Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial.

abstract：:POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare variant of plasma cell dyscrasia with multiple systemic manifestations. We followed the progress of 20 patients with POEMS syndrome in our institution over a 10-yr period. Pulmonary hypertension (PH) was ob...

journal_title：American journal of respiratory and critical care medicine

authors： Lesprit P,Godeau B,Authier FJ,Soubrier M,Zuber M,Larroche C,Viard JP,Wechsler B,Gherardi R

更新日期：1998-03-01 00:00:00

abstract：INTRODUCTION:Proteinases with a disintegrin and a metalloproteinase domain (ADAMs) have not been well studied in COPD. We investigated whether ADAM9 is linked to COPD in humans and mice. METHODS:ADAM9 blood and lung levels were measured in COPD patients versus controls, and air- versus cigarette smoke (CS)-exposed wil...

journal_title：American journal of respiratory and critical care medicine

authors： Wang X,Polverino F,Rojas-Quintero J,Zhang D,Sánchez J,Yambayev I,Lindqvist E,Virtala R,Djukanovic R,Davies DE,Wilson S,O'Donnell R,Cunoosamy D,Hazon P,Higham A,Singh D,Olsson H,Owen CA

更新日期：2018-06-04 00:00:00

abstract：RATIONALE:Data regarding the influence of ambient air pollution on infant bronchiolitis are few. OBJECTIVES:We evaluated the impact of several air pollutants and their sources on infant bronchiolitis. METHODS:Infants in the Georgia Air Basin of British Columbia with an inpatient or outpatient clinical encounter for b...

journal_title：American journal of respiratory and critical care medicine

authors： Karr CJ,Demers PA,Koehoorn MW,Lencar CC,Tamburic L,Brauer M

更新日期：2009-11-15 00:00:00

abstract：:Lung transplant (LTx) recipients have a low peak work rate, peak oxygen consumption (V O2peak), and early lactate threshold on incremental exercise. We hypothesized that LTx recipients have reduced oxidative function and altered fiber type proportion in peripheral skeletal muscle. Seven stable LTx recipients and seven...

journal_title：American journal of respiratory and critical care medicine

authors： Wang XN,Williams TJ,McKenna MJ,Li JL,Fraser SF,Side EA,Snell GI,Walters EH,Carey MF

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:Neutrophils are key players in chronic obstructive pulmonary disease (COPD), and increased numbers of neutrophils are present in sputum and lung tissue of patients with COPD. Interestingly, immunoglobulin free light chains (IgLC) are able to prolong the life of neutrophils; therefore, IgLC may contribute to t...

journal_title：American journal of respiratory and critical care medicine

authors： Braber S,Thio M,Blokhuis BR,Henricks PA,Koelink PJ,Groot Kormelink T,Bezemer GF,Kerstjens HA,Postma DS,Garssen J,Kraneveld AD,Redegeld FA,Folkerts G

更新日期：2012-04-15 00:00:00

abstract：:Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma targeting airway smooth muscle (ASM). Observational studies have shown ASM mass reduction after BT, but appropriate control groups are lacking. Furthermore, as treatment response is variable, identifying optimal candidates for BT tre...

journal_title：American journal of respiratory and critical care medicine

authors： Goorsenberg AWM,d'Hooghe JNS,Srikanthan K,Ten Hacken NHT,Weersink EJM,Roelofs JJTH,Kemp SV,Bel EH,Shah PL,Annema JT,Bonta PI,TASMA research group.

更新日期：2021-01-15 00:00:00

abstract：:Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components, and several candidate genes have been reported to be linked to atopy in Caucasian populations. We conducted a study of linkage between asthma and markers on chromosomes 5q31-q33 and 11q13 in 68 Japa...

journal_title：American journal of respiratory and critical care medicine

authors： Noguchi E,Shibasaki M,Arinami T,Takeda K,Maki T,Miyamoto T,Kawashima T,Kobayashi K,Hamaguchi H

更新日期：1997-11-01 00:00:00

abstract：:Although sleep-disordered breathing (SDB) has been shown to be very prevalent in the elderly, little has been done to examine differences between the elderly of different racial groups. It has been well documented that SDB often results in hypertension and that hypertension is more common in African-Americans than in ...

journal_title：American journal of respiratory and critical care medicine

authors： Ancoli-Israel S,Klauber MR,Stepnowsky C,Estline E,Chinn A,Fell R

更新日期：1995-12-01 00:00:00

abstract：:The effect of suplatast tosilate, which has been proven to inhibit T-cell synthesis of IL-4 and IL-5, on the response to antigen inhalation challenge was investigated in sensitized guinea pigs. The animals were given an oral dose of 30 or 100 mg/kg of suplatast or vehicle (distilled water) daily for 1 wk before antige...

journal_title：American journal of respiratory and critical care medicine

authors： Iijima H,Tamura G,Hsiue TR,Liu Y,Taniguchi H,Shirato K

更新日期：1999-07-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the major pathogen responsible for acute bronchiolitis in infancy. However, evaluation of the relative importance of rhinovirus or multiple viral infections has been hampered by the lack of sensitive diagnostic methodologies. Therefore, in this study we used the reverse transcripti...

journal_title：American journal of respiratory and critical care medicine

authors： Papadopoulos NG,Moustaki M,Tsolia M,Bossios A,Astra E,Prezerakou A,Gourgiotis D,Kafetzis D

更新日期：2002-05-01 00:00:00

abstract：RATIONALE:Cystic fibrosis (CF) is characterized by dietary antioxidant deficiencies, which may contribute to an oxidant-antioxidant imbalance and oxidative stress. OBJECTIVES:Evaluate the effects of an oral antioxidant-enriched multivitamin supplement on antioxidant concentrations, markers of inflammation and oxidativ...

journal_title：American journal of respiratory and critical care medicine

authors： Sagel SD,Khan U,Jain R,Graff G,Daines CL,Dunitz JM,Borowitz D,Orenstein DM,Abdulhamid I,Noe J,Clancy JP,Slovis B,Rock MJ,McCoy KS,Strausbaugh S,Livingston FR,Papas KA,Shaffer ML

更新日期：2018-09-01 00:00:00

abstract：RATIONALE:Systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) portends worse outcome than other forms of PAH. Vasoconstrictive and vascular remodeling actions of endothelin (ET) 1 and angiotensin (Ang) II via endothelin receptor type A (ETAR) and Ang receptor type-1 (AT1R) activation are implicate...

journal_title：American journal of respiratory and critical care medicine

authors： Becker MO,Kill A,Kutsche M,Guenther J,Rose A,Tabeling C,Witzenrath M,Kühl AA,Heidecke H,Ghofrani HA,Tiede H,Schermuly RT,Nickel N,Hoeper MM,Lukitsch I,Gollasch M,Kuebler WM,Bock S,Burmester GR,Dragun D,Riemekasten

更新日期：2014-10-01 00:00:00

abstract：:Airway obstruction (AO) in exercise-induced asthma (EIA) is considered a postexercise phenomenon. However, many with EIA complain of respiratory distress during exercise. We evaluated AO in six asthmatic subjects during a short (SX = 6 min) and a long (LX = 20 min) exercise session. We measured peak expiratory flow (P...

journal_title：American journal of respiratory and critical care medicine

authors： Suman OE,Babcock MA,Pegelow DF,Jarjour NN,Reddan WG

更新日期：1995-07-01 00:00:00

abstract：:Phosphatidylglycerol (PG) and phosphatidylinositol (PI) are anionic phospholipids (APLs) present in lung surfactant of virtually all species studied, although their specific contribution to function is unknown. This study examines how APLs influence surfactant monolayer stability and adsorption under static and dynami...

journal_title：American journal of respiratory and critical care medicine

authors： Ingenito EP,Mora R,Mark L

更新日期：2000-03-01 00:00:00

abstract：RATIONALE:Poor adherence is common in difficult-to-control asthma. Distinguishing patients with difficult-to-control asthma who respond to inhaled corticosteroids (ICS) from refractory asthma is an important clinical challenge. OBJECTIVES:Suppression of fractional exhaled nitric oxide (FeNO) with directly observed ICS...

journal_title：American journal of respiratory and critical care medicine

authors： Heaney LG,Busby J,Bradding P,Chaudhuri R,Mansur AH,Niven R,Pavord ID,Lindsay JT,Costello RW,Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

更新日期：2019-02-15 00:00:00

abstract：:Airway inflammation is involved in the pathogenesis of bronchial asthma. Intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen-1 alpha (LFA-1 alpha) and has been shown to be required for leukocyte migration into inflamed area. The purpose of this report was to investigate th...

journal_title：American journal of respiratory and critical care medicine

authors： Nagase T,Fukuchi Y,Matsuse T,Sudo E,Matsui H,Orimo H

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:In the absence of a surgical lung biopsy, patients diagnosed with idiopathic pulmonary fibrosis (IPF) in clinical practice could participate in the INPULSIS trials of nintedanib if they had honeycombing and/or traction bronchiectasis plus reticulation, without atypical features of usual interstitial pneumonia...

journal_title：American journal of respiratory and critical care medicine

authors： Raghu G,Wells AU,Nicholson AG,Richeldi L,Flaherty KR,Le Maulf F,Stowasser S,Schlenker-Herceg R,Hansell DM

更新日期：2017-01-01 00:00:00

abstract：RATIONALE:β2-Agonists are the treatment of choice for exercise-induced bronchoconstriction (EIB) and act through specific receptors (ADRB2). Arg16Gly polymorphisms have been shown to affect responses to regular use of β2-agonists. OBJECTIVES:To evaluate the influence of the Arg16Gly receptor polymorphism on salmeterol...

journal_title：American journal of respiratory and critical care medicine

authors： Bonini M,Permaul P,Kulkarni T,Kazani S,Segal A,Sorkness CA,Wechsler ME,Israel E

更新日期：2013-12-15 00:00:00

abstract：RATIONALE:Controlled mechanical ventilation (CMV) results in atrophy of the human diaphragm. The autophagy-lysosome pathway (ALP) contributes to skeletal muscle proteolysis, but its contribution to diaphragmatic protein degradation in mechanically ventilated patients is unknown. OBJECTIVES:To evaluate the autophagy pa...

journal_title：American journal of respiratory and critical care medicine

authors： Hussain SN,Mofarrahi M,Sigala I,Kim HC,Vassilakopoulos T,Maltais F,Bellenis I,Chaturvedi R,Gottfried SB,Metrakos P,Danialou G,Matecki S,Jaber S,Petrof BJ,Goldberg P

更新日期：2010-12-01 00:00:00

abstract：:The six-minute walk test is a submaximal exercise test that can be performed even by a patient with heart failure not tolerating maximal exercise testing. To elucidate the clinical significance and prognostic value of the six-minute walk test in patients with primary pulmonary hypertension (PPH), we sought (1) to asse...

journal_title：American journal of respiratory and critical care medicine

authors： Miyamoto S,Nagaya N,Satoh T,Kyotani S,Sakamaki F,Fujita M,Nakanishi N,Miyatake K

更新日期：2000-02-01 00:00:00

abstract：RATIONALE:Donor mesenchymal stromal/stem cell (MSC) expansion and fibrotic differentiation is associated with development of bronchiolitis obliterans syndrome (BOS) in human lung allografts. However, the regulators of fibrotic differentiation of these resident mesenchymal cells are not well understood. OBJECTIVES:This...

journal_title：American journal of respiratory and critical care medicine

authors： Walker NM,Badri LN,Wadhwa A,Wettlaufer S,Peters-Golden M,Lama VN

更新日期：2012-01-01 00:00:00

abstract：:DNA fingerprinting of Mycobacterium tuberculosis is used to study the epidemiology of tuberculosis, but the specificity of the widely used IS6110 technique has not been validated. Isolates from Denver, Colorado from December 1988 through June 1994 were fingerprinted with the IS6110 technique. Available records were re...

journal_title：American journal of respiratory and critical care medicine

authors： Burman WJ,Reves RR,Hawkes AP,Rietmeijer CA,Yang Z,el-Hajj H,Bates JH,Cave MD

更新日期：1997-03-01 00:00:00

abstract：RATIONALE:Density-based morphometric studies have demonstrated decreased capillary density in infants with bronchopulmonary dysplasia (BPD) and in BPD-like animal models, leading to the prevailing view that microvascular development is disrupted in BPD. OBJECTIVE:To perform a comprehensive analysis of the early and la...

journal_title：American journal of respiratory and critical care medicine

authors： De Paepe ME,Mao Q,Powell J,Rubin SE,DeKoninck P,Appel N,Dixon M,Gundogan F

更新日期：2006-01-15 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：:Long-term effects of high doses of inhaled corticosteroids (ICS) on bone density and metabolism are still uncertain. Fifty-one patients (37 male, 14 female) using beclomethasone or budesonide at a daily dose > 800 microgram/d (high-dose group [Group HD] mean: 983 microgram/d [prescribed dose x estimated compliance]) o...

journal_title：American journal of respiratory and critical care medicine

authors： Boulet LP,Milot J,Gagnon L,Poubelle PE,Brown J

更新日期：1999-03-01 00:00:00

abstract：:Important features of both stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) are skeletal muscle weakness and wasting. Limb muscle dysfunction during an exacerbation has been linked to various adverse outcomes, including prolonged hospitalization, readmission, and mortality. The contributin...

journal_title：American journal of respiratory and critical care medicine

authors： Abdulai RM,Jensen TJ,Patel NR,Polkey MI,Jansson P,Celli BR,Rennard SI

更新日期：2018-02-15 00:00:00

abstract：RATIONALE:Patients with acute lung injury have impaired function of the lung surfactant system. Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation and have suggested that treatment of patients with severe d...

journal_title：American journal of respiratory and critical care medicine

authors： Spragg RG,Taut FJ,Lewis JF,Schenk P,Ruppert C,Dean N,Krell K,Karabinis A,Günther A

更新日期：2011-04-15 00:00:00

abstract：:The incidence of mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in children with intermediate sweat chloride levels is unknown. The results of 2,349 sweat tests performed at two Belgian university hospitals were reviewed. Intermediate chloride concentrations were observed in 98 subjec...

journal_title：American journal of respiratory and critical care medicine

authors： Lebecque P,Leal T,De Boeck C,Jaspers M,Cuppens H,Cassiman JJ

更新日期：2002-03-15 00:00:00

abstract：:Rapid and selective recruitment of neutrophils into the airspace in response to LPS facilitates the clearance of bacterial pathogens. However, neutrophil infiltration can also participate in the development and progression of environmental airway disease. Previous data have revealed that Toll-like receptor 4 (tlr4) is...

journal_title：American journal of respiratory and critical care medicine

authors： Hollingsworth JW,Chen BJ,Brass DM,Berman K,Gunn MD,Cook DN,Schwartz DA

更新日期：2005-04-15 00:00:00

abstract：:Little is known about the anti-asthmatic effects of powerful anti-inflammatory agents such as aspirin-like drugs. We compared the effects of two aspirin-like drugs with different pharmacologic activities, sodium salicylate (SSA) and indomethacin, with the effect of lysine acetylsalicylate (LASA), inhaled 30 min before...

journal_title：American journal of respiratory and critical care medicine

authors： Sestini P,Refini RM,Pieroni MG,Vaghi A,Robuschi M,Bianco S

更新日期：1999-04-01 00:00:00