Presentation of AIDS-related pulmonary Kaposi's sarcoma diagnosed by bronchoscopy.

abstract：:Pharyngeal dilator muscle activation (GGEMG) during wakefulness is greater in patients with obstructive sleep apnea (OSA) than in healthy control subjects, representing a neuromuscular compensatory mechanism for a more collapsible airway. As previous work from our laboratory has demonstrated a close relationship betwe...

journal_title：American journal of respiratory and critical care medicine

authors： Fogel RB,Malhotra A,Pillar G,Edwards JK,Beauregard J,Shea SA,White DP

更新日期：2001-12-01 00:00:00

abstract：:Most patients with cystic fibrosis (CF) are infected by Pseudomonas aeruginosa. Dextran exhibits anti-adhesive effects in preventing attachment of P. aeruginosa to epithelial cells (1). The initial purpose of this study was to evaluate the potential of dextran to alter the rheology and ciliary transportability of CF s...

journal_title：American journal of respiratory and critical care medicine

authors： Feng W,Garrett H,Speert DP,King M

更新日期：1998-03-01 00:00:00

abstract：:Regular short-acting inhaled beta-agonist therapy is of uncertain benefit in patients with chronic obstructive pulmonary disease (COPD). We conducted a randomized, concealed, double-blind, placebo-controlled crossover trial in two periods, each of 3-mo duration, involving 53 patients with a smoking history of > 20 pac...

journal_title：American journal of respiratory and critical care medicine

authors： Cook D,Guyatt G,Wong E,Goldstein R,Bedard M,Austin P,Ramsdale H,Jaeschke R,Sears M

更新日期：2001-01-01 00:00:00

abstract：:The molecular sources of reactive oxygen species (ROS) in skeletal muscles are not well understood. We hypothesized that nonphagocyte NAD(P)H oxidase could be a source of ROS in muscle fibers. We thus investigated the existence, structure, and contribution of nonphagocyte NAD(P)H oxidase to ROS production in rat skele...

journal_title：American journal of respiratory and critical care medicine

authors： Javeshghani D,Magder SA,Barreiro E,Quinn MT,Hussain SN

更新日期：2002-02-01 00:00:00

abstract：RATIONALE:There is a need to develop novel noninvasive imaging biomarkers that help to evaluate antiinflammatory asthma treatments. OBJECTIVES:To investigate whether the extent of the segmental lung edema measured noninvasively using turbo-inversion recovery-magnitude magnetic resonance imaging (TIRM MRI) corresponds ...

journal_title：American journal of respiratory and critical care medicine

authors： Vogel-Claussen J,Renne J,Hinrichs J,Schönfeld C,Gutberlet M,Schaumann F,Winkler C,Faulenbach C,Krug N,Wacker FK,Hohlfeld JM

更新日期：2014-03-15 00:00:00

abstract：:In this study, 12 male baboons were delivered by hysterotomy at 75% of gestation. The development of a nonlethal baboon model permitted a study of lung growth and development in long-term survivors. Control animals were ventilated with clinically appropriate oxygen for the 21 d study period. BPD animals were ventilate...

journal_title：American journal of respiratory and critical care medicine

authors： Coalson JJ,Winter V,deLemos RA

更新日期：1995-08-01 00:00:00

abstract：:The upper airway undergoes progressive changes during childhood. Using magnetic resonance imaging (MRI), we studied the growth relationships of the tissues surrounding the upper airway (bone and soft tissues) in 92 normal children (47% males; range, 1 to 11 yr) who underwent brain MRI. None had symptoms of sleep-disor...

journal_title：American journal of respiratory and critical care medicine

authors： Arens R,McDonough JM,Corbin AM,Hernandez ME,Maislin G,Schwab RJ,Pack AI

更新日期：2002-01-01 00:00:00

abstract：:Rationale: Growing evidence suggests that compromised lung health may be linked to dementia and worsening cognitive ability. Objectives: To test the hypothesis that impaired lung function or lung disease in midlife is associated with greater risk of incident dementia and mild cognitive impairment (MCI) later in life. ...

journal_title：American journal of respiratory and critical care medicine

authors： Lutsey PL,Chen N,Mirabelli MC,Lakshminarayan K,Knopman DS,Vossel KA,Gottesman RF,Mosley TH,Alonso A

更新日期：2019-06-01 00:00:00

abstract：RATIONALE:The development of host-targeted, prophylactic, and therapeutic interventions against tuberculosis requires a better understanding of the immune mechanisms that determine the outcome of infection with Mycobacterium tuberculosis. OBJECTIVES:To identify T-cell-dependent mechanisms that are protective in tuberc...

journal_title：American journal of respiratory and critical care medicine

authors： Busch M,Herzmann C,Kallert S,Zimmermann A,Höfer C,Mayer D,Zenk SF,Muche R,Lange C,Bloom BR,Modlin RL,Stenger S,TBornotTB Network.

更新日期：2016-08-01 00:00:00

abstract：:Bronchoalveolar lavage (BAL) is increasingly used in the pediatric age group. However, normal values for BAL fluid (BALF) constituents are lacking. As part of an investigation to define reference values in children, we studied lymphocyte surface markers of BALF in 28 children 3 to 16 yr of age without bronchopulmonary...

journal_title：American journal of respiratory and critical care medicine

authors： Ratjen F,Bredendiek M,Zheng L,Brendel M,Costabel U

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:Cytomegalovirus (CMV), which is one of the most common infections after lung transplantation, is associated with chronic lung allograft dysfunction and worse post-transplantation survival. Current approaches for at-risk patients include a fixed duration of antiviral prophylaxis despite the associated cost and...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder LD,Chan C,Kwon D,Yi JS,Martissa JA,Copeland CA,Osborne RJ,Sparks SD,Palmer SM,Weinhold KJ

更新日期：2016-01-01 00:00:00

abstract：RATIONALE:Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) increase in inflammatory pulmonary diseases. OBJECTIVES:To study whether arterial Hb-CO is useful to monitor disease activity in patients with chronic obstructive pulmonary disease (COPD) who had stopped smoking. METHOD...

journal_title：American journal of respiratory and critical care medicine

authors： Yasuda H,Yamaya M,Nakayama K,Ebihara S,Sasaki T,Okinaga S,Inoue D,Asada M,Nemoto M,Sasaki H

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:No methodical assessment of the lung, cardiac, and sleep function of patients surviving an acute hypercapnic respiratory failure episode requiring admission to the intensive care unit (ICU) has been reported in the literature. OBJECTIVES:To prospectively investigate the prevalence and impact of comorbidities...

journal_title：American journal of respiratory and critical care medicine

authors： Adler D,Pépin JL,Dupuis-Lozeron E,Espa-Cervena K,Merlet-Violet R,Muller H,Janssens JP,Brochard L

更新日期：2017-07-15 00:00:00

abstract：:The role of nitric oxide (NO) in the host-defense against human tuberculosis (TB) is controversial. Although experimental evidence indicates that NO may play an important role in controlling TB, its expression in human tuberculous lungs has not been systematically characterized. We therefore investigated the expressio...

journal_title：American journal of respiratory and critical care medicine

authors： Choi HS,Rai PR,Chu HW,Cool C,Chan ED

更新日期：2002-07-15 00:00:00

abstract：RATIONALE:The incidence of influenza-associated acute respiratory failure is unknown. OBJECTIVES:To estimate the population-based incidence of influenza-associated acute respiratory failure hospitalizations. METHODS:This is a cohort study from January 2003 through March 2009 using hospitalization databases for Arizon...

journal_title：American journal of respiratory and critical care medicine

authors： Ortiz JR,Neuzil KM,Rue TC,Zhou H,Shay DK,Cheng PY,Cooke CR,Goss CH

更新日期：2013-09-15 00:00:00

abstract：:The role of lipoxygenase metabolites in the pathogenesis of endotoxin (LPS)-induced lung injury remains to be clarified. We investigated the contribution of peptide leukotrienes to LPS-induced acute lung injury using a potent antagonist, ONO-1078 (ONO). Experimental groups consisted of a saline group (n = 10), an LPS ...

journal_title：American journal of respiratory and critical care medicine

authors： Ishizaka A,Hasegawa N,Sakamaki F,Tasaka S,Nakamura H,Kishikawa K,Yamada A,Obata T,Sayama K,Urano T

更新日期：1994-11-01 00:00:00

abstract：:The rise in childhood asthma prevalence suggests a role for environmental factors in the etiology of this evolving epidemic; however, genetics also influence the occurrence of asthma. Glutathione S-transferase (GST) M1 may play a role in asthma and wheezing occurrence among those exposed to tobacco smoke, as it functi...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Li YF,Dubeau L,Berhane K,Avol E,McConnell R,Gauderman WJ,Peters JM

更新日期：2002-08-15 00:00:00

abstract：RATIONALE:The causal direction between asthma and lung function deficit is unknown, but important for the focus of preventive measures and research into the origins of asthma. OBJECTIVES:To analyze the interaction between lung function development and asthma from birth to 7 years of age. METHODS:The Copenhagen Prospe...

journal_title：American journal of respiratory and critical care medicine

authors： Bisgaard H,Jensen SM,Bønnelykke K

更新日期：2012-06-01 00:00:00

abstract：:During Operation Everest III (Comex '97), to assess the consequences of altitude-induced hypoxia, eight volunteers were decompressed in a hypobaric chamber, with a decompression profile simulating the climb of Mount Everest. Cardiac function was assessed using a combination of M-mode and two-dimensional echocardiograp...

journal_title：American journal of respiratory and critical care medicine

authors： Boussuges A,Molenat F,Burnet H,Cauchy E,Gardette B,Sainty JM,Jammes Y,Richalet JP

更新日期：2000-01-01 00:00:00

abstract：RATIONALE:The airway surface liquid, the thin layer of liquid covering the airways, is essential for mucociliary clearance and as a barrier against microbial and other noxious agents. Proteins secreted into the airway surface liquid by epithelial and nonepithelial cells may be important in innate immunity and to improv...

journal_title：American journal of respiratory and critical care medicine

authors： Candiano G,Bruschi M,Pedemonte N,Caci E,Liberatori S,Bini L,Pellegrini C,Viganò M,O'Connor BJ,Lee TH,Galietta LJ,Zegarra-Moran O

更新日期：2005-11-01 00:00:00

abstract：:Female Fisher 344 rats (n = 25) were inoculated intrapleurally with a single 20-mg dose of (JM-100) fibrous glass. The mean length (2.2 microns) and width (0.15 microns) of the fibrous glass particles was within respirable range. Following inoculation, the rats were killed at timed intervals ranging from 2 to 430 d fr...

journal_title：American journal of respiratory and critical care medicine

authors： Fraire AE,Greenberg SD,Spjut HJ,Roggli VL,Dodson RF,Cartwright J,Williams G,Baker S

更新日期：1994-08-01 00:00:00

abstract：:Methodologies used to assess airway responsiveness (AR) in children administer the same dosage schedule to all children despite the great range in the size of subjects. The aim of this study was to examine the hypothesis that the level of AR is size dependent within same-age cohorts and between different ages. Among a...

journal_title：American journal of respiratory and critical care medicine

authors： Le Souëf PN,Sears MR,Sherrill D

更新日期：1995-08-01 00:00:00

abstract：:The inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1 beta), have been associated with accelerated metabolism and protein turnover following exogenous administration in normal humans. We hypothesized that these inflammatory cytokines might contribute to the weight-losing proc...

journal_title：American journal of respiratory and critical care medicine

authors： de Godoy I,Donahoe M,Calhoun WJ,Mancino J,Rogers RM

更新日期：1996-02-01 00:00:00

abstract：:A respiratory therapist-driven weaning protocol incorporating daily screens, spontaneous breathing trials (SBT), and prompts to caregivers has been associated with superior outcomes in mechanically ventilated medical patients. To determine the effectiveness of this approach in neurosurgical (NSY) patients, we conducte...

journal_title：American journal of respiratory and critical care medicine

authors： Namen AM,Ely EW,Tatter SB,Case LD,Lucia MA,Smith A,Landry S,Wilson JA,Glazier SS,Branch CL,Kelly DL,Bowton DL,Haponik EF

更新日期：2001-03-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) is elevated in human fibrotic lung diseases and in animal models of pulmonary fibrosis, implicating IGF-I in the pathogenesis of fibrotic lung disease. We questioned whether IGF-I protein levels were enhanced in fibroproliferative acute respiratory distress syndrome (FP-ARDS). Seri...

journal_title：American journal of respiratory and critical care medicine

authors： Krein PM,Sabatini PJ,Tinmouth W,Green FH,Winston BW

更新日期：2003-01-01 00:00:00

abstract：:We present a case of a pulmonary nodular lesion in an immunocompetent patient documented at open lung biopsy to be due to Mycobacterium haemophilum. This organism has recently been recognized as a cause of disease in immunocompromised patients, presenting predominantly as skin lesions, arthritis, and rarely pneumonia....

journal_title：American journal of respiratory and critical care medicine

authors： White DA,Kiehn TE,Bondoc AY,Massarella SA

更新日期：1999-10-01 00:00:00

abstract：:The mechanism responsible for the increased air-space permeability in cigarette smokers is unknown. The aim of this study was to assess the acute and chronic effects of cigarette smoking on epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Fourteen cigarette smokers underwent 99mT...

journal_title：American journal of respiratory and critical care medicine

authors： Morrison D,Rahman I,Lannan S,MacNee W

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:Increasing epithelial repair and regeneration may hasten resolution of lung injury in patients with the acute respiratory distress syndrome (ARDS). In animal models of ARDS, keratinocyte growth factor (KGF) reduces injury and increases epithelial proliferation and repair. The effect of KGF in the human alveol...

journal_title：American journal of respiratory and critical care medicine

authors： Shyamsundar M,McAuley DF,Ingram RJ,Gibson DS,O'Kane D,McKeown ST,Edwards A,Taggart C,Elborn JS,Calfee CS,Matthay MA,O'Kane CM

更新日期：2014-06-15 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR nuclear hormone receptor family, but the role of PPAR-β/δ in sepsis is unknown. OBJECTIVES:We investigated the role of PPAR-β/δ in murine models of LPS-induced organ injury and dysfunction and cecal ligat...

journal_title：American journal of respiratory and critical care medicine

authors： Kapoor A,Shintani Y,Collino M,Osuchowski MF,Busch D,Patel NS,Sepodes B,Castiglia S,Fantozzi R,Bishop-Bailey D,Mota-Filipe H,Yaqoob MM,Suzuki K,Bahrami S,Desvergne B,Mitchell JA,Thiemermann C

更新日期：2010-12-15 00:00:00

abstract：:The incidence of mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in children with intermediate sweat chloride levels is unknown. The results of 2,349 sweat tests performed at two Belgian university hospitals were reviewed. Intermediate chloride concentrations were observed in 98 subjec...

journal_title：American journal of respiratory and critical care medicine

authors： Lebecque P,Leal T,De Boeck C,Jaspers M,Cuppens H,Cassiman JJ

更新日期：2002-03-15 00:00:00