clinical mic...

journal_title：American journal of respiratory and critical care medicine

authors： Whiteson KL,Bailey B,Bergkessel M,Conrad D,Delhaes L,Felts B,Harris JK,Hunter R,Lim YW,Maughan H,Quinn R,Salamon P,Sullivan J,Wagner BD,Rainey PB

更新日期：2014-06-01 00:00:00

abstract：RATIONALE:Recent findings have demonstrated that muscarinic M(3) receptor stimulation enhances airway smooth muscle proliferation to peptide growth factors in vitro. Because both peptide growth factor expression and acetylcholine release are known to be augmented in allergic airway inflammation, it is possible that ant...

journal_title：American journal of respiratory and critical care medicine

authors： Gosens R,Bos IS,Zaagsma J,Meurs H

更新日期：2005-05-15 00:00:00

abstract：:Loss of lung elastic recoil causing hyperinflation with increased TLC and decreased diffusing capacity and expiratory airflow are physiologic hallmarks of emphysema. We studied lung mechanics in 10 patients (seven men and three women) aged 69 +/- 9 yr (mean +/- SD) who had fixed, severe expiratory airflow limitation w...

journal_title：American journal of respiratory and critical care medicine

authors： Gelb AF,Zamel N,Hogg JC,Müller NL,Schein MJ

更新日期：1998-09-01 00:00:00

abstract：RATIONALE:Whether a nurse-implemented goal-directed sedation protocol resulting in more awake yet calm intubated children affects postdischarge functional status, health-related quality of life, or risk for post-traumatic stress disorder is unknown. OBJECTIVES:To compare postdischarge outcomes in children with acute r...

journal_title：American journal of respiratory and critical care medicine

authors： Watson RS,Asaro LA,Hertzog JH,Sorce LR,Kachmar AG,Dervan LA,Angus DC,Wypij D,Curley MAQ,RESTORE Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

更新日期：2018-06-01 00:00:00

abstract：RATIONALE:Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of renal endothelial cell injury) associated with hypoxemia. OBJECTIVES:To determine whether (1) cigarette smoke (CS)-induced pulmonary and renal endothelial cell injury explains the association between albumin...

journal_title：American journal of respiratory and critical care medicine

authors： Polverino F,Laucho-Contreras ME,Petersen H,Bijol V,Sholl LM,Choi ME,Divo M,Pinto-Plata V,Chetta A,Tesfaigzi Y,Celli BR,Owen CA

更新日期：2017-06-01 00:00:00

abstract：RATIONALE:Plasma transfusions are frequently prescribed for critically ill children, although their indications lack a strong evidence base. Plasma transfusions are largely driven by physician conceptions of need, and these are poorly documented in pediatric intensive care patients. OBJECTIVES:To identify patient char...

journal_title：American journal of respiratory and critical care medicine

authors： Karam O,Demaret P,Shefler A,Leteurtre S,Spinella PC,Stanworth SJ,Tucci M,Canadian Critical Care Trials Group (CCCTG).,Pediatric Acute Lung Injury and Sepsis Investigators (PALISI).,BloodNet.,PlasmaTV Investigators.

更新日期：2015-06-15 00:00:00

abstract：RATIONALE:Tissue resident memory T cells play a critical role in the defense against inhaled pathogens. The isolation and study of human lung tissue resident memory T cells and lung resident macrophages is limited by experimental constraints. OBJECTIVES:To characterize the spatial and functional relationship between l...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder ME,Sembrat J,Noda K,Myerburg MM,Craig A,Mitash N,Harano T,Furukawa M,Pilewski J,McDyer J,Rojas M,Sanchez P

更新日期：2020-12-11 00:00:00

abstract：RATIONALE:Fluid accumulation in the legs and its overnight redistribution into the neck appears to play a causative role in obstructive sleep apnea (OSA) in sedentary men. Chronic venous insufficiency (CVI) promotes fluid accumulation in the legs that can be counteracted by compression stockings. OBJECTIVES:To test th...

journal_title：American journal of respiratory and critical care medicine

authors： Redolfi S,Arnulf I,Pottier M,Lajou J,Koskas I,Bradley TD,Similowski T

更新日期：2011-11-01 00:00:00