Sleep-disordered breathing in African-American elderly.

abstract：:The present study was designed to examine whether clenbuterol (CLEN) could reduce dexamethasone (DEX)-induced diaphragm dysfunction. We studied four groups of New Zealand white (NZW) rabbits, each receiving one of the following daily injections subcutaneously for 2 wk: saline (control), DEX 3 mg/kg, DEX 3 mg/kg + CLEN...

journal_title：American journal of respiratory and critical care medicine

authors： Jiang TX,Cairns A,Road JD,Wilcox PG

更新日期：1996-12-01 00:00:00

abstract：:11beta-hydroxysteroid dehydrogenases (11beta-HSD) are responsible for the conversion of bioactive glucocorticoids to and from inactive metabolites. 11beta-HSD2 is generally considered a high-affinity inactivator of natural glucocorticoids, although its activity with synthetic compounds in vivo is unknown. Inhaled cort...

journal_title：American journal of respiratory and critical care medicine

authors： Orsida BE,Krozowski ZS,Walters EH

更新日期：2002-04-01 00:00:00

abstract：:Chronic beryllium disease (CBD) provides a model system in which to evaluate the antigen-stimulated, cell-mediated, immune response that leads to granulomatous lung disease. We hypothesized that beryllium salts would stimulate bronchoalveolar lavage (BAL) cell release of tumor necrosis factor-alpha (TNF-alpha) and lnt...

journal_title：American journal of respiratory and critical care medicine

authors： Tinkle SS,Newman LS

更新日期：1997-12-01 00:00:00

abstract：:Numerous in vitro and in vivo studies in both animals and patients with asthma have shown that interleukin (IL)-9 is an important inflammatory mediator in asthma. To examine the effects of IL-9 antagonism on airway inflammation, ovalbumin-sensitized BALB/c mice were intravenously given anti-IL-9 antibody or an isotype...

journal_title：American journal of respiratory and critical care medicine

authors： Cheng G,Arima M,Honda K,Hirata H,Eda F,Yoshida N,Fukushima F,Ishii Y,Fukuda T

更新日期：2002-08-01 00:00:00

abstract：:Most patients with cystic fibrosis (CF) are infected by Pseudomonas aeruginosa. Dextran exhibits anti-adhesive effects in preventing attachment of P. aeruginosa to epithelial cells (1). The initial purpose of this study was to evaluate the potential of dextran to alter the rheology and ciliary transportability of CF s...

journal_title：American journal of respiratory and critical care medicine

authors： Feng W,Garrett H,Speert DP,King M

更新日期：1998-03-01 00:00:00

abstract：:Pulmonary hypertension associated with congestive heart failure carries a risk of right ventricular failure after cardiac transplantation. Few data, however, are available on the hemodynamic behavior of the pulmonary circulation in these patients. We therefore studied mean pulmonary artery pressure minus left atrial p...

journal_title：American journal of respiratory and critical care medicine

authors： Naeije R,Lipski A,Abramowicz M,Lejeune P,Mélot C,Antoine M,De Smet JM,Leclerc JL,Primo G

更新日期：1994-04-01 00:00:00

abstract：RATIONALE:Tissue injury and repair involve highly conserved processes governed by mechanisms that can be co-opted in tumors. We hypothesized that soluble factors released during the repair response to lung injury would promote orthotopic tumor growth. OBJECTIVES:To determine whether lung injury promoted growth of orth...

journal_title：American journal of respiratory and critical care medicine

authors： Arenberg D,Luckhardt TR,Carskadon S,Zhao L,Amin MA,Koch AE

更新日期：2010-10-15 00:00:00

abstract：RATIONALE:Protein kinase C zeta (PKCζ) has been reported to act as a tumor suppressor. Deletion of PKCζ in experimental cancer models has been shown to increase tumor growth. However, the mechanisms of PKCζ down-regulation in cancerous cells have not been previously described. OBJECTIVES:To determine the molecular mec...

journal_title：American journal of respiratory and critical care medicine

authors： Queisser MA,Dada LA,Deiss-Yehiely N,Angulo M,Zhou G,Kouri FM,Knab LM,Liu J,Stegh AH,DeCamp MM,Budinger GR,Chandel NS,Ciechanover A,Iwai K,Sznajder JI

更新日期：2014-09-15 00:00:00

abstract：:Oral mandibular advancement devices are becoming an increasingly important treatment alternative for obstructive sleep apnea (OSA). The first aim of the study was to determine whether a new oral elastic mandibular advancement device (EMA) prevents pharyngeal airway closure during sleep in patients with OSA. The second...

journal_title：American journal of respiratory and critical care medicine

authors： Henke KG,Frantz DE,Kuna ST

更新日期：2000-02-01 00:00:00

abstract：RATIONALE:Pulmonary hypertension (PH) is a life-threatening disease, characterized by vascular remodeling and vasoconstriction. Evidence suggests that oxidative stress may contribute to the pathogenesis and/or development of PH. OBJECTIVES:In the present study, we examined whether intratracheal gene transfer of human ...

journal_title：American journal of respiratory and critical care medicine

authors： Kamezaki F,Tasaki H,Yamashita K,Tsutsui M,Koide S,Nakata S,Tanimoto A,Okazaki M,Sasaguri Y,Adachi T,Otsuji Y

更新日期：2008-01-15 00:00:00

abstract：:Bronchial hyperresponsiveness (BHR), the increased sensitivity to a wide variety of stimuli that narrow the airways, is a central abnormality in patients with asthma, and is frequently observed in patients with chronic obstructive pulmonary disease. In the study of the underlying mechanisms of BHR, various animal mode...

journal_title：American journal of respiratory and critical care medicine

authors： Rabe KF

更新日期：1998-11-01 00:00:00

abstract：:In 1976-1992 245 new cases of asthma induced by diisocyanates were diagnosed, caused by hexamethylene diisocyanate (HDI) in 39%, diphenylmethane diisocyanate (MDI) in 39%, and toluene diisocyanate (TDI) in 17% of the cases. Our aim was to study the clinical outcome of diisocyanate-induced asthma. A questionnaire was s...

journal_title：American journal of respiratory and critical care medicine

authors： Piirilä PL,Nordman H,Keskinen HM,Luukkonen R,Salo SP,Tuomi TO,Tuppurainen M

更新日期：2000-08-01 00:00:00

abstract：:The potential role of nitric oxide synthase-2 (NOS2) in acute lung injury (ALI) has gained increasing attention. This study evaluates the effects of hypoxia, an important feature of ALI, on NOS2 expression in a rat model of ALI caused by exposure to hypoxia and LPS. Exposure to hypoxia alone had no effect on the expre...

journal_title：American journal of respiratory and critical care medicine

authors： Agorreta J,Garayoa M,Montuenga LM,Zulueta JJ

更新日期：2003-08-01 00:00:00

abstract：:Leukotrienes have been implicated in the bronchoconstriction caused by indirect stimuli. In the present study we examined the effect of oral ABT-761, a novel 5-lipoxygenase (5-LO) inhibitor, on exercise- and adenosine (AMP)-induced bronchoconstriction in nine asthmatics. At the four 1-d, single-dose treatment periods,...

journal_title：American journal of respiratory and critical care medicine

authors： Van Schoor J,Joos GF,Kips JC,Drajesk JF,Carpentier PJ,Pauwels RA

更新日期：1997-03-01 00:00:00

abstract：:Sensitive measures of lung function applicable to young subjects are needed to detect early cystic fibrosis (CF) lung disease. Forty children with CF aged 2 to 5 years and 37 age-matched healthy control subjects performed multiple-breath inert gas washout, plethysmography, and spirometry. Thirty children in each group...

journal_title：American journal of respiratory and critical care medicine

authors： Aurora P,Bush A,Gustafsson P,Oliver C,Wallis C,Price J,Stroobant J,Carr S,Stocks J,London Cystic Fibrosis Collaboration.

更新日期：2005-02-01 00:00:00

abstract：:Background: This document provides evidence-based clinical practice guidelines on the management of adult patients with community-acquired pneumonia.Methods: A multidisciplinary panel conducted pragmatic systematic reviews of the relevant research and applied Grading of Recommendations, Assessment, Development, and Ev...

journal_title：American journal of respiratory and critical care medicine

authors： Metlay JP,Waterer GW,Long AC,Anzueto A,Brozek J,Crothers K,Cooley LA,Dean NC,Fine MJ,Flanders SA,Griffin MR,Metersky ML,Musher DM,Restrepo MI,Whitney CG

更新日期：2019-10-01 00:00:00

abstract：:A variety of substances including human meconium have been found to affect adversely the surface tension-lowering activity of pulmonary surfactants, and this effect may be important in the pathogenesis of a number of human diseases. To find whether inactivation of surfactant could be prevented or reduced by nonionic p...

journal_title：American journal of respiratory and critical care medicine

authors： William Taeusch H,Lu KW,Goerke J,Clements JA

更新日期：1999-05-01 00:00:00

abstract：:Noninvasive and invasive diagnostic techniques have been shown to achieve comparable performances in the evaluation of suspected ventilator-associated pneumonia (VAP). We studied the impact of both approaches on outcome in a prospective, open, and randomized study in three intensive care units (ICUs) of a 1,000-bed te...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Torres A,Ewig S,Marcos MA,Alcón A,Lledó R,Asenjo MA,Maldonaldo A

更新日期：2000-07-01 00:00:00

abstract：RATIONALE:Although intermittent, three-times-weekly therapy is recommended for the initial treatment of noncavitary nodular bronchiectatic Mycobacterium avium complex (MAC) lung disease, supporting data are limited. OBJECTIVES:To evaluate the clinical efficacy of intermittent therapy compared with daily therapy for no...

journal_title：American journal of respiratory and critical care medicine

authors： Jeong BH,Jeon K,Park HY,Kim SY,Lee KS,Huh HJ,Ki CS,Lee NY,Shin SJ,Daley CL,Koh WJ

更新日期：2015-01-01 00:00:00

abstract：RATIONALE:The American Thoracic Society/European Respiratory Society International Consensus Classification panel identified the clinical entity idiopathic nonspecific interstitial pneumonia (NSIP) as a provisional diagnosis and recommended further study. OBJECTIVES:We hypothesized that idiopathic NSIP is an autoimmun...

journal_title：American journal of respiratory and critical care medicine

authors： Kinder BW,Collard HR,Koth L,Daikh DI,Wolters PJ,Elicker B,Jones KD,King TE Jr

更新日期：2007-10-01 00:00:00

abstract：:The aim of the study was to determine risk factors for severe community-acquired pneumonia (CAP) as well as to compare microbial patterns of severe CAP to a previous study from our respiratory intensive care unit (ICU) originating from 1984 to 1987. Patients admitted to the ICU according to clinical judgment were defi...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Ewig S,Torres A,Arancibia F,Marco F,Mensa J,Sanchez M,Martinez JA

更新日期：1999-09-01 00:00:00

abstract：:Alveolar macrophages (AMs) are considered major effector cells in host defense against respiratory tract infections by virtue of their potent phagocytic properties. In addition, AMs may regulate the host inflammatory response to infection by production of cytokines and by their capacity to phagocytose apoptotic polymo...

journal_title：American journal of respiratory and critical care medicine

authors： Knapp S,Leemans JC,Florquin S,Branger J,Maris NA,Pater J,van Rooijen N,van der Poll T

更新日期：2003-01-15 00:00:00

abstract：:Erythromycin inhibits mucus glycoconjugate secretion from airway cells in vitro and may increase mucus clearance in patients with asthma or diffuse panbronchiolitis. Because mucus hypersecretion is common in purulent rhinitis, we questioned whether clarithromycin would change the properties of nasal mucus from subject...

journal_title：American journal of respiratory and critical care medicine

authors： Rubin BK,Druce H,Ramirez OE,Palmer R

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:The causal direction between asthma and lung function deficit is unknown, but important for the focus of preventive measures and research into the origins of asthma. OBJECTIVES:To analyze the interaction between lung function development and asthma from birth to 7 years of age. METHODS:The Copenhagen Prospe...

journal_title：American journal of respiratory and critical care medicine

authors： Bisgaard H,Jensen SM,Bønnelykke K

更新日期：2012-06-01 00:00:00

abstract：:The etiology of sleep disruption in patients in intensive care units (ICUs) is poorly understood, but is thought to be related to environmental stimuli, especially noise. We sampled 203 patients (121 males and 82 females) from different ICUs (cardiac [CCU], cardiac stepdown [CICU], medical [MICU], and surgical [SICU])...

journal_title：American journal of respiratory and critical care medicine

authors： Freedman NS,Kotzer N,Schwab RJ

更新日期：1999-04-01 00:00:00

abstract：:The objective of this study was to evaluate the effectiveness of an asthma education program on morbidity, knowledge, and compliance with inhaled corticosteroid treatment using a prospective, randomized, controlled, one-year-before/one-year-after protocol. After rigorous optimization of asthma therapy under the care o...

journal_title：American journal of respiratory and critical care medicine

authors： Coté J,Cartier A,Robichaud P,Boutin H,Malo JL,Rouleau M,Fillion A,Lavallée M,Krusky M,Boulet LP

更新日期：1997-05-01 00:00:00

abstract：:A group of male amateur cyclists was studied in the summer of 1991 in the east of the Netherlands. Lung function was measured before and after training sessions or competitive races on a number of occasions. Continuous heart rate monitors were employed to document exercise levels. Heart rate averaged 161 beats/min dur...

journal_title：American journal of respiratory and critical care medicine

authors： Brunekreef B,Hoek G,Breugelmans O,Leentvaar M

更新日期：1994-10-01 00:00:00

abstract：RATIONALE:In cigarette smoking-induced chronic obstructive pulmonary disease, structural and functional derangements are characterized by parenchymal destruction and pulmonary hypertension. Statins are 3-hydroxy-3-methyl-glutaryl-coenzyme-A reductase inhibitors that have been used as lipid-lowering agents. These drugs ...

journal_title：American journal of respiratory and critical care medicine

authors： Lee JH,Lee DS,Kim EK,Choe KH,Oh YM,Shim TS,Kim SE,Lee YS,Lee SD

更新日期：2005-10-15 00:00:00

abstract：RATIONALE:Reactivation tuberculosis (TB) occurs as a result of reactivation of latent TB infection (LTBI), and was reported to occur in the United States at a rate of 0.10 to 0.16 cases per 100 person-years in the 1950s; it has not been measured since. OBJECTIVES:To calculate the rate of reactivation TB in a U.S. comm...

journal_title：American journal of respiratory and critical care medicine

authors： Horsburgh CR Jr,O'Donnell M,Chamblee S,Moreland JL,Johnson J,Marsh BJ,Narita M,Johnson LS,von Reyn CF

更新日期：2010-08-01 00:00:00

abstract：:Studies of the hemodynamic effects of nasal continuous positive airway pressure (n-CPAP) in normal subjects have had conflicting results. The largest study (n = 19) found no effect of up to 15 cm H2O on heart rate (HR), cardiac stroke volume (SV), or cardiac index. We hypothesized that n-CPAP, by increasing intrathora...

journal_title：American journal of respiratory and critical care medicine

authors： Montner PK,Greene ER,Murata GH,Stark DM,Timms M,Chick TW

更新日期：1994-06-01 00:00:00