当前位置： SCI文献检索 > AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE期刊下所有文献 > Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection.

Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection.

Abstract：

RATIONALE:Chronic infection with Pseudomonas aeruginosa is associated with an increased exacerbation frequency, a more rapid decline in lung function, and increased mortality in patients with bronchiectasis. OBJECTIVES:To perform a randomized placebo-controlled study assessing the efficacy and safety of inhaled colistin in patients with bronchiectasis and chronic P. aeruginosa infection. METHODS:Patients with bronchiectasis and chronic P. aeruginosa infection were enrolled within 21 days of completing a course of antipseudomonal antibiotics for an exacerbation. Participants were randomized to receive colistin (1 million IU; n = 73) or placebo (0.45% saline; n = 71) via the I-neb twice a day, for up to 6 months. MEASUREMENTS AND MAIN RESULTS:The primary endpoint was time to exacerbation. Secondary endpoints included time to exacerbation based on adherence recorded by the I-neb, P. aeruginosa bacterial density, quality of life, and safety parameters. All analyses were on the intention-to-treat population. Median time (25% quartile) to exacerbation was 165 (42) versus 111 (52) days in the colistin and placebo groups, respectively (P = 0.11). In adherent patients (adherence quartiles 2-4), the median time to exacerbation was 168 (65) versus 103 (37) days in the colistin and placebo groups, respectively (P = 0.038). P. aeruginosa density was reduced after 4 (P = 0.001) and 12 weeks (P = 0.008) and the St. George's Respiratory Questionnaire total score was improved after 26 weeks (P = 0.006) in the colistin versus placebo patients, respectively. There were no safety concerns. CONCLUSIONS:Although the primary endpoint was not reached, this study shows that inhaled colistin is a safe and effective treatment in adherent patients with bronchiectasis and chronic P. aeruginosa infection. Clinical trial registered with http://www.isrctn.org/ (ISRCTN49790596).

journal_name

Am J Respir Crit Care Med

journal_title

American journal of respiratory and critical care medicine

authors

Haworth CS,Foweraker JE,Wilkinson P,Kenyon RF,Bilton D

doi

10.1164/rccm.201312-2208OC

subject

Has Abstract

pub_date

2014-04-15 00:00:00

pages

975-82

issue

8

eissn

1073-449X

issn

1535-4970

journal_volume

189

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE文献大全
  • Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease.

    abstract：:Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of lung hyperinflation as measured by the inspiratory capacity-to-total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pul...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1164/rccm.200407-867OC

    authors： Casanova C,Cote C,de Torres JP,Aguirre-Jaime A,Marin JM,Pinto-Plata V,Celli BR

    更新日期：2005-03-15 00:00:00

  • Predisposing conditions to bacterial infections in chronic obstructive pulmonary disease.

    abstract：:In normal airways, invasion of small numbers of pathogenic bacteria will not give rise to injury or local colonization. In chronic obstructive pulmonary disease, however, local conditions are changed, which may impair local defense systems and facilitate infection. These include: (1) factors promoting bacterial adhere...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,评审

    doi：10.1164/ajrccm.151.6.7767560

    authors： Jansen HM,Sachs AP,van Alphen L

    更新日期：1995-06-01 00:00:00

  • Effects of allergen challenge on eosinophils, eosinophil cationic protein, and granulocyte-macrophage colony-stimulating factor in mild asthma.

    abstract：:Allergen inhalation challenge is associated with increases in eosinophil number and activation, and provides a useful model for investigating airway inflammation in asthma. Limited information, however, is available on the effect of allergen challenge on cytokines regulating eosinophil function. We investigated allerg...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.151.6.7767540

    authors： Woolley KL,Adelroth E,Woolley MJ,Ellis R,Jordana M,O'Byrne PM

    更新日期：1995-06-01 00:00:00

  • Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis.

    abstract：:Sensitive measures of lung function applicable to young subjects are needed to detect early cystic fibrosis (CF) lung disease. Forty children with CF aged 2 to 5 years and 37 age-matched healthy control subjects performed multiple-breath inert gas washout, plethysmography, and spirometry. Thirty children in each group...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200407-895OC

    authors： Aurora P,Bush A,Gustafsson P,Oliver C,Wallis C,Price J,Stroobant J,Carr S,Stocks J,London Cystic Fibrosis Collaboration.

    更新日期：2005-02-01 00:00:00

  • Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers.

    abstract：BACKGROUND:The relative roles of mucus plugs and emphysema in mechanisms of airflow limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) are uncertain. METHODS:We analyzed computed tomography (CT) lung images and lung function in participants in the Subpopulations and Intermediate Outc...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.202006-2248OC

    authors： Dunican EM,Elicker BM,Henry T,Gierada DS,Schiebler ML,Anderson W,Barjaktarevic I,Barr RG,Bleecker ER,Boucher RC,Bowler RP,Christenson SA,Comellas A,Cooper CB,Couper D,Criner GJ,Dransfield M,Doerschuk CM,Drummond MB,

    更新日期：2020-11-12 00:00:00

  • Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters: role of histamine.

    abstract：:Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particles (DEPs) are prothrombotic. Here, we investigated the time course and the mechanisms. At 1, 6, and 24 hours after instillation ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200306-801OC

    authors： Nemmar A,Nemery B,Hoet PH,Vermylen J,Hoylaerts MF

    更新日期：2003-12-01 00:00:00

  • Prevalence and clinical course of pleural effusions at 30 days after coronary artery and cardiac surgery.

    abstract：:The present prospective study was designed to determine the prevalence of pleural effusion at approximately 28 days after cardiac surgery and their subsequent course. This consecutive case study included 389 patients; 312 had only coronary artery bypass graft surgery (CABG) surgery, 37 had both valve and CABG surgery,...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200203-184OC

    authors： Light RW,Rogers JT,Moyers JP,Lee YC,Rodriguez RM,Alford WC Jr,Ball SK,Burrus GR,Coltharp WH,Glassford DM Jr,Hoff SJ,Lea JW 4th,Nesbitt JC,Petracek MR,Starkey TD,Stoney WS,Tedder M

    更新日期：2002-12-15 00:00:00

  • Elevated urinary leukotriene E4 in chronic lung disease of extreme prematurity.

    abstract：:We determined if pulmonary peptidoleukotrienes contribute to the pathogenesis of chronic lung disease of extreme prematurity (CLD) by measuring urinary leukotriene E4 (uLTE4). Study patients had a birth weight < 1000 g and were about 28 d old when they were classified as normal control subjects (n = 8) or as having CL...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm/151.3_Pt_1.841

    authors： Davidson D,Drafta D,Wilkens BA

    更新日期：1995-03-01 00:00:00

  • Detecting Stenotrophomonas maltophilia does not reduce survival of patients with cystic fibrosis.

    abstract：:Stenotrophomonas maltophilia is a gram-negative bacterium that has been cultured with increasing prevalence from the sputum of patients with cystic fibrosis (CF). We conducted a cohort study, using the Cystic Fibrosis Foundation Registry, to assess the effect of S. maltophilia on survival. We studied all patients in t...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.2109078

    authors： Goss CH,Otto K,Aitken ML,Rubenfeld GD

    更新日期：2002-08-01 00:00:00

  • Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs.

    abstract：RATIONALE:In cigarette smoking-induced chronic obstructive pulmonary disease, structural and functional derangements are characterized by parenchymal destruction and pulmonary hypertension. Statins are 3-hydroxy-3-methyl-glutaryl-coenzyme-A reductase inhibitors that have been used as lipid-lowering agents. These drugs ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200501-041OC

    authors： Lee JH,Lee DS,Kim EK,Choe KH,Oh YM,Shim TS,Kim SE,Lee YS,Lee SD

    更新日期：2005-10-15 00:00:00

  • One-night mandibular advancement titration for obstructive sleep apnea syndrome: a pilot study.

    abstract：:The effect of a dental appliance (DA) is usually evaluated in a single mandibular position reached after several weeks and corresponding to either improvement of symptoms or intolerance to any further advancement. The purpose of this study was to test the feasibility of one-night evaluation of the efficacy of a DA. Th...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.165.8.2108056

    authors： Pételle B,Vincent G,Gagnadoux F,Rakotonanahary D,Meyer B,Fleury B

    更新日期：2002-04-15 00:00:00

  • Galactomannan in bronchoalveolar lavage for diagnosing invasive fungal disease.

    abstract：RATIONALE:Invasive fungal disease (IFD) is a significant cause of morbidity and mortality in immunocompromised patients. OBJECTIVES:We hypothesize that galactomannan (GM), a component of fungal cell wall, as measured in bronchoalveolar lavage (BAL) might be a diagnostic adjunct in hematologic malignancies. METHODS:A ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201403-0431OC

    authors： Affolter K,Tamm M,Jahn K,Halter J,Passweg J,Hirsch HH,Stolz D

    更新日期：2014-08-01 00:00:00

  • Upper airway collapsibility and cephalometric variables in patients with obstructive sleep apnea.

    abstract：:Increased pharyngeal collapsibility and abnormal anatomic structures have been postulated to contribute to the pathophysiology of obstructive sleep apnea (OSA) syndrome. It is unclear whether the abnormal craniofacial and soft tissue features may affect the pharyngeal collapsibility and contribute to the apnea density...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.161.2.9810091

    authors： Sforza E,Bacon W,Weiss T,Thibault A,Petiau C,Krieger J

    更新日期：2000-02-01 00:00:00

  • Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression.

    abstract：RATIONALE:Nasal polyps (NPs) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. However, the mechanisms underlying NP retention of plasma proteins in their submucosa remain unclear. OBJECTIVES:We hypothesized that formation of a fibrin mesh retains plasma protei...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201207-1292OC

    authors： Takabayashi T,Kato A,Peters AT,Hulse KE,Suh LA,Carter R,Norton J,Grammer LC,Cho SH,Tan BK,Chandra RK,Conley DB,Kern RC,Fujieda S,Schleimer RP

    更新日期：2013-01-01 00:00:00

  • De Novo DQ Donor-Specific Antibodies Are Associated with Chronic Lung Allograft Dysfunction after Lung Transplantation.

    abstract：RATIONALE:Despite increasing evidence about the role of donor-specific human leukocyte antigen (HLA) antibodies in transplant outcomes, the incidence and impact of de novo donor-specific antibodies (dnDSA) after lung transplantation remains unclear. OBJECTIVES:To describe the incidence, characteristics, and impact of ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201509-1857OC

    authors： Tikkanen JM,Singer LG,Kim SJ,Li Y,Binnie M,Chaparro C,Chow CW,Martinu T,Azad S,Keshavjee S,Tinckam K

    更新日期：2016-09-01 00:00:00

  • Developmental changes in crossbridge properties and myosin isoforms in hamster diaphragm.

    abstract：:The aim of this study was to determine the effects of maturation on crossbridge properties and myosin isoform composition in hamster diaphragm muscle. Diaphragm strips were obtained at postnatal Days 1 and 8 and in adults (10 to 12 wk). Peak isometric tension and maximum unloaded shortening velocity (Vmax) increased w...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.156.3.9701051

    authors： Coirault C,Lambert F,Joseph T,Blanc FX,Chemla D,Lecarpentier Y

    更新日期：1997-09-01 00:00:00

  • Airway obstruction in boilermakers exposed to fuel oil ash. A prospective investigation.

    abstract：:We prospectively investigated the lower airway response in boilermakers overhauling an oil-powered boiler. We studied 26 male boilermakers with a mean age (SD) of 43.3 (8.6) yr. Pre-exposure spirometry and methacholine challenge tests were performed before beginning the boiler overhaul; postexposure tests were perform...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.152.5.7582280

    authors： Hauser R,Elreedy S,Hoppin JA,Christiani DC

    更新日期：1995-11-01 00:00:00

  • Sleep-disordered breathing in African-American elderly.

    abstract：:Although sleep-disordered breathing (SDB) has been shown to be very prevalent in the elderly, little has been done to examine differences between the elderly of different racial groups. It has been well documented that SDB often results in hypertension and that hypertension is more common in African-Americans than in ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.152.6.8520760

    authors： Ancoli-Israel S,Klauber MR,Stepnowsky C,Estline E,Chinn A,Fell R

    更新日期：1995-12-01 00:00:00

  • Airway obstruction during exercise in asthma.

    abstract：:Airway obstruction (AO) in exercise-induced asthma (EIA) is considered a postexercise phenomenon. However, many with EIA complain of respiratory distress during exercise. We evaluated AO in six asthmatic subjects during a short (SX = 6 min) and a long (LX = 20 min) exercise session. We measured peak expiratory flow (P...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.152.1.7599830

    authors： Suman OE,Babcock MA,Pegelow DF,Jarjour NN,Reddan WG

    更新日期：1995-07-01 00:00:00

  • 17β-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects.

    abstract：RATIONALE:17β-Estradiol (E2) attenuates hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension (HPH) through an unknown mechanism that may involve estrogen receptors (ER) or E2 conversion to catecholestradiols and methoxyestradiols with previously unrecognized effects on cardiopulmonary vascular remodeli...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201107-1293OC

    authors： Lahm T,Albrecht M,Fisher AJ,Selej M,Patel NG,Brown JA,Justice MJ,Brown MB,Van Demark M,Trulock KM,Dieudonne D,Reddy JG,Presson RG,Petrache I

    更新日期：2012-05-01 00:00:00

  • Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes.

    abstract：:The cysteinyl leukotrienes (CysLTs) are important mediators of human asthma. Pharmacologic and clinical studies show that the CysLTs exert most of their bronchoconstrictive and proinflammatory effects through activation of a putative, 7-transmembrane domain, G-protein-coupled receptor, the CysLT1 receptor. The initial...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.163.1.2003101

    authors： Figueroa DJ,Breyer RM,Defoe SK,Kargman S,Daugherty BL,Waldburger K,Liu Q,Clements M,Zeng Z,O'Neill GP,Jones TR,Lynch KR,Austin CP,Evans JF

    更新日期：2001-01-01 00:00:00

  • Quantitative upper airway imaging with anatomic optical coherence tomography.

    abstract：BACKGROUND:Measurements of upper airway size and shape are important in investigating the pathophysiology of obstructive sleep apnea (OSA) and in devising, applying, and determining the effectiveness of treatment modalities. We describe an endoscopic optical technique (anatomic optical coherence tomography, aOCT) that ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200507-1148OC

    authors： Armstrong JJ,Leigh MS,Sampson DD,Walsh JH,Hillman DR,Eastwood PR

    更新日期：2006-01-15 00:00:00

  • Prevention of gram-negative translocation reduces the severity of hepatopulmonary syndrome.

    abstract：:Hepatopulmonary syndrome (HPS) is characterized by intrapulmonary vascular dilatations and an increased alveoloarterial oxygen difference (AaPO(2)). These abnormalities are related to augmented pulmonary nitric oxide (NO) production, dependent primarily on increases in the expression and activity of inducible NO-synth...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200201-027OC

    authors： Rabiller A,Nunes H,Lebrec D,Tazi KA,Wartski M,Dulmet E,Libert JM,Mougeot C,Moreau R,Mazmanian M,Humbert M,Hervé P

    更新日期：2002-08-15 00:00:00

  • An oral elastic mandibular advancement device for obstructive sleep apnea.

    abstract：:Oral mandibular advancement devices are becoming an increasingly important treatment alternative for obstructive sleep apnea (OSA). The first aim of the study was to determine whether a new oral elastic mandibular advancement device (EMA) prevents pharyngeal airway closure during sleep in patients with OSA. The second...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.161.2.9903079

    authors： Henke KG,Frantz DE,Kuna ST

    更新日期：2000-02-01 00:00:00

  • Exogenous reinfection with tuberculosis on a European island with a moderate incidence of disease.

    abstract：:The frequency and determinants of exogenous reinfection and of endogenous reactivation of tuberculosis in patients previously treated are poorly understood. In Gran Canaria Island, Spain, between 1991 and 1996, 962 tuberculosis cases were confirmed by culture. Drug susceptibility testing was performed on available bac...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.163.3.2003070

    authors： Caminero JA,Pena MJ,Campos-Herrero MI,Rodríguez JC,Afonso O,Martin C,Pavón JM,Torres MJ,Burgos M,Cabrera P,Small PM,Enarson DA

    更新日期：2001-03-01 00:00:00

  • Nasal high-flow versus Venturi mask oxygen therapy after extubation. Effects on oxygenation, comfort, and clinical outcome.

    abstract：RATIONALE:Oxygen is commonly administered after extubation. Although several devices are available, data about their clinical efficacy are scarce. OBJECTIVES:To compare the effects of the Venturi mask and the nasal high-flow (NHF) therapy on PaO2/FiO2SET ratio after extubation. Secondary endpoints were to assess effec...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1164/rccm.201402-0364OC

    authors： Maggiore SM,Idone FA,Vaschetto R,Festa R,Cataldo A,Antonicelli F,Montini L,De Gaetano A,Navalesi P,Antonelli M

    更新日期：2014-08-01 00:00:00

  • A simple "new" method to accelerate clearance of carbon monoxide.

    abstract：:The currently recommended prehospital treatment for carbon monoxide (CO) poisoning is administration of 100% O(2). We have shown in dogs that normocapnic hyperpnea with O(2) further accelerates CO elimination. The purpose of this study was to examine the relation between minute ventilation (V E) and the rate of elimin...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1164/ajrccm.161.6.9907038

    authors： Takeuchi A,Vesely A,Rucker J,Sommer LZ,Tesler J,Lavine E,Slutsky AS,Maleck WH,Volgyesi G,Fedorko L,Iscoe S,Fisher JA

    更新日期：2000-06-01 00:00:00

  • Antibody to interleukin-5 inhibits virus-induced airway hyperresponsiveness to histamine in guinea pigs.

    abstract：:In humans, respiratory viral infections lead to increased airway responsiveness and exacerbations of asthma. In the present study, the role of interleukin-5 (IL-5) in virus-induced airway hyperresponsiveness and inflammation was examined in guinea pigs. In animals treated with control antibody, parainfluenza-3 virus s...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.151.1.7812550

    authors： van Oosterhout AJ,van Ark I,Folkerts G,van der Linde HJ,Savelkoul HF,Verheyen AK,Nijkamp FP

    更新日期：1995-01-01 00:00:00

  • Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome.

    abstract：RATIONALE:E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped e-liquids are unknown. OBJECTIVES:To determine the effects of chronic vaping on pulmonary epithelia. METHODS:We performed research bronchoscopies on h...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201710-2033OC

    authors： Ghosh A,Coakley RC,Mascenik T,Rowell TR,Davis ES,Rogers K,Webster MJ,Dang H,Herring LE,Sassano MF,Livraghi-Butrico A,Van Buren SK,Graves LM,Herman MA,Randell SH,Alexis NE,Tarran R

    更新日期：2018-07-01 00:00:00

  • A simple automated method for measuring pressure-volume curves during mechanical ventilation.

    abstract：:Measurement of respiratory compliance is advocated for assessing the severity of acute respiratory failure (ARF). Recently, the administration of an automated constant flow of 15 L/min was proposed as a method easier to implement at the bedside than supersyringe or inspiratory occlusions methods. However, pressure-vol...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.159.1.9802082

    authors： Lu Q,Vieira SR,Richecoeur J,Puybasset L,Kalfon P,Coriat P,Rouby JJ

    更新日期：1999-01-01 00:00:00