Cardiopulmonary effects of aerosolized prostaglandin E1 and nitric oxide inhalation in patients with acute respiratory distress syndrome.

abstract：:Obstructive sleep apnea (OSA) is traditionally diagnosed using overnight polysomnography. Decision rules may provide an alternative to polysomnography. A consecutive series of patients referred to a tertiary sleep center underwent prospective evaluation with the upper airway physical examination protocol, followed by ...

journal_title：American journal of respiratory and critical care medicine

authors： Tsai WH,Remmers JE,Brant R,Flemons WW,Davies J,Macarthur C

更新日期：2003-05-15 00:00:00

abstract：:Although airway inflammation is recognized as a key feature of asthma, the characteristics of airway inflammation in children with acute severe asthma are not well defined. The aim of this study was to describe the characteristics of airway inflammation in children with an acute exacerbation of asthma using sputum cel...

journal_title：American journal of respiratory and critical care medicine

authors： Norzila MZ,Fakes K,Henry RL,Simpson J,Gibson PG

更新日期：2000-03-01 00:00:00

abstract：:Respiratory system compliance (Crs) in infants with cystic fibrosis (CF) has been reported as decreased or not different compared with healthy control subjects; however, the reported measurements of Crs were "quasi-static" or by the single-breath occlusion technique, with all measurements limited to tidal lung volume,...

journal_title：American journal of respiratory and critical care medicine

authors： Tepper RS,Weist A,Williams-Nkomo T,Kisling J

更新日期：2004-09-01 00:00:00

abstract：:Neutrophil adherence to tumor necrosis factor-alpha (TNF-alpha)-treated human pulmonary microvascular endothelial cells (PMECs) induces cytoskeletal changes in endothelial cells that require intercellular adhesion molecule-1 (ICAM-1)-dependent signaling events. This study determined whether similar changes occurred in...

journal_title：American journal of respiratory and critical care medicine

authors： Wang Q,Pfeiffer GR 2nd,Stevens T,Doerschuk CM

更新日期：2002-09-15 00:00:00

abstract：RATIONALE:Patients of Hispanic origin with cystic fibrosis (CF) are the largest growing minority, representing 8.5% of patients with CF in the United States. No national survival analysis of this group has ever been undertaken. OBJECTIVES:We aimed to determine whether Hispanic ethnicity within the CF population is ass...

journal_title：American journal of respiratory and critical care medicine

authors： Rho J,Ahn C,Gao A,Sawicki GS,Keller A,Jain R

更新日期：2018-10-15 00:00:00

abstract：:Rationale: Limited information is available on racial/ethnic differences in pulmonary arterial hypertension (PAH).Objectives: Determine effects of race/ethnicity and ancestry on mortality and disease outcomes in diverse patients with PAH.Methods: Patients with Group 1 PAH were included from two national registries wit...

journal_title：American journal of respiratory and critical care medicine

authors： Karnes JH,Wiener HW,Schwantes-An TH,Natarajan B,Sweatt AJ,Chaturvedi A,Arora A,Batai K,Nair V,Steiner HE,Giles JB,Yu J,Hosseini M,Pauciulo MW,Lutz KA,Coleman AW,Feldman J,Vanderpool R,Tang H,Garcia JGN,Yuan JX,K

更新日期：2020-06-01 00:00:00

abstract：RATIONALE:Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. OBJECTIVES:We defined the burden of life-threatening (O(2) saturation [O(2) sat] ≤ ...

journal_title：American journal of respiratory and critical care medicine

authors： Ferolla FM,Hijano DR,Acosta PL,Rodríguez A,Dueñas K,Sancilio A,Barboza E,Caría A,Gago GF,Almeida RE,Castro L,Pozzolo C,Martínez MV,Grimaldi LA,Rebec B,Calvo M,Henrichsen J,Nocito C,González M,Barbero G,Losada JV,

更新日期：2013-05-01 00:00:00

abstract：:We aimed to elucidate the relationships between pleural (Ppl), esophageal (Pes), and superimposed gravitational pressures in acute lung injury, and to understand the mechanisms of recruitment and derecruitment. In six dogs with oleic acid respiratory failure, we measured Pes and Ppl in the uppermost, middle, and most ...

journal_title：American journal of respiratory and critical care medicine

authors： Pelosi P,Goldner M,McKibben A,Adams A,Eccher G,Caironi P,Losappio S,Gattinoni L,Marini JJ

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVES:To assess the reliability and the minimal clinically important differences (MCID) for FVC% predicted in the Scleroderma Lung Study I and II. METHODS:Using data from SLS I and II (N=300), we evaluated the test-retest reliability for FVC% predicted (FVC%; screening vs. baseline) using intra-class correlation ...

journal_title：American journal of respiratory and critical care medicine

authors： Kafaja S,Clements PJ,Wilhalme H,Tseng CH,Furst DE,Kim GH,Goldin J,Volkmann ER,Roth MD,Tashkin DP,Khanna D

更新日期：2018-03-01 00:00:00

abstract：RATIONALE:Exploring prenatal factors influencing childhood wheeze may inform programming mechanisms. OBJECTIVES:We examined associations among prenatal maternal cortisol profiles, maternal obesity, and repeated wheeze up to age 2 years (n = 261). METHODS:Salivary cortisol was collected five times per day over 3 days ...

journal_title：American journal of respiratory and critical care medicine

authors： Wright RJ,Fisher K,Chiu YH,Wright RO,Fein R,Cohen S,Coull BA

更新日期：2013-06-01 00:00:00

abstract：:We derived reference values for slow vital capacity (VC) and flow-volume curve indexes (FVC, FEV(1), and flows) from the 1,185 tracings provided by 1,039 "normal" subjects who participated in one or both cross-sectional surveys of the Po River Delta study in 1980-1982 and in 1988-1991. Definition of "normal" was based...

journal_title：American journal of respiratory and critical care medicine

authors： Pistelli F,Bottai M,Viegi G,Di Pede F,Carrozzi L,Baldacci S,Pedreschi M,Giuntini C

更新日期：2000-03-01 00:00:00

abstract：RATIONALE:Dysregulation of cellular metabolism has been shown to participate in several pathologic processes. However, the role of metabolic reprogramming is not well appreciated in the pathogenesis of organ fibrosis. OBJECTIVES:To determine if glycolytic reprogramming participates in the pathogenesis of lung fibrosis...

journal_title：American journal of respiratory and critical care medicine

authors： Xie N,Tan Z,Banerjee S,Cui H,Ge J,Liu RM,Bernard K,Thannickal VJ,Liu G

更新日期：2015-12-15 00:00:00

abstract：:Vitamin D receptor (VDR) polymorphisms have been associated with several immune-related diseases, and VDR and vitamin D itself modulate T cell differentiation. VDR maps to chromosome 12q, near a region commonly linked to asthma. We evaluated VDR as part of a 12q positional candidate survey, and in response to observat...

journal_title：American journal of respiratory and critical care medicine

authors： Raby BA,Lazarus R,Silverman EK,Lake S,Lange C,Wjst M,Weiss ST

更新日期：2004-11-15 00:00:00

abstract：:Airway smooth muscle (ASM) accumulation and enrichment of the extracellular matrix (ECM) with type I collagen and fibronectin are major pathologic features of airway remodeling in asthma. These ECM components confer enhanced ASM proliferation in vitro, but a requirement for specific integrin ECM receptors has not been...

journal_title：American journal of respiratory and critical care medicine

authors： Nguyen TT,Ward JP,Hirst SJ

更新日期：2005-02-01 00:00:00

abstract：:Allergen-induced bronchoconstriction involves mast cell activation. Tryptase is a mast cell serine protease that is released during this process, but little is known about the action of tryptase in the airway. The purpose of this study was to determine: (1) if aerosolized tryptase causes bronchoconstriction, and (2) t...

journal_title：American journal of respiratory and critical care medicine

authors： Molinari JF,Scuri M,Moore WR,Clark J,Tanaka R,Abraham WM

更新日期：1996-09-01 00:00:00

abstract：:In anaphylactic shock (AS), the relative effects of the autacoids including histamine, prostaglandins, and leukotrienes on causing cardiovascular collapse and the extent to which receptor blocking agents and pathway inhibitors may prevent this collapse are not clear. In a ragweed model of anaphylaxis, we examined whet...

journal_title：American journal of respiratory and critical care medicine

authors： Chrusch C,Sharma S,Unruh H,Bautista E,Duke K,Becker A,Kepron W,Mink SN

更新日期：1999-10-01 00:00:00

abstract：:The factors that lead to increased production of specific IgG subclasses are still largely unknown. Recent studies suggest that increased IgG4 responses may be related to prolonged antigen exposure. We present data showing that increased IgG4 responses are found under conditions of chronic exposure to Aspergillus fumi...

journal_title：American journal of respiratory and critical care medicine

authors： Tomee JF,Dubois AE,Koëter GH,Beaumont F,van der Werf TS,Kauffman HF

更新日期：1996-06-01 00:00:00

abstract：RATIONALE:Asthma is a chronic inflammatory airway disease that affects more than 300 million individuals worldwide. Asthma is caused by interaction of genetic and environmental factors. Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and results from increased sensitivity of the airways to physical or chemi...

journal_title：American journal of respiratory and critical care medicine

authors： Koppelman GH,Meyers DA,Howard TD,Zheng SL,Hawkins GA,Ampleford EJ,Xu J,Koning H,Bruinenberg M,Nolte IM,van Diemen CC,Boezen HM,Timens W,Whittaker PA,Stine OC,Barton SJ,Holloway JW,Holgate ST,Graves PE,Martinez FD,

更新日期：2009-11-15 00:00:00

abstract：:We have tested two surfactant preparations with the same phospholipid (PL) composition, containing recombinant surfactant protein-C (rSP-C surfactant) and without SP-C (plain PL surfactant). The effects of rSP-C surfactant were compared with the bovine-derived surfactant preparations Alveofact, bLES, and Infasurf in a...

journal_title：American journal of respiratory and critical care medicine

authors： Häfner D,Germann PG,Hauschke D

更新日期：1998-07-01 00:00:00

abstract：:We investigated the source of intravascular fat in systemic organs (brain, heart, and kidney) after massive pulmonary fat embolism during cemented arthroplasty. We used a bilateral cemented arthroplasty (BCA) in anesthetized mongrel dogs that simulates a cemented total-hip replacement procedure. We hypothesized that d...

journal_title：American journal of respiratory and critical care medicine

authors： Byrick RJ,Mullen JB,Mazer CD,Guest CB

更新日期：1994-11-01 00:00:00

abstract：:The involvement of platelet-activating factor (PAF) in bronchial hyperresponsiveness (BHR) in bronchial asthma has been controversial. To determine whether PAF is involved in BHR in humans, we carried out a randomized, double-blind, placebo-controlled, two-phase cross-over study on the effects of Y-24180, a potent, sp...

journal_title：American journal of respiratory and critical care medicine

authors： Hozawa S,Haruta Y,Ishioka S,Yamakido M

更新日期：1995-10-01 00:00:00

abstract：:Rationale: Tidal expiratory flow limitation (tidal-EFL) is not completely avoidable by applying positive end-expiratory pressure and may cause respiratory and hemodynamic complications in ventilated patients with lungs prone to collapse. During spontaneous breathing, expiratory diaphragmatic contraction counteracts ti...

journal_title：American journal of respiratory and critical care medicine

authors： Pellegrini M,Gudmundsson M,Bencze R,Segelsjö M,Freden F,Rylander C,Hedenstierna G,Larsson AS,Perchiazzi G

更新日期：2020-05-15 00:00:00

abstract：:Nitric oxide (NO) produced in the airways can be either detrimental or protective to the host. To investigate the role of NO in the pathogenesis of exercise-induced bronchoconstriction (EIB), we measured exhaled NO (ENO) after exercise challenge in 39 asthmatic and six normal children. FEV(1) and ENO were measured bef...

journal_title：American journal of respiratory and critical care medicine

authors： Terada A,Fujisawa T,Togashi K,Miyazaki T,Katsumata H,Atsuta J,Iguchi K,Kamiya H,Togari H

更新日期：2001-11-15 00:00:00

abstract：:Studies of the hemodynamic effects of nasal continuous positive airway pressure (n-CPAP) in normal subjects have had conflicting results. The largest study (n = 19) found no effect of up to 15 cm H2O on heart rate (HR), cardiac stroke volume (SV), or cardiac index. We hypothesized that n-CPAP, by increasing intrathora...

journal_title：American journal of respiratory and critical care medicine

authors： Montner PK,Greene ER,Murata GH,Stark DM,Timms M,Chick TW

更新日期：1994-06-01 00:00:00

abstract：RATIONALE:End-tidal CO2 (EtCO2) is used to monitor cardiopulmonary resuscitation (CPR), but it can be affected by intrathoracic airway closure. Chest compressions induce oscillations in expired CO2, and this could reflect variable degrees of airway patency. OBJECTIVES:To understand the impact of airway closure during ...

journal_title：American journal of respiratory and critical care medicine

authors： Grieco DL,J Brochard L,Drouet A,Telias I,Delisle S,Bronchti G,Ricard C,Rigollot M,Badat B,Ouellet P,Charbonney E,Mancebo J,Mercat A,Savary D,Richard JM

更新日期：2019-03-15 00:00:00

abstract：:Stenotrophomonas maltophilia is a gram-negative bacterium that has been cultured with increasing prevalence from the sputum of patients with cystic fibrosis (CF). We conducted a cohort study, using the Cystic Fibrosis Foundation Registry, to assess the effect of S. maltophilia on survival. We studied all patients in t...

journal_title：American journal of respiratory and critical care medicine

authors： Goss CH,Otto K,Aitken ML,Rubenfeld GD

更新日期：2002-08-01 00:00:00

abstract：:Genetic factors are likely to contribute to the variable presentation of community-acquired pneumonia (CAP). The purpose of this prospective cohort study was to determine whether the LTalpha+250 (TNFbeta+250) and TNFalpha-308 gene polymorphisms are associated with different presentations of CAP. Septic shock (SS) was ...

journal_title：American journal of respiratory and critical care medicine

authors： Waterer GW,Quasney MW,Cantor RM,Wunderink RG

更新日期：2001-06-01 00:00:00

abstract：:Although the incidence of pulmonary hypertension is higher in female patients, numerous experimental studies have demonstrated better outcome in female animals, exacerbation of the disease after ovariectomy, and a strong protective effect of estrogen: a phenomenon known as the "estrogen paradox" of pulmonary hypertens...

journal_title：American journal of respiratory and critical care medicine

authors： Umar S,Rabinovitch M,Eghbali M

更新日期：2012-07-15 00:00:00

abstract：UNLABELLED:Although local tissue activation of the endothelin (ET) system contributes to the development of pulmonary hypertension, the impact of isolated chronic plasma hyperendothelinemia on the pulmonary circulation is unknown. METHODS:Mini-osmotic pumps were implanted in rats to deliver ET-1 during 7 or 28 days. A...

journal_title：American journal of respiratory and critical care medicine

authors： Migneault A,Sauvageau S,Villeneuve L,Thorin E,Fournier A,Leblanc N,Dupuis J

更新日期：2005-03-01 00:00:00

abstract：:Asthma in children and young adults is strongly associated with immediate hypersensitivity to indoor allergens, notably those derived from the house dust mite. In addition, outdoor air pollution is considered to aggravate existing asthma. We investigated the prevalence of asthma and the pattern of allergen sensitizati...

journal_title：American journal of respiratory and critical care medicine

authors： Sporik R,Ingram JM,Price W,Sussman JH,Honsinger RW,Platts-Mills TA

更新日期：1995-05-01 00:00:00