Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends.

Abstract:

:Survival is linked to the histopathologic distinction between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP), the most commonly encountered fibrotic idiopathic interstitial pneumonia. We retrospectively compared the prognostic significance of histopathologic diagnoses, baseline pulmonary function indices, and serial trends in pulmonary function indices (diffusing capacity, FVC, FEV1, the recently defined composite physiologic index) at 6 and 12 months in 104 patients (UIP, n = 63; fibrotic NSIP, n = 41). Survival was lower in UIP than in fibrotic NSIP (p = 0.001) but not in patients with severe functional impairment; mortality during the first 2 years was linked solely to the severity of functional impairment at presentation. The composite physiologic index was the strongest determinant of outcome (p < 0.001). At 6 months, serial diffusing capacity levels (p = 0.003) and histopathologic diagnosis (p = 0.002) were prognostically equivalent. At 12 months, serial pulmonary function trends were the only major prognostic determinant (p < 0.0005 for all variables), with no independent significance associated with the distinction between UIP and fibrotic NSIP. We conclude that at 12 months, serial pulmonary function trends have considerable prognostic value in UIP and NSIP. Their histologic distinction provides no additional prognostic information when pulmonary function trends are clear cut or when functional impairment is severe.

authors

Latsi PI,du Bois RM,Nicholson AG,Colby TV,Bisirtzoglou D,Nikolakopoulou A,Veeraraghavan S,Hansell DM,Wells AU

doi

10.1164/rccm.200210-1245OC

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

531-7

issue

5

eissn

1073-449X

issn

1535-4970

pii

200210-1245OC

journal_volume

168

pub_type

杂志文章
  • Factors influencing cardiopulmonary effects of inhaled nitric oxide in acute respiratory failure.

    abstract::The aim of this prospective study was to determine factors influencing effects of inhaled nitric oxide (NO) on the pulmonary circulation and on gas exchange in critically ill patients with acute lung injury. Twenty-one hypoxemic patients with acute respiratory failure (PaO2 = 127 +/- 69 mm Hg during intermittent posit...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1164/ajrccm.152.1.7599840

    authors: Puybasset L,Rouby JJ,Mourgeon E,Cluzel P,Souhil Z,Law-Koune JD,Stewart T,Devilliers C,Lu Q,Roche S

    更新日期:1995-07-01 00:00:00

  • Soluble TNF receptors (TNF-sR55 and TNF-sR75) in lung allograft recipients displaying cytomegalovirus pneumonitis.

    abstract::Two distinct types of tumor necrosis factor receptors (TNF-R) have been identified (TNF-R55 and TNF-R75). Both TNF-R also exist in soluble forms (TNF-sR), resulting from the release of the extracellular domains (TNF-sR55 and TNF-sR75). TNF-sR may play an important role in vivo as they can bind to TNF alpha and prevent...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.149.6.8004330

    authors: Humbert M,Roux-Lombard P,Cerrina J,Magnan A,Simonneau G,Dartevelle P,Galanaud P,Dayer JM,Emilie D

    更新日期:1994-06-01 00:00:00

  • Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats.

    abstract:RATIONALE:Pulmonary hypertension (PH) is a life-threatening disease, characterized by vascular remodeling and vasoconstriction. Evidence suggests that oxidative stress may contribute to the pathogenesis and/or development of PH. OBJECTIVES:In the present study, we examined whether intratracheal gene transfer of human ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200702-264OC

    authors: Kamezaki F,Tasaki H,Yamashita K,Tsutsui M,Koide S,Nakata S,Tanimoto A,Okazaki M,Sasaguri Y,Adachi T,Otsuji Y

    更新日期:2008-01-15 00:00:00

  • Risk assessment of tuberculosis in immunocompromised patients. A TBNET study.

    abstract:RATIONALE:In the absence of active tuberculosis, a positive tuberculin skin test (TST) or interferon-γ release assay (IGRA) result defines latent infection with Mycobacterium tuberculosis, although test results may vary depending on immunodeficiency. OBJECTIVES:This study compared the performance of TST and IGRAs in f...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201405-0967OC

    authors: Sester M,van Leth F,Bruchfeld J,Bumbacea D,Cirillo DM,Dilektasli AG,Domínguez J,Duarte R,Ernst M,Eyuboglu FO,Gerogianni I,Girardi E,Goletti D,Janssens JP,Julander I,Lange B,Latorre I,Losi M,Markova R,Matteelli A,M

    更新日期:2014-11-15 00:00:00

  • Ethnic differences in the effect of asthma on pulmonary function in children.

    abstract:RATIONALE:The impact of asthma on chronic lung function deficits is well known. However, there has been little study of ethnic differences in these asthma-associated deficits. OBJECTIVES:To examine whether there are ethnic differences in the effects of asthma on children's lung function. METHODS:We evaluated the impa...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200912-1863OC

    authors: Zhang Y,McConnell R,Gilliland F,Berhane K

    更新日期:2011-03-01 00:00:00

  • Determination of gas exchange threshold by nonparametric regression.

    abstract::The gas exchange threshold (GET) has been used an an index of anaerobic threshold because it can be measured noninvasively. GET is estimated from a breakpoint in breath by breath values of carbon dioxide uptake (Vco2) and oxygen uptake (Vo2) obtained during a progressive exercise test. Three methods of estimating GET ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.151.1.7812580

    authors: Magalang UJ,Grant BJ

    更新日期:1995-01-01 00:00:00

  • Lavage administration of dilute surfactants after acute lung injury in neonatal piglets.

    abstract::Exogenous surfactant therapy is not standard in the acute respiratory distress syndrome (ARDS) because of a lack of proven benefit. Nonuniform surfactant distribution after either bolus or aerosol administration may be an important factor limiting response. In a previous study of acute lung injury, we demonstrated tha...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.158.1.9704119

    authors: Balaraman V,Meister J,Ku TL,Sood SL,Tam E,Killeen J,Uyehara CF,Egan E,Easa D

    更新日期:1998-07-01 00:00:00

  • De Novo DQ Donor-Specific Antibodies Are Associated with Chronic Lung Allograft Dysfunction after Lung Transplantation.

    abstract:RATIONALE:Despite increasing evidence about the role of donor-specific human leukocyte antigen (HLA) antibodies in transplant outcomes, the incidence and impact of de novo donor-specific antibodies (dnDSA) after lung transplantation remains unclear. OBJECTIVES:To describe the incidence, characteristics, and impact of ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201509-1857OC

    authors: Tikkanen JM,Singer LG,Kim SJ,Li Y,Binnie M,Chaparro C,Chow CW,Martinu T,Azad S,Keshavjee S,Tinckam K

    更新日期:2016-09-01 00:00:00

  • Mechanism underlying accelerated arterial oxygen desaturation during recurrent apnea.

    abstract:RATIONALE:Brief recurrent apneas in preterm infants and adults can precipitate rapid and severe arterial O(2) desaturation for reasons that remain unclear. OBJECTIVES:We tested a mathematically derived hypothesis that when breathing terminates apnea, mixed-venous hypoxemia continues into the subsequent apnea; as a res...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201003-0477OC

    authors: Sands SA,Edwards BA,Kelly VJ,Skuza EM,Davidson MR,Wilkinson MH,Berger PJ

    更新日期:2010-10-01 00:00:00

  • Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model.

    abstract::Numerous in vitro and in vivo studies in both animals and patients with asthma have shown that interleukin (IL)-9 is an important inflammatory mediator in asthma. To examine the effects of IL-9 antagonism on airway inflammation, ovalbumin-sensitized BALB/c mice were intravenously given anti-IL-9 antibody or an isotype...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.2105079

    authors: Cheng G,Arima M,Honda K,Hirata H,Eda F,Yoshida N,Fukushima F,Ishii Y,Fukuda T

    更新日期:2002-08-01 00:00:00

  • Patient perception of sleep quality and etiology of sleep disruption in the intensive care unit.

    abstract::The etiology of sleep disruption in patients in intensive care units (ICUs) is poorly understood, but is thought to be related to environmental stimuli, especially noise. We sampled 203 patients (121 males and 82 females) from different ICUs (cardiac [CCU], cardiac stepdown [CICU], medical [MICU], and surgical [SICU])...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.159.4.9806141

    authors: Freedman NS,Kotzer N,Schwab RJ

    更新日期:1999-04-01 00:00:00

  • Interleukin-1 beta inhibits airway smooth muscle contraction via epithelium-dependent mechanism.

    abstract::To determine whether the cytokine interleukin (IL)-1 beta directly affects airway smooth muscle functions and, if so, what the mechanism of action is, we studied canine isolated bronchial segments under isometric conditions in vitro. Incubation of tissues with human recombinant IL-1 beta (10 ng/ml) for 150 min decreas...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.149.1.8111570

    authors: Tamaoki J,Yamawaki I,Takeyama K,Chiyotani A,Yamauchi F,Konno K

    更新日期:1994-01-01 00:00:00

  • Disrupted prenatal maternal cortisol, maternal obesity, and childhood wheeze. Insights into prenatal programming.

    abstract:RATIONALE:Exploring prenatal factors influencing childhood wheeze may inform programming mechanisms. OBJECTIVES:We examined associations among prenatal maternal cortisol profiles, maternal obesity, and repeated wheeze up to age 2 years (n = 261). METHODS:Salivary cortisol was collected five times per day over 3 days ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1164/rccm.201208-1530OC

    authors: Wright RJ,Fisher K,Chiu YH,Wright RO,Fein R,Cohen S,Coull BA

    更新日期:2013-06-01 00:00:00

  • Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.

    abstract:RATIONALE:Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin this disease's complex pathophysiology, yet these cells have been little studied. OBJECTIVES:To examine the functional and transcriptional profiles of pa...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201509-1818OC

    authors: Juss JK,House D,Amour A,Begg M,Herre J,Storisteanu DM,Hoenderdos K,Bradley G,Lennon M,Summers C,Hessel EM,Condliffe A,Chilvers ER

    更新日期:2016-10-15 00:00:00

  • Clinical advances in the diagnosis and therapy of the interstitial lung diseases.

    abstract::The last century experienced remarkable advances in the classification, diagnosis, and understanding of the pathogenesis of the interstitial lung diseases. Technological advances, particularly physiologic testing, lung imaging studies, bronchoalveolar lavage, surgical lung biopsy, and histopathologic assessment, impro...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1164/rccm.200503-483OE

    authors: King TE Jr

    更新日期:2005-08-01 00:00:00

  • Assessment of neonatal diaphragm function using magnetic stimulation of the phrenic nerves.

    abstract::A nonvolitional test to assess diaphragm strength in neonates has not been previously described. Our aim was to assess the feasibility of cervical (CMS) and anterior (AMS) magnetic stimulation of the phrenic nerves in neonates. Double circular stimulating coils (90-mm) were used. For CMS, one coil was placed over the ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.162.6.2004019

    authors: Rafferty GF,Greenough A,Dimitriou G,Kavadia V,Laubscher B,Polkey MI,Harris ML,Moxham J

    更新日期:2000-12-01 00:00:00

  • Nosocomial acquisition of Burkholderia gladioli in patients with cystic fibrosis.

    abstract::Burkholderia gladioli has been reported as colonizing the airways of patients with cystic fibrosis (CF) but has not previously been associated with adverse outcome. We describe six patients with CF in whom the same strain of B. gladioli, on the basis of ribotyping and biochemical characteristics, was grown in their sp...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.155.4.9105090

    authors: Wilsher ML,Kolbe J,Morris AJ,Welch DF

    更新日期:1997-04-01 00:00:00

  • Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis.

    abstract:RATIONALE:Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs. OBJECTIVES:To determine whether whole blood gene expression signatures reflect inflamm...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201106-1143OC

    authors: Koth LL,Solberg OD,Peng JC,Bhakta NR,Nguyen CP,Woodruff PG

    更新日期:2011-11-15 00:00:00

  • A new tongue advancement technique for sleep-disordered breathing: side effects and efficacy.

    abstract::We examined the efficacy and the acceptance of an oral device (SnorEx) causing a forward displacement of the tongue for the treatment of sleep-disordered breathing (SDB). Twenty-three consecutive subjects with SDB were investigated. Noncompliance (NC) of use of the oral appliance was observed in 74% (17 of 23) of the ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.155.2.9032220

    authors: Schönhofer B,Stoohs RA,Rager H,Wenzel M,Wenzel G,Köhler D

    更新日期:1997-02-01 00:00:00

  • Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury.

    abstract:RATIONALE:Patients with acute lung injury have impaired function of the lung surfactant system. Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation and have suggested that treatment of patients with severe d...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1164/rccm.201009-1424OC

    authors: Spragg RG,Taut FJ,Lewis JF,Schenk P,Ruppert C,Dean N,Krell K,Karabinis A,Günther A

    更新日期:2011-04-15 00:00:00

  • Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team.

    abstract::The effect of long-term exposure to air pollutants was studied in a cross-sectional population-based sample of adults (aged 18 to 60 yr; n = 9,651) residing in eight different areas in Switzerland. Standardized medical examination included questionnaire data, lung function tests, skin-prick testing, and end-expiratory...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.155.1.9001300

    authors: Ackermann-Liebrich U,Leuenberger P,Schwartz J,Schindler C,Monn C,Bolognini G,Bongard JP,Brändli O,Domenighetti G,Elsasser S,Grize L,Karrer W,Keller R,Keller-Wossidlo H,Künzli N,Martin BW,Medici TC,Perruchoud AP,Schöni

    更新日期:1997-01-01 00:00:00

  • Nutritional status and mortality in chronic obstructive pulmonary disease.

    abstract::The role of nutritional status in the prognosis of subjects with severe chronic obstructive pulmonary disease was studied in a cohort of Canadian men and women followed for 3 to 5 yr. A total of 348 subjects who were recruited for a study of negative pressure ventilation were evaluated for lung function and body weigh...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.153.3.8630580

    authors: Gray-Donald K,Gibbons L,Shapiro SH,Macklem PT,Martin JG

    更新日期:1996-03-01 00:00:00

  • Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes.

    abstract::From an Aspergillus fumigatus complementary deoxyribonucleic acid (cDNA) library displayed on phage surface, an allergen formally termed rAsp f 3 was cloned. The open-reading frame of the cloned gene for the allergen encodes a protein of 168 amino acids with a predicted molecular mass of 18.5 kD, showing 36% identity ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.156.6.9702087

    authors: Hemmann S,Blaser K,Crameri R

    更新日期:1997-12-01 00:00:00

  • Exposure-response relationship between passive smoking and adult pulmonary function.

    abstract::The effects of exposure to environmental tobacco smoke (ETS) on pulmonary function were investigated in a random sample of 1,033 adults aged 40 to 69 yr from a residential area in Beijing. Compared with those not exposed, those exposed to ETS either at home or at work were associated with a 102-ml (SE = 40 ml) reducti...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.151.1.7812570

    authors: Xu X,Li B

    更新日期:1995-01-01 00:00:00

  • Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma.

    abstract::Bronchial overproduction of leukotrienes and inhibition of prostaglandin synthesis are involved in the pathogenesis of aspirin-induced asthma. We investigated whether inhaled prostaglandin E2 (PGE2) attenuates the response to bronchial challenge with lysine acetylsalicylate (LASA) and the associated increase in urinar...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1164/ajrccm.153.2.8564100

    authors: Sestini P,Armetti L,Gambaro G,Pieroni MG,Refini RM,Sala A,Vaghi A,Folco GC,Bianco S,Robuschi M

    更新日期:1996-02-01 00:00:00

  • Evolution of Diaphragm Thickness during Mechanical Ventilation. Impact of Inspiratory Effort.

    abstract:RATIONALE:Diaphragm atrophy and dysfunction have been reported in humans during mechanical ventilation, but the prevalence, causes, and functional impact of changes in diaphragm thickness during routine mechanical ventilation for critically ill patients are unknown. OBJECTIVES:To describe the evolution of diaphragm th...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201503-0620OC

    authors: Goligher EC,Fan E,Herridge MS,Murray A,Vorona S,Brace D,Rittayamai N,Lanys A,Tomlinson G,Singh JM,Bolz SS,Rubenfeld GD,Kavanagh BP,Brochard LJ,Ferguson ND

    更新日期:2015-11-01 00:00:00

  • Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1/vital capacity ratio: a longitudinal population study from childhood to adulthood.

    abstract::Airway remodeling may lead to irreversible loss of lung function in asthma. The impact of childhood asthma, airway responsiveness, atopy, and smoking on airway remodeling was investigated in a birth cohort studied longitudinally to age 26. A low postbronchodilator ratio of forced exhaled volume in 1 second (FEV1) to v...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.2108009

    authors: Rasmussen F,Taylor DR,Flannery EM,Cowan JO,Greene JM,Herbison GP,Sears MR

    更新日期:2002-06-01 00:00:00

  • Airway Sensory Nerve Density Is Increased in Chronic Cough.

    abstract::Rationale: Chronic cough is characterized by frequent urges to cough and a heightened sensitivity to inhaled irritants. Airway sensory nerves trigger cough. We hypothesized that sensory nerve density is increased in chronic cough, which may contribute to excessive and persistent coughing.Objectives: To measure airway ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201912-2347OC

    authors: Shapiro CO,Proskocil BJ,Oppegard LJ,Blum ED,Kappel NL,Chang CH,Fryer AD,Jacoby DB,Costello RW,Drake MG

    更新日期:2021-02-01 00:00:00

  • Retinoic acid-related orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysema.

    abstract:RATIONALE:The discovery that retinoic acid-related orphan receptor (Rora)-α is highly expressed in lungs of patients with COPD led us to hypothesize that Rora may contribute to the pathogenesis of emphysema. OBJECTIVES:To determine the role of Rora in smoke-induced emphysema. METHODS:Cigarette smoke extract in vitro ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201111-2023OC

    authors: Shi Y,Cao J,Gao J,Zheng L,Goodwin A,An CH,Patel A,Lee JS,Duncan SR,Kaminski N,Pandit KV,Rosas IO,Choi AM,Morse D

    更新日期:2012-09-01 00:00:00

  • Genioglossal activation in patients with obstructive sleep apnea versus control subjects. Mechanisms of muscle control.

    abstract::Pharyngeal dilator muscle activation (GGEMG) during wakefulness is greater in patients with obstructive sleep apnea (OSA) than in healthy control subjects, representing a neuromuscular compensatory mechanism for a more collapsible airway. As previous work from our laboratory has demonstrated a close relationship betwe...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.164.11.2102048

    authors: Fogel RB,Malhotra A,Pillar G,Edwards JK,Beauregard J,Shea SA,White DP

    更新日期:2001-12-01 00:00:00