Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends.

abstract：RATIONALE:Extracellular nucleotides have recently been identified as proinflammatory mediators involved in asthma pathogenesis by signaling via purinergic receptors, but the role of the purinergic receptor type 6 (P2Y6R) has not been previously investigated. OBJECTIVES:To investigate the role of P2Y6R in asthma pathog...

journal_title：American journal of respiratory and critical care medicine

authors： Vieira RP,Müller T,Grimm M,von Gernler V,Vetter B,Dürk T,Cicko S,Ayata CK,Sorichter S,Robaye B,Zeiser R,Ferrari D,Kirschbaum A,Zissel G,Virchow JC,Boeynaems JM,Idzko M

更新日期：2011-07-15 00:00:00

abstract：:To investigate the effect of smoking cessation on the airway inflammatory process present in nonatopic subjects with chronic bronchitis, we obtained bronchial biopsies from nine current smokers and seven exsmokers, all with symptoms of chronic bronchitis at the time of the study, and from seven healthy nonsmoking subj...

journal_title：American journal of respiratory and critical care medicine

authors： Turato G,Di Stefano A,Maestrelli P,Mapp CE,Ruggieri MP,Roggeri A,Fabbri LM,Saetta M

更新日期：1995-10-01 00:00:00

abstract：:Although skeletal muscle abnormalities have been described in association with human immunodeficiency virus (HIV), the effects of HIV infection on respiratory muscle function have not been well characterized. We hypothesized that HIV+ individuals may develop respiratory muscle weakness and that respiratory muscle dysf...

journal_title：American journal of respiratory and critical care medicine

authors： Schulz L,Nagaraja HN,Rague N,Drake J,Diaz PT

更新日期：1997-03-01 00:00:00

abstract：RATIONALE:Roflumilast is a therapeutic agent in the treatment of chronic obstructive pulmonary disease (COPD). It has antiinflammatory effects; however, it is not known whether it can affect a biologic pathway implicated in COPD pathogenesis and progression. The self-propagating acetyl-proline-glycine-proline (AcPGP) p...

journal_title：American journal of respiratory and critical care medicine

authors： Wells JM,Jackson PL,Viera L,Bhatt SP,Gautney J,Handley G,King RW,Xu X,Gaggar A,Bailey WC,Dransfield MT,Blalock JE

更新日期：2015-10-15 00:00:00

abstract：RATIONALE:The around-the-clock presence of an in-house attending critical care physician (24/7 coverage) is purported to be associated with improved outcomes among high-risk children with critical illness. OBJECTIVES:To evaluate the association of 24/7 in-house coverage with outcomes in children with critical illness....

journal_title：American journal of respiratory and critical care medicine

authors： Gupta P,Rettiganti M,Rice TB,Wetzel RC

更新日期：2016-12-15 00:00:00

abstract：RATIONALE:In cigarette smoking-induced chronic obstructive pulmonary disease, structural and functional derangements are characterized by parenchymal destruction and pulmonary hypertension. Statins are 3-hydroxy-3-methyl-glutaryl-coenzyme-A reductase inhibitors that have been used as lipid-lowering agents. These drugs ...

journal_title：American journal of respiratory and critical care medicine

authors： Lee JH,Lee DS,Kim EK,Choe KH,Oh YM,Shim TS,Kim SE,Lee YS,Lee SD

更新日期：2005-10-15 00:00:00

abstract：:Ten patients with acute respiratory distress syndrome (ARDS) received in random order nitric oxide (NO) inhalation, aerosolized prostaglandin E1 (PGE1), infusion of PGE1, or no intervention. Inhalation of either aerosolized PGE1 (10 +/- 1 ng/kg/min) or NO (7 +/- 1 ppm) reduced pulmonary vascular resistance (PVR) from ...

journal_title：American journal of respiratory and critical care medicine

authors： Putensen C,Hörmann C,Kleinsasser A,Putensen-Himmer G

更新日期：1998-06-01 00:00:00

abstract：:Although sleep-disordered breathing (SDB) has been shown to be very prevalent in the elderly, little has been done to examine differences between the elderly of different racial groups. It has been well documented that SDB often results in hypertension and that hypertension is more common in African-Americans than in ...

journal_title：American journal of respiratory and critical care medicine

authors： Ancoli-Israel S,Klauber MR,Stepnowsky C,Estline E,Chinn A,Fell R

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:Neutrophils are key players in chronic obstructive pulmonary disease (COPD), and increased numbers of neutrophils are present in sputum and lung tissue of patients with COPD. Interestingly, immunoglobulin free light chains (IgLC) are able to prolong the life of neutrophils; therefore, IgLC may contribute to t...

journal_title：American journal of respiratory and critical care medicine

authors： Braber S,Thio M,Blokhuis BR,Henricks PA,Koelink PJ,Groot Kormelink T,Bezemer GF,Kerstjens HA,Postma DS,Garssen J,Kraneveld AD,Redegeld FA,Folkerts G

更新日期：2012-04-15 00:00:00

abstract：RATIONALE:Despite increasing recognition of bone morphogenetic protein (BMP) signaling in tissue remodeling, the expression pattern of ligands and signaling pathways remain undefined in the asthmatic airway. OBJECTIVES:To determine expression of BMP ligands (BMP-2, BMP-4, and BMP-7) and type I and type II receptors (A...

journal_title：American journal of respiratory and critical care medicine

authors： Kariyawasam HH,Xanthou G,Barkans J,Aizen M,Kay AB,Robinson DS

更新日期：2008-05-15 00:00:00

abstract：RATIONALE:Hyponatremia is associated with decompensated heart failure and poor prognosis in patients with left ventricular systolic dysfunction. OBJECTIVES:We sought to determine if hyponatremia is associated with right heart failure and worse prognosis in patients with pulmonary arterial hypertension (PAH). METHODS:...

journal_title：American journal of respiratory and critical care medicine

authors： Forfia PR,Mathai SC,Fisher MR,Housten-Harris T,Hemnes AR,Champion HC,Girgis RE,Hassoun PM

更新日期：2008-06-15 00:00:00

abstract：:Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of lung hyperinflation as measured by the inspiratory capacity-to-total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pul...

journal_title：American journal of respiratory and critical care medicine

authors： Casanova C,Cote C,de Torres JP,Aguirre-Jaime A,Marin JM,Pinto-Plata V,Celli BR

更新日期：2005-03-15 00:00:00

abstract：:Impaired lung epithelial Na(+) channel (ENaC) activity at the time of birth results in respiratory distress. To investigate potential mechanisms, the ontogeny and cellular distribution of the alphaENaC subunit mRNA expression was studied in normal, immature, and abnormal (hypoplastic) human fetal lungs using nonradioi...

journal_title：American journal of respiratory and critical care medicine

authors： Smith DE,Otulakowski G,Yeger H,Post M,Cutz E,O'Brodovich HM

更新日期：2000-04-01 00:00:00

abstract：:Increased pharyngeal collapsibility and abnormal anatomic structures have been postulated to contribute to the pathophysiology of obstructive sleep apnea (OSA) syndrome. It is unclear whether the abnormal craniofacial and soft tissue features may affect the pharyngeal collapsibility and contribute to the apnea density...

journal_title：American journal of respiratory and critical care medicine

authors： Sforza E,Bacon W,Weiss T,Thibault A,Petiau C,Krieger J

更新日期：2000-02-01 00:00:00

abstract：:Early experience suggests that lung volume reduction surgery improves exercise tolerance as measured by the 6-min walk distance in patients with emphysema. To identify the physiologic mechanism(s) by which lung volume reduction surgery improved exercise, we performed progressive cardiopulmonary exercise testing, inclu...

journal_title：American journal of respiratory and critical care medicine

authors： Benditt JO,Lewis S,Wood DE,Klima L,Albert RK

更新日期：1997-08-01 00:00:00

abstract：:Monocyte deactivation has been identified as a major factor of immunosuppression in sepsis and is associated with a loss of surface human leukocyte antigen-DR (HLA-DR) expression on circulating monocytes. Using flow cytometry, quantitative reverse transcription-polymerase chain reaction, we investigated this phenomeno...

journal_title：American journal of respiratory and critical care medicine

authors： Le Tulzo Y,Pangault C,Amiot L,Guilloux V,Tribut O,Arvieux C,Camus C,Fauchet R,Thomas R,Drénou B

更新日期：2004-05-15 00:00:00

abstract：:Rationale: Pulmonary arterial hypertension (PAH) is a life-shortening condition. The European Society of Cardiology and European Respiratory Society and the REVEAL (North American Registry to Evaluate Early and Long-Term PAH Disease Management) risk score calculator (REVEAL 2.0) identify thresholds to predict 1-year m...

journal_title：American journal of respiratory and critical care medicine

authors： Lewis RA,Johns CS,Cogliano M,Capener D,Tubman E,Elliot CA,Charalampopoulos A,Sabroe I,Thompson AAR,Billings CG,Hamilton N,Baster K,Laud PJ,Hickey PM,Middleton J,Armstrong IJ,Hurdman JA,Lawrie A,Rothman AMK,Wild JM,

更新日期：2020-02-15 00:00:00

abstract：RATIONALE:Improved understanding of the lung microbiome in HIV-infected individuals could lead to better strategies for diagnosis, therapy, and prophylaxis of HIV-associated pneumonias. Differences in the oral and lung microbiomes in HIV-infected and HIV-uninfected individuals are not well defined. Whether highly activ...

journal_title：American journal of respiratory and critical care medicine

authors： Beck JM,Schloss PD,Venkataraman A,Twigg H 3rd,Jablonski KA,Bushman FD,Campbell TB,Charlson ES,Collman RG,Crothers K,Curtis JL,Drews KL,Flores SC,Fontenot AP,Foulkes MA,Frank I,Ghedin E,Huang L,Lynch SV,Morris A,Pa

更新日期：2015-12-01 00:00:00

abstract：:Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma targeting airway smooth muscle (ASM). Observational studies have shown ASM mass reduction after BT, but appropriate control groups are lacking. Furthermore, as treatment response is variable, identifying optimal candidates for BT tre...

journal_title：American journal of respiratory and critical care medicine

authors： Goorsenberg AWM,d'Hooghe JNS,Srikanthan K,Ten Hacken NHT,Weersink EJM,Roelofs JJTH,Kemp SV,Bel EH,Shah PL,Annema JT,Bonta PI,TASMA research group.

更新日期：2021-01-15 00:00:00

abstract：RATIONALE:Little is known about the long-term outcomes and costs of survivors of acute respiratory distress syndrome (ARDS). OBJECTIVES:To describe functional and quality of life outcomes, health care use, and costs of survivors of ARDS 2 yr after intensive care unit (ICU) discharge. METHODS:We recruited a cohort of ...

journal_title：American journal of respiratory and critical care medicine

authors： Cheung AM,Tansey CM,Tomlinson G,Diaz-Granados N,Matté A,Barr A,Mehta S,Mazer CD,Guest CB,Stewart TE,Al-Saidi F,Cooper AB,Cook D,Slutsky AS,Herridge MS

更新日期：2006-09-01 00:00:00

abstract：:Neutrophil infiltration is a major feature in the pathogenesis of the common cold, and respiratory viral infection is the major cause of asthma exacerbations. The factors regulating the neutrophil influx are unknown. Interleukin-8 (IL-8) is a potent neutrophil chemoattractant, which has been implicated in several infl...

journal_title：American journal of respiratory and critical care medicine

authors： Teran LM,Johnston SL,Schröder JM,Church MK,Holgate ST

更新日期：1997-04-01 00:00:00

abstract：:In 1976-1992 245 new cases of asthma induced by diisocyanates were diagnosed, caused by hexamethylene diisocyanate (HDI) in 39%, diphenylmethane diisocyanate (MDI) in 39%, and toluene diisocyanate (TDI) in 17% of the cases. Our aim was to study the clinical outcome of diisocyanate-induced asthma. A questionnaire was s...

journal_title：American journal of respiratory and critical care medicine

authors： Piirilä PL,Nordman H,Keskinen HM,Luukkonen R,Salo SP,Tuomi TO,Tuppurainen M

更新日期：2000-08-01 00:00:00

abstract：RATIONALE:Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM). OBJECTIVES:To relate ASM hypertrophy, ASM hyperplasia, and deposition of ECM to the severity and duration of asthma. METHODS:Airways from ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Elliot JG,Jones RL,Carroll ML,Mauad T,Bai TR,Abramson MJ,McKay KO,Green FH

更新日期：2012-05-15 00:00:00

abstract：RATIONALE:Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) increase in inflammatory pulmonary diseases. OBJECTIVES:To study whether arterial Hb-CO is useful to monitor disease activity in patients with chronic obstructive pulmonary disease (COPD) who had stopped smoking. METHOD...

journal_title：American journal of respiratory and critical care medicine

authors： Yasuda H,Yamaya M,Nakayama K,Ebihara S,Sasaki T,Okinaga S,Inoue D,Asada M,Nemoto M,Sasaki H

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Numerous studies have been published on the new Mycobacterium tuberculosis (MTB)-specific IFN-gamma release assays. However, their prognostic value for progression from latent tuberculosis infection (LTBI) to active TB has yet to be established. OBJECTIVES:To compare the QuantiFERON-TB Gold In-Tube assay (QF...

journal_title：American journal of respiratory and critical care medicine

authors： Diel R,Loddenkemper R,Meywald-Walter K,Niemann S,Nienhaus A

更新日期：2008-05-15 00:00:00

abstract：:Reduced bronchodilatation in response to deep inspiration (DI) has been demonstrated in asthmatics. We have previously shown that inhibition of DI for 10 min or more during methacholine inhalation increases airway narrowing in normals. We tested the hypothesis that inhibition of DIs during methacholine inhalation in a...

journal_title：American journal of respiratory and critical care medicine

authors： King GG,Moore BJ,Seow CY,Paré PD

更新日期：2001-07-15 00:00:00

abstract：RATIONALE:Vitamin D has been shown to be involved in the host immune response toward Mycobacterium tuberculosis. OBJECTIVES:To test whether vitamin D supplementation of patients with tuberculosis (TB) improved clinical outcome and reduced mortality. METHODS:We conducted a randomized, double-blind, placebo-controlled ...

journal_title：American journal of respiratory and critical care medicine

authors： Wejse C,Gomes VF,Rabna P,Gustafson P,Aaby P,Lisse IM,Andersen PL,Glerup H,Sodemann M

更新日期：2009-05-01 00:00:00

abstract：:Airway pathology has been extensively investigated in adulthood asthma, whereas only few studies examined bronchial biopsies in childhood asthma. To evaluate the airway pathology in children with asthma, we analyzed bronchial biopsies obtained from 23 children undergoing bronchoscopy for clinical indications other tha...

journal_title：American journal of respiratory and critical care medicine

authors： Barbato A,Turato G,Baraldo S,Bazzan E,Calabrese F,Tura M,Zuin R,Beghe B,Maestrelli P,Fabbri LM,Saetta M

更新日期：2003-10-01 00:00:00

abstract：:Airway obstruction (AO) in exercise-induced asthma (EIA) is considered a postexercise phenomenon. However, many with EIA complain of respiratory distress during exercise. We evaluated AO in six asthmatic subjects during a short (SX = 6 min) and a long (LX = 20 min) exercise session. We measured peak expiratory flow (P...

journal_title：American journal of respiratory and critical care medicine

authors： Suman OE,Babcock MA,Pegelow DF,Jarjour NN,Reddan WG

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:Platelets are essential for pulmonary leukocyte recruitment, airway hyperresponsiveness, and bronchial remodeling in animals with allergic inflammation and can be found in bronchoalveolar lavage of sensitized animals. No studies, however, have explored the direct migration of platelets to lungs. OBJECTIVES:T...

journal_title：American journal of respiratory and critical care medicine

authors： Pitchford SC,Momi S,Baglioni S,Casali L,Giannini S,Rossi R,Page CP,Gresele P

更新日期：2008-03-15 00:00:00