当前位置： SCI文献检索 > AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE期刊下所有文献 > De Novo DQ Donor-Specific Antibodies Are Associated with Chronic Lung Allograft Dysfunction after Lung Transplantation.

De Novo DQ Donor-Specific Antibodies Are Associated with Chronic Lung Allograft Dysfunction after Lung Transplantation.

Abstract：

RATIONALE:Despite increasing evidence about the role of donor-specific human leukocyte antigen (HLA) antibodies in transplant outcomes, the incidence and impact of de novo donor-specific antibodies (dnDSA) after lung transplantation remains unclear. OBJECTIVES:To describe the incidence, characteristics, and impact of dnDSA after lung transplantation. METHODS:We investigated a single-center cohort of 340 lung transplant recipients undergoing transplant during 2008 to 2011. All patients underwent HLA-antibody testing quarterly pretransplant and at regular intervals over the first 24 months after transplant. The patients received modified immunosuppression depending on their pretransplant sensitization status. Risk factors for dnDSA development, as well as the associations of dnDSA with patient survival and chronic lung allograft dysfunction (CLAD), were determined using multivariable analysis. MEASUREMENTS AND MAIN RESULTS:The cumulative incidence of dnDSA was 47% at a median of 86 days (range, 44-185 d) after lung transplantation. Seventy-six percent of recipients with dnDSA had DQ-DSA. Male sex and the use of ex vivo lung perfusion were associated with an increased risk of dnDSA, whereas increased HLA-DQB1 matching was protective. DQ-dnDSA preceded or coincided with the diagnosis of CLAD in all cases. Developing dnDSA (vs. no dnDSA) was associated with a twofold increased risk of CLAD (hazard ratio, 2.04; 95% confidence interval, 1.13-3.69). This association appeared to be driven by the development of DQ-dnDSA. CONCLUSIONS:dnDSA are common after lung transplantation, with the majority being DQ DSA. DQ-dnDSA are associated with an increased risk of CLAD. Strategies to prevent or treat DQ-dnDSA may improve outcomes for lung transplant recipients.

journal_name

Am J Respir Crit Care Med

journal_title

American journal of respiratory and critical care medicine

authors

Tikkanen JM,Singer LG,Kim SJ,Li Y,Binnie M,Chaparro C,Chow CW,Martinu T,Azad S,Keshavjee S,Tinckam K

doi

10.1164/rccm.201509-1857OC

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

596-606

issue

5

eissn

1073-449X

issn

1535-4970

journal_volume

194

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE文献大全
  • Mycobacterium tuberculosis infection after travel to or contact with visitors from countries with a high prevalence of tuberculosis.

    abstract：:To assess whether there is increased risk of tuberculous infection in children who traveled to or had a household visitor from a country having a high prevalence of tuberculosis, we conducted a case-control study. Children younger than 6 yr of age who had a tuberculin skin test read at public health clinics in areas o...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.158.6.9804106

    authors： Lobato MN,Hopewell PC

    更新日期：1998-12-01 00:00:00

  • Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection.

    abstract：RATIONALE:Chronic infection with Pseudomonas aeruginosa is associated with an increased exacerbation frequency, a more rapid decline in lung function, and increased mortality in patients with bronchiectasis. OBJECTIVES:To perform a randomized placebo-controlled study assessing the efficacy and safety of inhaled colist...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1164/rccm.201312-2208OC

    authors： Haworth CS,Foweraker JE,Wilkinson P,Kenyon RF,Bilton D

    更新日期：2014-04-15 00:00:00

  • Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial.

    abstract：RATIONALE:Corticosteroids are the antiinflammatory treatment of choice in asthma. Treatment guidelines are mainly symptom-driven but symptoms are not closely related to airway inflammation. The fraction of nitric oxide in exhaled air (FENO) is a marker of airway inflammation in asthma. OBJECTIVE:We evaluated whether t...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1164/rccm.200503-458OC

    authors： Pijnenburg MW,Bakker EM,Hop WC,De Jongste JC

    更新日期：2005-10-01 00:00:00

  • Bactericidal and sterilizing activities of antituberculosis drugs during the first 14 days.

    abstract：:Colony-forming units of Mycobacterium tuberculosis in sputum were counted at 2-day intervals in 100 patients treated with 22 regimens of isoniazid, rifampin, pyrazinamide, ethambutol, or streptomycin, given alone or in combinations. The exponential fall in colony-forming units was measured by linear regression coeffic...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200210-1125OC

    authors： Jindani A,Doré CJ,Mitchison DA

    更新日期：2003-05-15 00:00:00

  • Maximizing the utilization of donor organs offered for lung transplantation.

    abstract：:The number of patients awaiting lung transplantation (LT) and waiting time for surgery is increasing. In Australia, LT rates are 4. 6/million population/yr, which despite low organ donation rates, are the highest published in the world. The Australian organ allocation system allows identification of marginal donors an...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.160.1.9811017

    authors： Gabbay E,Williams TJ,Griffiths AP,Macfarlane LM,Kotsimbos TC,Esmore DS,Snell GI

    更新日期：1999-07-01 00:00:00

  • Imbalance between 95 kDa type IV collagenase and tissue inhibitor of metalloproteinases in sputum of patients with cystic fibrosis.

    abstract：:A growing body of evidence suggests that neutrophil-derived proteinases play a major role in lung tissue damage in cystic fibrosis (CF). Most previous studies have focused on serine proteinases such as neutrophil elastase, providing no information on the extent to which metalloproteinases participate in proteolytic pr...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.152.2.7633740

    authors： Delacourt C,Le Bourgeois M,D'Ortho MP,Doit C,Scheinmann P,Navarro J,Harf A,Hartmann DJ,Lafuma C

    更新日期：1995-08-01 00:00:00

  • Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study.

    abstract：:Inhaled nitric oxide (NO) improves systemic oxygenation (PaO2/FIO2) in adult patients with acute respiratory distress syndrome (ARDS). However, individual response varies, and previous trials demonstrated no outcome benefit. This prospective, randomized study in 40 ARDS patients analyzed dose-response (DR) characteris...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1164/rccm.2108121

    authors： Gerlach H,Keh D,Semmerow A,Busch T,Lewandowski K,Pappert DM,Rossaint R,Falke KJ

    更新日期：2003-04-01 00:00:00

  • Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends.

    abstract：:Survival is linked to the histopathologic distinction between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP), the most commonly encountered fibrotic idiopathic interstitial pneumonia. We retrospectively compared the prognostic significance of histopathologic diagnoses, baseline pulmon...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200210-1245OC

    authors： Latsi PI,du Bois RM,Nicholson AG,Colby TV,Bisirtzoglou D,Nikolakopoulou A,Veeraraghavan S,Hansell DM,Wells AU

    更新日期：2003-09-01 00:00:00

  • Language of dyspnea in assessment of patients with acute asthma treated with nebulized albuterol.

    abstract：:To investigate whether the language of dyspnea provides relevant clinical information in addition to that provided by ratings of overall dyspnea intensity when assessing subjective response to therapy, we conducted a prospective study in a cohort of 25 patients with acute asthma presenting to the emergency department ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.158.3.9707088

    authors： Moy ML,Lantin ML,Harver A,Schwartzstein RM

    更新日期：1998-09-01 00:00:00

  • Comparison between automatic and fixed positive airway pressure therapy in the home.

    abstract：:We tested the hypothesis that continuous positive airway pressure (CPAP) use and outcomes can be improved by an autotitrating CPAP device in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) who require higher CPAP (10 cm H2O or more). In this multisite randomized single-blind cross-over study, 44 patien...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1164/rccm.200201-022OC

    authors： Massie CA,McArdle N,Hart RW,Schmidt-Nowara WW,Lankford A,Hudgel DW,Gordon N,Douglas NJ

    更新日期：2003-01-01 00:00:00

  • Differential properties of mucous glycoproteins in rat nasal epithelium. A comparison between allergic inflammation and lipopolysaccharide stimulation.

    abstract：:To examine the differential properties of mucous glycoproteins, we produced hypertrophic and metaplastic changes in goblet cells of rat nasal epithelium by intranasal instillation of ovalbumin (OVA) in OVA-sensitized rats, and by intranasal lipopolysaccharide (LPS) instillation. The epithelial mucosubstance was quanti...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.164.6.2012058

    authors： Shimizu T,Hirano H,Shimizu S,Kishioka C,Sakakura Y,Majima Y

    更新日期：2001-09-15 00:00:00

  • Improved clearability of cystic fibrosis sputum with dextran treatment in vitro.

    abstract：:Most patients with cystic fibrosis (CF) are infected by Pseudomonas aeruginosa. Dextran exhibits anti-adhesive effects in preventing attachment of P. aeruginosa to epithelial cells (1). The initial purpose of this study was to evaluate the potential of dextran to alter the rheology and ciliary transportability of CF s...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.157.3.9703059

    authors： Feng W,Garrett H,Speert DP,King M

    更新日期：1998-03-01 00:00:00

  • Effect of the beta-agonist clenbuterol on dexamethasone-induced diaphragm dysfunction in rabbits.

    abstract：:The present study was designed to examine whether clenbuterol (CLEN) could reduce dexamethasone (DEX)-induced diaphragm dysfunction. We studied four groups of New Zealand white (NZW) rabbits, each receiving one of the following daily injections subcutaneously for 2 wk: saline (control), DEX 3 mg/kg, DEX 3 mg/kg + CLEN...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.154.6.8970370

    authors： Jiang TX,Cairns A,Road JD,Wilcox PG

    更新日期：1996-12-01 00:00:00

  • The impact of genomic changes on treatment of lung cancer.

    abstract：:The remarkable success of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in patients with EGFR mutations and ALK rearrangements, respectively, introduced the era of targeted therapy in advanced non-small cell lung cancer (NSCLC), shifting treatment from platinum...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,评审

    doi：10.1164/rccm.201305-0843PP

    authors： Cardarella S,Johnson BE

    更新日期：2013-10-01 00:00:00

  • Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis.

    abstract：RATIONALE:Studies in patients and experimental animals provide compelling evidence of the involvement of the major thrombin receptor, proteinase-activated receptor-1 (PAR(1)), and the potent chemokine, chemokine (CC motif) ligand-2 (CCL2)/monocyte chemotactic protein-1, in the pathogenesis of idiopathic pulmonary fibro...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200712-1827OC

    authors： Mercer PF,Johns RH,Scotton CJ,Krupiczojc MA,Königshoff M,Howell DC,McAnulty RJ,Das A,Thorley AJ,Tetley TD,Eickelberg O,Chambers RC

    更新日期：2009-03-01 00:00:00

  • Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada.

    abstract：RATIONALE:Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationsh...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1164/rccm.201006-0940OC

    authors： Olsson AC,Gustavsson P,Kromhout H,Peters S,Vermeulen R,Brüske I,Pesch B,Siemiatycki J,Pintos J,Brüning T,Cassidy A,Wichmann HE,Consonni D,Landi MT,Caporaso N,Plato N,Merletti F,Mirabelli D,Richiardi L,Jöckel KH,Ah

    更新日期：2011-04-01 00:00:00

  • Objective predictors of response for staple versus laser emphysematous lung reduction.

    abstract：:Recently described surgical approaches to the treatment of emphysema, including buttressed stapled volume reduction and laser coagulation, are associated with variable clinical outcomes. We examined objective preoperative factors as predictors of response to treatment in patients enrolled in a randomized trial of stap...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1164/ajrccm.155.4.9105070

    authors： Brenner M,McKenna R Jr,Gelb A,Osann K,Schein MJ,Panzera J,Wong H,Berns MW,Wilson AF

    更新日期：1997-04-01 00:00:00

  • Nosocomial acquisition of Burkholderia gladioli in patients with cystic fibrosis.

    abstract：:Burkholderia gladioli has been reported as colonizing the airways of patients with cystic fibrosis (CF) but has not previously been associated with adverse outcome. We describe six patients with CF in whom the same strain of B. gladioli, on the basis of ribotyping and biochemical characteristics, was grown in their sp...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.155.4.9105090

    authors： Wilsher ML,Kolbe J,Morris AJ,Welch DF

    更新日期：1997-04-01 00:00:00

  • Vascular reactivity in sepsis: importance of controls and role of nitric oxide.

    abstract：:We have previously reported differential impairment of pulmonary and systemic vascular contractility in hyperdynamic sepsis. The objectives of this study were (1) to determine whether the magnitude of this phenomenon depends on the control group chosen for comparison, and (2) to examine the role of nitric oxide (NO) i...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm/151.3_Pt_1.706

    authors： Yaghi A,Paterson NA,McCormack DG

    更新日期：1995-03-01 00:00:00

  • Expression of mRNA for gastrin-releasing peptide receptor by human bronchial epithelial cells. Association with prolonged tobacco exposure and responsiveness to bombesin-like peptides.

    abstract：:Bombesin-like peptides (BLPs) are important regulators of lung development and may also act as autocrine growth factors in lung tumors. We have previously demonstrated expression of mRNA for the three BLP receptor subtypes (neuromedin B [NMB]) receptor, gastrin-releasing peptide [GRP] receptor, and bombesin receptor s...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.156.2.9608047

    authors： Siegfried JM,DeMichele MA,Hunt JD,Davis AG,Vohra KP,Pilewski JM

    更新日期：1997-08-01 00:00:00

  • Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America.

    abstract：:Background: This document provides evidence-based clinical practice guidelines on the management of adult patients with community-acquired pneumonia.Methods: A multidisciplinary panel conducted pragmatic systematic reviews of the relevant research and applied Grading of Recommendations, Assessment, Development, and Ev...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,实务指引

    doi：10.1164/rccm.201908-1581ST

    authors： Metlay JP,Waterer GW,Long AC,Anzueto A,Brozek J,Crothers K,Cooley LA,Dean NC,Fine MJ,Flanders SA,Griffin MR,Metersky ML,Musher DM,Restrepo MI,Whitney CG

    更新日期：2019-10-01 00:00:00

  • Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome?

    abstract：:Levels of oleic acid (OA) are elevated in plasma and bronchoalveolar lavage fluids of patients with acute respiratory distress syndrome (ARDS). OA is also widely used to provoke edema, by unknown mechanisms, in experimental models of ARDS. We investigated the impact of intravascularly applied OA on epithelial lining f...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200407-954OC

    authors： Vadász I,Morty RE,Kohstall MG,Olschewski A,Grimminger F,Seeger W,Ghofrani HA

    更新日期：2005-03-01 00:00:00

  • Endotoxin contamination causes neutrophilia following pulmonary allergen challenge.

    abstract：:Segmental bronchoprovocation (SBP) with allergen was used in an attempt to study eosinophils recruited to the airway 24 h after challenge. Unexpectedly, in the first four patients, neutrophils (rather than eosinophils) were recruited in the bronchoalveolar lavage (BAL) fluids, and we hypothesized that the allergen ext...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.149.6.8004300

    authors： Hunt LW,Gleich GJ,Ohnishi T,Weiler DA,Mansfield ES,Kita H,Sur S

    更新日期：1994-06-01 00:00:00

  • Complement receptor 1 gene polymorphisms are associated with idiopathic pulmonary fibrosis.

    abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrotic disorder underlain by aberrant wound healing of repeated lung injury. Environmental triggers and genetic background are likely to act as modifiers of the fibrotic response. Erythrocyte complement receptor 1 is a membrane protein mediating the transport of immu...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200302-221OC

    authors： Zorzetto M,Ferrarotti I,Trisolini R,Lazzari Agli L,Scabini R,Novo M,De Silvestri A,Patelli M,Martinetti M,Cuccia M,Poletti V,Pozzi E,Luisetti M

    更新日期：2003-08-01 00:00:00

  • Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients.

    abstract：:The inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1 beta), have been associated with accelerated metabolism and protein turnover following exogenous administration in normal humans. We hypothesized that these inflammatory cytokines might contribute to the weight-losing proc...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.153.2.8564110

    authors： de Godoy I,Donahoe M,Calhoun WJ,Mancino J,Rogers RM

    更新日期：1996-02-01 00:00:00

  • House dust endotoxin and wheeze in the first year of life.

    abstract：:We examined endotoxin exposure and wheezing episodes during the first year of life in a birth cohort of 499 infants with one or both parents having a history of asthma or allergy. We measured endotoxin in settled dust from the baby's bed, bedroom floor, family room, and kitchen floor within the first 3 mo after birth....

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.163.2.2002088

    authors： Park JH,Gold DR,Spiegelman DL,Burge HA,Milton DK

    更新日期：2001-02-01 00:00:00

  • Airway hyperresponsiveness in asthma. Not just a problem of smooth muscle relaxation with inspiration.

    abstract：:Airway hyperresponsiveness in asthma has been attributed to impaired ability of deep inspiration (DI) to stretch airway smooth muscle. We have retested this hypothesis by comparing the responses to methacholine of 10 asthmatic and 10 control subjects. After each dose subjects breathed tidally without deep inspiration ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.158.1.9707125

    authors： Burns GP,Gibson GJ

    更新日期：1998-07-01 00:00:00

  • Presentation of AIDS-related pulmonary Kaposi's sarcoma diagnosed by bronchoscopy.

    abstract：:Kaposi's sarcoma (KS) is the most common neoplasm in persons infected with the human immunodeficiency virus (HIV). However, information about the presenting features of pulmonary KS is limited. To describe the clinical, laboratory, and radiographic features of pulmonary KS, medical records and chest radiographs of 168...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.153.4.8616570

    authors： Huang L,Schnapp LM,Gruden JF,Hopewell PC,Stansell JD

    更新日期：1996-04-01 00:00:00

  • House dust endotoxin and allergic sensitization in children.

    abstract：:A higher exposure to endotoxin was hypothesized to contribute to lower prevalence of allergic sensitization and hay fever in children growing up on a farm. We studied the association between house dust endotoxin and allergic sensitization. We randomly selected 740 children, aged between 5 and 10 years, from a group of...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200203-256OC

    authors： Gehring U,Bischof W,Fahlbusch B,Wichmann HE,Heinrich J

    更新日期：2002-10-01 00:00:00

  • Dilatation of the constricted human airway by tidal expansion of lung parenchyma.

    abstract：RATIONALE:In the normal lung, breathing and deep inspirations potently antagonize bronchoconstriction, but in the asthmatic lung this salutary effect is substantially attenuated or even reversed. To explain these findings, the prevailing hypothesis focuses on contracting airway smooth muscle and posits a nonlinear dyna...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201202-0368OC

    authors： Lavoie TL,Krishnan R,Siegel HR,Maston ED,Fredberg JJ,Solway J,Dowell ML

    更新日期：2012-08-01 00:00:00