Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends.

abstract：:The lungs of newborn rats exposed to 60% oxygen for 14 days develop an injury that shares morphologic similarities to human bronchopulmonary dysplasia (BPD). Neutrophil influx into the lung, as part of an inflammatory response, may play a pivotal role in the development of BPD. A neutrophil chemokine, cytokine-induced...

journal_title：American journal of respiratory and critical care medicine

authors： Yi M,Jankov RP,Belcastro R,Humes D,Copland I,Shek S,Sweezey NB,Post M,Albertine KH,Auten RL,Tanswell AK

更新日期：2004-12-01 00:00:00

abstract：:Human neutrophil elastase (HNE), an enzyme secreted by activated neutrophils, can bind to and degrade extracellular matrix including human lung elastin. This protease is believed to play an important role in several destructive processes including pulmonary emphysema. In this study, we hypothesized that an alveolar ma...

journal_title：American journal of respiratory and critical care medicine

authors： Fujita J,Sköld CM,Daughton DM,Ertl RF,Takahara J,Rennard SI

更新日期：1999-09-01 00:00:00

abstract：:Exhaled nitric oxide (eNO) is elevated in patients with inflammatory pulmonary diseases and it has attracted increasing interest as a simple, noninvasive marker of airway inflammation. Little is known, however, about factors that might affect eNO in healthy subjects. We measured eNO in 157 healthy 7- to 13-yr-old chil...

journal_title：American journal of respiratory and critical care medicine

authors： Franklin PJ,Taplin R,Stick SM

更新日期：1999-01-01 00:00:00

abstract：:Exogenous surfactant therapy is not standard in the acute respiratory distress syndrome (ARDS) because of a lack of proven benefit. Nonuniform surfactant distribution after either bolus or aerosol administration may be an important factor limiting response. In a previous study of acute lung injury, we demonstrated tha...

journal_title：American journal of respiratory and critical care medicine

authors： Balaraman V,Meister J,Ku TL,Sood SL,Tam E,Killeen J,Uyehara CF,Egan E,Easa D

更新日期：1998-07-01 00:00:00

abstract：:The mechanisms of exertional dyspnea relief in response to supplemental oxygen (O2) in chronic airflow limitation (CAL) are not precisely known and are likely multifactorial. To explore factors contributing to the relief of dyspnea after oxygen administration, 11 patients with severe CAL (FEV1.0 = 39 +/- 3% predicted,...

journal_title：American journal of respiratory and critical care medicine

authors： O'Donnell DE,Bain DJ,Webb KA

更新日期：1997-02-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), also called basigin, is present in the lung during development, but its expression in normal adult lung is minimal. Increases of EMMPRIN have been found in various forms of experimental lung injury. To determine whether EMMPRIN might be involved in alveolar inj...

journal_title：American journal of respiratory and critical care medicine

authors： Betsuyaku T,Tanino M,Nagai K,Nasuhara Y,Nishimura M,Senior RM

更新日期：2003-07-15 00:00:00

abstract：RATIONALE:Allergic asthma is characterized by reversible airway obstruction, lung inflammation, and airway hyperresponsiveness (AHR). Previous studies using leukotriene B(4) (LTB(4)) receptor 1-deficient mice and adoptive transfer experiments have suggested that LTB(4) plays a role in lung inflammation and AHR. OBJECT...

journal_title：American journal of respiratory and critical care medicine

authors： Rao NL,Riley JP,Banie H,Xue X,Sun B,Crawford S,Lundeen KA,Yu F,Karlsson L,Fourie AM,Dunford PJ

更新日期：2010-05-01 00:00:00

abstract：RATIONALE:Recent studies have suggested that both embryonic stem cells and adult bone marrow stem cells can participate in the regeneration and repair of diseased adult organs, including the lungs. However, the extent of airway epithelial remodeling with adult marrow stem cells is low, and there are no available in viv...

journal_title：American journal of respiratory and critical care medicine

authors： Sueblinvong V,Loi R,Eisenhauer PL,Bernstein IM,Suratt BT,Spees JL,Weiss DJ

更新日期：2008-04-01 00:00:00

abstract：RATIONALE:Fibroblast growth factor receptor-1alpha(IIIc) [FGF-R1alpha(IIIc)] regulates recovery of neonatal rat lung growth, after 95% oxygen-mediated growth arrest. Its role in normal postnatal alveologenesis is unknown. OBJECTIVE:To determine if FGF-R1alpha(IIIc) regulates normal postnatal alveologenesis. METHODS:T...

journal_title：American journal of respiratory and critical care medicine

authors： Yi M,Belcastro R,Shek S,Luo D,Post M,Tanswell AK

更新日期：2006-09-01 00:00:00

abstract：:The aim of this prospective study was to detect subjects in the general population with objective signs of chronic obstructive pulmonary disease (COPD) or asthma at an early stage. This was done by means of a two-stage protocol involving screening and a subsequent 2-yr monitoring of all subjects with positive results ...

journal_title：American journal of respiratory and critical care medicine

authors： van den Boom G,van Schayck CP,van Möllen MP,Tirimanna PR,den Otter JJ,van Grunsven PM,Buitendijk MJ,van Herwaarden CL,van Weel C

更新日期：1998-12-01 00:00:00

abstract：:To study whether the individual inflammatory response to ozone was reproducible, dose-dependent, and time-dependent, we performed two exposures to 250 ppb ozone, one to 125 ppb and one to filtered air, each for 3 h of intermittent exercise and separated by at least 1 wk. Twenty-one healthy and 15 asthmatic subjects pa...

journal_title：American journal of respiratory and critical care medicine

authors： Holz O,Jörres RA,Timm P,Mücke M,Richter K,Koschyk S,Magnussen H

更新日期：1999-03-01 00:00:00

abstract：:The involvement of platelet-activating factor (PAF) in bronchial hyperresponsiveness (BHR) in bronchial asthma has been controversial. To determine whether PAF is involved in BHR in humans, we carried out a randomized, double-blind, placebo-controlled, two-phase cross-over study on the effects of Y-24180, a potent, sp...

journal_title：American journal of respiratory and critical care medicine

authors： Hozawa S,Haruta Y,Ishioka S,Yamakido M

更新日期：1995-10-01 00:00:00

abstract：:Sarcoidosis is a systemic, granulomatous disorder with a high rate of spontaneous remission indicating the presence of antiinflammatory mechanisms. Antiinflammatory mediators such as interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) should be able to induce spontaneous remission of sarcoidosis. By ...

journal_title：American journal of respiratory and critical care medicine

authors： Zissel G,Homolka J,Schlaak J,Schlaak M,Müller-Quernheim J

更新日期：1996-09-01 00:00:00

abstract：:Many time series studies have found that individuals with primary cardiac conditions were susceptible to the adverse effects associated with increased ambient particle levels. However, the mechanism(s) of these associations is not yet understood. In this study, we evaluate whether individuals with nonrespiratory prima...

journal_title：American journal of respiratory and critical care medicine

authors： De Leon SF,Thurston GD,Ito K

更新日期：2003-04-15 00:00:00

abstract：RATIONALE:The American Thoracic Society/European Respiratory Society International Consensus Classification panel identified the clinical entity idiopathic nonspecific interstitial pneumonia (NSIP) as a provisional diagnosis and recommended further study. OBJECTIVES:We hypothesized that idiopathic NSIP is an autoimmun...

journal_title：American journal of respiratory and critical care medicine

authors： Kinder BW,Collard HR,Koth L,Daikh DI,Wolters PJ,Elicker B,Jones KD,King TE Jr

更新日期：2007-10-01 00:00:00

abstract：RATIONALE:Asthma is a chronic inflammatory airway disease that affects more than 300 million individuals worldwide. Asthma is caused by interaction of genetic and environmental factors. Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and results from increased sensitivity of the airways to physical or chemi...

journal_title：American journal of respiratory and critical care medicine

authors： Koppelman GH,Meyers DA,Howard TD,Zheng SL,Hawkins GA,Ampleford EJ,Xu J,Koning H,Bruinenberg M,Nolte IM,van Diemen CC,Boezen HM,Timens W,Whittaker PA,Stine OC,Barton SJ,Holloway JW,Holgate ST,Graves PE,Martinez FD,

更新日期：2009-11-15 00:00:00

abstract：RATIONALE:Long-term intermittent hypoxia (LTIH) exposure in adult mice, modeling oxygenation patterns of moderate-severe obstructive sleep apnea, results in lasting hypersomnolence and is associated with nitration and oxidation injuries in many brain regions, including wake-active regions. OBJECTIVES:We sought to dete...

journal_title：American journal of respiratory and critical care medicine

authors： Zhan G,Fenik P,Pratico D,Veasey SC

更新日期：2005-06-15 00:00:00

abstract：:The relationship between asthma medication and the perception of asthma symptoms is of interest for daily practice. Poor perception of asthma symptoms might influence patients' health care behavior and subsequently might lead to undertreatment and deterioration of their disease. This study investigated the influence o...

journal_title：American journal of respiratory and critical care medicine

authors： Bijl-Hofland ID,Cloosterman SG,Folgering HT,van den Elshout FJ,van Weel C,van Schayck CP

更新日期：2001-09-01 00:00:00

abstract：RATIONALE:Few studies have examined associations between exposure to air pollution and childhood lung function after implementation of strict air quality regulations in the 1990s. OBJECTIVES:To assess traffic-related pollution exposure and childhood lung function. METHODS:We geocoded addresses for 614 mother-child pa...

journal_title：American journal of respiratory and critical care medicine

authors： Rice MB,Rifas-Shiman SL,Litonjua AA,Oken E,Gillman MW,Kloog I,Luttmann-Gibson H,Zanobetti A,Coull BA,Schwartz J,Koutrakis P,Mittleman MA,Gold DR

更新日期：2016-04-15 00:00:00

abstract：:Tracheal gas insufflation (TGI) has been recommended as an adjunct to mechanical ventilation in the presence of elevated Pa CO2. Based on our initial clinical experience with continuous flow TGI and pressure control ventilation (PCV), we were concerned about elevation in peak airway pressure as TGI was applied. In a l...

journal_title：American journal of respiratory and critical care medicine

authors： Imanaka H,Kacmarek RM,Ritz R,Hess D

更新日期：1996-03-01 00:00:00

abstract：:There is a need for quick, reliable, and noninvasive lung function tests to assess airway obstruction in preschool children both for pediatric pulmonary care as well as for research purposes. We studied feasibility, reproducibility, and validity of measurements of the respiratory system using the interrupter technique...

journal_title：American journal of respiratory and critical care medicine

authors： Merkus PJ,Mijnsbergen JY,Hop WC,de Jongste JC

更新日期：2001-05-01 00:00:00

abstract：:Oral mandibular advancement devices are becoming an increasingly important treatment alternative for obstructive sleep apnea (OSA). The first aim of the study was to determine whether a new oral elastic mandibular advancement device (EMA) prevents pharyngeal airway closure during sleep in patients with OSA. The second...

journal_title：American journal of respiratory and critical care medicine

authors： Henke KG,Frantz DE,Kuna ST

更新日期：2000-02-01 00:00:00

abstract：:We tested the hypothesis that in advanced pulmonary fibrosis, edema is redistributed away from the relatively noncompliant interstitium and predominantly floods alveoli. Severe left lung fibrosis was produced in six dogs with radiation and intratracheal bleomycin and, 24 mo later, hydrostatic edema was induced by infu...

journal_title：American journal of respiratory and critical care medicine

authors： Zwikler MP,Iancu D,Michel RP

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:Cytomegalovirus (CMV), which is one of the most common infections after lung transplantation, is associated with chronic lung allograft dysfunction and worse post-transplantation survival. Current approaches for at-risk patients include a fixed duration of antiviral prophylaxis despite the associated cost and...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder LD,Chan C,Kwon D,Yi JS,Martissa JA,Copeland CA,Osborne RJ,Sparks SD,Palmer SM,Weinhold KJ

更新日期：2016-01-01 00:00:00

abstract：:We developed a bronchial provocation test (BPT) with a dry powder preparation of mannitol. The mannitol was inhaled from gelatin capsules containing 5, 10, 20, or 40 mg to a cumulative dose of 635 mg, and was delivered via an inhalator, Halermatic, or Dinkihaler device. We studied the airway sensitivity to inhaled man...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson SD,Brannan J,Spring J,Spalding N,Rodwell LT,Chan K,Gonda I,Walsh A,Clark AR

更新日期：1997-09-01 00:00:00

abstract：RATIONALE:Whether a nurse-implemented goal-directed sedation protocol resulting in more awake yet calm intubated children affects postdischarge functional status, health-related quality of life, or risk for post-traumatic stress disorder is unknown. OBJECTIVES:To compare postdischarge outcomes in children with acute r...

journal_title：American journal of respiratory and critical care medicine

authors： Watson RS,Asaro LA,Hertzog JH,Sorce LR,Kachmar AG,Dervan LA,Angus DC,Wypij D,Curley MAQ,RESTORE Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

更新日期：2018-06-01 00:00:00

abstract：:The role of ventilatory-control abnormalities in predisposing to familial sleep-disordered breathing (SDB) was assessed in 31 subjects 28 +/- 10 yr of age (mean +/- SD). Subjects with (n = 10) and without SDB (n = 12) were recruited from 13 families having two or more members with SDB. Nine age- and gender-matched con...

journal_title：American journal of respiratory and critical care medicine

authors： Redline S,Leitner J,Arnold J,Tishler PV,Altose MD

更新日期：1997-07-01 00:00:00

abstract：RATIONALE:Superoxide dismutase (SOD) 3 inhibits oxidative fragmentation of lung matrix components collagen I, hyaluronan, and heparan sulfate. Inherited change in SOD3 expression or function could affect lung matrix homeostasis and influence pulmonary function. OBJECTIVES:To identify novel SOD3 polymorphisms that are ...

journal_title：American journal of respiratory and critical care medicine

authors： Dahl M,Bowler RP,Juul K,Crapo JD,Levy S,Nordestgaard BG

更新日期：2008-11-01 00:00:00

abstract：:It is known that the ventilatory response to carbon dioxide (CO2) is increased in asthmatics with airway obstruction. Increased vagal afferent activity as well as increased airway resistance have been postulated as the causative mechanisms. However, whether increased vagal afferent activity without bronchoconstriction...

journal_title：American journal of respiratory and critical care medicine

authors： Midorikawa J,Kikuchi Y,Taguchi O,Hida W,Okabe S,Takishima T,Shirato K

更新日期：1994-12-01 00:00:00

abstract：:The aim of this study was to determine the effects of maturation on crossbridge properties and myosin isoform composition in hamster diaphragm muscle. Diaphragm strips were obtained at postnatal Days 1 and 8 and in adults (10 to 12 wk). Peak isometric tension and maximum unloaded shortening velocity (Vmax) increased w...

journal_title：American journal of respiratory and critical care medicine

authors： Coirault C,Lambert F,Joseph T,Blanc FX,Chemla D,Lecarpentier Y

更新日期：1997-09-01 00:00:00